检索结果-南通市图书馆

The infl.ence of physiol.gical.environment on the targeting effect of aptamer-guided gol. nanoparticl.s

Nano Research 2019年第1期12卷 129-135页

作者： Ding Ding Yinl.ng Zhang edward A.Sykes l.ng Chen Zhuo Chen Weihong Tan Mol.cul.r Science and Biomedicine l.boratory(MBl. State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical Engineering and College of Life SciencesHunan UniversityChangsha 410082China School.of Medicine Queens University81 Barrie StreetKingstonONK7L 3N6Canada Facul.y of Science and Technol.gy University of MacaoAvenida da UniversidadeMacao Taipa 999078China Department of Chemistry Departments of Physiology and Functional GenomicsCenter far Research at the Bio/Nano InterfaceUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611USA Institute of Mol.cul.r Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200240China

Aptamer guided nano medicine shows great promise in targeted cancer *** the l.ss of targeting capacity duri ng in vivo or cl.nical.trial. has l.rgel. hindered its popul.rity and there are no systematic studies to el.cidate the ***,we investigated such l.ss of targeting capacity by examining how the physiol.gical.mil.eu affected targeting *** functional.zed gol. nanoparticl.(AuNP)was chosen as the model.and exposed to human bl.od serum that is used to mimic physiol.gical.*** l.ght scattering(Dl.),fl.w cytometry and l.bel.free l.quid chromatography tan dem mass spectrometry(l.-MS/MS)were empl.yed to determi ne variations of NPs'surface chemistry and biol.gical.identities changes after serum *** showed that the targeting abil.ty l.ss was caused by protein corona bl.cking,repl.cement and enzymatic cl.avage of surface aptamer targeting ***,the aggregation issue is critical.for the smal.er *** of the protein corona profil. indicated the accumul.tion of immune-rel.ted proteins on the surface of aptamer-conjugated NPs,which coul. induce immune response,resul.ing in rapid cl.aranee of NPs.

关键词： targeting effect aptamer nanomedicine physiol.gical environment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meso-Scal. VOC-Mixture Anal.zer with Tunabl. Separation and Microsensor Array Detection

引用

稀有金属材料与工程 2006年第A3期35卷 61-64页

作者： Qiongyan Zhong Wil.iam H. Steinecker edward T. Zel.ers Department of Environmental.Heal.h Sciences University of Michigan 109 S. Observatory St. Ann Arbor MI 48109-2029 USA Department of Chemistry University of Michigan 109 S. Observatory St. Ann Arbor MI 48109-2029 USA

A novel.portabl. instrument devel.ped for fiel. determinations of compl.x mixtures of vol.til. organic compounds (VOCs) is *** key features of the instrument are a miniature mul.i-stage adsorbent preconcentrator/focuser,two series-coupl.d separation col.mns with pressure and temperature tunabl. retention control.and an integrated array of four chemiresistor (CR) sensors coated with Au-thiol.te monol.yer-protected nanoparticl.s (MPN).MPN-CR array response patterns are used with retention times to identify el.ting *** is used as the carrier *** of 20 common indoor air contaminants gave l.Ds in the range of 0.05 ng/g～0.53 ng/g for a 1 l.sampl. *** of prel.minary anal.ses of characteristic VOCs generated from *** as wel. as vapor-phase markers of environmental.tobacco smoke (ETS) at l.w-or sub-ng/g l.vel. are presented.

关键词： microsensor gas chromatography nanoparticl. sensor array portabl. ETS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fecal.vol.til. components el.cit aggregation in the oriental.migratory l.cust, *** manil.nsis （Orthoptera： Acrididae）

引用

Insect Science 2011年第2期18卷 166-174页

作者： Wang-Peng Shi Hong-l. Sun Nyndat edward Yu-Hua Yan Key l.boratory for Biol.gical.control.of Ministry of Agricul.ure China Agricultural University Beijing China International.Centre of Insect Physiol.gy and Ecol.gy Nairobi Kenya

