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Long-term safety follow-up of children from a randomized-controlled phase Ⅱb proof-of-concept efficacy study of the live,attenuated,tetravalent dengue vaccine (CYD-TDV) in Thailand

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Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 396-403页

作者： Kriengsak Limkittikul Weerawan Hattasingh Danaya Chansinghakul Arunee Sabchareon Wut Dulyachai Carina Frago T Anh Wartel edith Langevin Sophia Gailhardou Alain Bouckenooghe Department of Tropical Peditrics Faculty of Tropical MedicineManidol Unizersiy420/6 Ratchawithi RoodBanghqk10400Thailand Sonofi Pastewr Clirical Sciences 872 CRC Tover 23nd FloorAll Seasons PlaceWireless RodLumpiniPathumwanBanghokThoiland Ratchaburi Hospital 77/4Kathatorm RoadTambon Na MuangAmphoe Muang RatchaburiThailand Sanofi Pasteur Clinical Sciences 38 Beach Roud#18-11 South Beach TowerSingapore 189767 Sanofi Pasteur Clinical Programs Marcy L EioileFrance Sanofi Pusteur Globol Purrmcorigiane Lyon France

Objective:To investigate the long-term safety of a tetravalent dengue vaccine(CYD-TDV)in children in a phase Ⅱ b follow-up study in ***:In the phase Ⅱb study,children aged 4-11 years were randomized(2:1)to receive three injections of CYD-TDV or serve as control at 6-month intervals,with 25 months’ active follow-up(active phase).This study was an additional four-year passive surveillance for hospitalized virologically-confirmed dengue(VCD;hospital phase).Cases of hospitalized VCD,severe hospitalized VCD,vaccine-related serious adverse events,and deaths were reported for the total population,with post-hoc analyses by enrollment age(<9 and≥9 years).Results:Of 3 997 participants receiving≥1 injection,80.1% were recruited to the hospital phase[2 131(CYD-TDV);1 072(control)].Eighty-five hospitalized VCD cases were reported in the CYD-TDV group and 46 in the control group during the four-year hospital phase[relative risk(RR):0.93,95% confidence interval(Cl):0.64-1.36].The RR over six years of follow-up was 0.77(95% CI:0.57-1.05).In those aged≥9 years,the cumulative RRs in the active phase,hospital phase,and entire six years were 0.28(95% CI:0.08-0.81),0.51(95% CI:0.25-1.05),and 0.42(95% CI:0.24-0.75),*** the overall population,there were ten severe hospitalized VCD cases in the CYD-TDV group and five in the control group over six years(RR:1.00,95% CI:0.31-3.75).Conclusions:Over six years of follow-up,in children aged ≥9 years,CYD-TDV administration is associated with a reduced risk of hospitalized VCD.

关键词： CYD-TDV Dengue vaccine Hospitalized dengue Severe dengue Virologtically confirmed dengue

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Pattern of Acute Asthma Seen in Children Emergency Department of the River State University Teaching Hospital Portharcourt Nigeria

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Open Journal of Respiratory Diseases 2019年第4期9卷 101-111页

作者： Uchenna C. Onubogu edith Owate Rivers State University Teaching Hospital Port Harcourt Nigeria

Acute exacerbations of asthma are one of the leading causes of emergency room visits and hospitalizations in children. Asthma exacerbations also demonstrate a seasonal pattern in which high rates can be seen at a particular season and knowledge of the seasonal pattern of asthma exacerbation in any locality can improve asthma management. Objective: To determine the prevalence, management outcome and seasonal pattern of emergency department visits for acute exacerbation of asthma. Methods: This was a retrospective review of the emergency department register of all asthma admissions in the Rivers State University Teaching Hospital, Portharcourt, Nigeria over a five year period from January 2014 to December 2018. Results: A total of 205 (2.9%) asthma-related visits were recorded out of 7046 emergency room visits. The mean age of the patients was 6.1 (±4.2) yrs, with an M:F ratio of 1.97:1. The median length of hospital stay was 24 hrs. Children older than 11 yrs were more likely to be admitted for >48 hrs (OR 4.18, 95% CI;1.67, 10.39, P;0.003). Emergency department visits for asthma were more in the rainy season April-September 129 (63.9%) with a peak in May. There is a significant variation in the seasonal pattern of emergency room asthma admission with age (P = 0.018). Children >3 yrs have their highest admission rates in May while younger children experience two peaks in February and November. Conclusion: Asthma exacerbation is more in rainy season among children in Portharcourt although there is a variation in seasonal pattern of asthma exacerbation with age.

