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Mechan.sms of action.of leptin.in.preven.in. gastric ulcer

2005'全国微波毫米波会议

作者： W.Che J.G.Wan. edward K.n.Yun. Departmen. of Commun.cation.En.in.erin. n.n.in. Un.versity of Scien.e & Techn.logy Departmen. of Electron.c En.in.erin. City Un.versity of Hon. Kon.

＜正＞Several n.vel structures of ferroelectric phase shifters（FEPS） have been.in.estigated in.this *** characteristics of phase shift an. in.ertion.loss have been.illustrated,an. their figure of merit has been.*** simulation.results have in.icated that it is most of importan. to choose an.appropriate structure for the con.truction.of the ferroelectric phase shifter employed for phased arrays.

关键词： Ferroelectric phase shifter phase shift in.ertion.loss microstrip slotlin.

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World Journ.l of Gastroen.erology 2005年第27期11卷 4154-4160页

作者： edward O.Adeyemi Salim A.Bastaki Irwin.S.Chan.ran.th Mohammed Y.Hasan.Mohammed Fahim Abdu Adem Departmen. of In.ern.l Medicin. Departmen. of Pharmacology Departmen. of Physiology

To in.estigate the effects of leptin.（1-20μg/kg） on.acidified ethan.l （AE）- an. in.omethacin.（In.o）-in.uced gastric lesion. in.rats an. compare it with ran.tidin., lan.oprazole, an. omeprazole an. to determin. its mechan.sms of ***： Gastric ulcers, which were approximately 1 mm in.width, formed in.the glan.ular portion.of the gastric mucosa produced by oral admin.stration.of either AE or In.o were taken.as ulcer in.ex. The in.ibitory effect of subcutan.ous admin.stration.of leptin. two proton.pump in.ibitors （PPIs） lan.oprazole an. omeprazole, or H2-receptor an.agon.st ran.tidin. 30 min.before AE or In.o was evaluated.A radioimmun.assay was used to determin. the PGE2 con.en.ration.in.the homogen.te of the glan.ular portion.of the stomach. We performed histological study of the glan.ular stomach for the evaluation.of total, acidic, an. sulfated mucus ***： Subcutan.ous admin.stration.of leptin. two PPI slan.oprazole an. omeprazole or H2-receptor an.agon.st ran.tidin. 30 min.before AE or In.o produced a dosedepen.en. an. reproducible in.ibition.of gastric ulcers （GUs）. This in.ibition.was foun. to be more poten. than.other an.agon.sts used. In.n.G-n.tro L-argin.n. methyl ester （L-n.ME）-pretreated an.mals, the ulcer preven.ion.ability of leptin.in.AE-in.uced ulcer was sign.fican.ly reduced,compared to rats without L-n.ME pretreatmen.. However,the ulcer preven.ion.ability of leptin.was n.t altered by L-n.ME treatmen. in.In.o-in.uced ulcers. Leptin.produced a dose-depen.en. in.rease in.PGE2 level in.the gastric glan.ular tissues. Leptin.also in.reased mucus ***： The results of the presen. study show that leptin.in.ibits GU formation.by AE or In.o in.a dosedepen.en. an. reproducible man.er in.rats. The results also suggest that leptin.preven.s ulcer formation.by in.reasin. the activities of the cyclo-oxygen.se an./or n.tric oxide pathways an. by in.reasin. mucus secretion.

关键词： In.omethacin Acidified ethan.l Gastric ulcer Prostaglan.in Ran.tidin. Omeprazole Lan.oprazole l^-n.tro L-argin.n. methyl ester Wistar rats

Models to predict in.ury, physical fitn.ss failure an. attrition.in.recruit train.n.: a retrospective cohort study

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Military Medical Research 2020年第4期7卷 391-400页

作者： Robin.M.Orr Bruce S.Cohen.Stephen.C.Allison.Lakmin. Bulathsin.ala edward J.Zambraski Mark Jaffrey Tactical Research Un.t Bond University2 Promethean WayGold CoastRobinaQLD 4226Australia Un.ted States Army Research In.titute for En.iron.en.al Medicin. NatickMA 01760USA Defen.e Scien.e an. Techn.logy Group Port MelbourneVIC 3207Australia

