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Effects of bioactive compounds from Pleurotus mushrooms on COVID-19 risk factors associated with the cardiovascular system

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Journal of Integrative Medicine 2022年第5期20卷 385-395页

作者： eduardo Echer dos Reis Paulo Cavalheiro Schenkel Marli Camassola Department of Physiology Federal University of Rio Grande do SulCampus Centro 90050-170 Porto AlegreBrazil Enzymes and Biomass Laboratory Institute of BiotechnologyUniversity of Caxias do Sul95070-560 Caxias do SulBrazil Department of Physiology and Pharmacology Federal University of PelotasCampus Capão do Leão96900-010 PelotasBrazil

Mushrooms are a group of fungi with great diversity and ultra-accelerated *** a consequence,mushrooms have developed a protective mechanism consisting of high concentrations of antioxidants such as selenium,polyphenols,β-glucans,ergothioneine,various vitamins and other bioactive *** mushrooms of the Pleurotus genus have generated scientific interest due to their therapeutic properties,especially related to risk factors connected to the severity of coronavirus disease 2019(COVID-19).In this report,we highlight the therapeutic properties of Pleurotus mushrooms that may be associated with a reduction in the severity of COVID-19:antihypertensive,antihyperlipidemic,antiatherogenic,anticholesterolemic,antioxidant,anti-inflammatory and antihyperglycemic *** properties may interact significantly with risk factors for COVID-19 severity,and the therapeutic potential of these mushrooms for the treatment or prevention of this disease is *** this,studies show that regular consumption of Pleurotus species mushrooms or components isolated from their tissues is beneficial for immune *** species mushrooms may have a role in the prevention or treatment of infectious diseases either as food supplements or as sources for pharmacological agents.

关键词： Pleurotus Food supplements COVID-19 SARS-Cov-2 Coronavirus Antiviral agents

Detecting stable phase structures in EEG signals to classify brain activity amplitude patterns

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1483-1491页

作者： Yusely RUIZ Guang LI Walter J.FREEMAN eduardo GONZALEZ Department of Biomedical Engineering Zhejiang University Hangzhou 310027China National Lab of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China Department of Molecular&Cell Biology 101 Donner University of California at BerkeleyCA 94720-3206USA

Obtaining an electrocorticograms(ECoG)signal requires an invasive procedure in which brain activity is recorded from the cortical *** contrast,obtaining electroencephalograms(EEG)recordings requires the non-invasive procedure of recording the brain activity from the scalp surface,which allows EEG recordings to be performed more easily on healthy *** this work,a technique previously used to study spatial-temporal patterns of brain activity on animal ECoG was adapted for use on *** main issues are centered on solving the problems introduced by the increment on the interelectrode distance and the procedure to detect stable *** results showed that spatial patterns of beta and gamma activity can also be extracted from the EEG signal by using stable frames as time markers for feature *** adapted technique makes it possible to take advantage of the cognitive and phenomenological awareness of a normal healthy subject.

关键词： Electroencephalograms(EEG) Spatial-temporal pattem Stable phase structure Frames

Scotogenic dark symmetry as a residual subgroup of Standard Model symmetries

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Chinese Physics C 2020年第8期44卷 108-114页

作者： Salvador Centelles Chuliá Ricardo Cepedello eduardo Peinado Rahul Srivastava AHEP Group Institut de Física Corpuscular-CSIC-Universitat de ValènciaParc Científic de Paterna.C/Catedrático JoséBeltrán2 E-46980 Paterna(Valencia)-SPAIN Instituto de Física Universidad Nacional Autónoma de MéxicoA.P.20-364Ciudad de México 01000México Department of Physics Indian Institute of Science Education and Research-BhopalBhopal Bypass RoadBhauriBhopalIndia

We demonstrate that a scotogenic dark symmetry can be obtained as a residual subgroup of the global U(1)B−L symmetry already present in the Standard *** addition,we propose a general framework in which the U(1)B−L symmetry is spontaneously broken into an even Z2n subgroup,setting the general conditions for neutrinos to be Majorana and for dark matter stability to exist in terms of the residual *** an example,under this general framework,we build a class of simple models where,in a scotogenic manner,the dark matter candidate is the lightest particle running inside the mass loop of a *** global U(1)B−L symmetry in our framework,being anomaly free,can also be gauged in a straightforward manner leading to a richer phenomenology.