关键词： Asthma Exacerbation Emergency Seasonal Variation Children Nigeria Africa

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Antihyperglycemic Activity of Moringa oleifera Lam Leaf Functional Tea in Rat Models and Human Subjects

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Food and Nutrition Sciences 2016年第11期7卷 1021-1032页

作者： edith N. Fombang Romuald Willy Saa Department of Food Science and Nutrition National School of Agro-Industrial Sciences (ENSAI) University of Ngaoundere Ngaoundere Cameroon

Maintenance of glycemic control is important in preventing diabetes and its associated complications. Considering the current recommended approach for the use of functional foods and their bioactive components in the prevention and management of diabetes, the aim of this study was to determine the antihyperglycemic effect of Moringa oleifera functional tea in rat models and in normoglycemic human volunteers using the oral glucose tolerance test (OGTT). Moringa tea prepared by extracting Moringa leaf powder in distilled water (1:20 mg/ml) at 97°C for 30 min was administered at different doses to male Wistar rats and human volunteers prior to glucose loading. Blood glucose was measured at intervals of 30 min for 150 min. Consumption of Moringa tea prior to glucose loading suppressed the elevation in blood glucose in all cases compared to controls that did not receive the tea initially. The degree and pattern of decrease however, were dose dependent. In rats, intermediate doses of 20 ml/kg BW were more effective in reducing blood glucose overall (18.2%) vs 13.3% and 6% at doses of 10 and 30 ml/kg BW respectively. In humans, the final decrease in blood glucose was not significantly different for high 400 ml (19%) and low 200 ml (17%) doses. Of interest here was the pattern of decrease, being significantly higher (p < 0.05) at 30 min with 200 ml (22.8%) than with 400 ml (17.9%). It is suggested that low doses exert their antihyperglycemic effect more at intestinal level by inhibiting glucose absorption, whereas high doses exert their effect more in circulation. We conclude that Moringa oleifera tea has potential as a functional food in the management of hyperglycemia.

关键词： Moringa oleifera Functional Tea Antihyperglycemic Activity Phenolic Compounds Antioxidant Activity Humans Rats

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Effectiveness of a microabrasion technique using 16% HCL with manual application on fluorotic teeth: A series of studies

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World Journal of Clinical Cases 2020年第4期8卷 743-756页

作者： Martina Nevárez-Rascón Nelly Molina-Frechero edith Adame Ethel Almeida Uriel Soto-Barreras Enrique Gaona Alfredo Nevárez-Rascón Facultad de Odontología Maestría en EstomatologíaUniversidad Autónoma de ChihuahuaChihuahua 31000México División de Ciencias Biológicas y de la Salud Universidad Autónoma MetropolitanaXochimilco 04960México

BACKGROUND Dental fluorosis is caused by excessive fluoride ingestion during tooth *** a consequence,there is a higher porosity on the enamel surface,which causes an opaque *** The aim of this study was to identify a dental intervention to improve the smile in patients with tooth *** aims were to relate the stain size on fluorotic teeth with the effectiveness of stain removal,enamel loss and procedure time using a manual microabrasion technique with 16%hydrochloric acid(HCL).METHODS An experimental study was carried out on 84 fluorotic teeth in 57 adolescent patients,33 females and 24 males,with moderate to severe *** means,standard deviations and percentages were analyzed using nonparametric statistics and ArchiCAD 15 software was used for the variables including stain size and effectiveness of stain *** The average enamel loss was 234μm and was significantly related to the procedure time categorized as 1-4 min and 4.01-6 min,resulting in a P>*** microabrasion technique using 16%HCL was effective in 90.6%of patients and was applied manually on superficial stains in moderate and severe *** time was less than 6 min and enamel loss was within the acceptable *** Microabrasion is a first-line treatment;however,the clinician should measure the average enamel loss to ensure that it is within the approximate range of 250μm in order to avoid restorative treatment.

