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自身免疫性肝炎（1）

中国农村医学杂志 2006年第3期4卷 9-12页

作者： edward l．krawitt 美国伯灵顿佛蒙特大学

自身免疫性肝炎是一种原因不明的慢性进展性肝炎，发生于儿童和各年龄期段的成年人。有时候病情有所波动，病变活动性时而加重，时而减轻。其诊断是根据组织学异常、特征性的临床和生化检查所见以及包括自身抗体在内的血清球蛋白异常。... 详细信息

自身免疫性肝炎是一种原因不明的慢性进展性肝炎，发生于儿童和各年龄期段的成年人。有时候病情有所波动，病变活动性时而加重，时而减轻。其诊断是根据组织学异常、特征性的临床和生化检查所见以及包括自身抗体在内的血清球蛋白异常。自从50多年前有人首次描述这种病以来，人们曾经对其冠以多种名称，但现在普遍认为“自身免疫性肝炎”是最恰当、最简洁的命名。除此之外，还存在变异型、重叠型或混合型自身免疫性肝炎，这些疾病与其他公认的自身免疫性肝病、原发性胆汁性肝硬化、原发性硬化性胆管炎有些相同的特征。目前很有必要描述一下这些疾病的区别。

关键词：自身免疫性肝炎原发性胆汁性肝硬化原发性硬化性胆管炎自身免疫性肝病蛋白异常病变活动性原因不明自身抗体生化检查进展性

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自身免疫性肝炎（2）

中国农村医学杂志 2006年第4期4卷 9-11页

作者： edward l．krawitt 美国伯灵顿佛蒙特大学

3 变异综合征虽然我们早就知道，所谓的重叠性、混合性变异综合征的临床、组织学和血清学特点，不同于经典的自身免疫性肝炎、原发性胆汁性肝硬化和原发性硬化性胆管炎，但对其分类一直没有形成共识。曾经有很多术语用于描述兼有自身... 详细信息

3 变异综合征虽然我们早就知道，所谓的重叠性、混合性变异综合征的临床、组织学和血清学特点，不同于经典的自身免疫性肝炎、原发性胆汁性肝硬化和原发性硬化性胆管炎，但对其分类一直没有形成共识。曾经有很多术语用于描述兼有自身免疫性肝炎和原发性胆汁性肝硬化特点的病人，如“重叠综合征”、“抗线粒体抗体阴性胆汁性肝硬化”、“自身免疫性胆管炎”、“免疫性胆管病”和“肝炎／胆汁淤积综合征”等。

关键词：自身免疫性肝炎原发性胆汁性肝硬化原发性硬化性胆管炎自身免疫性胆管炎重叠综合征胆汁淤积综合征抗体阴性抗线粒体重叠性混合性

Vapor-phase decomposition of dimethyl methylphosphonate (DMMP),a sarin surrogate,in presence of metal oxides

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Defence Technology（防务技术） 2021年第4期17卷 1095-1114页

作者： Shomik Mukhopadhyay Mirko Schoenitz edward l.Dreizin New Jersey Institute of Technology NewarkNJUSA

Chemical warfare agents(CWA)are stockpiled in large quantities across the *** stored in inaccessible facilities need to be destroyed rapidly without dispersing the compounds to surrounding ***-based energetic formulations are used in such prompt defeat applications to rapidly decompose the CWA by generating a high temperature *** alternate,and possibly a more effective decomposition pathway could be provided by chemicidal action of aerosolized condensed combustion products,which typically consist of metal *** fumes that escape the high temperature blast zone can be neutralized by smoke generated during combustion,depending on the particle size,surface characteristics,chemical properties,and concentration of this *** review considers relevant experimental and modeling studies quantifying decomposition of CWA comprising organophosphorus compounds and their surrogates on the surface of various metal *** methylphosphonate(DMMP),a sarine surrogate,was used most commonly for such *** reported efforts focused on the mechanisms of adsorption of DMMP to various metal oxides and initial reaction steps cleaving various bonds from the chemisorbed *** selected oxides,these experiments were supported by quantum-mechanical *** other studies,the capacity of oxide surfaces to adsorb and decompose DMMP was *** most cases,porous catalysts were used although limited experimental data are available for aerosolized nonporous oxide *** reported experimental data applicable to scenarios involving prompt decomposition of CWA are *** is noted that information is lacking describing respective heterogeneous reaction *** estimates of aerosolized smoke particle concentrations required to destroy CWA are made considering gas phase diffusion rates and reported values of the oxide capacity to decompose CWA or their surrogates.

关键词： Chemical weapon agents Prompt defeat Metal combustion Heterogeneous reactions

Rapid destruction of sarin surrogates by gas phase reactions with focus on diisopropyl methylphosphonate(DIMP)

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Defence Technology（防务技术） 2021年第3期17卷 703-714页

作者： Elif Irem Senyurt Mirko Schoenitz edward l.Dreizin New Jersey Institute of Technology NewarkNJ07102USA Tomsk State University TomskRussia

Rapid destruction of stockpiles of sarin and other chemical weapon agents(CWA)requires understanding and quantitative description of the relevant chemical *** reactions at elevated temperatures are of particular interest for prompt agent defeat *** methylphosphonate(DIMP)is a sarin surrogate particularly well suited to model sarin thermal decomposition and is often used in *** article is a review of different experimental methods addressing decomposition of gasified DIMP,respective results and their *** early decomposition products are propene,methylphosphonic acid,methyl(oxo)phosphoniumolate,and *** computational work using available kinetic data for fluorine and the phosphorus-fluorine bond predicted the decomposition under incineration *** using an isothermal flow reactor operated at 700-800 K were used to model DIMP decomposition as unimolecular reaction with results that were consistent with the earlier theoretical *** in dynamic environments was studied using DIMP supported on rapidly heated *** results showed different decomposition products and product sequences forming at different heating rates,suggesting the need for revised reaction ***,species quantification in such experiments is difficult because of inherent large temperature *** produced in a corona discharge was also reported to lead to rapid DIMP decomposition at low *** products were distinct from those observed at high *** tube experiments may be well suited to study decomposition of organophosphorus compounds like DIMP following their rapid heating in diverse ***,presently,only sarin surrogates other than DIMP have been investigated,and no intermediate reaction products,important for developing a validated mechanism,could be detected.

