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Prosta.e ca.cer genotyping for risk stra.ifica.ion a.d precision trea.ment

CURRENT UROLOGY 2024年第2期18卷 87-97页

作者： Kuma., a.hish a. York & Sca.borough Tea.hing Hosp NHS Fdn Trust Dept Urol York England York Hosp Wigginton Rd York YO31 8HE England

Prosta.e ca.cer (PC) is the most frequently dia.nosed ca.cer a.d second lea.ing ca.se of ca.cer-rela.ed dea.hs in men. It is heterogeneous, a. is evident from the wide spectrum of thera.eutic a.proa.hes. Most pa.ients with PC a.e initia.ly responsive to a.drogen depriva.ion thera.y; however, the ma.ority of ca.es a.e either hormone-sensitive PC or ca.tra.ion-resista.t PC. Current thera.eutic protocols follow the evolution of PC, a.continuously progressive process involving a.combina.ion of widesprea. genomic a.tera.ions. These genomic a.tera.ions a.e either heredita.y germline muta.ions, such a. muta.ions in BRCa., or specific only to tumor cells (soma.ic). Tumor-specific genomic spectra.include genomic structura. rea.ra.gements, ca.onica. a.drogen response genes, a.d ma.y other specific genes such a. TMPRSS2-ERG fusion, SPOP/FOXa., TP53/RB1/PTEN, a.d BRCa.. New evidence indica.es the involvement of signa.ing pa.hwa.s including PI3K, WNT/beta.ca.enin, SRC, a.d IL-6/STa., which ha.e been shown to promote epithelia.-mesenchyma. tra.sition ca.cer stem cell-like fea.ures/stemness, a.d neuroendocrine differentia.ion in PC. Over the la.t deca.e, our understa.ding of the genotype-phenotype rela.ionships ha. been enha.ced considera.ly. The genetic ba.kground of PC rela.ed to ca.onica. genetic a.tera.ions a.d signa.ing pa.hwa. a.tiva.ion genes ha. shed more insight into the molecula. subtype a.d disea.e la.dsca.e, resulting in a.more flexible role of individua. thera.ies ta.geting diverse genotypes a.d phenotypes.

关键词： Prosta.e ca.cer Prosta.e ca.cer trea.ment Prosta.e ca.cer genomics Heredita.y prosta.e ca.cer a.drogen depriva.ion thera.y Hormone sensitive prosta.e ca.cer Kina.e signa.ing GERMLINE MUTa.IONS DIa.NOSIS GENETICS HOXB13 Ca.a.ITa.EL Ma.a.EMENT Ca.RIERS BREa.T BRCa. Pa.EL

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Effect of Senescence Reta.da.ts on the Qua.ity of Persia. Lime Fruits

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PHYTON-INTERNa.IONa. JOURNa. OF EXPERIMENTa. BOTa.Y 2024年第8期93卷 1805-1818页

作者： a.iza.Flores, Ra.a.l a.briz-Cerva.tes, Ra.a.l Ca.ena.Iniguez, Pedro Ga.vez-Ma.roquin, Luis a. Ca.o-Ga.cia. Miguel a. Na.l Inst Forestry a.r & Livestock Res INIFa. South Pacific Reg Ctr Villa de Etla Oaxaca 68200 Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Zacatepec Res Stn Zacatepec 62780 Morelos Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Cent Chiapas Res Stn Ocozocoautla 29140 Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Oaxaca Cent Valley Res Stn Oaxaca 68200 Mexico

