检索结果-南通市图书馆

Neural Regeneration Research 2023年第8期18卷 1645-1651页

作者： Renata Guedes de Jesus Gonçalves Juliana ferreira Vasques Almir Jordão da Silva-Junior Fernanda Gubert Rosalia Mendez-Otero Instituto de Biofísica Carlos Chagas filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa Rio de JaneiroBrazil Plataformas Inovadoras em Terapias Avançadas Departamento de Ciência e Tecnologia-Ministério da Saúde(DECIT-MS)Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Brazil Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro Rio de JaneiroBrazil Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Programa Redes de Pesquisa em Nanotecnologia no Estado do Rio de Janeiro Rio de JaneiroBrazil

Alzheimer's disease is a severe, highly disabling neurodegenerative disease, clinically characterized by a progressive decline in cognitive functions, and is the most common form of dementia in the elderly. For decades, the search for disease-modifying therapies has focused on the two main Alzheimer's disease histopathological hallmarks, seeking to prevent, mitigate, or clear the formation of extracellular aggregates of β-amyloid peptide and intracellular neurofibrillary tangles of tau protein, although without clinical success. Mesenchymal stem cell-based therapy has emerged as a promising alternative for the treatment of Alzheimer's disease, especially because it also targets other crucial players in the pathogenesis of the disease, such as neuroinflammation, synaptic dysfunction/loss, oxidative stress, and impaired neurogenesis. Herein, we review current knowledge of the therapeutic potential of mesenchymal stem cells and their extracellular vesicles for Alzheimer's disease, discussing the most recent findings in both preclinical and clinical trials as well as how advanced technologies have helped to overcome some limitations and contributed to stimulate the development of more effective treatments.

关键词： Alzheimer's disease amyloid-β cell therapy cell transplantation exosomes extracellular vesicles mesenchymal stem cell micro vesicles neuroinflammation tau protein

Development and Body Composition of Quarter Horse Foals during Nursing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2014年第11期4卷 276-280页

作者： Monica Miranda Hunka Helena Emília Cavalcanti da Costa Cordeiro Manso Ramona Bastos Bernardo Elizabeth Regina Rodrigues da Silva Lúcia Maia Cavalcante ferreira Hélio Cordeiro Manso filho Núcleo de Pesquisa Equina Departamento de Zootecnia Universidade Federal Rural de Pernambuco Recife Brazil

The monitoring and development of foals, based on biometric indices, and the determination of body composition could be important for genetic improvement and the elaboration of nutritional plans for horses. Considering that little information was available, the aim of the present study was to assess the growth and determine the body composition of suckling Quarter Horse foals. Animals (n = 46) of both sexes were monitored monthly from birth until the fifth month of age, using an ultrasound device and the following measurements: Wither Height (WH);Chest Perimeter (CP);Cannon Bone Circumference (CBC) Cannon Bone Girth (CG);Body Mass (BM);and Rump Fat Thickness (RFT). These tests determined the Fat-Free Mass (FFM), BM, Fat Percentage (FP) and Fat Thickness (FT). The data were analyzed using ANOVA and Tukey’s test, with differences considered statistically significant when P ≤ 0.05. The results demonstrated that the parameters analyzed changed significantly during the study period. The BM was ~41 at birth and ~177 kg at the point of weaning. Conversely, the FM was ~3.8 at birth and 18.1 kg at the point of weaning. The FFM was ~37 and ~160 kg at the time of birth and weaning, respectively. The FP varied from 9.3 at birth to 9.54 at weaning. The mean FT was ~1.39 and ~1.91 cm at birth and weaning, respectively. The WH measured ~91 at birth and 116 cm at weaning. In conclusion, suckling foals gain BM quickly from the time of birth to the time of weaning. The main cause of this gain is FFM. Therefore, due to the significant changes in the parameters studied herein, it is important to monitor these values in order to prevent nutritional imbalances.