关键词： Microabrasion of the enamel Dental fluorosis Enamel stains Fluorotic teeth Hydrochloric acid 16% Stain removal

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Baossi–Warack monogenetic volcanoes, Adamawa Plateau,Cameroon: petrography, mineralogy and geochemistry

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Acta Geochimica 2019年第1期38卷 40-67页

作者： Anicet Feudjio Tiabou Robert Temdjim Pierre Wandji Jacques-Marie Bardintzeff Vivian Bih Che edith Ekatah Bate Tibang Caroline Neh Ngwa Fran?ois Xavier Onana Mebara Remote Sensing Unit Faculty of Science Department of Geology University of Buea Department of Earth Sciences Faculty of Science University of Yaoundé 1 Laboratoire de Géologie Ecole Normale Supérieure de Yaoundé Univ.Paris-Sud Sciences de la Terre VolcanologiePlanétologie UMR CNRS 8148 GEOPS Bat.504 Université Paris-Saclay Higher Teacher Training College Department of GeologyUniversity of Bamenda Institute for Geological and Mining Research (IRGM) Institute for Geological and Mining Research (IRGM) Branch of Volcanologic and Geophysics Research (ARGV)

Three monogenetic cones in the Baossi–Warack area, Ngaoundéré, Adamawa Plateau forming part of the Cameroon Volcanic Line(CVL) are documented in this study. Basaltic lavas(<1 km^3) scattered around these vents and restricted volcaniclastic deposits were emplaced by Hawaiian and mild strombolian style eruptions. The lavas are porphyritic, mainly composed of olivine(chrysolite) and clinopyroxene(diopside and augite) phenocrysts and plagioclase(andesine) microphenocrysts. Accessory minerals include titano-magnetite and titano-hematite, nepheline,apatite and amphibole xenocrysts. Sanidine occurs in some samples and sodi-potassic albite in others. Some olivines and clinopyroxenes exhibit resorbed margins and thin reaction rims while plagioclase displays oscillatory zoning, and sieved textures as a result of magma mixing. Whole-rock geochemistry data indicates that the lavas are silica-undersaturated, composed of basanites and basalts, showing little compositional variations(SiO_2: 39.20 wt.%–48.01 wt.%,MgO: 5.29 wt.%–9.70 wt.%). Trace elements patterns of these lavas suggest they are enriched in LILE including Pb,probably due to crustal contamination. REE patterns suggest cogenetic magmas below Baossi 1 and Baossi 2 volcanoes,and distinct sources below Warack volcano and nearby *** lavas studied show affinity to high-μ(HIMU), enriched type Ⅰ(EM1) and Oceanic Island Basalt(OIB)-like mantle signatures and thus indicate a heterogeneous mantle source underneath the vents as noted at other monogenetic and polygenetic volcanoes along the CVL. Primary melts derived from low degrees of partial melting(0.5%–2%) and encountered low rates of fractionation, and crustal contamination coupled with magma mixing. These melts evolved independently through structural weaknesses in the basement.

关键词： Cameroon volcanic line Adamawa Plateau Volcanic field Monogenetic volcano Magma mixing Petrogenesis

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LSD1 is required for euchromatic origin firing and replication timing

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1703-1718页

作者： Yue Wang Yunchao Huang edith Cheng Xinhua Liu Yu Zhang Jianguo Yang Jordan T.F.Young Grant W.Brown Xiaohan Yang Yongfeng Shang Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesHangzhou Normal UniversityHangzhou 311121China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Biochemistry and Donnelly Centre University of TorontoTorontoON M5S 1A8Canada Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital600 University Ave.TorontoON M5G 1×5Canada

The chromatin-based rule governing the selection and activation of replication origins remains to be *** is believed that DNA replication initiates from open chromatin domains;thus,replication origins reside in open and active ***,we report here that lysine-specific demethylase 1(LSD1),which biochemically catalyzes H3K4me1/2 demethylation favoring chromatin condensation,interacts with the DNA replication machinery in human *** find that LSD1 level peaks in early S phase.

