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Risk of fracture.in ce.iac dise.se.Ge.de.,die.ary compliance.or both?

World Journal of Gastroe.te.ology 2011年第25期17卷 3035-3042页

作者： María Inés Pinto Sánche. Adriana Mohaidle.Andre. Baistrocchi Dolore. Matoso Horacio Vázque. Andre. Gonzále. Robe.to Mazure.e.ange.ina Maffe. Guille.mina Fe.rari edgardo Sme.uol Adriana Crive.li Juan Andrés de.Paula Juan C Góme. Silvia Pe.re.ra e.uardo Maurio Julio César Bai Small Bowe. Se.tion Department of Medicine"Dr.C.Bonorino Udaondo" Gastroenterology Hospital De.artme.t of Gastroe.te.ology German Hospital Nutritional Support Unit and Malabsortion "San Martin" HIGA1900 La PlataArgentina De.artme.t of Gastroe.te.ology Italian Hospital

AIM:To de.e.mine.the.incide.ce.of pe.iphe.al fracture. in patie.ts with ce.iac dise.se.(CD) and the.e.fe.t of tre.tme.t on fracture.***:We.compare. the.incide.ce.and risk of pe.iphe.al fracture. be.ore.and afte. diagnosis be.we.n a cohort of 265 patie.ts who had be.n diagnose. with CD at le.st 5 ye.rs be.ore.study e.try and a cohort of 530 age.and se.-matche. controls who had be.n diagnose. with functional gastrointe.tinal *** we.e.colle.te. through in-pe.son inte.vie.s with an *** ove.all asse.sme.t window for patie.ts was 9843 patie.t-ye.rs (2815 patie.t-ye.rs afte. diagnosis).Re.ULTS:Compare. with the.control group,the.CD cohort showe. significantly highe. incide.ce.rate.and risk of first pe.iphe.al fracture.be.ore.diagnosis [adjuste. hazard ratio (HR):1.78,95% CI:1.23-2.56,P e. (HR:2.67,95% CI:1.37-5.22,P e.risk was significantly associate. with the.classic CD pre.e.tation with gastrointe.tinal symptoms (P e.time.pe.iod afte. diagnosis,the.risk of fracture. was comparable.be.we.n the.CD cohort and controls in both se.e. (HR:1.08,95% CI:0.55-2.10 for wome.;HR:1.57,95% CI:0.57-4.26 for me.).CONCLUSION:CD patie.ts have.highe. pre.ale.ce.of fracture. in the.pe.iphe.al ske.e.on be.ore.*** is associate. with male.se. and classic clinical *** fracture.risk was re.uce. afte. the.tre.tme.t.

关键词： Ce.iac dise.se Fracture.risk Pe.iphe.alfracture. Glute.-fre. die. Se. diffe.e.ce

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Taguchi-Optimize. Catalytic Growth of Carbon Nanotube. for Applications in e.e.tro-Catalysis

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Journal of Che.istry and Che.ical e.gine.ring 2013年第8期7卷 748-758页

作者： Save.ia Santange.o e.pida Pipe.opoulos Giuliana Faggio Maurizio Lanza giacomo Me.sina Candida Milone De.artme.t of Civil e.gine.ring Energy Environment and Materials Mediterranea University of Reggio Calabria ReggioCalabria 89122 Italy De.artme.t of e.e.tronic e.gine.ring Chemistry and Industrial Engineering University ofMessina Messina 98166 Italy De.artme.t of Information e.glish Infrastructures and Sustainable Energy Mediterranea University of Reggio Calabria ReggioCalabria 89122 Italy Italian National Re.e.rch Council Institute for Chemical-Physical Processes Messina 98158 Italy

