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英国医学杂志中文版 2010年第2期13卷 121-123页

作者： Andrew j edwards Giles F Maskell 张体江(译) 龚启勇(校) Royal Cornwall Hospital Truro TR1 3LJ 四川大学华西医院影像医学中心放射科

老年女性，81岁，因经直肠大量流血12小时入院，患者有缺血性心脏病，曾作冠状动脉支架置入，并有慢性阻塞性肺部疾病史。一直服用阿司匹林但未服用其他抗凝药，无其他任何相关病史。

关键词：急性下消化道出血冠状动脉支架置入缺血性心脏病肺部疾病史慢性阻塞性老年女性阿司匹林相关病史

昆虫保幼激素类似物双氧威作为长期储藏小麦的保护剂的总体评价

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粮食储藏 1993年第5期22卷 34-40页

作者： j.P.edwards j.E.SHORT L.ABRAHAM 黎万武英国农业渔业食品部ADAS中心实验室

昆虫保幼激素类似物双氧威处理小麦防治四种主要储粮甲虫的研究已进行了两年多,试验在模拟实际条件下进行,处理的小堆粮食约0.6吨,在0,6,12和18个月用赤拟谷盗、锯谷盗、谷蠹和谷象各300头进行感染。在药剂处理和害虫第一次引入后,每三... 详细信息

昆虫保幼激素类似物双氧威处理小麦防治四种主要储粮甲虫的研究已进行了两年多,试验在模拟实际条件下进行,处理的小堆粮食约0.6吨,在0,6,12和18个月用赤拟谷盗、锯谷盗、谷蠹和谷象各300头进行感染。在药剂处理和害虫第一次引入后,每三个月取一次样,检查害虫情况、粮食品质及粮食中杀虫剂残留。另外还评价了粮食制粉和烘焙品质,测定了面粉、麸皮和面包中药剂残留。双氧威的效果通过与对照和甲基毒死蜱处理的粮食进行比较评价。甲基毒死蜱3.9mg/kg处理的粮食能防治锯谷盗9个月,谷蠹和赤拟谷盗12个月,谷象15个月。用双氧威4.2mg/kg处理的粮食能防治锯谷盗、谷蠹、赤拟谷盗2年,但对谷象不完全有效。双氧威8.2mg/kg处理的粮食能防治所有的四种害虫2年。粮食品质和面包制作品质在害虫数量较低时能较好地保持。甲基毒死蜱和双氧威的残留在面粉和制作的面包中很低,但麸皮中明显较高。

关键词：小麦双氧威昆虫保幼激素贮藏

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走钢丝：对现代医学中过度诊断的沟通

英国医学杂志中文版 2016年第10期19卷 541-546页

作者： McCaffery Kirsten j jansen jesse Scherer Laura D Thornton Hazel Hersch jolyn Carter Stacy M Barratt Alexandra Sheridan Stacey Moynihan Ray Waller jo Brodersen john Pickles Kristen edwards Adrian 吴东(译者) School of Public Health University of Sydney New South Wales 2006 Australia Department of Psychological Sciences University of Missouri Columbia USA Department of Health Sciences University of Leicester Leicester UK Centre for Values Ethics and the Law in MedicineUniversity of Sydney Division of General Medicine and Clinical Epidemiology School of Medicine University of North Carolina Chapel Hill USA Bond University Queensland Australia Epidemiology and Public Health University College London UK Research Unit and Section of General Practice Department of Public Health University of Copenhagen Denmark Primary Health Care Research Unit Zealand Region Denmark Division of Population Medicine School of Medicine Cardiff University UK 北京协和医院消化科

Kirsten McCaffery和同事们认为对于过度诊断进行沟通，可以促进公众、患者、医务人员、卫生管理人员从不同角度思考：怎样才能建设一个更加可持续的医疗保健系统。

关键词：现代医学过度诊断医护人员医疗卫生行业

弥散质点对Al-Mg-Si合金疲劳裂纹扩展的影响

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轻合金加工技术 1987年第4期 26-29页

作者： L.edwards j.W.Martin 李宗耀

本文采用S—N曲线和疲劳裂纹扩展试验两种方法研究了三种Al-Mg-Si合金在峰值时效状态下的疲劳特性。这三种合金均无粗大的含铁的金属间化合物,它们的屈服应力与晶粒尺寸都相近,其循环—应力应变曲线也相似。其中,一种合金基本上是纯三... 详细信息