Backgroun.:Attrition.rate in.n.w army recruits is higher than.in.in.umben. *** the curren. study,we iden.ified the risk factors for attrition.due to in.uries an. physical fitn.ss failure in.recruit train.n..A variety of predictive models were ***:This retrospective cohort in.luded 19,769 Army soldiers of the Australian.Defen.e Force receivin. recruit train.n. durin. a period from 2006 to *** them,7692 reserve soldiers received a 28-day train.n. course,an. the remain.n. 12,077 full-time soldiers received an.80-day train.n. *** data in.luded an.hropometric measures,course-specific variables,in.ury,an. physical fitn.ss *** regression.was used to develop a variety of models to predict the rate of attrition.due to in.uries an. physical fitn.ss *** area un.er the receiver operatin. characteristic curve was used to compare the performan.e of the ***:In.the overall an.lysis that in.luded both the 28-day an. 80-day courses,the in.iden.e of in.ury of an. type was 27.8%.The 80-day course had a higher rate of in.ury if calculated per course(34.3%vs.17.6%in.the 28-day course),but lower n.mber of in.uries per person.year(1.56 vs.2.29).Fitn.ss test failure rate was sign.fican.ly higher in.the 28-day course(30.0%vs.12.1%).The overall attrition.rate was 5.2%an. 5.0%in.the 28-day an. 80-day courses,*** fracture was common.in.the 80-day course(n.44)an. rare in.the 28-day course(n.1).The areas un.er the receiver operatin. characteristic curves for the course-specific predictive models were relatively low(ran.in. from 0.51 to 0.69),con.isten. with"failed"to"poor"predictive *** course-combin.d models performed somewhat better than.the course-specific models,with two models havin. AUC of 0.70 an. 0.78,which are con.idered"fair"predictive ***:Attrition.rate was similar between.28-day an. 80-day *** comparison.to the 80-day full course,the 28-day course had a lower rat

关键词： Military train.n. Predictive modellin. Risk man.gemen. Soldier

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In.erpretable discovery of semicon.uctors with machin. learn.n.

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n.j Computation.l Materials 2023年第1期9卷 1150-1160页

作者： Hitarth Choubisa Petar Todorović Joao M.Pin. Darshan.H.Parmar Zilian. Li Oleksan.r Vozn.y Isaac Tamblyn.edward H.Sargen. Departmen. of Electrical an. Computer En.in.erin. University of Toronto10 King’s College RoadTorontoON M5S 3G4Canada Departmen. of Physical an. En.iron.en.al Scien.es University of TorontoScarboroughON M1C 1A4Canada Departmen. of Physics University of OttawaOttawaON K1N 6N5Canada Vector In.titute for Artificial In.elligen.e TorontoON M5G 1M1Canada

Machin. learn.n. models of material properties accelerate materials discovery,reproducin. den.ity fun.tion.l theory calculated results at a fraction.of the cost1–*** bridge the gap between.theory an. experimen.s,machin. learn.n. prediction. n.ed to be distilled in.the form of in.erpretable chemical rules that can.be used by *** we develop a framework to address this gap by combin.n. evolution.ry algorithm-powered search with machin.-learn.n. surrogate *** then.couple the search results with supervised learn.n. an. statistical *** strategy en.bles the efficien. search of a materials space while providin. in.erpretable design.*** demon.trate its effectiven.ss by developin. rules for the design.of direct ban.gap materials,stable UV emitters,an. IR perovskite ***,we con.lusively show how DARWIn.gen.rated rules are statistically more robust an. applicable to a wide ran.e of application. in.ludin. the design.of UV halide perovskites.

关键词： preta learn.n. perovskite

Safety an. Immun.gen.city of Two Rn.-Based Covid-19 Vaccin. Can.idates

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四川生理科学杂志 2021年第1期43卷 105-105页

作者： edward E Walsh From the Un.versity of Rochester an. Rochester Gen.ral Hospital Rochester (E.E.W. A.R.F.) Vaccine Research and Development Pfizer Pearl River (J.A. A.G. K.A.S. K.K. W.K. D.C. K.R.T. P.R.D. K.U.J. W.C.G.) and New York University Langone Vaccine Center and Grossman School of Medicine New York (M.J.M. V.R.) — all in New York Cin.in.ati Children.s Hospital Cincinnati (R.W.F.) Vaccin. Research an. Developmen. Pfizer Hurley United Kingdom (N.K. S.L. R.B.) the Un.versity of Marylan. School of Medicin. Center for Vaccine Development and Global Health Baltimore (K.N. K.E.L.) Vaccin. Research an. Developmen. Pfizer Collegeville PA (P.L.) the Un.versity of Texas Medical Bran.h Galveston (C.F.-G. P.-Y.S.) an. Bion.ech Mainz Germany (ÖT. U.Ş.).

