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Oral encapsulated transforming growth factorβ1 reduces endogenous levels:Effect on inflammatory bowel disease

World Journal of Gastrointestinal Pharmacology and Therapeutics 2020年第5期11卷 79-92页

作者： Laura Hammer Stacia Furtado edith Mathiowitz Dominick L Auci Department of Research and Development TherapyXBuffaloNY 14214United States Department of Molecular Pharmacology Brown UniversityProvidenceRI 02912United States

BACKGROUND TreXTAM®is a combination of the key regulatory cytokine transforming growth factor beta(TGFβ)and all trans retinoic acid(ATRA)microencapsulated for oral delivery to immune structures of the *** is in development as a novel treatment for inflammatory bowel disease(IBD).AIM To measure TGFβlevels in blood and tissue after oral administration of encapsulated TGFβ.METHODS Animals were orally administered encapsulated TGFβby *** of drug substance in blood and in gut tissues at various times after administration were measured by *** We made the surprising discovery that oral administration of TreXTAM dramatically(approximately 50%)and significantly(P=0.025)reduced TGFβlevels in colon,but not small intestine or mesenteric lymph ***,levels in rat serum after 25 d of thrice weekly dosing with either TreXTAM,or microencapsulated TGFβalone(denoted as TPX6001)were significantly(P<0.01)reduced from baseline *** tested in the SCID mouse CD4+CD25-adoptive cell transfer(ACT)model of IBD,oral TPX6001 alone provided only a transient benefit in terms of reduced weight *** These observations suggest a negative feedback mechanism in the gut whereby local delivery of TGFβresults in reduced local and systemic levels of the active form of TGFβ.Our findings suggest potential clinical implications for use of encapsulated TGFβ,perhaps in the context of IBD and/or other instances of fibrosis and/or pathological TGFβsignaling.

关键词： Transforming growth factor beta All trans retinoic acid Ulcerative colitis Crohn’s disease Inflammatory bowel disease Regulatory T cells

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Variability in Vitamin A Intake of Pregnant Women in Ngaoundere-Cameroon with Geographic Origin, Socio-Professional and Demographic Factors

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Food and Nutrition Sciences 2016年第2期7卷 74-82页

作者： edith N. Fombang Wilfred Damndja Ngaha Richard Aba Ejoh Department of Food Science and Nutrition National School of Agro-Industrial Sciences University of Ngaoundere Ngaound&eacute ré Cameroon College of Technology University of Bamenda Bambili Cameroon

Variability in vitamin A (VA) intake of pregnant women in Ngaoundere town according to geographic origin, socio-professional and demographic factors was studied. A total of 100 pregnant women attending ante natal visits at the Regional Hospital in Ngaoundere were involved in the survey. A questionnaire was used to obtain information on geographic origin, socio-professional status, birth history, demographic and anthropometric factors. Dietary intake was assessed using 24-hour dietary recall. Meals potentially rich in VA consumed by these women were collected, their carotenoids contents quantified and VA activity determined by conversion. Results indicated that daily VA intake of these women varied significantly (p < 0.05) with geographic origin, level of education and age of pregnancy. VA intake of pregnant women of Northern origin (Adamawa, North and Far North Regions) was significantly (p < 0.05) lower (496 μg/day/woman) than that of women of Southern origin (588 μg/day/woman), although both were below the recommended intake of 800 μg/day/woman. The more educated a woman and the older her pregnancy, the higher her VA intake. VA consumption of pregnant women of Northern origin was significantly influenced by their age, whereas for pregnant women of Southern origin, BMI (Body Mass Index) equally had a significant influence on their VA intake. Socio-professional status, marital status and number of children did not significantly influence the daily VA intake of these women. Thus, a pregnant woman originating from the Northern part of the country and having no formal education, consumed less foods rich in carotenoids and therefore was more at risk for vitamin A deficiency.

