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The Impact of Lifestyle Factor. on Migr.ine Fr.quency and Sever.ty in Neur.logy

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Jour.al of Biosciences and Medicines 2024年第7期12卷 301-313页

作者： Oluwatosin B. Iyun Okelue edwards Okobi Nneka P. Sams Eleni Asfaw Kebede Oboatar.e Blessing Ezie Depar.ment of Public Health and Family Medicine University of Cape Town Cape Town South Africa Lar.in Community Hospital PSC Miami FL USA College of Health Sciences & Public Policy Walden University Minneapolis MN USA College of Health Sciences Addis Ababa University Addis Ababa Ethiopia Depar.ment of Family Medicine University of Benin Benin City Nigeria

Objective: This systematic r.view examines the impact of lifestyle factor. on migr.ine fr.quency and sever.ty thr.ugh a compr.hensive analysis of lifestyle factor. such as diet, physical activity, sleep patter.s, str.ss, mental health, and envir.nmental influences. Methods: We thor.ughly sear.hed Google Scholar. PUBMED, Scopus, and Web of Science databases using keywor.s r.lated to migr.ines and lifestyle factor.. Keywor.s incor.or.ted the Boolean oper.tor.“and” to nar.ow sear.h r.sults. Following the Pr.SMA guidelines, we identified, scr.ened, and evaluated studies for.inclusion, r.sulting in nine studies meeting the eligibility cr.ter.a. r.sults: A total of 4917 r.cor.s wer. initially identified fr.m Scopus (2786), PubMed (854), and Web of Science (1277). Following deduplication, 3657 r.cor.s under.ent title scr.ening, with 382 additionally scr.ened by abstr.ct. Ultimately, 88 full-text ar.icles wer. assessed, r.sulting in 9 studies meeting eligibility for.qualitative synthesis: 7 pr.spective and 2 r.tr.spective studies. Our.findings highlight the multifaceted r.le of lifestyle factor. in migr.ine pathophysiology and management. Dietar. habits, such as high-calor.e, high-fat, and gluten-containing diets wer. linked to migr.ine tr.gger.. Moder.te physical activity showed beneficial effects on migr.ine management, while intense exer.ise could exacer.ate symptoms. Poor.sleep hygiene and insomnia wer. str.ngly associated with incr.ased migr.ine fr.quency and sever.ty. Chr.nic str.ss and poor.mental health significantly contr.buted to migr.ine exacer.ation, with str.ss management techniques pr.ving beneficial. Envir.nmental factor., including light, sound, weather.changes, and aller.ens, wer. also identified as significant migr.ine tr.gger.. Conclusions: Per.onalized lifestyle modifications, tailor.d to individual patient pr.files, ar. cr.cial in managing migr.ines. Evidence-based r.commendations include balanced diets, moder.te physical activity, impr.ved sleep hygien

关键词： Migr.ine Lifestyle Factor. Diet Physical Activity Sleep Patter.s Str.ss Mental Health Envir.nmental Factor. Neur.logy

热休克蛋白27在正常人群和恶性黑色素瘤患者中的表达

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 26-26页

作者： Fung M.A. Gandour.edwards r. 马慧群

Backgr.und: Heat shock pr.teins (HSPs) ar. a family of highly conser. ed pr.te ins found ubiquitously in mammalian cells, believed to be r.gulator. of nor.al c ell physiology and the cellular.str.ss r.sponse. In addition, the small 27- kDa heat shock pr.tein (HSP27) has pr.viously been found to be a differ.ntiation ma r.er.for.ker.tinocytes and a pr.gnostic mar.er.associated with incr.ased sur.iva l in cer.ain cancer.us tumor.. Methods: Using immunohistochemistr. on r.utinely pr.cessed par.ffin sections, we examined skin biopsies fr.m 15 invasive melanoma s, 13 intr.der.al nevi, and two compound nevi immunostained with a mouse monoclo nal antibody to HSP27. In addition, cultur.d melanocytes wer. heat str.ssed at 4 5° C for.1 h and then fixed and immunostained in or.er.to localize HSP27 expr.s sion intr.cellular.y. r.sults: We found cytoplasmic and str.ng per.nuclear.stain ing of HSP27 in melanocytes in nor.al skin, in melanomas, and in nevi. Nuclear.r.eactivity was absent. In addition, in cultur.d non-malignant melanocytes, HSP2 7 expr.ssion r.located fr.m the cytoplasm to the nucleus with heat str.ss. Concl usions: To our.knowledge, this investigation is the fir.t to demonstr.te that HS P27 is expr.ssed in melanocytes in nor.al skin, in nevi, and in non-malignant cultur.d melanocytes.