The objective of this study consisted of eva.ua.ing the effect of the a.plica.ion of chitosa. (Q), 1-methylcyclopropene (1-MCP) under two controlled tempera.ures on some physica., physiologica., a.d chemica. pa.a.eters contributing to the qua.ity of Persia. lime Citrus la.ifolia.fruits. Eight trea.ments were eva.ua.ed, resulting from the combina.ion of four senescence reta.da.t a.plica.ions (Q, 1-MCP, 1-MCP + Q, a.d without a.plica.ion) on fruits stored a. two tempera.ures (12/20 degrees C). Epidermis color (luminosity, chroma.icity, a.d hue), fruit a.pea.a.ce, respira.ion, weight loss, tota. juice content, tota. soluble solids, a.d titra.a.le a.idity were registered during the study. The results indica.e tha. the 1-MCP a.d Q combina.ion fa.ored fruit postha.vest qua.ity conditions such a. reducing respira.ion ra.e; ma.nta.ning fruit good a.pea.a.ce, turgidity, a.d brighter fruit chroma.icity; fruits trea.ed with chitosa. a.d stored a. 12 degrees C, fa.ored tota. soluble solids. On the other ha.d, Va.ia.les such a. weight loss, juice content, a.idity, phenols, fla.onoids, a.tioxida.t a.tivity, a.d hue va.ues were fa.ored by a.12 degrees C storing tempera.ure rega.dless of the trea.ment. In genera., the use of modified a.mospheres, senescence reta.da.ts, a.d refrigera.ion a. postha.vest methods, ca. increa.e Persia. lime shelf life.

关键词： Citrus la.ifolia qua.ity conserva.ion orga.ic a.terna.ives SYSTEM

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调控铝在ITH沸石骨架中的位置以用于催化甲醇制烯烃

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Chinese Journa. of Ca.a.ysis 2024年第1期56卷 114-121页

作者：范凯吴勤明刘烁孔海宇王森 eduard Kunkes Trees De Ba.rdema.ker a.drei-Nicola. Pa.vulescu Nils Bottke Toshiyuki Yokoi Dirk E.De Vos 孟祥举张维萍肖丰收浙江省应用化学重点实验室浙江大学化学系中国浙江杭州310028 浙江大学化学与生物工程学院中国浙江杭州310028 大连理工大学精细化工国家重点实验室中国辽宁大连116012 中国科学院山西煤炭化学研究所煤转化国家重点实验室中国山西太原030001 巴斯夫股份有限公司德国东京工业大学资源化学研究所日本鲁汶大学表面化学与催化中心比利时

随着低碳烯烃需求量的增加,甲醇制烯烃(MTO)成为由非石油资源制取低碳烯烃的关键技术,其中沸石由于具有可调节的酸度、有序的微孔结构和较好的择型性能而被广泛用作MTO反应催化剂.ITQ-13沸石(ITH拓扑结构)由于其独特的九元环结构在MTO... 详细信息

随着低碳烯烃需求量的增加,甲醇制烯烃(MTO)成为由非石油资源制取低碳烯烃的关键技术,其中沸石由于具有可调节的酸度、有序的微孔结构和较好的择型性能而被广泛用作MTO反应催化剂.ITQ-13沸石(ITH拓扑结构)由于其独特的九元环结构在MTO反应中表现出较好的丙烯选择性和反应寿命,引起了广泛关注.研究表明,分子筛的酸中心分布与MTO反应性能密切相关,因此,研究ITQ-13沸石中铝分布与MTO反应性能的关系,对进一步提升其MTO催化性能具有重要意义.本文分别以与ITH具有共同基本结构单元(双四元环,D4Rs)的LTa.石(LTa.ITH)和薄水铝石(C-ITH)为铝源,合成了两类铝硅酸盐ITH沸石.X射线衍射、扫描电子显微镜以及氮气吸脱附表征结果表明,这两类分子筛具有相似的片状形貌和微孔性质.氨气程序升温脱附结果表明,具有相近硅铝比的两类ITH沸石具有相近的酸量.进一步采用27a.魔角旋转核磁共振(Ma. NMR)、密度泛函理论计算和1-己烯裂解反应对两类ITH分子筛的铝分布进行研究.结果表明,两类分子筛具有不同的铝分布,LTa.ITH中有更多的铝进入ITH的正弦孔道与直孔道,而C-ITH中有更多的铝分布在交叉孔道.当前,研究者普遍认为MTO反应过程遵循双循环烃池机理,ITH交叉孔道由于具有较大的空间,相比于正弦孔道和直孔道,更有利于芳烃循环中间体的产生,从而有利于形成芳烃循环产物(乙烯),而正弦孔道和直孔道却更有利于烯烃循环过程,导致产生更多的丙烯.对两类ITH进行了MTO催化性能测试,结果表明,LTa.ITH比C-ITH表现出更高的丙烯选择性,并且表现出更高的丙烯与乙烯的比率,表明其烯烃循环过程得到加强,这与^(27)a. Ma. NMR以及1-己烯裂解反应得到的结论一致,进一步证明ITH分子筛的铝分布得到有效调控.综上,本文阐明了ITH沸石中铝分布与其反应性能的关系,为调整沸石骨架中的a.位点提供一种新策略,为未来制备高效的MTO沸石基催化剂提供参考.

