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Efficacy of Autologous Cultured Fibroblast Cells as a Treatment for Patients with Facial Contour Defects: A Clinical Replication Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第4期7卷 306-317页

作者： edward charles R. Lee Kim Siea Lee Jezamine Lim Jason Yip Cheng Zhang Xu Zhang Han Bin To Lim Sabah Medical Centre Sabah Malaysia Loh Guan Lye Specialists Centre Pinang Malaysia Tissue Engineering Centre University Kebangsaan Kuala Lumpur Malaysia Astute Clinic Kuala Lumpur Malaysia Beijing Cell Technology Inc. Beijing China SB Clinical Research Malaysia

Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant advantage of producing longer lasting effect. Methods: This was a prospective open label single group clinical study to demonstrate the clinical efficacy of ACF that we have replicated in our lab. The study enrolled 18 patients with nasolabial folds from 2 centres in Malaysia in 2011-2012. ACF at dose of 23 or 92 million cells were injected on 3 occasions at 4 weeks interval. Efficacy at 6- and 12-month post treatment was assessed using a standardized 7-point scale which was performed by the 2 investigators as well as a panel of 7 independent evaluators. Results: We obtained a successful outcome (primary endpoint), defined as improvement in the appearance of the nasolabial fold of at least 2 points on the 7-point scale, in 33% of patients as assessed by investigators at 12-month follow-up and in 22% of patients assessed by independent evaluators. Investigators also found 78% of patients having had a 1-point improvement from baseline while independent evaluators found 83% of patients having improved by as much. Patients were uniformly (100%) satisfied with the improvement in their appearance. No treatment-related adverse event was reported. Baseline score and follow-up duration had significant effect on treatment response. The greater the baseline severity and the longer the post-treatment follow-up, the better the response to ACF. Larger dose of cells (92 million cells) has little additional effect suggesting that the 1 mL dose (23 million cells) is near optimal. Older patients showed a trend towards poorer response but this was not statistically significant. Conclusions: We have successfully replicated the laboratory method and clinical procedure to perform ACF treatment which was effective in improving the appearance of nasolabial folds in some patie

关键词： Facial Contour Defect Nasolabial Fold Wrinkle Autologous Cultured Fibroblast Cell Autologous Cell Therapy

The Caesarean Section in Dakar: Indications and Analysis Prognosis

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Open Journal of Obstetrics and Gynecology 2019年第9期9卷 1213-1220页

作者： Moussa Diallo Marie edward Faye Dieme Omar Gassama Astou Coly Niassy Diallo Mame Diarra Ndiaye Gueye Jean charles Moreau Service de Gynécologie-Obstétrique Centre Hospitalier National de Pikine Sis Camp de Thiaroye Dakar Sénégal Clinique Gynécologique et Obstétricale de l’Hopital Aristide Le Dantec Dakar Sénégal

The objective of this study was to analyze the indications of cesarean sections performed in a Level II clinic and to evaluate early maternal and neonatal outcome in the context of decentralization of obstetric and emergency newborn care. Material and Method: This was a retrospective descriptive and analytical study conducted at the maternity CSNC over a period of 12 months from 1 July 2010 to 30 June 2011. It included all women in childbirth by caesarean section and excluded patients admitted for management of complications of cesarean section performed in another structure. Results: During the study period, 595 caesarean sections were performed on a total of 4410 births, a rate of 13.5%. The average age of patients was 27 years. The mean parity was 2. The patients came from them even 55%. They were admitted with a single uterine scar in 28.40% of cases and bi-scar in 25.4% of cases. A pathology was associated with pregnancy in 31.6% of cases. These pathologies were dominated by vascular and renal syndromes (75.5%), anemia (13.8%) and the obstacles previa (10.1%). Caesarean sections were performed in 517 patients in emergency. The technique of Misgav Ladach was the most common 75.1%. The average hospital stay was 4.2 days with extremes of 0 and 15 days. Postoperative maternal mortality was 0.34%. Operative follow-up was simple in 98.3% of patients. Two patients (0.34%) died after surgery. In 92.4% of the cases, the newborns were alive. The Apgar score in the first minute was favorable (greater than or equal to 7/10) in 503 newborns (95.1%) and unfavorable (less than 7/10) in 47 cases (8.55%). At the fifth minute, he was favorable in 98.5% of the cases. Overall stillbirth was 72.26‰ with a total of 43 stillbirths including 3 macerated stillbirths. Conclusion: Cesarean section is by far the most accomplished action in gynecology and obstetrics. Its ease of implementation and low cost, and of course his results in terms of reduction of maternal-fetal morbidity and mor