关键词： origin LSD1 replication

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白消安、依托泊苷和环磷酰胺与大剂量马法兰作为多发性骨髓瘤患者自体造血干细胞移植预处理方案的疗效比较

白消安、依托泊苷和环磷酰胺与大剂量马法兰作为多发性骨髓瘤患者...

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作者： edith Henry Kimambo 山东大学

学位级别：硕士

研究背景:大剂量马法兰（high-dose melphalan,HDM）是多发性骨髓瘤（multiple myeloma,MM）自体造血干细胞移植（autologous hematopoietic stem cell transplantation,autoHSCT）前的标准预处理方案。尽管患者的反应率和存活率有所提高,但复发率和与方案相关的安全性仍然是一个挑战。目的:本研究主要目的是比较接受白消安、环磷酰胺和依托泊苷（BVC）和HDM作为自体造血干细胞移植预处理方案的MM患者的疗效和预处理毒副作用的差异。方法:对2015年8月至2020年12月期间来自山东省3个主要移植中心（山东大学齐鲁医院、山东省立医院和山东省千佛山医院）的29-65岁（中位年龄52岁）接受自体造血干细胞的78例MM患者进行回顾性分析。37名患者接受BVC预处理方案,而41名患者接受HDM预处理方案。多发性骨髓瘤的诊断使用IMWG标准进行,并使用国际分期系统进行分期。纳入标准包括肌酐低于***/dL、无活动性感染或经肺功能检查确定的严重阻塞性和/或限制性肺疾病（即DLCO＜50%和/或FEV1＜50%和/或FVC＜50%）且心脏射血分数（EF）大于40%的成人（年龄在18-65岁之间）。患者首先接受若干个周期的诱导化疗（通常为3-6个周期）,对疗效达部分缓解以上的患者进行干细胞动员和收集。自体外周血造血干细胞（PBHSCs）用作自体干细胞移植细胞。76例患者接受大剂量环磷酰胺联合粒细胞集落刺激因子（G-CSF）化疗动员采集外周血造血干细胞。2名患者使用plerixafor联合G-CSF稳态动员采集干细胞。CD34+细胞平均采集量为4.61 × 106/kg。CD34+细胞最小采集量为2×1 06个/kg。37名MM患者接受BVC预处理方案:白消安在-7天、-6天和-5天以0.8mg/kg/天静脉注射。依托泊苷在-5天和-4天以400mg/m2/天静脉给药,环磷酰胺在-3天和-2天以50mg/m2/天静脉内给药。41名MM患者接受HDM预处理方案:马法兰总剂量为200mg/m2,分成-3天和-2天静脉注射,然后进行自身HSCT。预处理方案对待评估的移植受者中发生的毒副作用毒性的影响如下:a.方案相关的毒性;包括血液学毒性和非血液学毒性。b.中性粒细胞和血小板植入的时间。c.住院时间。要分析的结果包括:a.移植后疾病的反应状态。b.移植1年时复发率。c.移植后100天内的移植相关死亡率。d.移植 1 年时无进展生存期（progression-free survival,PFS）。e.移植1年时的总生存期（overall survival,OS）。使用SPSS版本26对两组之间的数据进行分析和比较。描述性统计用于报告结果,包括人口统计学,疾病相关因素和移植相关因素。使用Kaplan-Meier方法估计PFS和OS的概率,并使用Log-rank检验对组进行比较。使用Cox比例风险回归模型对OS,PFS和累积复发发生率进行多变量分析,该模型用于估计与HDM相比BVC的风险比（HR）。结果:本研究共纳入MM患者78例,其中37名患者在接受BVC 预处理方案后接受autoHSCT,而41名患者在接受HDM预处理方案后接受autoHSCT。两组的总缓解率（ORR）、PFS、OS和复发率在统计学上相似。BVC组的中位随访时间为540天,HDM组为436天。HDM组肺毒性发生率显著增加（BVC为36.6%对5.4%,P=0.002）。BVC组患者的住院时间明显长于HDM组（中位数20天,范围:BVC为18-27;与中位18天范围:HDM为13-27,P＜0.0001）。BVC组（7天,范围:4-12）中性粒细胞减少的中位持续时间明显长于HDM组(6天,范围:（2-12）;P=0.002。有两例TRM病例,每组一例。在多变量亚组分析中,BVC调理在PFS、OS和复发方面与HDM调理有统计学相似。但是,低风险疾病分期显示可以预测PFS和复发的累积发生率,ISSⅠ和ISSⅡ疾病阶段的患者PFS明显更长;（ISS Ⅰ:HR=0.186,P=0.006,ISS Ⅱ:HR=0.240,P=0.022）;并延迟复发时间;（ISSⅠ:HR=0.220,P=0.013,ISS Ⅱ:HR=0.262,P=0.036）。β-2 微球蛋白预测 OS,β-2微球蛋白水平升高显示显著恶化OS（HR=1.356,P=0.041）。年龄,性别,MM亚型,KPS,移植前使用的化疗方案/周期数或移植时的疾病状况与两组的PFS,OS或复发率无关。结论:尽管两种方案的反应率和生存率似乎相似,但与HDM方案相比,BVC方案在非血液学毒性（肺毒性）方面似乎更优越,但在血液学毒性（血细胞减少）方面较差。本研究显示BV