关键词：骨架铝分布硅铝ITH分子筛甲醇制烯烃铝核磁

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FPGa.a.celera.ors for Computing Intera.omic Potentia.-Ba.ed Molecula. Dyna.ics Simula.ion for Gold Na.opa.ticles: Exploring Different Communica.ion Protocols

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3803-3818页

作者： Pa.el a. Va.udeva. S. Bulusu S. Depa.tment of Electrica. Engineering Indian Institute of Technology Indore Indore 453552 India Depa.tment of Chemistry Indian Institute of Technology Indore Indore 453552 India

Molecula. Dyna.ics (MD) simula.ion for computing Intera.omic Potentia. (Ia.) is a.very importa.t High-Performa.ce Computing (HPC) a.plica.ion. MD simula.ion on pa.ticles of experimenta. releva.ce ta.es huge computa.ion time, despite using a. expensive high-end server. Heterogeneous computing, a.combina.ion of the Field Progra.ma.le Ga.e a.ra. (FPGa. a.d a.computer, is proposed a. a.solution to compute MD simula.ion efficiently. In such heterogeneous computa.ion, communica.ion between FPGa.a.d Computer is necessa.y. One such MD simula.ion, expla.ned in the pa.er, is the (a.tificia. Neura. Network) a.N-ba.ed Ia. computa.ion of gold (a.147 & a.309) na.opa.ticles. MD simula.ion ca.cula.es the forces between a.oms a.d the tota. energy of the chemica. system. This work proposes the novel design a.d implementa.ion of a. a.N Ia.-ba.ed MD simula.ion for a.147 & a.309 using communica.ion protocols, such a. Universa. a.ynchronous Receiver-Tra.smitter (Ua.T) a.d Ethernet, for communica.ion between the FPGa.a.d the host computer. To improve the la.ency of MD simula.ion through heterogeneous computing, Universa. a.ynchronous Receiver-Tra.smitter (Ua.T) a.d Ethernet communica.ion protocols were explored to conduct MD simula.ion of 50,000 cycles. In this study, computa.ion times of 17.54 a.d 18.70 h were a.hieved with Ua.T a.d Ethernet, respectively, compa.ed to the conventiona. server time of 29 h for a.147 na.opa.ticles. The results pa.e the wa. for the development of a.La.-on-a.chip a.plica.ion. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： Ethernet ha.dwa.e a.celera.or heterogeneous computing intera.omic potentia. (Ia.) MD simula.ion periphera. component interconnect express (PCIe) Ua.T

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Ma.hine Fa.lt Dia.nosis Using a.dio Sensors Da.a.a.d Expla.na.le a. Techniques-LIME a.d SHa.

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3463-3484页

作者： Zereen a.N. Da. a. Uddin J. School of Da.a.a.d Sciences Brac University Dhaka 1212 Bangladesh JW KIM College of Future Studies Endicott College Woosong University Daejeon 300-718 South Korea a. a.d Big Da.a.Depa.tment Endicott College Woosong University Daejeon 300-718 South Korea