关键词： Body Mass Fat-Free Mass Fat Percentage Horse Ultrasound

Economic Viability of Production of Tree Parica （Schizolobium amazonicum Huber ex. Ducke） of Reforestation Project in the Municipality Paragominas-PA, Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Life Sciences 2014年第12期8卷 967-971页

作者： Manoel Tavares de Paula Altem Nascimento Pontes Helio Raymundo ferreira filho Lucy Anne Cardoso Lobao Gutierrez Ismael Matos da Silva Maria da Conceicao Silva Damasceno Aline Lima de Sena Center of Natural Science and Technology University of Pare State Belem 66095-100 Para State Brazil Center of Social Sciences and Education University of Pare State Belem 66095-100 Para State Brazil

The objective of this study was to analyze the profitability of production Parica reforestation in the municipality of Paragominas-PA. The study was conducted in the municipality of Paragominas Messoregiao located in the northeast of Para. The basic data used in the economic evaluation of production of planting parica （costs and revenues） were derived from primary source through raising production cost of parica with farmers from the municipality, analyzing the period of production horizon of seven years. The discount rate chosen for economic evaluation was 10% per year. NPV （net present value） calculation IRR （internal rate of return）, BCR （benefit-cost ratio） and EP （break-even point）. To check the economic feasibility of producing parica the following criteria were used for economic analysis. The results for NPV, IRR and BC ratio were respectively of $495,970, 28.83% and 2.43. For EP （break-even point） the value of 41.08% was found, which demonstrates the minimum amount of production, so that revenue equals costs. Based on the results obtained, it was found that the reforestation model with parica proposed in this paper presents economically viable for deployment.

关键词： Amazon parica reforestation

Heterologous Bovine Tunica Albuginea Graft Conserved in Honey as Abdominal Wall Reinforcement in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2020年第8期10卷 139-153页

作者： Fellipe ferreira Lemos de Medeiros Natasha Nogueira ferreira Cecília Ribeiro Castañon Tábata Maués Carla ferreira Farias Lancetta Viviane Alexandre Nunes Degani Maria de Lourdes Gonçalves ferreira Department of Pathology and Veterinary Clinic Faculty of Veterinary Universidade Federal Fluminense Rio de Janeiro Brazil Department of Morfology Universidade Castelo Branco Rio de Janeiro Brazil Professor Firmino Mársico filho Veterinary Teaching Hospital (HUVET) Universidade Federal Fluminense Rio de Janeiro Brazil Department of Morfology Universidade Federal Fluminense Rio de Janeiro Brazil

Complex abdominal wall defects might be challenging for human and veterinary surgeons worldwide. Defects from trauma or congenital causes may lead to hernias development. The introduction of meshes to reinforce hernia repairs has improved surgical outcomes and several synthetic and biologic materials have been used. In this context, biomaterial prosthesis seems to be a satisfactory solution when managing great abdominal wall defects. The aim of the current study is to evaluate the bovine tunica albuginea (BTA) preserved in honey as graft material for rats’ abdominal wall reinforcement in incisional herniorrhaphy surgery as well as its viability, cicatrization and integration into the host tissue. Wistar rats were assigned to two main groups: 1) animals (n = 20) underwent median longitudinal laparotomy followed by laparorraphy with suture of the bovine tunica albuginea (BTA) graft as abdominal wall reinforcement;and 2) animals (n = 20) underwent only laparotomy and subsequent laparorrhaphy. Rats were clinically evaluated until euthanasia at post-surgical day 7, 14, 21 and 28. Necropsy and histopathological analysis of abdominal wall fragments were performed to compare groups and subgroups findings. BTA promoted abundant fibrosis, providing resistance and low postoperative complication rates. Besides, animals did not show rejection signs to the implant. In conclusion, BTA preserved in honey is an affordable, easy collection and handling biomaterial for graft, demanding simple surgical implantation technique for abdominal wall repair in rats.

关键词： Biomaterial Hernia Reconstructive Surgery Xenograft

Case Report: Clinical and Diagnostic Aspects of Mayer-Rokitansky-Kuster-Hauser Syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2019年第10期11卷 1367-1372页

作者： Lucas ferreira de Paula filho Guilherme Carolino Neves Laís Figueira Bandoli Lucas Caraline de Almeida Coelho Nathália de Souza ferreira Feital Renan Vieira Murad Ana Luísa Conceiç o de Jesus Diana Aristótelis de Sá Larissa Bianca Cunha de Sá Jonathan Mwambire Alberto Krayyem Arbex IPEMED Medical School/AFYA Educational Postgraduation in Endocrinology Rio de Janeiro Brazil UNIFESO Medical School Teresópolis Brazil Department of Pediatrics Medical School University of So Paulo (USP) So Paulo Brazil Medical Clinic in Endocrinology and Diabetology Schleswig-Flensburg Germany.

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a rare disease characterized by total or partial vagina agenesis, karyotype 46, XX with normal secondary sexual characters. Still, it is the second leading cause of primary amenorrhea. The absence of obvious signs and symptoms often causes the syndrome to be diagnosed only after puberty. The case presented here highlights exactly this difficulty of early diagnosis, which meets the objective of the study, and is precisely to provide reliable material that facilitates the diagnosis and management of patients with MRKH syndrome.