关键词： Cesarean Section Indication Misgav Ladach Maternal and Fetal Prognosis

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人的能力它们的性质与度量

丛书名： 20世纪心理学通览

1999年

作者：（英）查尔斯·爱德华·斯皮尔曼（charles edward Spearman）袁军译

本书共分两部分，第一部分诸家释义，内容包括第一章至第九章；第二部分基本事实，内容包括第十章至二十四章。

ISBN: (数字)7533829239

ISBN: (纸本)7533829239

本书共分两部分，第一部分诸家释义，内容包括第一章至第九章；第二部分基本事实，内容包括第十章至二十四章。

关键词：能力研究

来源：汇雅图书（南通市图书馆... 评论

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多路共轴光学瞄准具和闭环火控系统

应用光学 1986年第1期 44-49页

作者： charles W.Schertz edward H.Ritter 唐彦

发明背景一般火控系统,特别在直升飞机和其它飞机上以及高炮系统中使用的火控系统,不能进行闭环瞄准误差校正,操作手是处在系统“环内”,至少是组成系统功能的一个部分。虽然在某种系统中可通过平视显示器给操作手提供炮弹弹道的可见指... 详细信息

发明背景一般火控系统,特别在直升飞机和其它飞机上以及高炮系统中使用的火控系统,不能进行闭环瞄准误差校正,操作手是处在系统“环内”,至少是组成系统功能的一个部分。虽然在某种系统中可通过平视显示器给操作手提供炮弹弹道的可见指示,以提高手控瞄准精度,但是,直到现在,这种系统的瞄准精度仍不能小于10毫弧。在对较高精度的火炮瞄准系统的研究中,提出了用于高炮及其它火炮的各种闭环误差校准系统的研制方案。这些闭环系统一般用雷达跟踪目标,同时测量在目标距离上目标矩心和弹道矩心的夹角。但是,雷达闭

关键词：炸点头盔闭环火控系统瞄准具闪光探测器

Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

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Journal of Animal Science and Biotechnology 2017年第2期8卷 378-390页

作者： Samuel M.Waititu Fugui Yin Rob Patterson Juan C.Rodriguez-Lecompte charles M.Nyachoti Department of Animal Science University of Manitoba201-12 Dafoe RoadWinnipegM6 R3T 2N2Canada Canadian Bio-systems Inc. CalgaryAB T2C OJTCanada Atlantic Veterinary College University of Prince Edward IslandCharlottetownPE C1A 4P3Canada

Background： This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter（AGP） on performance, immune status and gut structure after an E. coli lipopolysaccharide（LPS） challenge. Thirty-six pigs were allotted to six treatments including： a non-challenged control（NCC）; LPS-challenged control（CC）; CC ＋ AGP; CC ＋ yeast extract; CC ＋ enzymes; and CC ＋ enzymes ＋ yeast extract. On d 7, pigs were bled and thereafter injected with LPS or sterile saline. Blood samples were collected at 6, 48, and 96 h post-challenge. After 96 h post-challenge, pigs were euthanized to obtain duodenal, jejunal and ileal ***： Overall（d 1 to 11）, compared with CC pigs, AGP attenuated the LPS-induced reduction in ADG（P = 0.004）,ADFI（P = 0.03） and gain/feed ratio（P = 0.01）. At 6 h post-challenge, AGP pigs had lower plasma urea N（PUN; P = 0.02）and serum TNF-α concentration（P = 0.07）, and higher platelet count（P = 0.04） and serum IL-10 concentration（P = 0.02） than CC pigs. At 48 h post-challenge, AGP pigs had lower PUN（P = 0.02） than CC pigs, whereas enzymes ＋ yeast extract interacted non-additively（P = 0.001） to reduce PUN. At 96 h post-challenge, AGP pigs had lower PUN（P = 0.02）and higher duodenal（P = 0.03）, jejunal（P = 0.01） and ileal（P = 0.07） villus height than CC pigs. In addition, enzymes ＋yeast extract interacted additively and non-additively to reduce ileal IFN-γ（P 0.10） were observed between AGP and enzymes ＋ yeast extract pigs on other measured parameters except for the downregulation of ileal IFN-γ（P ＆lt; 0.0001） and TNF-α（P = 0.003） in enzymes ＋ yeast extract pigs at 96 h ***： The LPS challenged piglets receiving enzymes ＋ yeast extract showed beneficial responses in gut structure and immunity commensurate with those receiving antibiotics, though the latter had better overall growth performance.