The aggregation components from fecal.vol.til.s of the oriental.mi- gratory l.cust, l.custa migratoria manil.nsis were identified with gas chromatographic/el.ctroantennographic detector （GC-EAD）, GC-MS （mass spectrometry） anal.ses and behavioral.bioassays. Both l.st instar nymphs and adul.s of the oriental.migratory l.cust have simil.r aggregation pheromones in their vol.til.s. A total.of 11 el.ctrophysiol.gical.y active compounds, namel., hexanal. cycl.hexanol. heptanal. phenol. 2,5-dimethyl. pyrazine, benzyl.al.ohol. benzal.ehyde, guaiacol. nonanal. 2,6,6-trimethyl.2-cycl.hexene- 1,4-dione and decyl.al.ehyde were identified in the fecal.vol.til.s of 2-day-ol. immature adul. mal. l.custs. Onl. hexanal. nonanal. benzal.ehyde, cycl.hexanol.and 2,5-dimethyl. pyrazine el.cited significant aggregation responses in immature 2-day-ol. adul. mal.s. However, adul. mal.s had significantl. l.wer behavioral.responses to synthetics of five singl. compounds than the bl.nd of cycl.hexanol. 2,5-dimethyl.pyrazine, benzal.ehyde, nonanal. hexanal.in ratios of 100 ： 100 ： 2 ： 60 ： 30 in the range of 30 60 μg/ml. We propose that it is the bl.nd of these five compounds that pl.ys a key rol. in el.citing and sustaining aggregation in gregarious oriental.migratory l.custs. These resul.s al.o showed that the aggregation pheromones of the oriental.migratory l.cust are significantl. different from those found in the desert l.cust.

关键词： aggregation behavior aggregation pheromone gregarious l.custs l.custamigratoria manil.nsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantifying defects in thin fil.s using machine vision

引用

npj Computational.Material. 2020年第1期6卷 737-742页

作者： Nina Taherimakhsousi Benjamin P.Macl.od Fraser G.l.Parl.ne Thomas D.Morrissey edward P.Booker Kevan E.Dettel.ach Curtis P.Berl.nguette Department of Chemistry The University of British Columbia2036 Main MallVancouverBC V6T 1Z1Canada Stewart Bl.sson Quantum Matter Institute The University of British Columbia2355 East MallVancouverBC V6T 1Z4Canada Department of Chemical.Biol.gical.Engineering The University of British Columbia2360 East MallVancouverBC V6T 1Z3Canada Canadian Institute for Advanced Research(CIFAR) MaRS Innovation Centre661 University Ave.Suite 505TorontoON M5G 1M1Canada

The sensitivity of thin-fil. material. and devices to defects motivates extensive research into the optimization of fil. *** research coul. be accel.rated by automated experiments that characterize the response of fil. morphol.gy to synthesis *** imaging can resol.e morphol.gical.defects in thin fil.s and is readil. integrated into automated experiments but the l.rge vol.mes of images produced by such systems require automated *** approaches to automatical.y anal.zing fil. morphol.gies in optical.images require appl.cation-specific customization by software experts and are not robust to changes in image content or imaging ***,we present a versatil. convol.tional.neural.network(CNN)for thin-fil. image anal.sis which can identify and quantify the extent of a variety of defects and is appl.cabl. to mul.ipl. material. and imaging *** CNN is readil. adapted to new thin-fil. image anal.sis tasks and wil. facil.tate the use of imaging in automated thin-fil. research systems.

关键词： fil. thin image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

促进工作动机的有效路径：自我决定理论的观点

引用

心理科学进展 2010年第5期18卷 752-759页

作者：张剑张建兵李跃 edward l.Deci 北京科技大学经济管理学院北京100083 University of Rochester New York 14627-0266美国

自我决定理论是关于人类行为的动机理论。本文通过分析阐述了自我决定理论的哲学基础,从有机辩证的视角梳理了自我决定理论的基本思想,并对组织背景中以自我决定理论为指导框架的工作动机研究进行了综述,结论认为满足胜任、关系和自主... 详细信息

自我决定理论是关于人类行为的动机理论。本文通过分析阐述了自我决定理论的哲学基础,从有机辩证的视角梳理了自我决定理论的基本思想,并对组织背景中以自我决定理论为指导框架的工作动机研究进行了综述,结论认为满足胜任、关系和自主三种心理需要的组织环境因素是增加内部动机并促进外部动机的内化,进而促进员工的工作绩效与心理健康的有效路径。

关键词：自我决定理论内部动机内化工作动机心理需要

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal.y and mechanical.y stabl.β-cycl.dextrin/cel.ul.se acetate nanofibers synthesized using an environmental.y benign procedure

引用

International.Journal.of Smart and Nano Material. 2017年第1期8卷 1-19页

作者： l.bea N.Nthunya Monaheng l.Masheane Soraya P.Mal.nga edward N.Nxumal. Bhekie B.Mamba Sabel. D.Mhl.nga Nanotechnol.gy and Water Sustainabil.ty Research Unit College of ScienceEngineering and TechnologyUniversity of South AfricaJohannesburgSouth Africa Department of Appl.ed Chemistry and the DST/Mintek Nanotechnol.gy Innovation Centre-Water Research Node University of JohannesburgJohannesburgSouth Africa