本文采用S—N曲线和疲劳裂纹扩展试验两种方法研究了三种Al-Mg-Si合金在峰值时效状态下的疲劳特性。这三种合金均无粗大的含铁的金属间化合物,它们的屈服应力与晶粒尺寸都相近,其循环—应力应变曲线也相似。其中,一种合金基本上是纯三元合金,另两种合金由于添加了锰而含有其体积百分数分别为0.22和0.61,其直径为0.1微米的金属间化合物弥散相质点。与先前对这一领域的研究有所不同的是发现在很宽的△K值范围内,弥散相质点降低裂纹扩展速率,而且在低△K值下,弥散相质点也影响到断裂通路由晶间型向穿晶型的转变。这种结果可以解释为由于弥散相质点存在的缘故,因为位错与这些质点的相互作用引起滑移带间距变小,从而使滑移的分布均匀,这就降低了裂纹尖端塑性区内滑移带前的应变集中。

关键词：疲劳裂纹扩展 Al-Mg-Si 裂纹尖端裂纹扩展速率塑性区弥散相合金相体积百分数应变集中应力应变曲线

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猪的增生性出血性肠病

兽医导刊 1984年第3期 48-52页

作者： R.j.Love D.N.Love M.j.edwards 林曦

一个最少发病的猪场,在一次增生性出血性肠病(ProIiferative haemorrhagicenteropathy,PHE)爆发的两次发作中,几个繁殖群里的372头成年猪受到了感染,死亡186头。第一次发作时,各种年龄繁殖母猪和公猪都曾发病,表明这是一种有很高易感性... 详细信息

一个最少发病的猪场,在一次增生性出血性肠病(ProIiferative haemorrhagicenteropathy,PHE)爆发的两次发作中,几个繁殖群里的372头成年猪受到了感染,死亡186头。第一次发作时,各种年龄繁殖母猪和公猪都曾发病,表明这是一种有很高易感性的感染。第一次发作猪群里的猪在随后的日子里都不呈现临诊症状,只有以后引入这繁殖群的猪才出现新的临诊病例。抗菌素拌料有预防效果。从病猪的肠粘膜曾分离

关键词：小母猪增生性育成猪青年公猪繁殖群出血性肠病肠疾病

Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy

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Infectious Microbes & Diseases 2019年第2期1卷 49-60页

作者： Sophonie jean Bernice Huang Hardik I.Parikh David j.edwards j.Paul Brooks Naren Gajenthra Kumar Nihar U.Sheth Vishal Koparde Ekaterina Smirnova Snehalata Huzurbazar Philippe H.Girerd Dayanjan S.Wijesinghe jerome F.StraussIII Myrna G.Serrano jennifer M.Fettweis Kimberly K.jefferson Gregory A.Buck Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVA Department of Statistical Sciences and Operations Research Virginia Commonwealth UniversityRichmondVA Supply Chain Management and Analytics School of BusinessVirginia Commonwealth UniversityRichmondVA Life Sciences Virginia Commonwealth UniversityRichmondVA DNAnexus Inc. Mountain ViewCA Frederick National Laboratory for Cancer Research FrederickMD Department of Biostatistics Virginia Commonwealth UniversityRichmondVA Department of Statistics University of WyomingLaramieWY Obstetrics and Gynecology Virginia Commonwealth UniversityRichmondVA Pharmacotherapy and Outcomes Science Virginia Commonwealth UniversityRichmondVA Department of Computer Science Virginia Commonwealth UniversityRichmondVA.

The vaginal microbiome likely influences host signaling compounds within the reproductive tract,including pro-inflammatory signals,which may play an important role during *** lactobacilli are associated with positive pregnancy outcome,whereas bacterial vaginosis,a dysbiosis of the vaginal microbiome,is associated with an increased risk of adverse pregnancy outcomes including preterm *** the host response could be predicted based on the taxonomic composition of the vaginal microbiome,particularly early in pregnancy,then those predictions could potentially be used to personalize intervention methods to reduce preterm birth and other adverse *** this proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in the Multi-Omic Microbiome Study-Pregnancy Initiative during early *** between the vaginal microbiome and the vaginal lipidome have not been previously *** from this study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sphingomyelins,and *** the biologic significance of these associations is not yet known,these results support the utility of such multi-omic approaches as a means to predict the impact of the microbiome on the host.

关键词： vaginal microbiome preterm birth multi-omics metagenomics cytokine profiles lipidomics

宫颈黏液抗体滴度评估不能提高以宫颈长度为指标预测早产的价值

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 17-18页

作者： edwards R.K. Ferguson R.j. Shuster j.j. 朱国栋 Dept. of Obstetrics and Gynecology University of Florida College of Medicine Gainesville FL United States Dr