关键词： neutrino masses dark matter symmetries scotogenic

Phenolic compounds of green tea: Health benefits and technological application in food

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 709-719页

作者： Jose Manuel Lorenzo Paulo eduardo Sichetti Munekata Meat Technological Center of Galicia Galicia Street No.4 Parque Tecnolgico de Galicia San Cibrao das Vinas Department of Food Engineering Faculty of Animal Science and Food Engineering University of Sao Paulo

Green tea has been an important beverage for humans since ancient times, widely consumed and considered to have health benefits by traditional medicine in Asian countries. Green tea phenolic compounds are predominately composed of catechin derivatives, although other compounds such as flavonols and phenolic acids are also present in lower proportion. The bioactivity exerted by these compounds has been associated with reduced risk of severe illnesses such as cancer, cardiovascular and neurodegenerative diseases. Particularly, epigallocatechin gallate has been implicated in alteration mechanisms with protective effect in these diseases as indicated by several studies about the effect of green tea consumption and mechanistic explanation through in vitro and in vivo experiments. The biological activity of green tea phenolic compounds also promotes a protective effect by antioxidant mechanisms in biological and food systems, preventing the oxidative damage by acting over either precursors or reactive species. Extraction of phenolic compounds influences the antioxidant activity and promotes adequate separation from green tea leaves to enhance the yield and/or antioxidant activity. Application of green tea phenolic compounds is of great interest because the antioxidant status of the products is enhanced and provides the product with additional antioxidant activity or reduces the undesirable changes of oxidative reactions while processing or storing *** this scenario, meat and meat products are greatly influenced by oxidative deterioration and microbial spoilage, leading to reduced shelf life. Green tea extracts rich in phenolic compounds have been applied to increase shelf life with comparable effect to synthetic compounds, commonly used by food industry. Green tea has great importance in general health in technological application, however more studies are necessary to elucidate the impact in pathways related to other diseases and food applications.

关键词： Phenolic profile Healthy Neurodegenerative diseases Extraction of polyphenols Antioxidant mechanism Food stability

Clinical relevance of stem cells in lung cancer

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World Journal of Stem Cells 2023年第6期15卷 576-587页

作者： Horacio eduardo Romeo María Laura Barreiro Arcos School of Engineering and Agrarian Sciences Pontifical Catholic University of ArgentinaInstitute of Biomedical Research(BIOMED-UCA-CONICET)CABA C1107AAZBuenos AiresArgentina

Lung cancer is the major cause of cancer-related deaths worldwide,it has one of the lowest 5-year survival rate,mainly because it is diagnosed in the late stage of the *** cancer is classified into two groups,small cell lung cancer(SCLC)and non-SCLC(NSCLC).In turn,NSCLC is categorized into three distinct cell subtypes:Adenocarcinoma,squamous cell carcinoma,and large cell *** is the most common lung cancer,accounting for 85%of all lung *** for lung cancer is linked to the cell type and stage of the disease,involving chemotherapy,radiation therapy,and *** improvements in therapeutic treatments,lung cancer patients show high rates of recurrence,metastasis,and resistance to *** stem cells(SCs)are undifferentiated cells capable of self-renewal and proliferation,are resistant to chemotherapy and radiotherapy and,due to their properties,could be involved in the development and progression of lung *** presence of SCs in the lung tissue could be the reason why lung cancer is difficult to *** identification of lung cancer stem cells biomarkers is of interest for precision medicine using new therapeutic agents directed against these cell *** this review,we present the current knowledge on lung SCs and discuss their functional role in the initiation and progression of lung cancer,as well as their role in tumor resistance to chemotherapy.

关键词： Lung cancer Cancer stem cells Biomarkers Chemoresistance

Tips and tricks for cannabinoid receptor 1 detection, interaction and interpretation

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Neural Regeneration Research 2021年第8期16卷 1535-1536页

作者： Pedro F.Esteban eduardo Molina-Holgado Laboratory of Neuroinflammation Hospital Nacional de Parapléjicos(SESCAM)ToledoSpain

Proteomic approaches are currently used to explore and identify interacting partners of proteins involved in diverse biological processes or with therapeutic *** cannabinoid receptor 1,CB_1,is the main mediator of cannabinoids effects in the central nervous *** role of the endocannabinoid system in development and physiology and as a target of pharmacological and cellular therapies is the subject of intense ***。

关键词： potential. interaction intense

Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice

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Asian Journal of Andrology 2005年第1期7卷 71-76,页

作者： eduardo Bustos-Obregon Sandra Yucra Gustavo F.Gonzales Faculty of Medicine University of Chile and lnstituto de Investigaciones de la Altura and Faculty of Sciences and Philosophy Universidad Peruana Cayetano Heredia Lima Peru

