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St.dies on t.e Lat.ic. Dist.rt.on and Subst.uc.ures of Shoc.ed Lamellae in Nat.rally Shoc.ed Quart.

Ac.a Geoc.imic. 1987年第1期6卷 19-32页

作者：谢先德 edward c. t. chao Inst.t.t. of Geoc.emist.y Ac.demia Sinic. Unit.d St.t.s Geologic.l Survey Mailst.p 929 Rest.n Va 22092 Unit.d St.t.s of Americ.

One unshoc.ed and 9 nat.rally shoc.ed single quart. c.yst.l grains wit. 1-6 set. of shoc. lamellaefrom t.e Ries, West.Germany, and t.e Lake Lappajarvi, Finland, c.vering a range from unshoc.ed quart.wit. _disibledevent=1.544 t. nearly c.mplet.ly glassy quart. wit. _disibledevent=1.461 have been used for X-ray prec.ssionand Laue invest.gat.ons. Four of t.e shoc.ed grains have preliminarily been st.died under a t.ansmissionelec.ron mic.osc.pe. It.is found t.at.quart. having No less t.an 1.539 shows int.nsive anisot.opic.c.llexpansion and lat.ic. disordering whic. gradually inc.ease as No dec.eases. Shoc.-induc.d lat.ic. dist.rt.onof quart. is c.early shown on bot. prec.ssion and Laue phot.graphs. For t.e weakly shoc.ed quart. (pt.t. pronounc.d spreading of spot. is observed. When t.e pressure reac.es 200 kb, bot. c.nc.nt.ic.preading of spot. having long ‘t.ils' and c.nc.nt.ic.rings (powder pat.ern) are revealed on t.e samephot.graph, whic. means t.at.besides a part.of single c.yst.l t.ere also exist.randomly orient.d t.ny‘fragment.' of quart. in t.is shoc.ed quart. grain. As pressure inc.eases from 230 t. 315 kb, more and morec.yst.lline puases in t.e quart. grains have t.ansformed from solid st.t. int. silic. glass, and t.e c.nc.nt.ic.ings and t.e long ‘t.ils' disappear and t.e spot.spreading bec.mes slight.again, but.reflec.ion int.nsit.esbec.me muc. lower in c.mparison wit. t.ose of weakly shoc.ed quart.. t.M invest.gat.ons show t.ree kinds of subst.uc.ures of shoc. lamellae. t.e glass c.nt.nt. of t.o oft.e four grains (73% and 84% respec.ively) were measured on t.M phot.graphs wit. t.e help of an imageanalysis syst.m. On t.e basis of above invest.gat.ons a six-t.rminal-st.t. model for t.e mec.anism of deformat.on inshoc. met.morphosed quart. is present.d.

关键词： St.dies on t.e Lat.ic. Dist.rt.on and Subst.uc.ures of Shoc.ed Lamellae in Nat.rally Shoc.ed Quart.

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In-sit. c.arac.erizat.on of met.l nanopart.c.es and t.eir organic.c.at.ngs using laser-vaporizat.on aerosol mass spec.romet.y

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Nano Researc. 2015年第12期8卷 3780-3795页

作者： Pat.ik t. Nilsson Axel c. Eriksson Linus Ludvigsson Maria E. Messing Erik Z. Nordin Anders Gudmundsson Bengt.O. Meuller Knut.Deppert.edward c. Fort.er t.mot.y B. Onasc. Joakim H. Pagels Ergonomic. and Aerosol t.c.nology Lund University P.O. Box 118 Lund SE-22100 Sweden Nuc.ear Physic. Lund University P.O. Box 118 LundSE-22100 Sweden Solid St.t. Physic. Lund University P.O. Box 118 Lund SE-22100 Sweden Sync.rot.on Radiat.on Researc. Lund University P.O. Box 118 Lund SE-22100 Sweden Aerodyne Researc. Inc. Billefica MA 01821-3976 USA

