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宫颈黏液抗体滴度评估不能提高以宫颈长度为指标预测早产的价值

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 17-18页

作者： edwards r.k. Ferguson r.J. Shuster J.J. 朱国栋 Dept. of Obstetrics and Gynecology University of Florida College of Medicine Gainesville FL United States Dr

Objective: The purpose of this study was to determine if cervical fluid antibody concentrations can enhance the value of cervical length in predicting risk of preterm delivery. Study design: We obtained cervical fluid samples with preweighed cellulose wicks from a prospective cohort of women 23 to 32 weeks’ gestation with signs and symptoms of preterm labor and intact membranes. Total immunoglobulin A and G (IgA and IgG) concentrations were determined by enzyme- linked immunosorbent assay. Bacterial vaginosis was diagnosed by Gram stain, and cervical length was measured with endovaginal ultrasound. results: For subjects with term (n = 77) and preterm (n = 24) deliveries, median IgA and IgG concentrations were 736 vs 643 μ g/mL (P =. 33) and 1528 vs 1769 μ g/mL (P =. 85). For subjects with normal flora (n = 71), intermediate flora (n = 14), and bacterial vaginosis (n = 16), median IgA and IgG concentrations were 717, 624, and 774 μ g/mL (P =. 90) and 1383, 1553, and 2731 μ g/mL (P =. 02). In a forward stepwise logistic regression model, cervical length was the only factor associated with preterm delivery (P ring the concentrations of IgA and IgG in cervical fluid does not enhance the value of cervical length in predicting risk of preterm delivery.

关键词：宫颈长度宫颈黏液指标预测抗体滴度早产孕妇阴道菌群细菌性阴道病革兰染色法足月产酶联免疫吸附法

Understanding the initial use stage of cement mortar lining in drinking water distribution systems:Silicon and aluminum as stability indicators

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Journal of Environmental Sciences 2024年第1期135卷 495-505页

作者： Qiaozhi Liu Yuan Zhuang Guiwei Li Yao Zhang Marc A.edwards Baoyou Shi key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Civil and Environmental Engineering Virginia TechBlacksburgVA 24061USA

The cement mortar lining(CML)of commonly used ductile iron pipes can severely deteriorate the drinking water quality at the initial stage of use,but the behavioral characteristics of different elements release from the CML in this stage is still *** this study,dynamic immersion experiments with new cement mortar lined ductile iron pipe reactors were conducted under different feed water hardness and alkalinity *** results showed that the release of alkaline substances from the CML at the initial stage of use could strongly influence the pH of water,which consequently greatly impacted the release/precipitation behaviors of calcium,aluminum and *** pH and aluminum concentration of the effluent water could reach 11.5 and 700μg/L within 24 hr of hydraulic retention time,respectively,under conditions of relatively lower hardness and *** to the pH elevation,calcium carbonate precipitation could occur even at much lower feed water *** the aluminum and silicon could keep release from the CML in soluble form at different hardness and alkalinity levels,and their release rate depended on the amount of calcium carbonate ***,aluminum and silicon were more suitable as indicators of the corrosion intensity at the initial stage of CML use rather than the traditional calcium carbonate precipitation *** feed water hardness and alkalinity levels for mitigating the initial intense corrosion of CML were proposed:hardness>40 mg/L(CaCO_(3)),alkalinity>100 mg/L(CaCO_(3)).

关键词： Cement mortar lining Hardness Alkalinity Elemental release Drinking water supply

Learning from Neighbors and Differentiating Export Quality

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China & World Economy 2024年第4期32卷 1-32页

作者： Qiming Liu Bin Qiu Huw edwards Bo Gao School of Economics and Management Southeast UniversityChina Business school Loughborough UniversityUK

This paper explores how learning from neighboring firms affects new exporters' product quality. It builds a Bayesian learning model to study how new exporters revise their prior beliefs about foreign customers' preferences for product quality from neighboring pioneering exporters. The model shows that a new exporter improves its product quality when it receives a positive quality-preference signal from its neighbors. The learning process of a firm depends on the number of neighbors, the level and heterogeneity of their export quality, and its own prior.k.owledge of the market. Highly disaggregated firm–product–country level transaction data provide robust evidence for this. The results also suggest that the impact of neighboring signals on a new exporter's quality can be channeled through the importation of high-quality intermediate inputs and more fixed investment. Learning effects are heterogeneous across firms and learning can influence other aspects of export performance.