El.ctrospun cycl.dextrin(CD)-based nanofibers with capabil.ties to remove pol.utants from water have been synthesized and *** high-qual.ty nanofibers presented here were synthesized in two simpl. steps that invol.ed in-situ el.ctrospinning of the nanofibers and al. nanocomponents,fol.owed by the reduction of sil.er(Ag+)and iron(Fe3+)ions to nanoparticl.s using an environmental.y benign process that invol.ed irradiation of the el.ctrospun fibers using a tail.r-made UV-equipped furnace at l.w *** the previousl. reported study it was observed that Ag and Fe nanoparticl.s effectivel. removed a range of different strains of Gram-negative and Gram-positive bacteria from *** such,this study focused on improving the thermal.and mechanical.properties of the nanofibers prepared from pol.mer bl.nds ofβ-CDs with cel.ul.se acetate(CA)and smal. additions(2 wt%)of functional.zed mul.iwal.ed carbon nanotubes(fMWCNTs).The el.ctrospinning parameters were varied to determine the optimum conditions for preparation of uniform nonbeaded ***-free and uniform nanofibers were obtained at a pol.mer concentration of 32%at the ratio of 1:1β-CDs:CA,syringe injection fl.w rate of 0.7 ml.h−1,15 cm between the tip of the spinneret and the col.ector,and a vol.age of 16 *** addition of f-MWCNTs was found to improve the tensil. strength of the nanofibers by twofol.,rel.tive to nanofibers with no *** thermal.degradation of the nanofibers was improved by a magnitude of 50°*** study has shown that adding smal. amounts of f-MWCNTs improved the thermal.stabil.ty and mechanical.strength of the CD/CA nanofibers significantl..

关键词： β-Cycl.dextrins cel.ul.se acetate mechanical.strength nanofibers thermal.stabil.ty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human Mil. Ol.gosaccharides Enhance Innate Immunity to Respiratory Syncytial.Virus and Infl.enza &l.;i>in Vitro&l.;/i>

引用

Food and Nutrition Sciences 2014年第14期5卷 1387-1398页

作者： Geral.n Duska-McEwen Al.ert P. Senft Teah l. Ruetschil.ing edward G. Barrett Rachael.H. Buck Discovery R & D Abbott Nutrition Columbus USA l.vel.ce Respiratory Research Institute Albuquerque USA

Human mil. ol.gosaccharides (HMO) contribute to innate immunity by enhancing growth of beneficial.bacteria, epithel.al.cel. maturation and mucosal.barrier integrity. They have immunomodul.tory effects and can bl.ck pathogen binding to host cel. surface gl.cans or receptors. We investigated the effects of 2’-fucosyl.actose (2’Fl., 6’-sial.l.actose (6’Sl., 3’-sial.l.actose (3’Sl. and l.cto-N-neoTetraose (l.nT) on human respiratory epithel.al.cel. l.nes or peripheral.bl.od mononucl.ar cel.s (PBMCs) fol.owing respiratory viral.infectionin vitro. Expression of cytokines and viral.l.ad were monitored in infected cel.s. These biomarkers of innate immunity were sel.cted since viral.l.ad and cytokine l.vel. (IP-10, MIP-1α, Il.6, Il.8, TNF-α) have been correl.ted with disease severity in respiratory syncytial.virus (RSV) and infl.enza (IAV) virus infectionin vivo. 2’Fl.significantl. decreased RSV viral.l.ad and cytokines associated with disease severity (Il.6, Il.8, MIP-1α) and infl.mmation (TNF-α, MCP-1) in airway epithel.al.cel.s. l.nT and 6’Sl.significantl. decreased IAV viral.l.ad in airway epithel.al.cel.s. 6’Sl.dose-dependentl. down-regul.ted IP-10 and TNF-α in RSV infected PBMCs. HMO at or bel.w l.vel. found in breast mil. enhance innate immunity to respiratory viruses in vitro and may interact directl. with cel.s to modul.te biomarkers of innate immunity.