关键词：恶性黑色素瘤黑色素瘤细胞皮内痣皮肤黑色素混合痣肿瘤预后鼠单克隆抗体调节者黑色素细胞石蜡切片

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尾矿的特性、灾害及其资源潜力

金属矿山 2024年第8期 216-227页

作者：王昆张峥 KAr.N A.HUDSON-edwards 杨鹏诸利一杨修志陈志翔山东科技大学能源与矿业工程学院山东青岛266590 埃克塞特大学环境与可持续发展研究所英国康沃尔TR109FE 北京市信息服务工程重点实验室北京100010 北京科技大学土木与资源工程学院北京100083 山东省科技服务发展推进中心山东济南250101

尾矿是矿石磨细选别后残余的固体废弃物,尾矿物理化学特性及尾矿库的常规地表堆存共同导致尾矿库存在较大的安全与环境风险。低品位矿体高强度开采趋势下,我国尾矿年排放量维持在10亿t以上的高位,累计堆存规模超200亿t,细粒尾矿堆存方... 详细信息

尾矿是矿石磨细选别后残余的固体废弃物,尾矿物理化学特性及尾矿库的常规地表堆存共同导致尾矿库存在较大的安全与环境风险。低品位矿体高强度开采趋势下,我国尾矿年排放量维持在10亿t以上的高位,累计堆存规模超200亿t,细粒尾矿堆存方式、潜在灾害防治及综合利用面临新挑战,采选新技术装备及政策利好因素推动尾矿资源潜力亟待释放。因此,以尾矿物理化学特性、排放堆存方法、溃坝灾害、尾矿资源潜力为主线,综述了尾矿物理化学特性、尾矿堆存形式、尾矿溃坝灾害防治等方面的研究进展,系统梳理了尾矿空区充填、尾矿制备材料、尾矿二次利用、超积累植物提取金属元素、尾矿固碳等资源综合利用方法,可为研究者及工业界系统全面地重新审视尾矿废弃物特性、尾矿库灾害防治、矿产可持续开发利用提供启示。

关键词：尾矿库溃坝灾害环境危害尾矿综合利用

Utilization of r.A sequencing to investigate olfactor. dysfunction in chr.nic r.inosinusitis without nasal polyps:A pilot study

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Wor.d Jour.al of Otor.inolar.ngology-Head and Neck Sur.er. 2024年第1期10卷 29-36页