关键词： Bayesian learning export quality information spillovers uncertainty

Chronic effects of stretching on range of motion with consideration of potential moderating variables:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 186-194页

作者： Andreas konrad Shahab Alizadeh Abdolhamid Daneshjoo Saman Hadjizadeh Anvar Andrew Graham Ali Zahiri reza Goudini Chris edwards Carina Scharf David George Behm Institute of Human Movement Science Sport and HealthGraz UniversityGraz A-8010Austria School of Human kinetics and recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of Sport Injuries and Corrective Exercises Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is well known that stretch training can induce prolonged increases in joint range of motion(rOM).However,to date more information is needed regarding which training variables might have greater influence on improvements in ***,the purpose of this metaanalysis was to investigate the effects of stretch training on rOM in healthy participants by considering potential moderating variables,such as stretching technique,intensity,duration,frequency,and muscles stretched,as well as sex-specific,age-specific,and/or trained state-specific adaptations to stretch ***:We searched through PubMed,Scopus,Web of Science,and SportDiscus to find eligible studies and,finally,assessed the results from 77 studies and 186 effect sizes by applying a random-effect ***,by applying a mixed-effect model,we performed the respective subgroup *** find potential relationships between stretch duration or age and effect sizes,we performed a ***:We found a significant overall effect,indicating that stretch training can increase rOM with a moderate effect compared to the controls(effect size=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;proup analysis showed a significant difference between the stretching techniques(p=0.01)indicating that proprioceptive neuromuscular facilitation and static stretching produced greater rOM than did ballistic/dynamic ***,there was a significant effect between the sexes(p=0.04),indicating that females showed higher gains in rOM compared to ***,further moderating analysis showed no significant relation or ***:When the goal is to maximize rOM in the long term,proprioceptive neuromuscular facilitation or static stretching,rather than ballistic/dynamic stretching,should be *** to consider in future research as well as sports practice is that neither volume,intensity,nor frequency of stretching were

关键词： Flexibility Long-term stretching Stretch training

比较米索前列醇两种用药方案终止中期妊娠的结局

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 16-16页

作者： edwards r.k. Sims S.M. Devoe L. 朱晓明 Department of Obstetrics and Gynecology University of Florida College of Medicine Gainesville FL United States Dr

Objective: The purpose of this study was to compare outcomes of second-trimester pregnancy terminations with misoprostol between our previous low- (200 μ g every 12 h) and present high-dose (400 μ g every 6 h) regimens. Study design: This was an historic cohort study that was conducted from June 1996 to February 2004 on women undergoing medical termination of pregnancy at 13 to 27 weeks. Exclusion criteria were multiple gestation, placenta previa, and primary use of another medication. results: The cohort consisted of 147 women. For the low- (n = 100) and high -dose (n = 47) groups, respectively, median times to delivery were 22.5 vs 13.25 hours (P = .001). More patients in the high-dose group were delivered vaginally within 24 (81% vs 54% ; P = .002) and 48 hours (98% vs 84% ; P = .014). Fewer patients in the high-dose group required a second abortifacient (6% vs 27% ; P = .004). Clinical chorioamnionitis was more common in the high-dose group (P = .03). One patient experienced a uterine rupture and is included in the analysis. Side effects were uncommon and did not differ between groups. Conclusion: Our present high-dose regimen for misoprostol terminations of pregnancy effects delivery more rapidly without an appreciable increase in side effects or complications.

