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Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?

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World Journal of Gastroenterology 2014年第20期20卷 6092-6101页

作者： Carlos Aguado Beatriz García-Paredes Miguel Jhonatan Sotelo Javier Sastre eduardo díaz-rubio department of Medical Oncology Hospital Clínico San Carlos 28040 Madrid Spain

Fluoropyrimidines play a central role in the first-line treatment of metastatic colorectal cancer. Our aim was to review whether capecitabine was a safer, non-inferior, economically superior and more convenient alternative to 5-fluorouracil. Capecitabine has previously been compared to 5-fluorouracil-either as a monotherapy or in combination with oxaliplatin, irinotecan, or biological drugs-and has been found to have comparable efficacy and safety profiles. Furthermore, pharmacoeconomic data and patients’ preferences for oral chemotherapy further favor capecitabine. Therefore, capecitabine appears to be an effective and safe alternative to fluorouracil in the first-line treatment of metastatic colorectal cancer.

关键词： Capecitabine 5-Fluorouracil Metastatic colorectal cancer

Role of cetuximab in first-line treatment of metastatic colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4208-4219页

作者： Miguel Jhonatan Sotelo Beatriz García-Paredes Carlos Aguado Javier Sastre eduardo díaz-rubio Center affiliate to the "Red Temática de Investigación Cooperativa (Rd12/0036/006)" Instituto Carlos ⅢSpanish Ministry of Economy and Competitivity. Oncology DepartmentHospital Clínico San Carlos28040 MadridSpain department of Medicine School of MedicineUniversidad Complutense de Madrid28040 MadridSpain

The treatment of metastatic colorectal cancer(mCRC)has evolved considerably in the last decade,currently allowing most mCRC patients to live more than two *** antibodies targeting the epidermal growth factor receptor(EGFR)and vascular endothelial growth factor play an important role in the current treatment of these ***,only antibodies directed against EGFR have a predictive marker of response,which is the mutation status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS).Cetuximab has been shown to be effective in patients with KRAS wild-type *** CRYSTAL study showed that adding cetuximab to FOLFIRI(regimen of irinotecan,infusional fluorouracil and leucovorin)significantly improved results in the first-line treatment of KRAS wildtype ***,results that evaluate the efficacy of cetuximab in combination with oxaliplatin-based chemotherapy in this setting are *** the other hand,recent advances in the management of colorectal liver metastases have improved survival in these *** cetuximab to standard chemotherapy increases the response rate in patients with wild-type KRAS and can thus increase the resectability rate of liver metastases in this group of *** this paper we review the different studies assessing the efficacy of cetuximab in the first-line treatment of mCRC.

关键词： Cetuximab First-line Metastatic colorectal cancer Colorectal liver metastases Elderly patients

Telomere function in colorectal cancer

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 3-11页

作者： Cristina Frías Alberto Morán Carmen de Juan Paloma Ortega Tamara Fernández-Marcelo Andrés Sánchez-Pernaute Antonio José Torres eduardo díaz-rubio Manuel Benito Pilar Iniesta department of Biochemistry and Molecular Biology Faculty of PharmacyComplutense University Surgery Service San Carlos Hospital Oncology Service San Carlos Hospital

Colorectal cancer is the third most common form of cancer and the second leading cause of cancer-related death in the western *** cells acquire the hallmarks of cancer during the carcinogenic selection *** immortality is one of the principal features acquired during this process which involves the stabilization of telomere *** is achieved mainly,by telomerase ***,the discovery of telomeres and telomerase allowed an understanding of the mechanisms by which cells can become *** studies have shown that tumour cells have shorter telomeres than nontumour cells and have detected telomerase activity in the majority of *** studies have determined that telomere maintenance and telomerase activity are associated with poor *** into account all the results achieved by different groups,quantification and evaluation of telomerase activity and measurement of telomere length may be useful methods for additional biologic and prognostic staging of colorectal carcinoma.

关键词： Colorectal cancer Telomeres Immortality

differential colorectal carcinogenesis:Molecular basis and clinical relevance

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 151-158页

作者： Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres eduardo díaz-rubio Pilar Iniesta Manuel Benito the second department of Biochemistry and Molecular Biology School of PharmacyComplutense University Surgery Service Ⅱ Clínico San Carlos Hospital Oncology Service Clínico San Carlos Hospital

Colorectal cancer(CCR) is one of the most frequent cancers in developed *** poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal *** has been established that sporadic CCRs can arise from at least two different carcinogenic *** traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or *** in the Wnt pathway are also very common in this type of *** second main colorectal carcinogenesis pathway is the mutator *** pathway is present in nearly 15% of all cases of sporadic colorectal *** is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the dNA mismatch repair genes,mostly in hMLH1 or *** two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological *** strikingly,their clinical behaviours are completely different,having the "mutator" tumours a better outcome than the "suppressor" tumours.