Taguchi me.hod, large.y use. to optimize.proce.se. controlle. by manifold parame.e.s, has be.n utilize. to improve.the.synthe.is of carbon nanotube. by che.ical vapor de.osition of isobutane. Analyzing re.ults obtaine. in nine.suitably de.igne. re.ctions, the.influe.ce.of synthe.is （773-973 K）, calcinations （723-1,023 K） and re.uction （773-973 K） te.pe.ature. and catalyst-support （alumina, magne.ia or Na＋-e.change. K10 clay） on spe.ific yie.d and crystallization de.re. （i.e., C sp2 conte.t） of the.nanotube. has be.n ranke.. Afte. critical e.amination and adjusting of conditions pre.icte. to give.optimal re.ults, -50 g of nanotube. pe. gram of me.al are.obtaine. at 973 K ove. Fe.alumina catalysts calcine. at 723 K and re.uce. at 773 K. Unde. the.same.conditions, highly crystallize. nanotube. （with 73% of C sp2 bonds, as qualitative.y e.timate. from Raman spe.troscopy）, suitable.for e.e.tro-catalysis applications, are.synthe.ize. ove. Fe.clay catalysts.

关键词： Carbon nanotube. che.ical vapor de.osition Taguchi me.hod Raman spe.troscopy.

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De.p re.nforce.e.t le.rning for quantum multiparame.e. e.timation

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Advance. Photonics 2023年第1期5卷 58-70页

作者： Vale.ia Cimini Mauro Vale.i e.anue.e.Polino Simone.Piace.tini France.co Ce.care.li giacomo Corrie.li NicolòSpagnolo Robe.to Ose.lame.Fabio Sciarrino Sapie.za Unive.sitàdi Roma Dipartimento di FisicaRomaItaly Istituto di Fotonica e.Nanote.nologie Consiglio Nazionale delle RicercheMilanoItaly

e.timation of physical quantitie. is at the.core.of most scie.tific re.e.rch,and the.use.of quantum de.ice. promise. to e.hance.its *** re.l sce.arios,it is fundame.tal to conside. that re.ource. are.limite.,and Baye.ian adaptive.e.timation re.re.e.ts a powe.ful approach to e.ficie.tly allocate.during the.e.timation proce.s,all the.available.***,this frame.ork re.ie. on the.pre.ise.knowle.ge.of the.syste. mode.,re.rie.e. with a fine.calibration,with re.ults that are.ofte. computationally and e.pe.ime.tally *** introduce.a mode.-fre. and de.p-le.rning-base. approach to e.ficie.tly imple.e.t re.listic Baye.ian quantum me.rology tasks accomplishing all the.re.e.ant challe.ge.,without re.ying on any a priori knowle.ge.of the.*** ove.come.this ne.d,a ne.ral ne.work is traine. dire.tly on e.pe.ime.tal data to le.rn the.multiparame.e. Baye.ian *** the.syste. is se. at its optimal working point through fe.dback provide. by a re.nforce.e.t le.rning algorithm traine. to re.onstruct and e.hance.e.pe.ime.t he.ristics of the.inve.tigate. quantum ***,we.prove.e.pe.ime.tally the.achie.e.e.t of highe. e.timation pe.formance. than standard me.hods,de.onstrating the.stre.gth of the.combination of the.e.two black-box algorithms on an inte.rate. photonic *** work re.re.e.ts an important ste. toward fully artificial inte.lige.ce.base. quantum me.rology.

关键词： quantum se.sing inte.rate. photonics machine.le.rning for me.rology

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磁化率各向异性的原理及应用实例

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地质力学学报 2017年第1期23卷 135-140页

作者：张淑伟杨振宇王喜生 Maria TCioppa 乔彦松霍俊杰 edgardo Caón-Tapia 赵越中国地质科学院地质力学研究所北京100081 太原理工大学矿业工程学院太原030024 首都师范大学北京100048 De.artme.t of e.rth and e.vironme.tal Scie.ce. University of Windsor CICe.e Department of Earth Sciences

磁化率各向异性(AMS)在地质领域中的应用极为广泛,可以用来研究古流向造成的磁性矿物的定向排列,以及构造应力作用引起的岩石内磁性矿物的定向重结晶、定向排列及韧性变形。本文介绍了AMS的基本原理和参数,并并介绍了前人及作者应用AMS... 详细信息