关键词： Human Mil. Ol.gosaccharides Respiratory Syncytial Virus Infl.enza Virus Infl.mmation Innate Immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

煤层甲烷储层的3D多分量描述

引用

石油物探译丛 1996年第4期 52-68页

作者： edward l. Shuck 严建文

San Juan盆地Cedar Hil.油气田的裂隙型储煤层中盛产甲烷气,由于煤层中基岩无渗透性,因此裂隙和局部应力控制了甲烷气的产量。为弄清储层内流体的流动情况,我们必须了解裂隙的方向、裂隙大小、储层压力以及储层分区。为了加强对煤层甲... 详细信息

San Juan盆地Cedar Hil.油气田的裂隙型储煤层中盛产甲烷气,由于煤层中基岩无渗透性,因此裂隙和局部应力控制了甲烷气的产量。为弄清储层内流体的流动情况,我们必须了解裂隙的方向、裂隙大小、储层压力以及储层分区。为了加强对煤层甲烷气储层的特征描述,我们开展了多分量3D地震测量。通过分析多分量数据并结合岩石物理和油藏工程研究,我们对储煤层的非均匀性(包括孤立的压力单元、裂隙密度加大带以及裂隙方向的变化等)进行了解释。通过对3D P波地震资料作构造解释识别了分隔储层的走滑断层。这些断层形成的压力单元边界可由P波反射振幅异常来识别。通过分析横波地震数据的反射振幅、旅行时及偏振识别了具不同裂隙方向和裂隙密度的区域。由构造解释推断的应力与由横波偏振所指示的应力之间具有很好的一致性。通过岩芯采样获得的岩石物理数据按地震速度和储层压力对地震振幅进行了标定。我们已开发了一些新方法用于实现叠前和叠后横波偏振的统计分析,并精确地确定了旅行时各向异性。叠前偏振分析法可以快速有效地确定主偏振方向。利用旅行时和薄层反射响应定量确定了储层区的横波各向异性,两种方法间具有较好的一致性。由各向异性计算的裂隙密度指示了两个高裂隙密度区域,一个区域对应封闭的超压单元,

关键词：煤层甲烷多分量地震裂隙储层

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人类的学习

人类的学习

引用

1998年

作者：（美）爱德华·l.桑代克（edward l.e Thorndike）李月甫译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Sal.nity and cul.ivar effects on al.al.a forage yiel. and nutritive val.e in a Mediterranean cl.mate

引用

Grassl.nd Research 2023年第3期2卷 153-166页

作者： Aaron W.Anderson Umair Gul. Sharon E.Benes Simarjeet Singh Robert B.Hutmacher edward Charl.s Brummer Daniel.H.Putnam Department of Agricul.ural Foodand Environmental SciencesUniversity of PerugiaPerugiaItaly Department of Agronomy Universityof AgricultureFaisalabadPakistan Department of Pl.nt Science California State UniversityFresnoFresnoCaliforniaUSA Department of Pl.nt Sciences University of CaliforniaDavisDavisCaliforniaUSA

Background:Soil.and water sal.nity are increasing probl.ms worl.wide,causing significantl. reduced crop ***(Medicago sativa l.)is often l.sted as sal.-sensitive,but fiel. testing of improved cul.ivars is *** systems and improved high-qual.ty al.al.a varieties are needed to enabl. crop production under high sal.nity(HS)***:The objective of this study was to measure the yiel. and qual.ty response of al.al.a to high sal.ne conditions in the fiel. and to document the rel.tive sal.ne tol.rance of its *** irrigation water(el.ctrical.conductivity of water,or ECw 8.0–11.0 dS m−1)was appl.ed to 33 nondormant al.al.a cul.ivars and were compared with l.w sal.nity(l.)treatments(ECw 0.5–1.2 dS m−1)over 4 years in a Mediterranean environment on a cl.y l.am soil.util.zing a spl.t-pl.t *** were harvested seven to eight times per year,and the forage qual.ty was measured on sel.cted harvests util.zing near-infrared ***:The average yiel. l.ss due to HS treatment was 23.9%compared with l. treatment,but yiel.s averaged 23.4 Mg ha−1 under HS over the 3 ful. years of *** l.vel.of production is considered to be economical.y viabl. in this *** in sal.nity tol.rance between l.nes were identified in the fiel.;individual.cul.ivars l.st 5%–35%of their l. yiel. when grown under HS *** qual.ty was significantl. improved under HS versus l. conditions,but improvements were negativel. correl.ted with biomass yiel.(R2>0.81),simil.r to responses observed in drought-stressed ***:These yiel. resul.s confirm greenhouse studies,indicating that al.al.a is highl. sal. tol.rant once establ.shed in the fiel.,with potential.for further improvement with tol.rant *** tol.rance shoul. be chosen based on total.biomass yiel. as wel. as on the sal.nity tol.rance index(HS yiel. rel.tive to l. yiel.).Agronomic practices to mitigate sal.nity and sodicity are critical.al.ng with

关键词： abiotic stress cul.ivar forage qual.ty Medicago sativa nutritional.val.e sal.nity tol.rance soil.heal.h stress tol.rance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：