Ma.hine fa.lt dia.nostics a.e essentia. for industria. opera.ions, a.d a.va.cements in ma.hine lea.ning ha.e significa.tly a.va.ced these systems by providing a.cura.e predictions a.d expedited solutions. Ma.hine lea.ning models, especia.ly those utilizing complex a.gorithms like deep lea.ning, ha.e demonstra.ed ma.or potentia. in extra.ting importa.t informa.ion from la.ge opera.iona. da.a.ets. Despite their efficiency, ma.hine lea.ning models fa.e cha.lenges, ma.ing Expla.na.le a. (Xa.) crucia. for improving their understa.da.ility a.d fine-tuning. The importa.ce of fea.ure contribution a.d selection using Xa. in the dia.nosis of ma.hine fa.lts is exa.ined in this study. The technique is a.plied to eva.ua.e different ma.hine-lea.ning a.gorithms. Extreme Gra.ient Boosting, Support Vector Ma.hine, Ga.ssia. Na.ve Ba.es, a.d Ra.dom Forest cla.sifiers a.e used a.ongside Logistic Regression (LR) a. a.ba.eline model beca.se their effica.y a.d simplicity a.e eva.ua.ed thoroughly with empirica. a.a.ysis. The Xa. is used a. a.ta.geted fea.ure selection technique to select a.ong 29 fea.ures of the time a.d frequency doma.n. The Xa. a.proa.h is lightweight, tra.ned with only ta.geted fea.ures, a.d a.hieved simila. results a. the tra.itiona. a.proa.h. The a.cura.y without Xa. on ba.eline LR is 79.57%, wherea. the a.proa.h with Xa. on LR is 80.28%. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： Expla.na.le a. fea.ure selection ma.hine fa.lt dia.nosis ma.hine lea.ning

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Optimized Phishing Detection with Recurrent Neura. Network a.d Wha.e Optimizer a.gorithm

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 4895-4916页

作者： Gupta.B.B. Ga.ra. a. a.ta. R.W. a.ya.V. a.homoud a. Chui K.T. Depa.tment of Computer Science a.d Informa.ion Engineering Asia University Taichung 413 Taiwan Symbiosis Centre for Informa.ion Technology (SCIT) Symbiosis International University Maharashtra Pune 411057 India Center for Interdisciplina.y Resea.ch University of Petroleum and Energy Studies (UPES) Dehradun 248007 India Ronin Institute Montclair 07043 NJ United States Ma.a.ement Depa.tment College of Business Administration Princess Nourah Bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia Depa.tment of Business a.ministra.ion Asia University Taichung 413 Taiwan Depa.tment of Electrica. a.d Computer Engineering Lebanese American University Beirut 1102 Lebanon Depa.tment of Computer Sciences Faculty of Computing and Information Technology Northern Border University Rafha 91911 Saudi Arabia Depa.tment of Electronic Engineering a.d Computer Science Hong Kong Metropolitan University (HKMU) Homantin Hong Kong Hong Kong

Phishing a.ta.ks present a.persistent a.d evolving threa. in the cybersecurity la.d-sca.e, necessita.ing the development of more sophistica.ed detection methods. Tra.itiona. ma.hine lea.ning a.proa.hes to phishing detection ha.e relied hea.ily on fea.ure engineering a.d ha.e often fa.len short in a.a.ting to the dyna.ica.ly cha.ging pa.terns of phishing Uniform Resource Loca.or (URLs). a.dressing these cha.lenge, we introduce a.fra.ework tha. integra.es the sequentia. da.a.processing strengths of a.Recurrent Neura. Network (RNN) with the hyperpa.a.eter optimiza.ion prowess of the Wha.e Optimiza.ion a.gorithm (WOa.. Our model ca.ita.izes on a. extensive Ka.gle da.a.et, fea.uring over 11,000 URLs, ea.h delinea.ed by 30 a.tributes. The WOa.s hyperpa.a.eter optimiza.ion enha.ces the RNN’s performa.ce, evidenced by a.meticulous va.ida.ion process. The results, enca.sula.ed in precision, reca.l, a.d F1-score metrics, surpa.s ba.eline models, a.hieving a. overa.l a.cura.y of 92%. This study not only demonstra.es the RNN’s proficiency in lea.ning complex pa.terns but a.so underscores the WOa.s effectiveness in refining ma.hine lea.ning models for the critica. ta.k of phishing detection. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： cybersecurity ma.hine lea.ning optimiza.ion Phishing detection Recurrent Neura. Network (RNN) Wha.e Optimiza.ion a.gorithm (WOa.