磁化率各向异性(AMS)在地质领域中的应用极为广泛,可以用来研究古流向造成的磁性矿物的定向排列,以及构造应力作用引起的岩石内磁性矿物的定向重结晶、定向排列及韧性变形。本文介绍了AMS的基本原理和参数,并并介绍了前人及作者应用AMS详细分析研究了二个实例:(1)以假多畴(MD)高钛磁铁矿为主要载磁矿物的玄武岩样品的AMS变化及其对构造运动的响应;(2)以MD磁铁矿为主要载磁矿物的湖泊沉积物样品在沉积过程中AMS变化。AMS可以灵敏地检测样品中磁性矿物的定向排列,因此在在地质领域中具有很好的应用前景。

关键词：磁化率各向异性磁铁矿玄武岩湖泊沉积物岩石磁学

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Path-polarization hype.e.tangle. and cluste. state. of photons on a chip

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Light(Scie.ce.& Applications) 2016年第1期5卷 836-841页

作者： Mario Arnolfo Ciampini Ade.ine.Orie.x Ste.ano Pae.ani Fabio Sciarrino giacomo Corrie.li Andre. Cre.pi Robe.ta Ramponi Robe.to Ose.lame.Paolo Mataloni dipartime.to di Fisica-Sapie.za Unive.sitàdi Roma I-00185 RomaItaly Istituto di Fotonica e.Nanote.nologie.Consiglio Nazionale.de.le.Rice.che.IFN-CNR) I-20133 MilanoItaly dipartime.to di Fisica-Polite.nico di Milano I-20133 MilanoItaly Télécom ParisTe.h CNRS-LTCI46 rue BarraultF-75634 Paris CEDEX 13France Ce.tre.for Quantum Photonics H H Wills Physics Laboratory and De.artme.t of e.e.trical and e.e.tronic e.gine.ring University of BristolMerchant Ventures BuildingWoodland RoadBristol BS81UBUK.

e.coding many qubits in diffe.e.t de.re.s of fre.dom(DOFs)of single.photons is one.of the.route. toward e.larging the.Hilbe.t space.spanne. by a photonic quantum *** photon state.(that is,state. showing e.tangle.e.t in multiple.DOFs)have.de.onstrate. significant implications for both fundame.tal physics te.ts and quantum communication and *** the.numbe. of qubits of photonic e.pe.ime.ts re.uire. miniaturization and inte.ration of the.basic e.e.e.ts,and functions to guarante. the.se.up stability,which motivate. the.de.e.opme.t of te.hnologie. allowing the.pre.ise.control of diffe.e.t photonic DOFs on a *** de.onstrate.the.conte.tual use.of path and polarization qubits propagating within an inte.rate. quantum *** te.te. the.prope.tie. of four-qubit line.r cluste. state. built on both DOFs,and we.e.ploite. the. to pe.form the.Grove.'s se.rch algorithm according to the.one.way quantum computation *** re.ults pave.the.way toward the.full inte.ration on a chip of hybrid multi-qubit multiphoton state..

关键词： hype.e.tangle.e.t inte.rate. photonics quantum information quantum optics

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Fe.sibility of e. bloc thulium lase. e.ucle.tion of the.prostate.in a large.case.se.ie.. Are.re.ults e.hance. by e.pe.ie.ce.

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Asian Journal of Urology 2019年第4期6卷 339-345页

作者： Giovanni Sare.i giacomo Maria Pirola France.ca Ambrosini Simone.Barbie.i Lore.zo Be.ti Andre. Pacche.ti Dome.ico Iovino Giuse.pe.Ie.to Le.izia Libassi Giulio Carcano De.artme.t of Urology Ospedale di Circolo e Fondazione MacchiVareseItaly De.artme.t of Urology Usl Toscana Sud EstSan Donato HospitalArezzoItaly Ce.tro Cardiologico Monzino IRCCSMilanItaly De.artme.t of Urology University of GenovaGenovaItaly De.artme.t of Surge.y University of InsubriaVareseItaly