关键词： Pregnant Women Geographic Origin Socio-Demographic Factors Ngaoundere Vitamin A Intake

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移动上下文感知好友推荐研究

移动上下文感知好友推荐研究

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作者： MOUKALA BOTH SUZY edith（苏芮）上海应用技术大学

学位级别：硕士

移动技术的进步使得人们可以使用社交网络服务相互连接、共享内容、获取信息并购买商品。不同的社交网络会提供不同的推荐,如朋友、商品、工作、电影、书籍等。但是,它们都需要不断建立活跃用户的信誉。这些社交网络提供某种关注用户主... 详细信息

移动技术的进步使得人们可以使用社交网络服务相互连接、共享内容、获取信息并购买商品。不同的社交网络会提供不同的推荐,如朋友、商品、工作、电影、书籍等。但是,它们都需要不断建立活跃用户的信誉。这些社交网络提供某种关注用户主要偏好或兴趣选择的推荐服务。现有系统需要很长时间来识别新用户与其他人的正确联系。大多数网站使用简单的朋友推荐算法,如流行度、相似度或者朋友的朋友是我的朋友这些方法,这些都非常直观。在接收到请求后,朋友推荐系统进入数据进行查询,并给出具有最高推荐分数的好友列表。本文建立了一个基于社交网络的朋友推荐系统。第一,该系统计算用户活跃的频率,并根据活跃频率和强度更新数据集。然后使用K-最近邻算法,可以较容易地根据用户活跃情况进行分类。第二,实现了用户的日常生活日记。通过使用具有阈值算法的K-最近邻算法来从中提取用户的生活偏好。系统使用类似的方法来计算用户之间的生活方式或偏好的相似性,并根据公共-私人图形的兴趣来确定用户的影响。本文提出的推荐系统,对小型实验和大规模模拟进行了评估。结果表明,这些建议反映了用户在选择朋友时的偏好。本文提出的一种基于上下文感知的朋友推荐的创新方法,该方法将移动计算与人的关系结合起来,以提高用户的喜好度。

关键词：好友推荐情境感知推荐系统移动数据

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The anatomy and physiology learning system /

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2011年

作者： Applegate edith J.

ISBN: (纸本)9781437703931

Introduction to the human body -- Chemistry, matter, and life -- Cell structure and function -- Tissues and membranes -- Integumentary system -- Skeletal system -- Muscular system -- Nervous system -- Sensory system -- Endocrine system -- Cardiovascular system: the heart -- Cardiovascular system: blood vessels -- Cardiovascular system: blood -- Lymphatic system and body defense -- Respiratory syst

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Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway

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Horticulture Research 2021年第1期8卷 2949-2961页

作者： Camille Chalvin Stephanie Drevensek Françoise Gilard Caroline Mauve Christel Chollet Halima Morin edith Nicol Eva Heripre Lucie Kriegshauser Bertrand Gakiere Michel Dron Abdelhafid Bendahmane Adnane Boualem Universite Paris-Saclay CNRSINRAEUniv EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91405 OrsayFrance Molecular Chemistry Laboratory(LCM) UMR 9168CNRSEcole PolytechniqueInstitut Polytechnique de ParisRoute de Saclay91128 Palaiseau CedexFrance Laboratory of Mechanics of Soils Structures and Materials(MSSMAT)UMR 8579CNRSEcole CentraleSupelecUniversite Paris-SaclayBâtiment Eiffel8-10 rue Joliot-Curie91190 Gif-Sur-YvetteFrance

Sclareol,an antifungal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient *** is mainly produced in clary sage flower calyces;however,the cellular localization of the sclareol biosynthesis remains *** elucidate the site of sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–FTICR-MSI)and investigated the expression profile of sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specifically accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly *** next isolated a glabrous beardless mutant and demonstrate that more than 90%of the sclareol is produced by the large capitate *** experiments,using 1-13 C-glucose,and specific enzyme inhibitors further revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of isopentenyl diphosphate(IPP)precursor used for the biosynthesis of *** findings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of GTs as biofactories dedicated to the production of specialized metabolites.

