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Extracorporeal shock wave for plantar flexor spasticity in spinal cord injury:A case report and review of literature

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World Journal of Clinical Cases 2023年第1期11卷 127-134页

作者： Natalia Comino-Suárez Julio Gómez-Soriano Silvia Ceruelo-Abajo eduardo vargas-baquero Ana Esclarín Juan Avendaño-Coy Toledo Physiotherapy Research Group Faculty of Physiotherapy and NurseryCastilla La Mancha UniversityToledo 45071ToledoSpain Department of Physical and Rehabilitation Medicine Hospital Nacional de ParapléjicosSescamToledo 45071ToledoSpain

BACKGROUND Approximately 65%-78%of patients with a spinal cord injury(SCI)develop any symptom of *** aim of this study was to investigate the tolerability and short-term effects of radial extracorporeal shock wave therapy(r ESWT)on plantar flexor spasticity in a patient with incomplete *** SUMMARY An 18-year-old man with an incomplete SCI completed five sessions of r *** primary outcomes were the changes in ankle-passive range of motion(APROM)and passive resistive force to ankle *** outcomes were assessed at baseline(T0),immediately after treatment(T1)and 1 wk after the end of treatment(T2).The A-PROM increased by 15 degrees at T1 and 25 degrees at T2 compared with *** passive resistive force to ankle dorsiflexion at low velocity decreased by 33%at T1 and 55%at T2 in the gastrocnemius muscle and by 41%at T1 and 39%at T2 in the soleus muscle compared with *** high velocity,it also decreased by 44%at T1 and 30%at T2 in the gastrocnemius muscle compared with ***,in the soleus muscle,the change was minor,with a decrease of 12%at T1 and increased by 39%at T2 compared with *** In this patient,the findings showed that r ESWT combined with conventional therapy was well-tolerated and could be effective in improving A-PROM and passive resistive force to ankle dorsiflexion in the *** randomized controlled clinical trials with longer period of follow-up are necessary to confirm the results obtained in patients with SCI.

关键词： Spasticity Spinal cord injury Radial extracorporeal shock wave therapy Rehabilitation Case report

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Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex Dominguez-vargas Jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-vargas Susana Garcia Mauricio Arcos-Burgos eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari Joséeduardo vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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Analysing vaccine efficacy evaluated in phase 3 clinical trials carried out during outbreaks

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Infectious Disease Modelling 2024年第4期9卷 1027-1044页

作者： Francisco Antonio Bezerra Coutinho Marcos Amaku Fernanda Castro Boulos Jose Alfredo de Sousa Moreira Joao Italo DiasFranca Julio Antonio do Amaral Eliana Nogueira Castro de Barros Claudio Jose Struchiner Esper Jorge Kallas eduardo Massad School of Medicine University of Sao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil

In this paper we examine several definitions of vaccine efficacy(VE)that we found in the literature,for diseases that express themselves in outbreaks,that is,when the force of infection grows in time,reaches a maximum and then *** fact that the disease occurs in outbreaks results in several problems that we *** propose a mathematical model that allows the calculation of VE for several *** trials usually needs a large number of volunteers that must be ***,all volunteers should be enrolled in approximately the same time,but this is generally impossible for logistic reasons and they are enrolled in a fashion that can be replaced by a continuous density function(for example,a Gaussian function).The outbreak can also be replaced by a continuous density function,and the use of these density functions simplifies the ***,for example Gaussian functions,one of the problems one can immediately notice is that the peak of the two curves do not occur at the same *** model allows us to conclude:First,the calculated vaccine efficacy decreases when the force of infection increases;Second,the calculated vaccine efficacy decreases when the gap between the peak in the force of infection and the peak in the enrollment rate increases;Third,different trial protocols can be simulated with this model;different vaccine efficacy definitions can be calculated and in our simulations,all result are approximately the *** final,and perhaps most important conclusion of our model,is that vaccine efficacy calculated during outbreaks must be carefully examined and the best way we can suggest to overcome this problem is to stratify the enrolled volunteer's in a cohort-by-cohort basis and do the survival analysis for each cohort,or apply the Cox proportional hazards model for each cohort.