关键词： Chemical weapon agent Agent defeat Thermal decomposition Incineration Prompt reactions

High energy neutron and pion-decay gamma-ray emissions from solar flares

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Chinese Journal of Astronomy and Astrophysics 2009年第1期9卷 11-40页

作者： edward l.Chupp James M.Ryan Physics Department and Space Science Center in the Institute for the Study of Earth Oceans and Space University of New Hampshire

Solar flare gamma-ray emissions from energetic ions and electrons have been detected and measured to GeV energies since 1980. In addition, neutrons produced in solar flares with 100 MeV to GeV energies have been observed at the Earth. These emissions are produced by the highest energy ions and electrons accelerated at the Sun and they provide our only direct （albeit secondary） knowledge about the properties of the accelerator（s） acting in a solar flare. The solar flares, which have direct evidence for pion-decay gamma-rays, are unique and are the focus of this paper. We review our current knowledge of the highest energy solar emissions, and how the characteristics of the acceleration process are deduced from the observations. Results from the RHESSI, INTEGRAl and CORONAS missions will also be covered. The review will also cover the solar flare capabilities of the new mission, FERMI GAMMA RAY SPACE TElESCOPE, launched on 2008 June II. Finally, we discuss the requirements for future missions to advance this vital area of solar flare physics.

关键词： Sun -- Flares -- Particle Acceleration-Meson Production

The ascent of immune checkpoint inhibitors： is the understudy ready for a leading role？

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Cancer Biology & Medicine 2017年第4期14卷 341-347页

作者： Amy l. Cummings edward B. Garon Department of Hematology and Oncology David Geffen School of Medicine at the University of California Los Angeles 90095 USA

The recent approval of pembrolizumab as second-line treatment for any solid tumor with high-level microsatellite instability or mismatch repair deficiency agnostic of tissue and origin1 has shattered a glass ceiling for immune checkpoint *** longer bound to a specific cancer diagnosis but rather a biomarker,pembrolizumab has heightened a burgeoning optimism towards the drug *** how these agents should carve out additional

关键词： PD The ascent of immune checkpoint inhibitors:is the understudy ready for a leading role PFS OS ORR IHC

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell lines

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： edward Simpson Steven Chen Jill l.Reiter Yunlong liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBGlM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ElAVl RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBGlM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine

Non-iterative image reconstruction from sparse magnetic resonance imaging radial data without priors

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 84-91页

作者： Gengsheng l.Zeng edward V.DiBella Department of Radiology and Imaging Sciences University of Utah729 Arapeen DriveSalt Lake CityUT 84108USA Department of Engineering Utah Valley University800 West University ParkwayOrem 84058USA

The state-of-the-art approaches for image reconstruction using under-sampled k-space data are compressed sensing *** are iterative algorithms that optimize objective functions with spatial and/or temporal *** paper proposes a non-iterative algorithm to estimate the un-measured data and then to reconstruct the image with the efficient filtered backprojection *** feasibility of the proposed method is demonstrated with a patient magnetic resonance imaging *** proposed method is also compared with the state-of-the-art iterative compressed-sensing image reconstruction method using the total-variation optimization norm.

关键词： Tomographic image reconstruction Under-sampled measurements Fast magnetic resonance imaging Analytics reconstruction

Neural Network-Based Second Order Reliability Method(NNBSORM)for laminated Composite Plates in Free Vibration

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Computer Modeling in Engineering & Sciences 2018年第4期115卷 105-129页

作者： Mena E.Tawfik Peter l.Bishay edward E.Sadek Aerospace Engineering Department Faculty of EngineeringCairo UniversityEgypt Mechanical and Aerospace Engineering Department Rutgersthe State University of New JerseyNew BrunswickNJUSA Mechanical Engineering Department College of Engineering and Computer ScienceCalifornia State UniversityNorthridgeCAUSA.

Monte Carlo Simulations(MCS),commonly used for reliability analysis,require a large amount of data points to obtain acceptable accuracy,even if the Subset Simulation with Importance Sampling(SS/IS)methods are *** Second Order Reliability Method(SORM)has proved to be an excellent rapid tool in the stochastic analysis of laminated composite structures,when compared to the slower MCS ***,SORM requires differentiating the performance function with respect to each of the random variables involved in the *** most suitable approach to do this is to use a symbolic solver,which renders the simulations very slow,although still faster than ***,the inability to obtain the derivative of the performance function with respect to some parameters,such as ply thickness,limits the capabilities of the classical *** this work,a Neural Network-Based Second Order Reliability Method(NNBSORM)is developed to replace the finite element algorithm in the stochastic analysis of laminated composite plates in free *** of the ability to obtain expressions for the first and second derivatives of the NN system outputs with respect to any of its inputs,such as material properties,ply thicknesses and orientation angles,the need for using a symbolic solver to calculate the derivatives of the performance function no longer *** proposed approach is accordingly much faster,and easily allows for the consideration of ply thickness *** present analysis showed that dealing with ply thicknesses as random variables results in 37%increase in the laminate’s probability of failure.

关键词： Reliability analysis artificial neural network composite laminates subset simulation importance sampling Monte Carlo