t.e development.of met.ods t. produc. nanopart.c.es wit. unique propert.es via t.e aerosol rout. is progressing rapidly. t.pic.l c.arac.erizat.on t.c.niques ext.ac. part.c.es from t.e synt.esis proc.ss for subsequent.offiine analysis, whic. may alt.r t.e part.c.e c.arac.erist.c.. In t.is work, we use laser-vaporizat.on aerosol mass spec.romet.y （LV-AMS） wit. 70-eV elec.ron ionizat.on for real-t.me, in-sit. nanopart.c.e c.arac.erizat.on. t.e part.c.e c.arac.erist.c. are examined for various aerosol synt.esis met.ods, degrees of sint.ring, and for c.nt.olled c.ndensat.on of organic.mat.rial t. simulat. surfac. c.at.ng/func.ionalizat.on. t.e LV-AMS is used t. c.arac.erize several t.pes of met.l nanopart.c.es （Ag, Au, Pd, PdAg, Fe, Ni, and c.）. t.e degree of oxidat.on of t.e Fe and Ni nanopart.c.es is found t. inc.ease wit. inc.eased sint.ring t.mperat.re, while t.e surfac. organic.impurit. c.nt.nt.of t.e met.l part.c.es dec.eases wit. inc.eased sint.ring t.mperat.re. For aggregat. met.l part.c.es, t.e organic.impurit. c.nt.nt.is found t. be similar t. t.at.of a monolayer. By c.mparing different.equivalent.diamet.r measurement., we demonst.at. t.at.t.e LV-AMS c.n be used in t.ndem wit. a different.al mobilit. analyzer t. det.rmine t.e c.mpac.ness of synt.esized met.l part.c.es, bot. during sint.ring and during mat.rial addit.on for surfac. func.ionalizat.on. Furt.er, mat.rials supplied t. t.e part.c.e produc.ion line downst.eam of t.e part.c.e generat.rs are found t. reac. t.e generat.rs as c.nt.minant.. t.e c.pac.t. for suc. in-sit. observat.ons is import.nt. as it.fac.lit.t.s rapid response t. undesired behavior wit.in t.e part.c.e produc.ion proc.ss. t.is st.dy demonst.at.s t.e ut.lit. of real-t.me, in-sit. aerosol mass spec.romet.ic.measurement. t. c.arac.erize met.l nanopart.c.es obt.ined direc.ly from t.e synt.esis proc.ss line, inc.uding t.eir c.emic.l c.mposit.on, shape, and c.nt.minat.on, providing t.e pot.nt.al for effec.ive opt.mizat.on of proc.ss operat.ng p

关键词： met.l aeroso1 organic.surfac. c.at.ng c.nt.minat.on morphology alloy spark disc.arge

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Six psyc.ot.opic. for pre-sympt.mat.c.＆ early Alzheimer＇s (Mc.), Parkinson＇s, and Hunt.ngt.n＇s disease modific.t.on

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Neural Regenerat.on Researc. 2016年第11期11卷 1712-1726页

作者： edward c. Laut.rbac. Psyc.iat.y and Neurology Mercer University School of Medicine Macon GA USA

t.e quest.for neuroprot.c.ive drugs t. slow t.e progression of neurodegenerat.ve diseases （NDDs）, inc.uding Alzheimer＇s disease （AD）, Parkinson＇s disease （PD）, and Hunt.ngt.n＇s disease （HD）, has been largely unrewarding. Prec.inic.l evidenc. suggest. t.at.repurposing quet.apine, lit.ium, valproat., fluoxet.ne, donepezil, and memant.ne for early and pre-sympt.mat.c.disease-modific.t.on in NDDs may be promising and c.n spare regulat.ry barriers. t.e lit.rat.re of t.ese psyc.ot.opic. in early st.ge and pre-sympt.mat.c.AD, PD, and HD is reviewed and propit.ous findings follow. Mild c.gnit.ve impairment.（Mc.） phase of AD： salut.ry human randomized c.nt.olled t.ial findings for low-dose lit.ium and, in selec.ed pat.ent., donepezil await.replic.t.on. Pre-sympt.mat.c.AD： human epidemiologic.l dat. indic.t. t.at.lit.ium reduc. es AD risk. Animal model st.dies （AMS） reveal enc.uraging result. for quet.apine, lit.ium, donepezil, and memant.ne. Early PD： valproat. AMS findings show promise. Pre-sympt.mat.c.PD： lit.ium and valproat. AMS findings are enc.uraging. Early HD： unc.nt.olled c.inic.l dat. indic.t. non-progression wit. lit.ium, fluoxet.ne, donepezil, and memant.ne. Pre-sympt.mat.c.HD： lit.ium and valproat. are auspic.ous in AMS. Many ot.er promising findings await.ng replic.t.on （valproat. in Mc.; lit.ium, valproat., fluoxet.ne in pre-sympt.mat.c.AD; lit.ium in early PD; lit.ium, valproat., fluoxet.ne in pre-sympt.mat.c.PD; donepezil in early HD; lit.ium, fluoxet.ne, memant.ne in pre-sympt.mat.c.HD） are reviewed. Dose- and st.ge-dependent.effec.s are c.nsidered. Suggest.ons for signal-enhanc.ment.in human t.ials are provided for eac. NDD st.ge.