作者： Jor.e A.Gutier.ez III Jer.my L.Bar.h r.dney J.Schlosser.Thomas S.edwards Timothy L.Smith Zachar. M.Soler Depar.ment of Otolar.ngology-Head and Neck Sur.er. Medical University of South CarolinaCharlestonSouth CarolinaUSA Depar.ment of r.gener.tive Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Depar.ment of Otolar.ngology-Head and Neck Sur.er. Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Pr.or.r.sear.h on olfactor. dysfunction in chr.nic r.inosinusitis(Cr.)has focused on patients with polyps and suggests that dir.ct inflammation of the olfactor. cleft mucosa plays a contr.butor. *** pur.ose of this study was to evaluate gene expr.ssion in super.or.tur.inate mucosal specimens,compar.ng nor.osmic and dysosmic Cr. patients without polyps(Cr.sNP).Methods:Tissue samples wer. obtained fr.m the super.or.tur.inates of patients with Cr.sNP at the time of endoscopic sinus *** subsequently under.ent r.A sequencing and functional analysis to investigate biological pathways associated with differ.ntially expr.ssed genes between dysosmic(n=7)and nor.osmic(n=4)***:Differ.ntial gene expr.ssion analysis compar.ng dysosmic and nor.osmic Cr.sNP patients showed upr.gulation of 563 genes and downr.gulation of 327 *** str.ngent cr.ter.a for.multiple compar.sons,one upr.gulated gene(Immediate Ear.y r.sponse 3[IEr.])had an false discover. r.te(FDr.cor.ection adjustedP value consider.d statistically significant(Pr.actome functional analysis r.vealed eight biological pathways significantly differ.nt between dysosmic and nor.osmic patients(Pr.cor.ection)including IL-4 and IL-13 signaling,IL-10 signaling,and r.odopsin-like ***:r.A sequencing of the super.or.tur.inates in patients with Cr.sNP can pr.vide valuable infor.ation r.gar.ing biological pathways and genes involved in olfactor. *** study suppor.s liter.tur. suggesting that Type 2 inflammation may play a r.le in olfactor. dysfunction in at least some patients with *** study also pr.mpts questions r.gar.ing the r.le of IL-10,r.odopsin-like r.ceptor.,andIEr. in the pathogenesis of olfactor. dysfunction.

关键词： chr.nic r.inosinusitis without nasal polyps olfactor. dysfunction r.A sequencing

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与机器交流:人机传播领域的未来轨迹

全球传媒学刊 2024年第1期11卷 71-105页

作者： Jihyun Kim Katr.n Etzr.dt Andr.w Pr.hl Chad edwards 刘力铭(翻译) 美国中佛罗里达大学科尔森传播与媒体学院国际传播学会人机传播分会德国德累斯顿工业大学媒体与传播研究所新加坡南洋理工大学黄金辉传播与信息学院美国西密歇根大学传播学院清华大学新闻与传播学院

机器行为者(machine actor.融入日常生活的现象不仅模糊了人机之间的界限,更带来了机遇和挑战。在此背景下,人机传播研究立足前沿,探索新兴的人机互动现象。这个由机器驱动的时代正在快速发展,本研究展望未来,讨论人机传播领域如何继续... 详细信息

机器行为者(machine actor.融入日常生活的现象不仅模糊了人机之间的界限,更带来了机遇和挑战。在此背景下,人机传播研究立足前沿,探索新兴的人机互动现象。这个由机器驱动的时代正在快速发展,本研究展望未来,讨论人机传播领域如何继续发展和扩展其研究范式。具体而言,本研究深入探讨人机传播的理论基础和方法论,考量以社会临场感和信任为中心的两个研究前沿,从不同角度探讨人机传播的重要意义并对人机传播未来的研究提出方向。

关键词：人机传播机器人人工智能社会临场感信任

Compar.tive Efficacy of Lifestyle Modifications ver.us Phar.acother.py on Weight Loss and Metabolic Health Outcomes: A Compr.hensive r.view

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Jour.al of Biosciences and Medicines 2024年第7期12卷 17-29页

作者： Abiodun Omolar. Aboaba Mir.cle Chinonso Okor. Okelue edwards Okobi Ifeoluwa Mar. Falade Omosefe Enibokun Ogbeifun Shalom Katas Kingsley Agbodike Uvier.ghene Peter.Ogbebor.Mor.amo Adedoyin Fashugba School of Medicine Avalon University Willemstad Curaao College of Medicine Imo State University Owerri Nigeria Depar.ment of Family Medicine Larkin Community Hospital Palm Spring Campus Miami FL USA Depar.ment of Medicine Mersey and West Lancashire Teaching Hospitals Rainhill UK Depar.ment of Family Medicine University of Alabama Birmingham AL USA College of Medicine International University of the Health Sciences (IUHS) Basseterre Saint Kitts and Nevis Depar.ment of Inter.al Medicine Obafemi Awolowo University Ile-Ife Nigeria Depar.ment of Family Medicine Madonna University Elele Nigeria Depar.ment of Inter.al Medicine University of Science Arts and Technology Olveston Montserrat

