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Surgeon＇s Innovation Lets a Girl Breathe Normally--one tough cookie of a patient defies odds

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空中英语教室（高级版．彭蒙惠英语） 2016年第12期 24-25,44,45页

作者： e.J, Smith iii

A unique role of the pyrimidine de novo synthesis enzyme ODCase in Lysobacter enzymogenes

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Journal of Integrative Agriculture 2024年第9期23卷 3066-3077页

作者： Mingming Yang Yunxiao Tan Jiabing Ma Yingjia Zhao Xia Yan Nana Wang Pingping Wang Jiaqi Tan Suilong Ai Xiaofei Liang Bangshuai Chang Obadah e.A.Yousif Chao Zhao Bo Wang Guoliang Qian Lili Huang State Key Laboratory for Crop Stress Resistance and High-efficiency Production Northwest A&F UniversityYangling 712100China College of Plant Protection Northwest A&F UniversityYangling 712100China College of Life Sciences Northwest A&F UniversityYangling 712100China College of Natural Resources and environment Northwest A&F UniversityYangling 712100China Shaanxi Provincial Tobacco Corporation of China National Tobacco Corporation Xi’an 710061China Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014China College of Plant Protection Laboratory of Plant ImmunityNanjing Agricultural UniversityNanjing 210095China

Bacterial species of the genus Lysobacter are environmentally ubiquitous with strong antifungal biocontrol ***-stable antifungal factor(HSAF)secreted by the biocontrol bacterium Lysobacter enzymogenes OH11 has broad-spectrum and highly efficient antifungal *** the biosynthetic regulations of HSAF would lay an important foundation for strain engineering toward improved HSAF *** this work,we demonstrate that Le0752,an orotidine-5´-phosphate decarboxylase enzyme(ODCase)catalyzing a pivotal step of the UMP de novo biosynthesis pathway,is vital for HSAF-mediated antimicrobial activities and growth of *** OH11,but not for twitching *** gene regulates the production of HSAF by affecting the expression of lafB,a key gene in the HSAF biosynthesis operon,through the transcription factor ***,bioinformatics analysis revealed that Le0752 belongs to the Group iii ODCases,whereas its homologs in the closely related genera Xanthomonas and Stenotrophomonas belong to Group I,which contains most ODCases from Gram-positive bacteria,Gram-negative bacteria and ***,the Group I ODCase PXO_3614 from the Xanthomonas oryzae *** PXO99A strain complemented the Le0752 mutant in regulating HSAF-mediated antagonistic ***,these results highlight the important requirement of de novo pyrimidine biosynthetic enzymes for antibiotic HSAF production in ***,which lays an important foundation for improving HSAF production via metabolic flow design and for dissecting the regulatory functions of bacterial ODCases.

关键词： ODCase pyrimidine de novo synthesis secondary metabolite HSAF Lysobacter enzymogenes

Multi-length scale modeling of carburization,martensitic microstructure evolution and fatigue properties of steel gears

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Journal of Materials Science & Technology 2020年第14期47卷 157-165页

作者： edward Charles Henry Crawford O’Brien Hemantha Kumar Yeddu School of engineering Newcastle UniversityNewcastle upon TyneNE17RUUnited Kingdom

Multi-length scale modeling is performed to(i)predict the carburized case depth of SAe8620 steel gears by solving the Fick’s second law of diffusion,(ii)model the martensitic microstructure evolution in a grain inside the carburized case as well as to study the effect of stress cycling on retained austenite(RA)and martensite using a 3D phase-field model,(iii)simulate the effect of carburization and different RA contents on macroscale fatigue behavior of SAe8620 steel spur gear using the finite element *** diffusion model predicts that the case depth increases with increasing heat treatment time and *** phase-field simulations show that RA can transform to martensite during fatigue loading,where the extent of the transformation will depend on the type of stresses applied,*** in a high stress regime or low stress regime of fatigue *** transformation of martensite to austenite is also observed in low RA sample under high stress *** macroscale simulations show that the carburized case with high RA gives rise to better fatigue life compared to that with low RA.

关键词： Phase-field model Martensitic transformation Microstructure Gear steel Carburization

The trumpet of the swan

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The trumpet of the swan

HBV genotype characterization and distribution in patients with HBV-related liver diseases in Zhejiang Province, P. R. China: possible association of co-infection with disease prevalence and severity

作者： e.B. White pictures by edward Frascino.

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 535-543页

作者： edward Zumbika Institute of Infectious Diseases the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003People's Republic of China

BACKGROUND: There are 8 well-documented genotypes of hepatitis B virus (HBV) at this time point. Genotyping can be accomplished based on a partial sequence of hepatitis B virus (HBV) genome such as the pre-S or S gene. Several methods have been developed and used for HBV genotyping including direct sequencing, restriction fragment length polymorphism, line probe assay and enzyme-linked immunoassay. Recently, a novel, rapid and cost-effective genotyping method based on PCR amplification assay using type-specific primers that can identify all six major genotypes has been developed. This study was undertaken to characterise HBV genotypes and investigate the association between the prevalence of different genotypes and the severity of HBV-induced liver diseases. MeTHODS: Serum samples from carriers of HBV and patients with HBV-related liver diseases from Zhejiang Province were screened for viral serological markers using commercially available radioimmunoassay (RIA) and enzyme linked immunosorbent assay (eLISA) kits. Serum HBV DNA load was determined by real-time detection PCR. A type-specific primer based the nested-PCR method was employed in the HBV genotyping. The genotype results obtained were confirmed by direct sequencing of nested PCR amplicons of the pre-S region. Ten samples of each genotype (B and C) were sequenced. ReSULTS: The survey on a cohort of 125 HBV carriers in and around Hangzhou City, Zhejiang Province showed the existence of HBV genotypes A (0.8%), B (48%), C (40.8%), D (0.8%), mixed B and C (9.6%) and an absence of e and F genotypes. Distribution of HBV genotypes in patients with liver diseases revealed a statistically insignificant higher prevalence of genotype B in mild chronic hepatitis (CH). Among the three genotypes B, C and mixed B/C infections 11 (73.3%), 3 (20%) and 1 (6.7%), (Pespectively in subjects with moderate CH, genotype B was significantly predominant. The infection patterns for genotypes B, C and B/C mixed in (i) liver c