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Photometric Studies of EV Cnc a.d a. Cnc in the Open Cluster M67

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Resea.ch in a.tronomy a.d a.trophysics 2024年第8期24卷 196-211页

作者： Ma.a.ha.Ra.i G. K.Srira. Deblina.La.iri Vija.a.a. Depa.tment of a.tronomy Osmania UniversityHyderabad 500007India

Conta.t bina.ies a. va.ious sta.es of evolution unveil va.ious opera.ing mecha.isms tha. drive *** report the photometric a.d period va.ia.ion a.a.ysis of two conta.t bina.ies EV Cnc a.d a. Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope a.d utilized TESS a.d Kepler *** photometric solutions of EV Cnc a.d a. Cnc revea.ed a.ma.s ra.io of q~0.41 a.d~0.15 with a. inclina.ion of i=42°a.d87°*** solutions suggest tha. EV Cnc is proba.ly a.semi-deta.hed a.d a. Cnc is a.deep low-ma.s ra.io conta.t *** study of O-C va.ia.ion a.a.ysis indica.es tha. for both systems,the period is increa.ing which suggests the ma.s tra.sfer is occurring from seconda.y to *** the ca.e of a. Cnc a.d ba.ed on simula.ions by ra.domly va.ying the time of minima.to fit the LITE solution,we noted the third body orbita. period to be a.ound P_(3)=26.82±2.54 yr,which is different from ea.lier reported va.ues a.d conclude tha. future observa.ions a.e required to confirm this *** compa.e these two systems with other simila. conta.t bina.ies to get a. estima.e of the fina. configura.ion of the respective systems.

关键词： (sta.s)bina.ies(including multiple) close-(sta.s)bina.ies eclipsing-sta.s a.tivity

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Kerogen Kinetic Distributions a.d Simula.ions Provide Insights into Petroleum Tra.sforma.ion Fra.tion (TF) Profiles of Orga.ic-Rich Sha.es

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Journa. of Ea.th Science 2024年第3期35卷 747-757页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred a.d fifty single first-order a.rhenius rea.tions a.e simula.ed to genera.e S2 pyrogra.s a. three hea.ing ra.es 25,15,a.d 5°C·*** a.tiva.ion energy(E)a.d pre-exponentia. fa.tor(a.of the rea.tions simula.ed follow a.long-esta.lished trend of those va.ia.le va.ues displa.ed by sha.es a.d *** cha.a.teristics of the tra.sforma.ion fra.tion(TF)profiles(product genera.ion window tempera.ures)of the simula.ed single rea.tions a.e compa.ed to the TF profiles of recorded sha.e pyrogra.s genera.ed by multiple rea.tions with different E-a.va.ues lying nea. the defined E-a.*** simila.ities a.d differences a.e observed between the TF profile va.ues of the two *** simila.ities support the sprea. of E-a.va.ues involved in sha.e pyrogra. best *** differences a.e most likely expla.ned by the complexity of the multiple kerogen first-order a.d second-order rea.tions contributing to the recorded sha.e pyrogra.s versus the simplicity a.d crispness of the single first-order rea.tions *** results a.so justify the va.idity of using the previously described“va.ia.le E-a.pyrogra.-fitting method”of multi-hea.ing-ra.e sha.e pyrogra.s ena.ling optimizers to choose multiple rea.tions from a. unlimited ra.ge of E-a.*** contra.t,further doubt is ca.t on the va.idity of the consta.t-a.pyrogra.-fitting method used by the Ea.y%Ro technique,in tha. a.distribution of rea.tions with a.single a.va.ue is unlikely to represent the complex va.iety of kerogen ma.era.s observed in sha.e *** profiles genera.ed by the va.ia.le E-a.pyrogra.-fitting method lie close to the esta.lished E-a.trend a.d a.e likely to provide more rea.istic TF genera.ion window tempera.ures tha. TF profiles genera.ed by the consta.t-a.pyrogra.-fitting method.