关键词： drug reposit.oning neuroprot.c.ive agent. psyc.ot.opic.drugs neurodegenerat.ve diseases mildc.gnit.ve impairment humans animals animal models

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Raman Spec.rosc.py of Garnet.group Minerals

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c.inese Journal Of Geoc.emist.y 1994年第2期13卷 176-183页

作者：彭明生李迪恩 H.K.MAO E.c.t.chao 1. Division of Quant.m Mineralogy Depart.ent.of Geology Central University of Technology 410083 Changsha China 2. Geophysic.l Laborat.ry Carnegie Institution of Washington 2801 Upton Street N.W. 20008 Washington D.C. USA 3. U. S. Geologic.l Survey 959 National Center Reston 22092 Virginia USA

t.e Raman spec.ra of t.e nat.ral end members of t.e garnet.group minerals, whic. inc.ude pyrope, almandine and spessarit. of Fe-Al garnet.series and grossularit., andradit. and uvarovit. of c.-Fe garnet.series, have been st.died. Measured Raman spec.ra of t.ese minerals are reasonably and qualit.t.vely assigned t. t.e int.mal modes, t.anslat.onal and rot.t.ry modes of SiO4 t.t.ahedra,as well as t.e t.anslat.onal mot.on of bivalent.c.t.ons in t.e X sit.. t.e st.et.0} and rot.t.ry Alg modes for t.e Fe-Al garnet.series show obvious Raman shift. as c.mpared wit. t.ose for t.e c.-Fe garnet.series, owing t. t.e c.t.ons residing in t.e X sit. c.nnec.ed wit. SiO4 t.t.ahedra by sharing t.e t.o edges. t.e Raman shift. of all members wit.in eit.er of t.e series are at.ribut.d mainly t. t.e propert.es of c.t.ons in t.e X sit. for t.e Fe-Al garnet.series and in t.e Y sit. for t.e c.-Fe gamet.series.

关键词：拉曼光谱石榴石榴子石铁铝榴石晶体结构

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石榴子石族矿物的拉曼光谱

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光谱学与光谱分析 1991年第5期11卷 16-21页

作者：彭明生 H. K. Mao 李迪恩 E. c. t. chao 中南工业大学地质系量子矿物室长沙410083 美国华盛顿卡内基研究所地球物理实验室美国地质调查所

本文研究了石榴子石族各端员矿物(Fe-Al系列和c.-Fe系列)的拉曼光谱。它们的拉曼光谱可归因于其中SiO_4的内模式、平移与旋转模式,以及X位置中二价阳离子的平移。对于Fe-Al系列矿物,其SiO_4的伸缩和旋转A_(lg)模式比c.-Fe系列的有更大... 详细信息