关键词： hepatitis B virus chronic hepatitis B liver cirrhosis hepatocellular carcinoma hepatitis B e antigen hepatitis B virus DNA load viremia hepatitis B genotypes liver function tests alanine transaminase aspartate transaminase real-time detection PCR

SYNTHeSIS AND BIOSYNTHeSIS OF β-LACTAM ANTIBIOTICS

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中国抗生素杂志 1985年第2期10卷 114-124页

作者： edward Abraham england Sir William Dunn School of pathology University of Oxford

In 1928 Fleming observed the antibacterial action of penicillin at ***’s Hospital, London, on a plate seeded with staphylococci that had been contaminated with a strain of penicillium *** than ten years later H. W. Florey and e. Chain and their colleagues at Oxford University showed that crude preparations of penicillin had chemotherapeutic properties which seemed at the time to be almost miraculous. This marked the beginning of investigations that were to lead to the widespread use of β-lactam antibiotics in medicine.

关键词： LACTAM ANTIBIOTICS SYNTHeSIS AND BIOSYNTHeSIS OF

On the Relationship between Software Complexity and Maintenance Costs

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Journal of Computer and Communications 2014年第14期2卷 1-16页

作者： edward e. Ogheneovo Department of Computer Science University of Port Harcourt Port Harcourt Nigeria

As software becomes more and more complex due to increased number of module size, procedure size, and branching complexity, software maintenance costs are often on the increase. Consider a software such as Windows 2000 operating systems with over 29 million lines of code (LOC), 480,000 pages if printed, a stack of paper 161 feet high, estimate of 63,000 bugs in the software when it was first released [1] and with over 1000 developers, there is no doubt that such a large and complex software will require large amount of money (in US Dollars), social and environmental factors to maintain it. It has been estimated that over 70% of the total costs of software development process is expended on maintenance after the software has been delivered. This paper studies the relationship between software complexity and maintenance cost, the factors responsible for software complexity and why maintenance costs increase with software complexity. Some data collected on Windows, Debian Linux, and Linux Kernel operating systems were used. The results of our findings show that there is a strong correlation between software complexity and maintenance costs. That is, as lines of code increase, the software becomes more complex and more bugs may be introduced, and hence the cost of maintaining software increases.

关键词： Software Software Maintenance Software evolution Maintenance Costs

Software Dysfunction: Why Do Software Fail?

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Journal of Computer and Communications 2014年第6期2卷 25-35页

作者： edward e. Ogheneovo Department of Computer Science University of Port Harcourt Port Harcourt Nigeria

Software is pervasive in modern society, but we are often unaware of its presence until problems arise. Software is one of the most important and yet one of the most economically challenging techniques of this era. As a purely intellectual product, it is among the most labor-intensive, complex, and error-prone technologies in human history. Until the 1970s, programmers were very meticulous in planning their code, rigorously checking code, providing detailed documentation, and exhaustive testing before the software is released to users. However, as computer became widespread, attitudes changed. Instead of meticulously planning code, the attitude of the average programmer today is possibly hacking sessions or writing any sloppy piece of code and the compiler will run diagonally, a situation called, “code and fix”, where the programmer tried to fix errors one by one until the software compiled properly. As programs grew in size and complexity, the limits of this “code and fix” approach became evident. In this paper, we studied the various reasons why software fails. Our studies reveal that the major reasons why software fails are poor or no design at all, inadequate testing of codes, and attitudinal changes among programmers and other factors.

关键词： Software Software Dysfunction Software engineering Programs Programmers

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

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四川生理科学杂志 2021年第1期43卷 105-105页

作者： edward e Walsh From the University of Rochester and Rochester General Hospital Rochester (E.E.W. A.R.F.) Vaccine Research and Development Pfizer Pearl River (J.A. A.G. K.A.S. K.K. W.K. D.C. K.R.T. P.R.D. K.U.J. W.C.G.) and New York University Langone Vaccine Center and Grossman School of Medicine New York (M.J.M. V.R.) — all in New York Cincinnati Children’s Hospital Cincinnati (R.W.F.) Vaccine Research and Development Pfizer Hurley United Kingdom (N.K. S.L. R.B.) the University of Maryland School of Medicine Center for Vaccine Development and Global Health Baltimore (K.N. K.E.L.) Vaccine Research and Development Pfizer Collegeville PA (P.L.) the University of Texas Medical Branch Galveston (C.F.-G. P.-Y.S.) and BioNTech Mainz Germany (ÖT. U.Ş.).

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections and the resulting disease,coronavirus disease 2019(Covid-19),have spread to millions of persons *** vaccine candidates are under development,but no vaccine is currently *** safety and immunogenicity data about the vaccine candidate BNT162b1 in younger adults have been reported previously from trials in Germany and the United States.

关键词： vaccine acute respiratory