Obje.tive.To provide.the.first large.single.ope.ator case.se.ie. of patie.ts who unde.go“e. bloc”thulium lase. e.ucle.tion of the.prostate.ThuLe.)and to de.onstrate.an improve.e.t in e.ucle.tion e.ficacy with ***:We.prospe.tive.y e.aluate. a cohort of patie.ts with symptomatic be.ign prostatic hype.plasia(BPH)who unde.we.t“e. bloc”ThuLe. be.we.n May 2015 and Nove.be. *** be.we.n de.e.de.t variable.(de.ive.e. e.e.gy and ope.ating time.and inde.e.de.t variable.(ade.oma volume.and e.pe.ie.ce.we.e.e.timate. with re.re.sion *** e.pe.ie.ce.was calculate. as the.time.inte.val be.we.n the.date.of the.first ope.ation of the.se.ie. and the.date.of the.ope.ation be.ng ***:A total of 100 patie.ts we.e.re.iste.e. for the.*** ope.ative.time.was 56.5 min(inte.quartile.range.IQR]:40-85 min).Me.ian e.ucle.tion time.was 17.4 min(IQR:15-21.5 min).Me.ian e.ucle.tion inde.(e.ucle.tion time.pe. ade.oma gram)was 0.3 min/g(0.2-0.3 min/g).The.ove.all ope.ative.time.is not influe.ce. by e.pe.ie.ce.but we.re.iste.e. a significant tre.d towards a re.uction in the.total amount of e.e.gy de.ive.e. e.e.gy normalize. pe. ade.oma gram(p=0.0148).Conclusion:We.be.ie.e.that furthe. atte.tion is ne.de. for the.e.ne.“e. bloc”prostatic e.ucle.tion te.hnique.,which can facilitate.some.surgical ste.s,le.ding to a wide.pre.d use.of lase. te.hnology for BPH surgical tre.tme.t.

关键词： Be.ign prostatic hype.plasia e.doscopic e.ucle.tion of the.prostate Lase. surge.y Thulium lase. e.ucle.tion of the.prostate

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Advance. he.atoce.lular carcinoma and sorafe.ib: diagnosis, indications, clinical and radiological follow-up

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World Journal of He.atology 2015年第8期7卷 1041-1053页

作者： Ste.ano Colagrande.France.co Re.ini Gian giacomo Taliani Cosimo Nardi Andre. Lore.zo Inghile.i dipartime.to di Scie.ze.Biome.iche Sperimentali e Cliniche Università degli Studi di Firenze-Azienda Ospedaliero-Universitaria Careggi dipartime.to di Me.icina Spe.i-me.tale.e.Clinica Università degli Studi di Firenze-Azienda Ospedaliero-Universitaria Careggi

Advance. stage.he.atoce.lular carcinoma(HCC) is a cate.ory of dise.se.de.ine. by radiological, clinical and he.atic function parame.e.s, compre.e.ding a wide.range.of patie.ts with diffe.e.t ge.e.al conditions. The.main the.ape.tic option is re.re.e.te. by sorafe.ibtre.tme.t, a multi-kinase.inhibitor with anti-prolife.ative.and anti-angioge.ic e.fe.t. Trans-arte.ial Radio e.bolization also re.re.e.ts a promising ne. approach to inte.me.iate.advance. HCC. Post-marke.ing clinical studie. showe. that only a portion of patie.ts actually be.e.its from sorafe.ib tre.tme.t, and an e.e. smalle. pe.ce.tage.of patie.ts tre.te. shows partial/comple.e.re.ponse.on follow-up e.aminations, up against re.e.ant costs and an incide.ce.of drug re.ate. adve.se.e.fe.ts. Although the.tre.tme.t with sorafe.ib has shown a significant incre.se.in me.n ove.all survival in diffe.e.t studie., only a part of patie.ts actually shows re.l be.e.its, while.the.incide.ce.of drug re.ate. significant adve.se.e.fe.ts and the.e.onomic costs are.re.ative.y high. More.ve., only a small pe.ce.tage.of patie.ts also shows a re.ponse.in te.ms of le.ion dime.sions re.uction. Be.ng able.to prope.ly diffe.e.tiate.patie.ts who are.re.ponding to the.the.apy from non-re.ponde.s as e.rly as possible.is the. still difficult and could be.a pivotal challe.ge.for the.future. in fact it could spare.se.e.al patie.ts a the.apy ofte. difficult to be.r, dire.ting the. to othe. se.ond line.tre.tme.ts(many of which are.at the.mome.t still unde. inve.tigation). For this re.son, some.supple.e.tal crite.ia to be.adde. to the.standard modifie. Re.ponse.e.aluation Crite.ia in Solid Tumors e.aluation are.be.ng se.rche. for. In particular, finding some.parame.e.s(ce.lular de.sity, pe.fusion grade.and e.hance.e.t rate. able.to pre.ict the.se.sitivity of the.le.ions to anti-angioge.ic age.ts could he.p in stratifying patie.ts in te.ms of tre.tme.t re.ponsive.e.s be.ore.the.be.inning of the.the.apy itse.f, or in the.first we.ks of soraf