Objective: The purpose of this study was to determine if cervical fluid antibody concentrations can enhance the value of cervical length in predicting risk of preterm delivery. Study design: We obtained cervical fluid samples with preweighed cellulose wicks from a prospective cohort of women 23 to 32 weeks’ gestation with signs and symptoms of preterm labor and intact membranes. Total immunoglobulin A and G (IgA and IgG) concentrations were determined by enzyme- linked immunosorbent assay. Bacterial vaginosis was diagnosed by Gram stain, and cervical length was measured with endovaginal ultrasound. Results: For subjects with term (n = 77) and preterm (n = 24) deliveries, median IgA and IgG concentrations were 736 vs 643 μ g/mL (P =. 33) and 1528 vs 1769 μ g/mL (P =. 85). For subjects with normal flora (n = 71), intermediate flora (n = 14), and bacterial vaginosis (n = 16), median IgA and IgG concentrations were 717, 624, and 774 μ g/mL (P =. 90) and 1383, 1553, and 2731 μ g/mL (P =. 02). In a forward stepwise logistic regression model, cervical length was the only factor associated with preterm delivery (P <. 001). Conclusion: Measuring the concentrations of IgA and IgG in cervical fluid does not enhance the value of cervical length in predicting risk of preterm delivery.

关键词：宫颈长度宫颈黏液指标预测抗体滴度早产孕妇阴道菌群细菌性阴道病革兰染色法足月产酶联免疫吸附法

通过微观模拟对机械瓣膜与生物瓣膜主动脉瓣膜置换术后效果的比较研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 38-39页

作者： Puvimanasinghe j.P.A. Takkenberg j.j.M. edwards M.B. 张明娟 Department of Cardiothoracic Surgery Erasmus MC R otterdam Netherlands Dr.

Background: Mechanical valves and bioprostheses are widely used for aortic val ve replacement. Though previous randomised studies indicate that there is no imp ortant difference in outcome after implantation with either type of valve, knowl edge of outcomes after aortic valve replacement is incomplete. Objective: To pre dict age and sex specific outcomes of patients after aortic valve replacement wi th bileaflet mechanical valves and stented porcine bioprostheses, and to provide evidence based support for the choice of prosthesis. Methods: Meta analysis of published results of primary aortic valve replacement with bileaflet mechanical prostheses(nine reports, 4274 patients, and 25 726 patient years) and stented porcine bioprostheses (13 reports, 9007 patients, and 54 151 patient years) was used to estimate the annual risks of postoperative valve related events and th eir outcomes. These estimates were entered into a microsimulation model, which w as employed to calculate age and sex specific outcomes after aortic valve replac ement. Results: Life expectancy(LE) and event free life expectancy(EFLE) for a 65 year old man after implantation with a mechanical valve or a bioprosthesis we re 10.4 and 10.7 years and 7.7 and 8.4 years, respectively. The lifetime risk of at least one valve related event for a mechanical valve was 48%, and for a bio prosthesis, 44%. For LE and EFLE, the age crossover point between the two valve types was 59 and 60 years, respectively. Conclusions: Meta analysis based micr osimulation provides insight into the long term outcome after aortic valve repla cement and suggests that the currently recommended age threshold for implanting a bioprosthesis could be lowered further.

关键词：主动脉瓣膜机械瓣膜生物瓣膜微观模拟置换术双叶研究报告随机研究荟萃分析特异性

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蚯蚓生物学

蚯蚓生物学

英国婴儿痉挛研究中心进行的多中心随机对照试验:用药14d时氨己烯酸与去氢氢化可的松和替可克肽的药效对比

作者： C.A.·爱德华兹(C.A. edwards) j.R.·洛夫蒂(j.R. Lofty)

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 6-7页

作者： Lux A.L. edwards Hancock E. j.P.Osborne 李开 Roy.U.Hosp.Bath NHS Trust Sch. H. University of BathBathUnited Kingdom

研究背景:婴儿痉挛症为婴儿的一种严重癫痫性疾病,死亡率高且难治疗。既往几十年中,激素疗法(促肾上腺皮质激素和去氢氢化可的松)已成为主要的治疗方法,但却很少有证据支持此疗法。据记载,氨己烯酸对此病有效。目的:氨己烯酸与去氢化可... 详细信息

研究背景:婴儿痉挛症为婴儿的一种严重癫痫性疾病,死亡率高且难治疗。既往几十年中,激素疗法(促肾上腺皮质激素和去氢氢化可的松)已成为主要的治疗方法,但却很少有证据支持此疗法。据记载,氨己烯酸对此病有效。目的:氨己烯酸与去氢化可的松和替可克肽均可治疗婴儿痉挛症,本文对比分析两类药物的治疗效果。方法:本研究为多中心随机对照试验,在英国150所医院进行,由英国婴儿痉挛研究中心评测结果。以用药第13和14天时痉挛停止作为有效治疗结果指标。

关键词：氨己烯酸婴儿痉挛随机对照试验癫痫性研究中心去氢激素疗法癫痛 seizure 结果指标