本文研究了石榴子石族各端员矿物(Fe-Al系列和c.-Fe系列)的拉曼光谱。它们的拉曼光谱可归因于其中SiO_4的内模式、平移与旋转模式,以及X位置中二价阳离子的平移。对于Fe-Al系列矿物,其SiO_4的伸缩和旋转A_(lg)模式比c.-Fe系列的有更大的拉曼位移,其原因在于结构的X多面体与SiO_4以共两条边相联。而Fe-Al系列矿物的X阳离子不同,从而使SiO_4产生不同程度的畸变。Fe-Al系列矿物的拉曼位移主要归因于X阳离子,而c.-Fe系列矿物的拉曼位移则归因于Y阳离子的变化。

关键词：石榴子石矿物散射谱

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Modulat.on of Oxidat.ve St.ess Responses by Vit.min E, or Vit.min A plus Vit.min c.t.eat.ent.in Human Ret.nal Pigment.Epit.elial c.lls

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Nat.ral Sc.enc. 2015年第12期7卷 558-570页

作者： Jinggang Yin c.rist.na S. Winborn Fridt.of t.omas Quynh t. t.an John c. Lang edward c.aum From t.e Depart.ent. of Opht.almology University of Tennessee Health Science Center Memphis USA Prevent.ve Medic.ne University of Tennessee Health Science Center Memphis USA Depart.ent.of c.emist.y and Bioc.emist.y University of Texas at Arlington Arlington USA Anat.my and Neurobiology University of Tennessee Health Science Center Memphis USA

t.e purpose of t.is st.dy was t. c.arac.erize t.e pot.nt.al of vit.mins t. prot.c. t.e ret.nal pig-ment.epit.elium (RPE) from oxidat.ve st.ess (OS). We have previously shown t.at.OS induc.s t.e expression of AP1 t.ansc.ipt.on fac.ors (FOSB, c.OS and At.3), but.is modulat.d by pret.eat.ent.wit. vit.min c.(200 μM). We propose t.at.OS-induc.d AP1 expression c.n be used as a biomarker of OS t. t.st.t.e effic.c. of vit.mins t. limit.t.e impac. of OS in t.e RPE. Here we examined t.e effic.c. of vit.min E or c.mbined vit.min A plus vit.min c.t. modulat. OS-induc.d AP1 expression in t.e RPE. We pret.eat.d human ARPE-19 c.lls wit. vit.min E (0 - 7.5 μM) or wit. c.mbined vit.min A (10 or 15 μM) plus vit.min c.(50 or 100 μM) for 3 days prior t. exposure t. 500 μM H2O2 OS for 1 - 4 h. AP1 expression was assessed using qRt.Pc.. Pret.eat.ent.wit. ≥2.5 μM vit.min E signific.nt.y dec.eased OS-induc.d AP1 expression at.1 - 4 h OS, c.mpared t. c.nt.ols. Lower doses of vit.min E were ineffec.ive at.modulat.ng OS responses. Pret.eat.ent.wit. 100 μM vit.min c.c.mbined wit. 15 μM vit.min A prot.c.ed RPE c.lls from OS-induc.d AP1 expression. t.ere is an addit.ve and pot.nt.ally prot.c.ive effec. of 100 μM vit.min c.and 15 μM vit.min A on FOSB expression at.4 h, and a pot.nt.ally prot.c.ive effec. of 100 μM vit.min c.and 15 μM vit.min A on c.OS expression at.1 h OS. A prot.c.ive effec. was also seen wit. 15 μM vit.min A pret.eat.ent.alone on At.3 expression. t.us, “sub-t.erapeut.c. levels of mult.ple vit.mins may prot.c. RPE c.lls bet.er t.an higher doses of a single vit.min. t.is OS-induc.d AP1 expression biomarker assay may be useful t. ident.fy c.mplex ant.oxidant.formulat.ons as t.erapeut.c. for degenerat.ve diseases t.at.are t.ought.t. be c.used by OS, like age-relat.d mac.lar degenerat.on.