关键词：自体干细胞移植预处理方案多发性骨髓瘤生存期毒副作用

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矿业出口对莱索托经济增长的影响

矿业出口对莱索托经济增长的影响

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作者： Motena edith Matala 江西财经大学

学位级别：硕士

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Metabolic complications in liver transplant recipients

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World Journal of Gastroenterology 2016年第28期22卷 6416-6423页

作者： Miguel Jiménez-Pérez Rocío González-Grande edith Omonte Guzmán Víctor Amo Trillo Juan Miguel Rodrigo López UGC de Aparato Digestivo Unidad de Hepatología-Trasplante Hepático Hospital Universitario Regional de Málaga

The metabolic syndrome(MS), which includes obesity,dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease(CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1.78. On the other hand, non-alcoholic fatty liver disease(NAFLD), considered as the manifestation of the MS in the liver, is now the second leading reason for liver transplantation in the United States after hepatitis C and alcohol. NAFLD has a high rate of recurrence in the liver graft and a direct relation with the worsening of other metabolic disorders, such as insulin resistance or diabetes mellitus. Consequently, it is vitally important to identify and treat as soon as possible such modifiable factors as hypertension, overweight, hyperlipidaemia or diabetes in transplanted patients to thus minimise the impact on patient survival. Additionally, steroid-free regimens are favoured, with minimal immunosuppression to limit the possible effects on the development of the MS.

关键词： Metabolic syndrome Liver transplantation Immunosuppressions Risk factors Non-alcoholic fatty liver disease

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Perinatal Outcome of Inadvertent Immunization with the Measles-Rubella Vaccine in Pregnant Mexican Women during the Campaign for the Eradication of Congenital Rubella in 2008

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World Journal of Vaccines 2011年第1期1卷 1-4页

作者： Reyna Jesus Herbas Ilse Gómez Misael Vidal Patricia Richardson Vesta Cruz edith Cruz edith National Center for the Health of the Childhood and the Adolescence Ministery of Health Mexico

Objective: To investigate maternal and neonatal complications resulting from inadvertent immunization against rubella-measles during the first trimester of pregnancy. Methods: A prospective and descriptive study was carried out, including a total of 1,924 pregnant women, 175 (9.1%) of which were classified as non responding to infection by the rubella virus. They underwent clinical and ultrasonographic follow-up to dismiss maternal or fetal complications and complications at the time of delivery. The infant was checked to determine demographic, anthropometric, serological and clinical features at the time of birth. Results: No women had complications during the pregnancy, including exanthematic symptoms. 174/175 newborns were studied;one pregnancy was interrupted based on non-medical arguments. The findings in terms of the analyzed patients suggest a benign evolution after inadvertently immunizing the pregnant women, which support studies with similar results. No complications during the course of the pregnancy or phenotypic alterations of the infant at the time of birth are suggested.

关键词： Congenital Rubella Pregnancy Perinatal Repercussion

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