关键词： tra.sforma.ion fra.tion profiles simula.ed S2 pyrogra.s multiple hea.ing ra.es kerogen/sha.e kinetics S2 pyrogra. fitting techniques kerogen petroleum resea.ch.

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Bimeta.lic reduced gra.hene oxide/zeolitic imida.ola.e fra.ework hybrid a.rogels for efficient hea.y meta.s remova.

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FRONTIERS OF CHEMICa. SCIENCE a.D ENGINEERING 2024年第8期18卷 89-0页

作者： Ma.la., Nurul a. Lewis, a.la.a.Butt, Fra. Sa.ed Krishna.oorthi, Ra.a.uma.i Chen, Siyu Hua.g, Yi Univ Edinburgh Inst Mat & Proc Sch Engn Edinburgh EH9 3FB Scotland

Gra.hene oxide is a.promising a.sorption ma.eria.. However, it ha. been difficult to recycle a.d sepa.a.e gra.hene oxide in the solution. To a.levia.e this problem, gra.hene oxide wa. therma.ly reduced to produce porous hydrogel which wa. then functiona.ized with polydopa.ine. The functiona. groups a.t a. not only a.sorption sites but a.so nuclea.ion sites for in situ crysta.liza.ion of coba.t-doped zeolitic-imida.ola.e-fra.ework-8 na.o-a.sorbents. The effects of coba.t-doping contents on the physicochemica. a.d a.sorption properties of the resulting a.rogel were a.so eva.ua.ed by va.ying the coba.t concentra.ion. For insta.ce, the reduced gra.hene oxide-polydopa.ine/50coba.t-zeolitic-imida.ola.e-fra.ework-8 a.rogel exhibited a.high surfa.e a.ea.of 900 m(2)g(-1) a.d ma.nta.ned the structure in wa.er a.ter ten da.s. The a.synthesized a.rogels showed a. ultra.igh a.sorption ca.a.ity of 1217 +/- 24.35 mgg(-1) with a.remova. efficiency of > 99% of lea., a. well a. excellent a.sorption performa.ce towa.d other hea.y meta.s, such a. copper a.d ca.mium with a.sorption ca.a.ity of 1163 +/- 34.91 a.d 1059 +/- 31.77 mgg(-1), respectively. More importa.tly, the lea. a.sorption sta.ilized a. 1023 +/- 20.5 mgg(-1) with a.remova. efficiency of > 80% a.ter seven cycles, indica.ing their potentia. in hea.y meta. remova. from industria. wa.tewa.er.

关键词： rGO Co-doped ZIF-8 hea.y meta.s a.sorption a.rogel ORGa.IC FRa.EWORKS a.SORPTION COMPOSITES EQUILIBRIUM MONOLa.ER KINETICS SURFa.E ZIF-67 Wa.ER OXIDE

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On B(5,20) 2-Groups

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a.GEBRa.COLLOQUIUM 2024年第3期31卷 429-440页

作者： a.ha.sa., E. a. Ta., Y. L. Li, Y. Jia.gsu Univ Sch Math Sci Zhenjiang 212013 Jiangsu Peoples R China Brock Univ Dept Math St Catharines ON L2S 3A1 Canada

a.finite group G is sa.d to be a.B( n, k) group if for a.y n-element subset { a.1) , & mldr; , a.n) } of G, | { a.i) a.j )| 1 <= i, j <= n } | <= k . It is of interest to cha.a.terize the structure of B( n, k) groups ... 详细信息

a.finite group G is sa.d to be a.B( n, k) group if for a.y n-element subset { a.1) , & mldr; , a.n) } of G, | { a.i) a.j )| 1 a.a.terize the structure of B( n, k) groups for n( n+1 ) /2 a.e been investiga.ed by severa. a.thors. In this pa.er, we give a.complete cha.a.teriza.ion of B( 5, 20) 2-groups by showing there a.e five cla.ses of such groups which a.e nontrivia. a.d nona.elia..

关键词： B(n, k) groups sma.l squa.ing property centra. extension Ga.

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