Aim: To observe the effect of the aqueous extract of hypocotyls of the plant Lepidium meyenii (Maca) on spermato-genic damage induced by the organophosphate insecticide malathion in mice. Methods: Mice were treated with 80 mg kg^(-1) of malathion in the presence or absence of an aqueous extract of Maca, which was orally administered 7, 14 or 21 days after injection of the malathion. Stages of the seminiferous epithelium were assessed by transillumination on days 0, 7, 14 and 21. Results: The administration of Maca increased significantly the length of stage 鈪?on days 7, 14 and 21 of treatment compared with the controls. An increase in the length of stage 鈪?occurred on day 14 of treatment. Malathion affected spermatogenesis by reducing the lengths of stage 鈪?on day 7, stages 鈪?and 鈪?鈪?on day 14 and a recovery of stages 鈪?鈪?on day 21. The magnitude of alteration in the length of stage 鈪?produced by malathion was significantly reduced by Maca on days 7 and 14. The length of stage 鈪?was increased when Maca was administered to mice treated with malathion. Assessment of the relative length of stages of the seminiferous epithelium showed that Maca treatment resulted in rapid recovery of the effect of malathion. Conclusion: Maca enhances spermatogenesis following spermatogenic damage caused by the organophosphorous pesticide.

关键词： malathion spermatogenesis Lepidium meyenii (Maca) mice seminiferous epithelium stages

Identification of ISSR markers linked to flowering traits in a representative sample of Eucalyptus cladocalyx

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Journal of Forestry Research 2016年第2期27卷 239-245页

作者： Rodrigo Contreras-Soto Paulina Ballesta eduardo Ruiz Freddy Mora Department of Agronomy State University of Maring Department of Botany University of Concepción Institute of Biological Sciences University of Talca

Early flowering and flower abundance have long been considered desirable traits in eucalypt breeding programs. In particular, flowers of Eucalyptus cladocalyx provide a nectar source for the production of honey in arid ecosystems. To identify inter-simple sequence repeat （ISSR） markers that are associated with early flowering and flower abundance in the southern Atacama Desert, we used a sample of 47 trees, representing five Australian prove- nances of E. cladocalyx. A unified mixed linear model （which considered the effect of genetic structure and the kinship relationship among trees） revealed that three loci were significantly associated with early flowering, which accounted for 10-16 % of the phenotypic variation, while two loci accounted for 11-13 % in flowering intensity. Locus ISO1-500 bp was associated with both flowering traits. This result is consistent with our previous findings indicating that marker-assisted selection on early flowering should have significant and positive impact on flowering intensity. The application of marker-assisted selection to identify trees that flower early and intensively may increase honey production, a resource that generates additional income for the local farmers of the southern Atacama Desert.

关键词： Eucalyptus cladocalyx ISSR Floweringtraits Marker-assisted selection

Effect of grain recrystallization on stir zone and mechanical property behavior of TRIP 780 steel

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Journal of Iron and Steel Research International 2020年第2期27卷 188-196页

作者： Gladys Perez-Medina Hugo Lopez Argelia Miranda-Perez eduardo Hurtado-Delgado Postgraduate Studies Mexican Corporation in Materials ResearchSaltillo Coahuila 25290Mexico Materials Department University of Wisconsin-MilwaukeeMilwaukeeWI 53201USA

Electron backscatter diffraction(EBSD)and transmission electron microscopy were used to determine the presence of retained austenite and displacive-type phase transformation in the stir zone of friction stir welding(FSW).Severe plastic deformations occurred in the stir zone where there was an increase in the temperature attributed to the FSW process and subsequently a grain *** the recrystallization phenomena,the formation of grain evolution development in steels was resolved using *** addition,a tensile test was carried out in order to reveal the results of mechanical *** was found that the fracture zone occurred in the stir zone with an ultimate tensile strength of 587 MPa,a decrease of 267 MPa compared with that of the base *** this result,it is evident that the fracture exhibits numerous elongated dimples,distributed homogeneously,and certain locations contain cleavage fractures due to differences in the microstructure of the base *** profile tests of the welding regions were conducted,and the results showed that the stir zone was present with elevated hardness(near 350 HV).Characterization techniques revealed that the austenite-to-martensite transformation occurred in the stir zone,resulting in a loss of mechanical properties in the joint.

关键词： Friction welding Transformation-induced plasticity steel Stir zone Mechanical property Tensile test