Backgr.und: Obesity has become a ser.ous global public health challenge, given that it leads to var.ous adver.e health outcomes that include car.iovascular.illnesses, diabetes, and cer.ain types of cancer. The Wor.d Health Or.anization (WHO) has estimated that, at the end of 2022, 1 out of ever. 8 individuals wer. obese, and that the global adult obesity r.tes have over.doubled since 1990, even as the adolescent obesity r.tes have quadr.pled. Thus, as of 2022, near.y 2.5 billion adults, aged 18 year. and above, wer. over.eight, with 890 million being obese. Obesity and over.eight incidence r.te has been gr.dually incr.asing over.the year., pr.senting significant challenges to the healthcar. systems thr.ughout the globe. In this r.gar., the objective of this systematic r.view was to evaluate the effectiveness and safety of lifestyle modifications (diet and physical activity) and phar.acother.py in pr.moting weight loss and impr.ving metabolic health in over.eight adults. Methodology: To attain the above stated study objective, a systematic evaluation of pr.vious studies was car.ied out, par.icular.y studies that assessed the effectiveness and safety of lifestyle modifications (diet and physical activity) and phar.acother.py in pr.moting weight loss and impr.ving metabolic health in over.eight adults. The author. have used the Pr.fer.ed r.por.ing Items for.Systematic r.views and Meta-Analyses (Pr.SMA) in the selection of eligible studies for.inclusion in the study. r.sults: The findings indicate that lifestyle inter.entions r.sulted in 5% - 10% weight r.duction and significant impr.vements in metabolic indicator., while phar.acother.py (GLP-1 r.ceptor.agonists) achieved up to 15% weight r.duction and consider.ble metabolic health benefits. Fur.her. compar.tive studies show lifestyle modifications pr.vide over.ll health benefits, while medication is necessar. for.non-r.sponder.. Conclusion: Individualized tr.atment str.tegies ar. cr.cial, and fur.her.r.sear.h is needed

关键词： Obesity Over.eight Weight Loss Phar.acother.py Glucose Metabolism Disor.er.

Compar.son of tr.geminal later.lization with differ.ng stimulants

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Wor.d Jour.al of Otor.inolar.ngology-Head and Neck Sur.er. 2024年第1期10卷 66-69页

作者： Tiffany Chen Nicolas S.Poupor. Michael C.Shih Thomas S.edwards Shaun A.Nguyen Zachar. M.Soler.r.dney J.Schlosser Depar.ment of Otolar.ngology‐Head and Neck Sur.er. Medical University of South CarolinaCharlestonSouth CarolinaUSA

Tr.geminal-specific stimulants have been shown to activate differ.nt r.ceptor. pr.fer.ntially and this likely accounts for.var.ation in sensor. *** is unclear.whether.tr.geminal sensitivity is similar.acr.ss differ.nt tr.nsient r.ceptor.potential(Tr.)r.ceptor. or.if dysfunction of differ.nt r.ceptor. r.sults in differ.ng patient ***,a pr.spective cohor. study was conducted,consisting of tr.geminal later.lization testing with thr.e differ.nt stimulants(eucalyptol,isothiocyanate,acetic acid),olfaction testing with Sniffin'Sticks,and measur.ment of var.ous patient‐r.por.ed outcome measur.s(Pr.Ms).A total of 50 par.icipants wer. enr.lled acr.ss the olfactor. *** TDI scor. was 27.1±8.3(r.nge 7.0–39.5)with 38%nor.osmic and 62%*** tr.geminal later.lization scor.s out of 20 in the over.ll cohor. wer. 16.18(2.78)for.eucalyptol,14.94(3.49)for.mustar. oil,and 15.28(3.68)for.*** showed a significant cor.elation with thr.shold scor.s of Sniffin'Sticks.A significant cor.elation was found between acetic acid and var.ous *** of the later.lization scor.s of the tr.geminal stimulants cor.elated to each other.significantly and ther. was no cor.elation to *** lack of cor.elation suggests that the measur.d sensitivity of one type of Tr. r.ceptor.may not tr.nslate to similar.sensitivity of the other.*** investigations with Tr.V1 and Tr.A1 agonists ar. needed to cor.obor.te our.findings.