关键词： Antimicrobial growth promoter Feed enzymes Growth performance Immunity Nucleotides Piglets

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A review of potential conservation and fisheries benefits of breaching four dams in the Lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller charles E.Petrosky Robert L.Vadas Jr. Benjamin J.Clemens Gary Sprague Norman Mercado-Silva Brett Roper Michael J.Parsley edward Bowles Robert M.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)Snake River Basin Pacific Lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

The apple REFPOP—a reference population for genomics-assisted breeding in apple

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Horticulture Research 2020年第1期7卷 364-379页

作者： Michaela Jung Morgane Roth Maria JoséAranzana Annemarie Auwerkerken Marco Bink Caroline Denancé Christian Dujak charles-Eric Durel Carolina Font i Forcada Celia M.Cantin Walter Guerra Nicholas P.Howard Beat Keller Mariusz Lewandowski Matthew Ordidge Marijn Rymenants Nadia Sanin Bruno Studer edward Zurawicz François Laurens Andrea Patocchi Hélène Muranty Molecular Plant Breeding Institute of Agricultural SciencesETH Zurich8092 ZurichSwitzerland Breeding Research group Agroscope 8820 WädenswilSwitzerland IRTA(Institut de Recerca i Tecnologia Agroalimentàries) 08140 Caldes de MontbuiBarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UAB08193 BellaterraBarcelonaSpain Better3fruit N.V. 3202 RillaarBelgium Biometris Wageningen University and Research6708 PB WageningenThe Netherlands Hendrix Genetics Research Technology and Services B.V.PO Box 1145830AC BoxmeerThe Netherlands IRHS Universitéd’AngersINRAEInstitut AgroSFR 4207 QuaSaV49071 BeaucouzéFrance ARAID(Fundación Aragonesa para la Investigación y el Desarrollo) 50018 ZaragozaSpain Research Centre Laimburg 39040 AuerItaly Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institute of Biology and Environmental Sciences University of Oldenburg26129 OldenburgGermany Research Institute of Horticulture 96-100 SkierniewicePoland School of Agriculture Policy and DevelopmentUniversity of ReadingWhiteknights RG66AR ReadingUK Laboratory for Plant Genetics and Crop Improvement KU Leuven B-3001 LeuvenBelgium GAFL INRAE84140 MontfavetFrance

Breeding of apple is a long-term and costly process due to the time and space requirements for screening selection ***-assisted breeding utilizes genomic and phenotypic information to increase the selection efficiency in breeding programs,and measurements of phenotypes in different environments can facilitate the application of the approach under various climatic *** we present an apple reference population:the apple REFPOP,a large collection formed of 534 genotypes planted in six European countries,as a unique tool to accelerate apple *** population consisted of 269 accessions and 265 progeny from 27 parental combinations,representing the diversity in cultivated apple and current European breeding material,respectively.A high-density genome-wide dataset of 303,239 SNPs was produced as a combined output of two SNP arrays of different densities using marker imputation with an imputation accuracy of *** on the genotypic data,linkage disequilibrium was low and population structure was *** well-studied phenological traits of horticultural importance were *** found marker–trait associations in several previously identified genomic regions and maximum predictive abilities of 0.57 and 0.75 for floral emergence and harvest date,*** decreasing SNP density,the detection of significant marker–trait associations varied depending on trait *** of the trait,10,000 SNPs sufficed to maximize genomic prediction *** confirm the suitability of the apple REFPOP design for genomics-assisted breeding,especially for breeding programs using related germplasm,and emphasize the advantages of a coordinated and multinational effort for customizing apple breeding methods in the genomics era.

关键词： breeding planted utilize

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根据机织物的机械性质预测织物手感

国外纺织技术 1980年第27期 8-11页

作者： charles J.Kim edward A.Vanghn 李永椿

纺织工业的基本要素是纤维、纱线、织物和整理。在这些领域中的任一方面发生较重要的工艺进展时,其结果就会有新产品引入服装或家俱市场上去,首先试用的品质评定之一是织物手感。评定织物手感的一种途径是测量物理手感参数。它假设手感... 详细信息

纺织工业的基本要素是纤维、纱线、织物和整理。在这些领域中的任一方面发生较重要的工艺进展时,其结果就会有新产品引入服装或家俱市场上去,首先试用的品质评定之一是织物手感。评定织物手感的一种途径是测量物理手感参数。它假设手感现象是机械性能的结果,如果选择适当的物理参数,则手感现象完全可以由织物的机械性质来表示。这种概念具有一定的优点,它用组成的力学参数表示织物手感,因而避免了在纯粹主观评定中

关键词：织物手感机织物机织产品弯曲试验仪

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马克思主义经济学史 1929-1990