关键词： Vit.min Supplement.t.on AP1 t.ansc.ipt.on Fac.ors Oxidat.ve St.ess Ret.nal Pigment Epit.elium Age-Relat.d Mac.lar Degenerat.on

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Adapt.vit. and A Post.riori Error c.nt.ol for Bifurc.t.on Problems Ⅰ:t.e Brat. Problem

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c.mmunic.t.ons in c.mput.t.onal Physic. 2010年第9期8卷 845-865页

作者： K.Andrew c.iffe edward J.c.Hall Paul Houst.n Eric.t.Phipps Andrew G.Salinger Sc.ool of Mat.emat.c.l Sc.enc.s University of NottinghamUniversity ParkNottingham NG72RDUK c.mput.r Sc.enc. Researc. Inst.t.t. Sandia National LaboratoriesAlbuquerqueNew MexicoUSA

t.is art.c.e is c.nc.rned wit. t.e numeric.l det.c.ion of bifurc.t.on point. of nonlinear part.al different.al equat.ons as some paramet.r of int.rest.is *** part.c.lar,we st.dy in det.il t.e numeric.l approximat.on of t.e Brat. problem,based on exploit.ng t.e symmet.ic.version of t.e int.rior penalt. disc.nt.nuous Galerkin finit. element.met.od.A framework for a post.riori c.nt.ol of t.e disc.et.zat.on error in t.e c.mput.d c.it.c.l paramet.r value is developed based upon t.e applic.t.on of t.e dual weight.d residual(DWR)*** experiment. are present.d t. highlight.t.e prac.ic.l performanc. of t.e proposed a post.riori error est.mat.r.

关键词： Bifurc.t.on t.eory Brat. problem a post.riori error est.mat.on adapt.vit. disc.nt.nuous Galerkin met.ods

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Ac.ieving food and nut.it.onal sec.rit. t.rough agroforest.y: a c.se of Faidherbia albida in sub-Saharan Afric.

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Forest.y St.dies in c.ina 2011年第2期13卷 123-131页

作者： Neo c. MOKGOLODI Moffat.P. SEt.HOGO SHI Ling-ling LIU Yu-jun MA chao Nat.onal Engineering Laborat.ry for t.ee Breeding College of Biological Sciences and Biotechnology Beijing Forestry University Beijing 100083 E R. China Depart.ent.of Biologic.l Sc.enc.s University of Botswana Private Bag UB00704 Gaborone Botswana

Faidherbia albida is an ideal agroforest.y t.ee c.mmonly int.rc.opped wit. annual c.ops like millet.and groundnut. in t.e dry and densely populat.d areas of Afric.. Wit. it. pec.liar reverse phenology, it.makes growt. demands at.a different.t.me from t.at.of c.ops. In addit.on, it.deposit. great.amount.of organic.fert.lizer on food c.ops. Leaves ent.ring soils are c.mparable t. fert.lizat.on of almost.50 t.ha^-1year^-1 of manure in dense st.nds of 50 large t.ees per ha. t.ese nut.ient. help maximize agric.lt.ral produc.ion and reduc. t.e need for a fallow period on poorer soils. Researc. has shown t.at.millet.grown under F. albida yielded 2.5 and 3.4 fold inc.eases in grain and prot.in, respec.ively. Animals eat.pods whic. c.nt.in mean amount. of c.ude prot.in of 20.63% and c.rbohydrat. of 40.1% in seeds. Moreover, t.e c.nt.nued exist.nc. ofF. albida in agroforest.y parklands as in Et.iopia and Mali signifies t.e suc.ess of t.adit.onal c.nservat.on measures. Modem sc.ent.st. have also developed muc. int.rest.in t.e role of agroforest.y in maint.ining long-t.rm biologic.l balanc. bet.een agric.lt.re and livest.c. produc.ion syst.ms. t. ensure food sec.rit., whic. st.ll remains a major c.allenge in sub-Saharan Afric., and c.nc.rrent.y minimize environment.l degradat.on, promot.on of agroforest.y t.at.spec.fic.lly involves indigenous t.ees is c.uc.al. We disc.ss t.e prospec.ive role ofF. albida in alleviat.ng povert. while simult.neously prot.c.ing t.e environment.from fac.ors assoc.at.d wit., for example, deforest.t.on and loss of biodiversit.. t.e overall aim is t. promot. wide-sc.le adopt.on ofF. albida as a valuable t.ee c.op in farming syst.ms, part.c.larly in t.ose areas where it.remains unexploit.d.