关键词： Mayer-Rokitansky-Kuster-Hauser Syndrome Primary Amenorrhea Gonadal Dysgenesis

Promoting integrative medicine by computerization of traditional Chinese medicine for scientific research and clinical practice: The SuiteTCM Project

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2013年第2期11卷 135-139页

作者： Arthur de Sá ferreira Laboratory of Computational Simulation and Modeling in Rehabilitation Post-graduation Program of Rehabilitation Science Augusto Motta University Center

BACKGROUND： Chinese and contemporary Western medical practices evolved on different cultures and historical contexts and, therefore, their medical knowledge represents this cultural divergence. Computerization of traditional Chinese medicine （TCM） is being used to promote the integrative medicine to manage, process and integrate the knowledge related to TCM anatomy, physiology, semiology, pathophysiology, and therapy. METHODS： We proposed the development of the SuiteTCM software, a collection of integrated computational models mainly derived from epidemiology and statistical sciences for computerization of Chinese medicine scientific research and clinical practice in all levels of prevention. The software includes components for data management （DataTCM）, simulation of cases （SimTCM）, analyses and validation of datasets （SciTCM）, clinical examination and pattern differentiation （DiagTCM, TongueTCM, and PulseTCM）, intervention selection （AcuTCM, HerbsTCM, and DietTCM）, management of medical records （ProntTCM）, epidemiologic investigation of sampled data （ResearchTCM）, and medical education, training, and assessment （StudentTCM）. DISCUSSION： The SuiteTCM project is expected to contribute to the ongoing development of integrative medicine and the applicability of TCM in worldwide scientific research and health care. The SuiteTCM 1.0 runs on Windows XP or later and is freely available for download as an executable application.

关键词： traditional Chinese medicine evidence-based practice computer-assisted decision making

Clinical and Radiographic Evaluation of Cattle Tail before and after the <i>Vaquejada</i>Race

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2021年第6期11卷 165-176页

作者： Raíssa Karolliny Salgueiro Cruz Maria Luiza Albuquerque Ribeiro Juliano Sarmento Macedo Brunno Aguiar ferreira Marcelo Araújo Silva Anaemília das Neves Diniz Helena Emília Cavalcanti da Costa Cordeiro Manso Helio Cordeiro Manso filho Professor of the Veterinary Medicine course Cesmac University Center (CESMAC) Maceió-AL Brazil Veterinarian and Member of the Association of Veterinarians of Equidae and Bovids of Alagoas (AMVEBAL) Maceió-AL Brazil Adjunct Professor at the Federal University of Alagoas Maceió-AL Brazil Equine Research Center Federal Rural University of Pernambuco Recife-PE Brazil

The vaquejada race is a sport with animals which has the greatest socio-economic impact in Brazil and is responsible for generating an intense cultural and economic movement. However, this activity has been the subject of questions about well-being involving the environmental and mental comfort conditions offered to equine and cattle interactions. It is necessary to perform technical evaluations of the cattle involved on the basis of scientific study to better understand the processes of sport and, with this, promote their evolution on good welfare practices in the 21st century. Therefore, to test the hypothesis that the use of the official rules of the vaquejada where cattle use a protective harness on the tail protects the cattle’s tail from injuries in this region that compromise health. Before, during and after races, a study was developed that aimed to perform a general and radiological clinical evaluation in the proximal coccygeal region in cattle that ran in a modern cattle stall. Forty male bovines were evaluated (average: 2 year-old and 420 kg). Oxen were subjected to clinical and radiological examination before and after racing with official rules. Results of the clinical and radiological evaluations performed by veterinarians, did not observe clinical occurrences before and after the races in the 40 cattle evaluated. The increase in heart and respiratory rates was a reflection of temporary management stressors, as the animals returned to the feeding/rumination/interaction pattern after running in the rest pen. The radiographic findings in the tail, represented by the reduction of the intervertebral space and areas of subcutaneous radiolucency, suggest technical artifacts derived from

关键词： Zebu Physical Exercise Locomotor Health

SimTCM: A human patient simulator with application to diagnostic accuracy studies of Chinese medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2015年第1期13卷 9-19页

作者： Arthur de Sá ferreira Antonio Guilherme Pacheco Postgraduation Program in Rehabilitation Science Augusto Motta University Center Program of Scientific Computing