关键词： Vaccine efficacy Clinical trials Mathematical models Simulations Covid-19

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Driving Factors for Forest Fire Occurrence in Durango State of Mexico:A Geospatial Perspective

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Chinese Geographical Science 2010年第6期20卷 491-497页

作者： Diana Avila-Flores Marin Pompa-Garcia Xanat Antonio-Nemiga Dante A Rodriguez-Trejo eduardo vargas-Perez Javier Santillan-Perez Forestry Division University of Chapingo Faculty of Forestry Juarez University of the State of DurangoRio Papaloapan and Durango Blvd Faculty of Geography Autonomous University of Mexico StateCerro de Coatepec s/nCiudad Universitaria

Forest fire is one of the major causes of forest loss and therefore one of the main constraints for sustainable forest management *** the driving factors and understanding the contribution of each factor are essential for the management of forest fire *** objective of this study is to identify variables that are spatially related to the occurrence and incidence of the forest fire in the State of Durango,*** this purpose,data from forest fire records for a five-year period were *** spatial correlations between forest fire occurrence and intensity of land use,susceptibility of vegetation,temperature,precipitation and slope were tested by Geographically Weighted Regression(GWR) method,under an Ordinary Least Square *** show that the spatial pattern of the forest fire in the study area is closely correlated with the intensity of land use,and land use change is one of the main explanatory *** addition,vegetation type and precipitation are also the main driving *** fitting model indicates obvious link between the *** fire was found to be the consequence of a particular combination of the environmental factors,and when these factors coexist with human activities,there is high probability of forest fire *** regulation of human activities is a key strategy for forest fire prevention.

关键词： forest fire Geographically Weighted Regression(GWR) land use forest management Durango State Mexico

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Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice

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World Journal of Gastroenterology 2018年第4期24卷 461-474页

作者： Roberto Rodriguez-Echevarria Jose Macias-Barragan Marcela Parra-vargas Judith Rebeca Davila-Rodriguez eduardo Amezcua-Galvez Juan Armendariz-Borunda Institute for Molecular Biology and Gene Therapy-CUCS Department of Molecular Biology and GenomicsUniversity of GuadalajaraGuadalajara 44340Mexico Department of Health Sciences-CUValles University of GuadalajaraGuadalajara 46600Mexico Hospital Civil de Guadalajara Guadalajara 46600Mexico

AIM To study the effect of 18-hydroxy-eicosapentaenoic acid(18-HEPE) and 17-hydroxy-docosahexaenoic acid(17-HDHA) in a murine model of obesity/nonalcoholic fatty liver *** C57 BL/6 mice were fed with standard chow diet(CD) or high-fat, fructose-enriched diet(HFD) for 16 wk. Then, three groups were treated for 14 d with either, diet switch(HFD for CD), 18-HEPE, or 17-HDHA. Weightand fasting glucose were recorded on a weekly basis. Insulin tolerance test was performed at the end of treatment. Histological analysis(HE and Masson's trichrome stain) and determination of serum insulin, glucagon, glucagon-like peptide 1(GLP-1), glucose-dependent insulinotropic polypeptide, adiponectin and resistin were carried out as well as liver proteins by western *** Mice treated with hydroxy-fatty acids 18-HEPE and 17-HDHA displayed no weight loss or improved insulin sensitivity. However, these mice groups showed a significant amelioration on serum GLP-1, adiponectin and resistin levels. Also, a significant reduction on inflammatory infiltrate was observed at both portal and lobular zones. Furthermore, up-regulation of PPARα/γ protein levels was observed in liver tissue and it was associated with decreased levels of NF-κB also determined by western blot analysis. On the other hand, diet switch regimen resulted in a marked improvement in most parameters including: weight loss, increased insulin sensitivity, decreased steatosis, restored levels of insulin, glucagon, leptin, adiponectin and resistin. However, no significant changes were observed regarding inflammatory infiltrate in this last *** 18-HEPE and 17-HDHA differentially exert hepatoprotective effects through up-regulation of nuclear receptors PPARα/γ and amelioration of serum adipokines profile.

关键词： Nonalcoholic fatty liver disease Polyunsaturated fatty acids 18-hydroxy-eicosapentaenoic acid 17-hydroxy-docosahexaenoic acid Obesity

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Global stability for multi-species Lotka-Volterra cooperative systems： One hyper-connected mutualistic-species

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International Journal of Biomathematics 2015年第3期8卷 215-223页

作者： Cruz vargas-De-Leon Unidad de Medicina Experimental Hospital General de Mexico"Dr. eduardo Liceaga" DF 06726 Mexico

We propose two models of one hyper-connected mutualistic-species described by delay differential equations of Lotka-Volterra type. An hyper-connected model comprises a central species interacting with a number of peripheral species around it, that is to say, one animal species （pollinators or dispersers） that interacts with several plant species （flowering plants or fruit trees）, or several animal species that interact with one plant species. We derive a necessary and sufficient condition for the global asymptotic stability of the unique coexisting steady state of hyper-connected systems by means of novel Lyapunov functionals.