关键词： Modifie. Re.ponse e.aluation Crite.ia inSolid Tumors diffusion we.ghte. imaging Barce.onaclinic live. cance. Advance. he.atoce.lular carcinoma Sorafe.ib Advance. he.atoce.lular carcinoma se.ondline the.apie. Pe.fusion we.ghte. imaging Re.ponse.valuation He.atoce.lular carcinoma follow-up Re.ponse e.aluation Crite.ia in Solid Tumors

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Pancre.tic me.astasis from mycosis fungoide. mimicking primary pancre.tic tumor

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World Journal of Gastroe.te.ology 2016年第12期22卷 3496-3501页

作者： Paola Ce.iolo Vale.tina Fausti e.isa Cinotti Silvia Bonadio Lizzia Raffaghe.lo Giovanna Bianchi Giulio Frate.nali Orcioni Robe.to Fiocca Franco Rongiole.ti Vito Pistoia giacomo Borgonovo Course.in Pae.iatric Scie.ce Fetal-Perinatal and Paediatric Pathology University of Genoa Pathology Unit Istituto Giannina Gaslini Se.tion of De.matology IRCCS AOU San Martino-IST Pathology Unit IRCCS AOU San Martino-IST Laboratory of Oncology Istituto Giannina Gaslini Pathology Unit IRCCS AOU San Martino-IST and University of Genoa Surge.y Unit IRCCS AOU San Martino-IST and University of Genoa

Mycosis fungoide.(MF) is a cutane.us T-ce.l lymphoma that can unde.go local progre.sion with possible.syste.ic disse.ination. We.re.ort a case.of a patie.t affe.te. by MF with a pancre.tic mass that was a diagnostic challe.ge.be.we.n primitive.tumor and pancre.tic me.astasis from MF. Clinical se.ting findings and imaging studie. raise. the.suspicion of a pancre.tic primary ne.plasm. A diagnostic clue.was provide. by the.combine. histomorphologic/immunohistoche.ical study of pancre.tic and cutane.us biopsie., which re.e.le. a pancre.tic localization of MF. Conside.ing the.rarity of me.astatic localization of MF to the.pancre.s, we.ne.t inve.tigate. whe.he. che.okine.he.okine.re.e.tor inte.actions could be.involve. in the.phe.ome.on to provide.ne. insight into the.possible.me.hanisms unde.lying me.astatic localization of MF to the.pancre.s. Histological analyse. of archival pancre.tic tissue.de.onstrate. that glucagon-se.re.ing ce.ls of the.pancre.tic isle.s e.pre.se. the.CCL27 che.okine. which may have.attracte. in our case.me.astatic MF ce.ls e.pre.sing the.comple.e.tary re.e.tor CCR10.

关键词： diffe.e.tial diagnosis Pancre.tic mass e.tracutane.us localization Mycosis fungoide. CCL27 CCR10

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Risk pe.ce.tion and knowle.ge.of COVID-19 in patie.ts with ce.iac dise.se

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World Journal of Gastroe.te.ology 2021年第12期27卷 1213-1225页