关键词：药物流产子宫破裂阴道分娩率终止妊娠多胎妊娠羊膜炎前置胎盘分娩时间队列研究流产率

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena V.Svider.k.ya Masanobu Oshima Christopher edwards 张彦军 Yuri korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CrC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AkT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CrC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM rOS Stiffness

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感恩记录

疯狂英语（初中天地） 2024年第1期 21-24页

作者： richard edwards 不详

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享... 详细信息

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享受生命的美好,发现感恩的力量。

关键词：感恩享受生命用心记录

The Impact of Lifestyle Factors on Migraine Frequency and Severity in Neurology

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Journal of Biosciences and Medicines 2024年第7期12卷 301-313页

作者： Oluwatosin B. Iyun Okelue edwards Okobi Nneka P. Sams Eleni Asfaw kebede Oboatarhe Blessing Ezie Department of Public Health and Family Medicine University of Cape Town Cape Town South Africa Larkin Community Hospital PSC Miami FL USA College of Health Sciences & Public Policy Walden University Minneapolis MN USA College of Health Sciences Addis Ababa University Addis Ababa Ethiopia Department of Family Medicine University of Benin Benin City Nigeria

Objective: This systematic review examines the impact of lifestyle factors on migraine frequency and severity through a comprehensive analysis of lifestyle factors such as diet, physical activity, sleep patterns, stress, mental health, and environmental influences. Methods: We thoroughly searched Google Scholar, PUBMED, Scopus, and Web of Science databases using keywords related to migraines and lifestyle factors. keywords incorporated the Boolean operator “and” to narrow search results. Following the PrISMA guidelines, we identified, screened, and evaluated studies for inclusion, resulting in nine studies meeting the eligibility criteria. results: A total of 4917 records were initially identified from Scopus (2786), PubMed (854), and Web of Science (1277). Following deduplication, 3657 records underwent title screening, with 382 additionally screened by abstract. Ultimately, 88 full-text articles were assessed, resulting in 9 studies meeting eligibility for qualitative synthesis: 7 prospective and 2 retrospective studies. Our findings highlight the multifaceted role of lifestyle factors in migraine pathophysiology and management. Dietary habits, such as high-calorie, high-fat, and gluten-containing diets were linked to migraine triggers. Moderate physical activity showed beneficial effects on migraine management, while intense exercise could exacerbate symptoms. Poor sleep hygiene and insomnia were strongly associated with increased migraine frequency and severity. Chronic stress and poor mental health significantly contributed to migraine exacerbation, with stress management techniques proving beneficial. Environmental factors, including light, sound, weather changes, and allergens, were also identified as significant migraine triggers. Conclusions: Personalized lifestyle modifications, tailored to individual patient profiles, are crucial in managing migraines. Evidence-based recommendations include balanced diets, moderate physical activity, improved sleep hygien

关键词： Migraine Lifestyle Factors Diet Physical Activity Sleep Patterns Stress Mental Health Environmental Factors Neurology

Precise dating of abrupt shifts in the Asian Monsoon during the last deglaciation based on stalagmite data from Yamen Cave, Guizhou Province, China

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Science China Earth Sciences 2010年第5期53卷 633-641页

作者： edwards r. Lawrence Department of Geology and Geophysics University of Minnesota

Based on 33 U/Th dates and 1020 oxygen isotopic data from stalagmite Y1 from Yamen Cave, Guizhou Province, China, a record of the Asian Summer Monsoon (ASM) was established. The record covers the last deglaciation and the early Holocene (from 16.2 to 7.3 ka BP) with an average oxygen isotope resolution of 9 years. The main millennial-scale deglacial events first identified in Greenland (Greenland Interstadial Events: GIS 1e through GIS 1a) and later in China are clearly present in the Y1 record. By analogy to earlier work, we refer to these as Chinese Interstadials (CIS): CIS A.1e to CIS A.1a. The onset of these events in Y1 δ18O records are nominally dated at: 14750±50, 14100±60, 13870±80, 13370±80, and 12990±80 a BP. The end of CIS A.1a or the beginning of the Younger Dryas (YD) event is nominally at 12850±50 a BP and the end of the YD dates to 11500±40 a BP. The δ18O values shift by close to 3‰ during the transition into the Bφlling-Allerφd (BA, the onset of CIS A.1e) and at the end of the YD. Comparisons of Y1 to previously published early Holocene records show no significant phase differences. Thus, the East Asia Monsoon and the Indian Monsoon do not appear to have been out of phase during this interval. The Y1 record confirms earlier work that suggested that solar insolation and North Atlantic climate both affect the Asian Monsoon.

关键词： stalagmite Asian Monsoon the last deglaciation Holocene U-series dating Yamen Cave