Backgroun.:Severe acute respiratory syn.rome coron.virus 2(SARS-CoV-2)in.ection. an. the resultin. disease,coron.virus disease 2019(Covid-19),have spread to million. of person. *** vaccin. can.idates are un.er developmen.,but n. vaccin. is curren.ly *** safety an. immun.gen.city data about the vaccin. can.idate Bn.162b1 in.youn.er adults have been.reported previously from trials in.German. an. the Un.ted States.

关键词： vaccin. acute respiratory

An.ibiotic Resistan.e Gen.s in.the Human.Impacted En.iron.en.:A On. Health Perspective

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Pedosphere 2019年第3期29卷 273-282页

作者： James M. TIEDJE WAn. Fan. Celia M. MAn.IA Marko VIRTA SHEn. Hon.jie MA Lipin. ZHAn. Ton. edward TOPP Key Laboratory of Soil En.iron.en. an. Pollution.Remediation Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) Cen.er for Microbial Ecology Department of Plant Soil and Microbial Sciences Michigan State University East Lansing MI 48824 (USA) Un.versity of Chin.se Academy of Scien.es Beijing 100049 (China) Un.versidade Catolica Portuguesa CBQF-Centro de Biotecnologia e Quimica Fina一Laboratorio Associado Escola Superior de Biotecnologia Porto 4200-374 (Portugal) Departmen. of Microbiology University of Helsinki Helsinki 00014 (Finland) En.iron.en.al Biotechn.logy Lab The University of Hong Kong Hong Kong (China) Lon.on.Research an. Developmen. Cen.re Agriculture and Agri-Food Canada and University of Western Ontario London ON N6G 0J3 (Canada)

An.ibiotic resistan.e an. its en.iron.en.al compon.n. are gain.n. more atten.ion.as part of combatin. the growin. healthcare crisis. The On. Health framework, promulgated by man. global health agen.ies, recogn.zes that an.imicrobial resistan.e is a truly in.er-domain.problem in.which human.health, an.mal agriculture, an. the en.iron.en. are the core an. in.errelated *** prospectus presen.s the status an. issues relevan. to the en.iron.en.al compon.n. of an.ibiotic resistan.e, n.mely, the n.eds for advan.in. surveillan.e methodology: the en.iron.en.al reservoirs an. sources of resistan.e, n.mely, urban.wastewater treatmen. plan.s, aquaculture production.systems, soil receivin. man.re an. biosolid, an. the atmosphere which in.ludes lon.er ran.e ***, much work has been.don. describin. an.ibiotic resistan.e gen.s in.various en.iron.en.s;n.w quan.itative, mechan.stic,an. hypothesis-driven.studies are n.eded to iden.ify practices that reduce real risks an. main.ain.the effectiven.ss of our curren. an.ibiotics as lon. as possible. Advan.ed deployable detection.methods for an.ibiotic resistan.e in.diverse en.iron.en.al samples are n.eded in.order to provide the surveillan.e in.ormation.to iden.ify risks an. defin. barriers that can.reduce risks. Also n.eded are practices that reduce an.ibiotic use an. thereby reduce selection.for resistan.e, as well as practices that limit the dispersal of or destroy an.ibiotic-resistan. bacteria or their resistan.e gen.s that are feasible for these varied en.iron.en.al domain..

关键词： an.mal agriculture an.ibiotic-resistan. bacteria an.imicrobial resistan.e aquaculture human.health On. Health framework soil con.amin.tion wastewater an. sludge

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国际贸易中的铬矿——历史的展视

新疆有色金属 1985年第1期 79-84页

作者： edward n.Eadie 郑康福

世界铬矿的生产多年来的事实证明,主要的铬矿消费国,很少又是重要的铬矿生产国。因此,铬矿在国际贸易中的盛衰,很自然地和它的生产模式结成了紧密的关系。 1892—1980年期间,世界铬矿年产量,逐年增加,特别自1932年以来,产量有特别明显

关键词：铬矿原产国苏联南非苏维埃社会主义共和国联盟非洲进口国津巴布韦南罗得西亚

Proteomic iden.ification.an. fun.tion.l characterization.of MYH9, Hsc70, an. Dn.JA1 as n.vel substrates of HDAC6 deacetylase activity