关键词： Lotka Volterra cooperative system discrete delays distributed delays Lyapunov functional global stability.

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Construction of Dulac functions for mathematical models in population biology

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International Journal of Biomathematics 2015年第3期8卷 135-154页

作者： Osvaldo Osuna Cruz vargas-De-Leon Instituto de Fisica y Matematicas Universidad MichoacanaEdif. C-3 Cd. Universitaria CP 58040 Morelia Michoacan Mexico Unidad de Medicina Experimental Hospital General de Mexico "Dr. Eduardo Liceaga" DF 06726 Mdxieo

In this paper, we present a method for constructing a Dulac function for mathematical models in population biology, in the form of systems of ordinary differential equations in the plane.

关键词： Population models epidemic models chemostat models Dulac function nonexistence of periodic orbits.

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Liver disorders in COVID-19,nutritional approaches and the use of phytochemicals

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World Journal of Gastroenterology 2021年第34期27卷 5630-5665页

作者： Nancy vargas-Mendoza Jazmín García-Machorro Marcelo Angeles-Valencia Marlet Martínez-Archundia eduardo Osiris Madrigal-Santillán Ángel Morales-González Liliana Anguiano-Robledo JoséA Morales-González Laboratorio de Medicina de Conservacion Instituto Politécnico NacionalMéxico 11340Mexico Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica Instituto Politécnico NacionalMéxico 11340Mexico Superior de Medicina Instituto Politécnico NacionalMéxico 11340Mexico Escuela Superior de Cómputo Instituto Politécnico NacionalMéxico 07738Mexico Laboratorio de Farmacología Molecular Instituto Politécnico NacionalMéxico 11340Mexico Laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalMéxico 11340Mexico

Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),has affected millions of people *** was declared a pandemic by the World Health Organization in March *** hyperinflammatory response to the entry of SARS-CoV-2 into the host through angiotensin-converting enzyme 2 is the result of a“cytokine storm”and the high oxidative stress responsible for the associated *** only respiratory symptoms are reported,but gastrointestinal symptoms(diarrhea,vomiting,and nausea)and liver abnormalities(high levels of aspartate aminotransferase,alanine aminotransferase transaminases,and bilirubin)are observed in at least 30%of *** food intake and a delay in medical services may lead to malnutrition,which increases mortality and poor *** review provides some strategies to identify malnutrition and establishes nutritional approaches for the management of COVID-19 and liver injury,taking energy and nutrient requirements and their impact on the immune response into *** roles of certain phytochemicals in the prevention of the disease or as promising target drugs in the treatment of this disease are also considered.

关键词： COVID-19 Infection Liver Nutrition therapy Phytochemicals

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Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender

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World Journal of Hepatology 2018年第2期10卷 297-307页

作者： José A Morales-González María de Lourdes Sernas-Morales ángel Morales-González Laura Ligía González-López eduardo Osiris Madrigal-Santillán Nancy vargas-Mendoza Tomás Alejandro Fregoso-Aguilar Liliana Anguiano-Robledo eduardo Madrigal-Bujaidar Isela álvarez-González Germán Chamorro-Cevallos Laboratorio de Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico Nacional área Académica de Nutrición ICSa Universidad Autónoma del Estado de Hidalgo Depto. de Fisiología Laboratorio de Hormonas y Conducta ENCB campus Zacatenco Instituto Politécnico Nacional Laboratorio de Farmacología Molecular Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina-Instituto Politécnico Nacional Laboratorio de Genética Escuela Nacional de Ciencias Biológicas IPN Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional

AIM To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in *** Wistar rats weighing 170-200 g were divided into groups as follows:(1) Control groups; and(2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations:(1) Group of males or females with a consumption of a solution of alcohol at 40%; and(2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase(ALT), Aspartate Aminotransferase(AST), Lactate Dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. Liver samples from each group were employed to analyze morphological abnormalities by light *** In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding ALT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocel ular disorganization CONCLUSION The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.

关键词： Weekend alcohol consumption Liver morphology Transaminases Damage

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