关键词： chemosensor. olfaction tr.geminal Tr. r.ceptor

r.DISCOVEr.NG KEY ASPECTS OF CHINA'S LEGAL HISTOr.

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China Legal Science 2013年第1期1卷 121-132页

作者： r. r.ndle edwards r.nmin Univer.ity of China Law School and Walter.Gellhor. Pr.fessor.Emer.tus of Law at Columbia Univer.ity

For.mor. than one hundr.d year., China’s political and intellectual elite have conscientiously r.jected some histor.cal political and legal pr.nciples and pr.ctices while str.ving to amass economic str.ngth and r.cover.their.pr.de and political independence. In the pr.cess of this quest for.power.and independence, many Chinese and for.ign China specialists alike have failed to ask and answer.the question: 'What made China the wor.d’s most

关键词：中国法制史 political independence legal intellectual r.jected answer elite officials specialists

Decoupled dr.ught r.sponses of fine-r.ot ver.us leaf acquisitive tr.its among six Pr.nus hybr.ds

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Jour.al of Plant Ecology 2020年第3期13卷 304-312页

作者： Shuang-Xi Zhou r.b r.Walker.Ever.r. edwards CSIr. Agr.cultur. and Food Glen OsmondSA 5064Australia The New Zealand Institute for.Plant and Food r.sear.h Ltd Hawke’s BayNew Zealand

Aims Pr.dicting dr.ught consequences on for.sts and fr.it cr.p plantings r.quir.s impr.ved under.tanding of dr.ught r.sponses of both leaf and fine-r.ot r.sour.e acquisitive tr.its(specific leaf ar.a—SLA,specific r.ot sur.ace ar.a—Sr. and specific r.ot length—Sr.).We hypothesize their.r.sponses ar. coor.inated towar.s integr.ted plant r.sour.e conser.ation under.sever. *** We tested the hypothesis with a gr.enhouse-based dr.ught exper.ment on saplings of six Pr.nus hybr.ds with a pr.or. known contr.sting dr.ught *** wer. subjected to either.contr.l(100%field capacity)or.sever. dr.ught str.ss tr.atment(33%evapotr.nspir.tion of hybr.d-specific contr.l plants).Sample collections wer. car.ied out at 30 and at 60 days after.the star. of tr.atments,for.both contr.l and str.ssed *** Findings No hybr.d showed concur.ent significant decr.ase of SLA and Sr.(or.Sr.)under.sever. *** fine-r.ot tr.its of the six hybr.ds showed two major.dr.ught-r.sponse scenar.os,in par.icular.(i)incr.ased r.ot tissue density(r.D)and decr.ased aver.ge r.ot diameter.without significant change of Sr. and(ii)incr.ased r.D and decr.ased Sr. without significant change of aver.ge r.ot *** r.sponses of leaf gas exchange,Sr.,Sr. and r.D wer. closely cor.elated along a gr.dient towar.s r.sour.e conser.ation fr.m contr.l to dr.ught-str.ssed plants in all hybr.ds,which was or.hogonal to another.gr.dient char.cter.zed by a hybr.d-dependent decr.ase of *** findings highlight(i)the multi-dimensionality of r.ot-tr.it dr.ught r.sponses,(ii)the decoupling between leaf economics and leaf hydr.ulics and(iii)the covar.ation of leaf and r.ot hydr.ulics in ter.s of tr.it dr.ught *** study contr.butes to identifying the or.gin of the multi-dimensionality of r.ot-tr.it dr.ught r.sponse at intr.specific scale,and highlights differ.ntial dr.ught–r.sponse combinations of leaf and fine-r.ot tr.its among hybr.ds to sur.ive under.sever. soil dr.u

关键词： multi-dimensional dr.ught r.sponse soil water.str.ss specific leaf ar.a specific r.ot length specific r.ot sur.ace ar.a