关键词： Colorectal cancer Microsatellite instability Clinical outcome

design of a Novel Exoskeleton with Passive Magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.Rodríguez-León Betsy d.M.Chaparro-Rico daniele Cafolla Francesco Lago eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico department of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive degrees of Freedom(doF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

Pesticides in a temperate coastal lagoon in southwest Europe (Ria de Aveiro, Portugal) – Risk assessment and acute assays with Artemia and daphnia

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Emerging Contaminants 2024年第2期10卷 40-56页

作者： Maria João Rocha eduardo Rocha Laboratory of Histology and Embryology Department of MicroscopyICBAS-School of Medicine and Biomedical SciencesUniversity of Porto(U.Porto)Portugal Team of Animal Morphology and Toxicology Interdisciplinary Centre of Marine and Environmental Research(CIIMAR/CIMAR)U.PortoPortugal

The Ria de Aveiro lagoon has been considered one of the most important Southern European long-term monitoring sites(LTER-site)concerning climate change and anthropogenic ***,studies concerning pesticide contamination herein are few and mostly ***,56 pesticides dissolved in the aqueous phase(dAP)and suspended particulate matter(SPM)were examined to fill the knowledge gap,considering the hydrophobic nature of most evaluated *** samples were taken seasonally from eight sites,and both dAP and SPM fractions were analysed by gas-chromatography-mass *** annual average concentrations of fungicides,herbicides and insecticides were≈57 ng/L,≈409 ng/L and≈1058 ng/L in dAP and≈7μg/g,≈28μg/g and≈67μg/g in *** pesticides and the excessive phosphate concentrations suggest that the lagoon's water quality may be hazardous to biota and *** were identified as the most threatened trophic level using deterministic risk assessment,with chlorpyriphos and chlorfenvinphos being the primary *** experiments with Artemia and daphnia supported the suppositions.

关键词： Coastal lagoon Invertebrate bioassays Risk evaluation Waterborne pesticides

Impact of low alcohol consumption in the natural history of cirrhosis

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 161-164页

作者： david Marti-Aguado eduardo Vilar-Gomez digestive disease department Clinic University HospitalINCLIVA Health Research InstituteValenciaSpain division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisINUSA

Alcohol-related liver disease(ALd)and metabolic dysfunction-associated steatotic liver disease(MASLd)are the most common causes of chronic liver disease worldwide(1).daily alcohol consumption thresholds(day for women andday for men)are used to arbitrarily differentiate MASLd from ALd(2).However,“safe”levels of alcohol intake are difficult to define because of wide variations in the factors that contribute to its susceptibility and multiple effect *** MASLd,conflicting results on whether light alcohol intake is detrimental or beneficial.

关键词： Compensated cirrhosis alcohol consumption mortality hepatic decompensation

How far have we come?Review of main public policies to reduce landslide impacts in Brazil

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Journal of Mountain Science 2024年第9期21卷 2891-2904页

作者： Bianca Carvalho VIEIRA Tiago damas MARTINS Telma Mendes da SILVA Joséeduardo BONINI department of Geography University of São PauloAvenida Professor Lineu Prestes 05508-000Brazil Cities Institute Federal University of São PauloAvenida Jacu-Pêssego 08260-001Brazil department of Geography Federal University of Rio de JaneiroAvenida Athos da Silveira Ramos 21941-916Brazil

during the rainy season in Brazil,landslides can have catastrophic consequences,including loss of life,damage to urban infrastructure and significant economic ***,more than eight million people in Brazil live in disaster-prone *** objective of this article is to present a chronological review of the principal policies and programmes at the national,state,and municipal levels,with an emphasis on their key actions aimed at mitigating the impact of disasters related to natural hazards,particularly *** analysis was based on official records of public policies from the national,state,and municipal *** results show that several initiatives were initially developed at the local and regional ***,it was not until the late 1980s that a comprehensive organisation of civil protection at the national level emerged as a response *** is possible to highlight three phases(understanding,coexistence,and prevention)of institutional action focused on risk management in the face of *** the growing knowledge of risk scenarios,disasters continue to occur in Brazil on an annual basis,revealing several obstacles to reducing their impact,particularly given the social and economic disparities between Brazilian regions and the applicability of public policies that must overcome the limitations of each municipality.

关键词： disasters Risk Mitigation Prevention Legislation Civil defense Natural Hazards

Assembly structures of coastal woody species of eastern South America:Patterns and drivers

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Plant diversity 2024年第5期46卷 611-620页

作者： eduardo Vinícius da Silva Oliveira Myrna Friederichs Landim Sidney F.Gouveia Graduate Program in Ecology and Conservation Federal University of SergipeSão CristovãoSergipeBrazil National Institute of Science and Technology Ecology Evolution and Conservation of Biodiversity(INCT-EECBio)GoiâniaGoiasBrazil department of Biology Federal University of SergipeSão CristóvãoSergipeBrazil department of Ecology Federal University of SergipeSão CristóvãoSergipeBrazil

Tropical regions have provided new insights into how ecological communities are *** dry coastal communities,water stress has been hypothesized to determine plant assembly structure by favoring preadapted lineages from neighboring ecosystems,consistent with functional ***,it is unclear whether this hypothesis is sufficient to explain how coastal communities in tropical ecosystems are ***,we test whether water stress or other factors drive community assembly in woody plant communities across the coastal zone of Brazil,a tropical *** characterized functional and phylogenetic structures of these communities and determined the underlying environmental factors(e.g.,water stress,historical climate stability,edaphic constraints,and habitat heterogeneity)that drive their community *** of coastal woody species show geographically varied patterns,including stochastic arrangements,clustering,and overdispersion of species relative to their traits and phylogenetic *** complexity,water vapor pressure,and soil nutrient availability best explained the gradient in the functional *** deficit,water vapor pressure,and soil organic carbon were the best predictors of variation in phylogenetic *** results support the water-stress conservatism hypothesis on functional and phylogenetic structure,as well as the effect of habitat heterogeneity on functional structure and edaphic constraints on functional and phylogenetic *** effects are associated with increased phenotypic and phylogenetic divergence of woody plant assemblages,which is likely mediated by abiotic filtering and niche opportunities,suggesting a complex pattern of ecological assembly.

关键词： Brazil Completeness Clustering Restinga vegetation Water constraints