OBJECTIVE： The aim of this work is to develop and implement the SimTCM, an advanced computationa model that incorporates relevant aspects from traditional Chinese medicine （TCM） theory as well as advanced statistical and epidemiological techniques for simulation and analysis of human patients. METHODS： SimTCM presents five major attributes for simulation： representation of true and false profiles for any single pattern; variable count of manifestations for each manifestation profile; empirical distributions of patterns and manifestations in a disease-specific population; incorporation of uncertainty in clinical data; and the combination of the four examinations. The proposed model is strengthened by following international standards for reporting diagnostic accuracy studies, and incorporates these standards in its treatment of study population, sample size calculation, data collection of manifestation profiles, exclusion criteria and missing data handling, reference standards, randomization and blinding and test reproducibility. RESULTS： Simulations using data from patients diagnosed with hypertension and post-stroke sensory- motor impairments yielded no significant differences between expected and simulated frequencies of patterns （P = 0.22 or higher）. Time for convergence of simulations varied from 9.90 s （9.80, 10.27） to 28.31 s （26.33, 29.52）. The ratio iteration profile necessary for convergence varied between 1：1 and 5：1. CONCLUSION： This model is directly connected to forthcoming models in a large project to design and implement the Suite TCM： ProntTCM, SciTCM, DiagTCM, StudentTCM, Research TCM, HerbsTCM, AcuTCM, and DataTCM. It is expected that the continuity of the SuiteTCM project enhances the evidence-based practice of Chinese medicine.

关键词： medicine, Chinese traditional evidence-based medicine computer-assisted decision making rehabilitation medicine (TCM)

Hepatobiliary phases in magnetic resonance imaging using liverspecific contrast for focal lesions in clinical practice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第7期14卷 1459-1469页

作者： Daniel Alvarenga Fernandes Eduardo Andreazza Dal Lago Felipe Aguera Oliver Bruna Melo Coelho Loureiro Daniel Lahan Martins Thiago José Penachim Ricardo Hoelz de Oliveira Barros José de ArimatéiaBatista Araújo filho Larissa Bastos Eloy da Costa Áurea Maria Oliveira da Silva Elaine Cristina de Ataíde Ilka de Fátima Santana ferreira Boin Nelson Marcio Gomes Caserta Department of Radiology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazi Department of Radiology Medical SchoolSão Paulo State University-UNESPBotucatu 18618-970São PauloBrazil Instituto de Radiologia Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo-InRad/HC-FMUSPSão Paulo 05403-010SPBrazil Department of Radiology Sírio-Libanês HospitalSão Paulo 05652-900SPBrazil Department of Pathology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil Liver Transplant Unit Department of SurgerySchool of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil

BACKGROUND Challenging lesions,difficult to diagnose through non-invasive methods,constitute an important emotional burden for each patient regarding a still uncertain diagnosis(malignant x benign).In addition,from a therapeutic and prognostic point of view,delay in a definitive diagnosis can lead to worse *** of the main innovative trends currently is the use of molecular and functional methods to *** liver-specific contrast agents havebeen developed and studied in recent years to improve the performance of liver magnetic resonance imaging(MRI).More recently,one of the contrast agents introduced in clinical practice is gadoxetic acid(gadoxetate disodium).AIM To demonstrate the value of the hepatobiliary phases using gadoxetic acid in MRI for the characterization of focal liver lesions(FLL)in clinical *** Overall,302 Lesions were studied in 136 patients who underwent MRI exams using gadoxetic acid for the assessment of *** radiologists independently reviewed the MRI exams using four stages,and categorized them on a 6-point scale,from 0(lesion not detected)to 5(definitely malignant).The stages were:stage 1-images without contrast,stage 2-addition of dynamic phases after contrast(analogous to usual extracellular contrasts),stage 3-addition of hepatobiliary phase after 10 min(HBP 10’),stage 4-hepatobiliary phase after 20 min(HBP 20’)in addition to stage *** The interobserver agreement was high(weighted Kappa coefficient:0.81-1)at all stages in the characterization of benign and malignant *** diagnostic weighted accuracy(Az)was 0.80 in stage 1 and was increased to 0.90 in stage *** of the hepatobiliary phase increased Az to 0.98 in stage 3,which was also 0.98 in stage *** The hepatobiliary sequences improve diagnostic *** growing potential in the era of precision medicine,the improvement and dissemination of the method among medical specialties can bring benefits in the management of patients w

关键词： Liver Liver neoplasms Liver transplantation Medical oncology Diagnostic imaging Magnetic resonance imaging