关键词： agroforest.y Faidherbia albida food sec.rit. fodder nit.ogen fixat.on sub-Saharan Afric.

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Lac.at.: an int.ac.llular met.bolit. regulat.s c.ll c.c.e progression

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Life Met.bolism 2023年第4期2卷 1-2页

作者： Jinke c.eng edward t.H.Yeh Depart.ent.of Bioc.emist.y and Molec.lar c.ll Biology Shanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Depart.ent.of Int.rnal Medic.ne University of Arkansas for Medical SciencesLittle RockAR 72205United States

t.e c.ouc.ani lab rec.nt.y report.d in Nat.re t.at.a dynamic.int.ac.llular lac.at. is a physiologic.l regulat.r for c.ll c.c.e *** also showed t.at.ac.umulat.d lac.at. in c.ll mit.sis direc.ly binds and inhibit. Sent.in/SUMO-spec.fic.pro-t.ase 1 t. enric. SUMO2/3-modific.t.on of anaphase-promot.ing c.mplex 4(APc.),whic. promot.s t.e degradat.on of APc.c.c.mplexes,leading t. mit.sis exit.

关键词： c.c.e c.mplexes ac.umulat.d

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c.(II) Propionyl-t.iazole t.iosemic.rbazone c.mplexes: c.yst.l St.uc.ure, Inhibit.on of Human t.poisomerase IIα, and Ac.ivit. against.Breast.c.nc.r c.lls

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Open Journal of Medic.nal c.emist.y 2018年第2期8卷 30-46页

作者： edward c. Lisic.Vic.oria G. Rand Lana Ngo Pat.ic. Kent.Jeffrey Ric. Deidra Gerlac. Elizabet. t. Papish Xiaohua Jiang Depart.ent.of c.emist.y Tennessee Technological University Cookeville TN USA Depart.ent.of c.emic.l Engineering Tennessee Technological University Cookeville TN USA Depart.ent.of c.emist.y The University of Alabama Tuscaloosa Alabama USA

t.o new t.iosemic.rbazone ligands, 2-propionylt.iazole et.ylt.iosemic.rbazone (Pt.-Et.c., and 2-propionylt.iazole t.rt.but.lt.iosemic.rbazone (Pt.-t.t.c., along wit. t.eir t.o c.pper(II) c.mplexes, [c.(Pt.-Et.c.c.] and [c.(Pt.-t.t.c.c.], are report.d here for t.e first.t.me. Onc. c.arac.erized by NMR and MS, t.ese mono-anionic.t.ident.t. ligands were reac.ed wit. c.2+ t. form t.e square planar met.l c.mplexes [c.(Pt.-Et.c.c.] and [c.(Pt.-t.t.c.c.]. t.e x-ray c.yst.l st.uc.ure of t.e [c.(Pt.-t.t.c.c.] c.mplex shows t.at.t.e c.mplex adopt. a square planar arrangement.around t.e c.pper(II) ion, but.forms a sulfur-bridged dimer in t.e solid st.t.. Bot. of t.e c.pper c.mplexes displayed st.ong inhibit.on of human t.poisomerase IIα at.ac.ivit.es bet.een 2-4 μM for [c.(Pt.-Et.c.c.], and bet.een 8-10 μM for t.e [c.(Pt.-t.t.c.c.] c.mplex. t.e Ec.0 values for t.e MDA-MB-231 breast.c.nc.r c.ll line were 82.6 μM for (Pt.-Et.c., 17.9 μM for [c.(Pt.- Et.c.c.], 97.8 μM for (Pt.-t.t.c., and 1.41 μM for [c.(Pt.-t.t.c.c.]. t.e Ec.0 values for t.e Mc.7 breast.c.nc.r c.ll lines were 9.36 μM for (Pt.-Et.c., 0.13 μM for [c.(Pt.-Et.c.c.], 0.333 μM for (Pt.-t.t.c., and 0.093 μM for [c.(Pt.-t.t.c.c.].

关键词： t.poisomerase Breast c.nc.r t.iosemic.rbazones

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