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Protein.& Cell 2015年第1期6卷 42-54页

作者： Lin.in.Zhan. Shan.han.Liu n.n.n.n. Liu Yon. Zhan. Min.Liu Den.wen.Li edward Seto Tso-Pan.Yao Wen.in. Shui J-un.Zhou State Key Laboratory of Medicin.l Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China High-throughput Molecular Drug Discovery Cen.er Tianjin Joint Academy of Biotechnology and Medicine Tianjin 300457 China Molecular On.ology Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA Departmen. of Pharmacology an. Can.er Biology Duke University Durham NC 27710 USA

Histon. deacetylase 6 （HDAC6）, a predomin.n.ly cyto- plasmic protein.deacetylase, participates in.a wide ran.e of cellular processes through its deacetylase activity. However, the diverse fun.tion. of HDAC6 can. n.t be fully elucidated with its kn.wn.substrates. In.an.attempt to explore the substrate diversity of HDAC6, we performed quan.itative proteomic an.lyses to mon.tor chan.es in.the abun.an.e of protein.lysin. acetylation.in.respon.e to HDAC6 deficien.y. We iden.ified 107 protein. with elevated acetylation.in.the liver of HDAC6 kn.ckout mice. Three cytoplasmic protein., in.ludin. myosin.heavy chain.9 （MYH9）, heat shock cogn.te pro- tein.70 （HscT0）, an. dn.J homolog subfamily A member 1 （Dn.JA1）, were verified to in.eract with HDAC6. The acetylation.levels of these protein. were n.gatively regulated by HDAC6 both in.the mouse liver an. in.cultured cells. Fun.tion.l studies reveal that HDAC6- mediated deacetylation.modulates the actin.bin.in. ability of MYH9 an. the in.eraction.between.Hsc70 an. Dn.JA1. These fin.in.s con.olidate the n.tion.that HDAC6 serves as a critical regulator of protein.cetylation.with the capability of coordin.tin. various cellular fun.tion..

关键词： HDAC6 substrate lysin. acetylation.quan.itative proteomics in.eraction

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Detection.of Gen. Dosage in.Circulatin. Free Plasma Dn. as Biomarker for Lun. Can.er

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Journ.l of Can.er Therapy 2012年第4期3卷 343-351页

作者： Alba Mayerly Alvarez San.ra Jan.eth Perdomo Lara Dian. M. Palacios edward Fabián.Carrillo Luis Gerardo García Herreros Fidel Camacho Durán.Paulin. Ojeda León.Fabio A. Aristizábal 1Departamen.o de Farmacia Facultad de Ciencias Universidad Nacional de Colombia Bogotá Colombia Departamen.o de Farmacia Facultad de Ciencias Universidad Nacional de Colombia Bogotá Colombia Departamen.o de Patología Fundación Santa Fe de Bogotá (FSFB) Bogotá Colombia Departamen.o de Patología Hospital Santa Clara ESE Bogotá Colombia

The in.rease in.the n.mber of gen. copies at specific loci is a gen.tic alteration.frequen.ly associated with over expression.of the related protein.in.can.er cells. Gen.s whose dose is con.isten.ly augmen.ed in.can.er in.lude those in.olved in.cell cycle con.rol, proliferation. apoptosis, an. an.iogen.sis amon. others. In.this study, gen. dose of on. ogen.s MYCL1, MYCn. MYC, EGFR, ERBB2 an. AKT2 in.Dn. obtain.d from lun. tissue an. blood plasma, of patien.s with primary lun. can.er was evaluated with respect to n.rmal lun. tissue an. plasma Dn. of healthy in.ivid uals, to determin. the capacity of these gen.s to discrimin.te n.rmal an. n.oplastic phen.types. The n.mber of copies of each gen. was determin.d usin. real-time (2-△△CT). The AKT2 on.ogen. was foun. to be amplified frequen.ly in.plasma Dn. from patien.s (74% of cases). This marker showed a n.ticeable ability to discrimin.te n.rmal an. n.o-plastic phen.types, with a 76 to 89% probability of correctly recogn.ze a plasma sample provided by a lun. can.er patien. or a healthy in.ividual. For this reason. this detection.could be a very useful tool to supplemen. the existin. diagn.stic methods in.pulmon.ry can.er.

关键词： Lun. Can.er Gen. Amplification Plasma EGFR Family MYC Family