关键词： oxide. starting synthesis

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Mobile Application for Research Knowledge Sharing and Dissemination: The Case of Nm-Aist Univeristy Tanzania

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Journal of Software Engineering and Applications 2022年第7期15卷 209-219页

作者： Justine M. Kemhe edith T. Luhanga Michael Kisangiri School of Computational Communication Science and Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania

The utilization of mobile and web applications has surpassed all other platforms in terms of disseminating researchers’ knowledge among diverse communities throughout the world. The current method of disseminating researchers’ knowledge to the communities in the Arusha region in Tanzania is through meetings, workshops, and focus group discussions held by researchers, agricultural extension officers and community members after every three months or during field study. Yet the strategy is inefficient and ineffective in practice. The purpose of this study was to determine the most efficient and successful method of disseminating knowledge in communities. The study began with a qualitative phase, utilizing an interpretive technique and a qualitative multiple case study research design. The Arusha region in Tanzania was selected as a case study where different social activities were undertaken, including farming, livestock keeping, tourism activities and fishing. Individual participants were interviewed by using a semi-structured questionnaire. In addition, focus group discussions were conducted to gather more information regarding the needs of the mobile application. Through the implementation of the application, the second phase of the study led to the development of a mobile application that includes community members, agricultural extension officers, and researchers that will enable anyone to install the application on their mobile phones to access knowledge regarding activities undertaken in Arusha. According to the findings of the first phase of the research, a substantial percentage of community members own mobile phones, and hence a mobile application would be sufficient. The research also found that most researcher-community interactions occur at the data collection and intervention assessment (field trials) stages. Hence, the mobile application will benefit community members, district agricultural, irrigation, and cooperative officers (DAICO), and researchers.

关键词： Mobile Application Knowledge Sharing Knowledge Dissemination Community Based Participatory Research

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Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

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World Journal of Gastroenterology 2008年第4期14卷 563-568页

作者： edith Lahner Marco Intraligi Massimo Buscema Marco Centanni Lucy Vannella Enzo Grossi Bruno Annibale Department of Digestive and Liver Disease University "La Sapienza"2nd Medical SchoolOspedale Sant'AndreaRomeItaly Semeion Research Center Rome Italy Endocrinology Unit Department of Experimental Medicine and PathologyUniversity "La Sapienza"Polo PontinoLatinaItaly Bracco Imaging Spa MilanItaly

AIM: To investigate the role of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,T&T-IS protocol,TWIST protocol). The target variable was the presence of thyroid disease. RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. The increase of sensitivity of the TWIST protocol was statistically signifi cant compared to T&T-IS. CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

关键词： Atrophic body gastritis Thyroid disease Artificial neural networks

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A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

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Dietary Intake of Vitamin A and Macronutrients among Pregnant Women in Ngaoundere Town, Adamawa Region, Cameroon

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Food and Nutrition Sciences 2014年第21期5卷 2071-2080页

作者： Damndja Wilfred Ngaha edith N. Fombang Richard Aba Ejoh Department of Food Sciences and Nutrition National School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon College of Technology University of Bamenda Bambili Cameroon

This paper examines the risk of Vitamin A deficiency among selected pregnant women in Ngaoundere, Adamawa Region, Cameroon. A total of one hundred (100) pregnant women attending ante natal visits at the Regional Hospital in Ngaoundere were involved in a survey conducted in 2012 which used a 24-hour dietary recall to assess their dietary intake. Food models were used to assist memory and portion sizes of food taken. Carotenoids were quantified in the meals commonly consumed, as well as proteins, sugar, fibers and oil, nutrients intervening in carotenoids absorption and vitamin A metabolism. The results indicated that the dietary intake of vitamin A was inadequate with 37.5% of the selected pregnant women exposed to acute vitamin A deficiency, while 20% of them were exposed to the severe form. The daily consumption of vitamin A was about 539.09 ± 43.09 μg, corresponding to a contribution of 67.39% to the vitamin A requirement of the pregnant women. The dietary intake of macronutrients was also inadequate with a daily consumption of 57.28 ± 12 g for oils, 177.88 ± 29 g for sugars, 47.34 ± 11 g for proteins and 11.28 ± 3 g for fibers corresponding respectively to a contribution of 63.6%, 70.8%, 78.90% and 45.1% of these nutrients requirement in these women. Given that over 50% of the women surveyed were exposed to vitamin A deficiency, there is a need for urgent intervention programs in the area to alleviate this situation.

关键词： Vitamin A Intake Dietary Intake Vitamin a Deficiency Pregnant Women Ngaoundere

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欢乐屋

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作者： (美)伊迪丝·华顿(edith Wharton)

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