作者： Jamie.Zhe. Juan Pablo Ste.anolo María de.la Paz Te.prano Caroline.L Se.le. Albe.to Camine.o e.rique.de.Madaria Migue. Montoro Hugue. Vivas Santiago Sonia Isabe. Nive.oni edgardo Gustavo Sme.uol Luis Uzcanga Domingue. e.e.a Trucco Virginia Lope. Carolina Olano Pasquale.Mansue.o Antonio Carroccio Pe.e. H Gre.n Donald Due.kse. Andre. S Day Jason A Tye.din Julio César Bai Carolina Ciacci e.e.a F Ve.dú Be.jamin Le.wohl M Ine. Pinto-Sanche. De.artme.t of Me.icine Farncombe Family Digestive Health Research InstituteMcMaster University Medical CenterHamilton Health SciencesHamilton L8S4K1ONCanada De.artme.t of Me.icine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina De.artme.t of Pancre.tic Unit Hospital General Universitario de AlicanteAlicante 03010Spain De.artme.t of Me.icine Instituto Aragonés de Ciencias de la Salud(IACS)Zaragoza 50009Spain De.artme.t of Me.icine Hospital Universitario San Jorge.HuescaZaragoza 50004Spain De.artme.t of Gastroe.te.ology Univ Hosp LeonGastroenterol UnitAltos de Nava S-NLeon 24071Spain De.artme.t of Me.icine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico DF 14080Mexico De.artme.t of Me.icine Universidad de la RepublicMontevideo 11800Uruguay De.artme.t of Inte.nal Me.icine PROMISE DepartmentUniversity of PalermoPalermo 90127Italy De.artme.t of Inte.nal Me.icine V.Cervello HospitalPROMISE DepartmentUniversity of PalermoPalermo 90127Italy Ce.iac dise.se.Ce.te. Columbia University Medical CenterColumbia UnivCeliac Dis CtrDiv Digest and Liver DisNew YorkNY 10032United States De.artme.t of Me.icine St Boniface Gen HospUniversity of ManitobaWinnipeg R2H 2A6Canada De.artme.t of Pae.iatrics University of Otago ChristchurchChristchurch 8041New Zealand De.artme.t of Gastroe.te.ology Royal Melbourne HospitalImmunology DivisionWalter and Eliza Hall InstituteMelbourne 3052Australia De.artme.t of Me.icine Surgery and DentryScuola Medica SalernitanaUniversity of SalernoCeliac Center at the University Hospital San Giovanni di Dio e Ruggi di AragonaSalerno 84131Italy De.artme.t of Me.icine Farncombe Family Digestive Research InstituteMcMaster UniversityHamilton L8S4K1ONCanada The.Ce.iac dise.se.Ce.te. Columbia UniversityNew YorkNY 10032United States

BACKGROUND We.re.e.tly de.onstrate. that the.odds of contracting coronavirus dise.se.2019(COVID-19)in patie.ts with ce.iac dise.se.Ce.)is similar to that of the.ge.e.al ***,how patie.ts with Ce. pe.ce.ve.the.r COVID-19 risk may diffe. from the.r actual *** To inve.tigate.risk pe.ce.tions of contracting COVID-19 in patie.ts with Ce. and de.e.mine.the.factors that may influe.ce.the.r *** We.distribute. a surve. throughout 10 countrie. be.we.n March and June.2020 and colle.te. data on de.ographics,die.,COVID-19 te.ting,and risk pe.ce.tions of COVID-19 in patie.ts with *** we.e.re.ruite. through various ce.iac associations,clinic visits,and social *** pe.ce.tion was asse.se. by asking individuals whe.he. the. be.ie.e.patie.ts with Ce. are.at an incre.se. risk of contracting COVID-19 whe. compare. to the.ge.e.al *** re.re.sion was use. to de.e.mine.the.influe.cing factors associate. with COVID-19 risk pe.ce.tion,such as age.se.,adhe.e.ce.to a glute.-fre. die.(GFD),and comorbiditie. such as cardiac conditions,re.piratory conditions,and *** was pre.e.te. as adjuste. odds ratios(aORs)Re.ULTS A total of 10737 participants with Ce. comple.e. the.*** the.,6019(56.1%)patie.ts with Ce. pe.ce.ve. the. we.e.at a highe. risk or we.e.unsure.if the. we.e.at a highe. risk of contracting COVID-19 compare. to the.non-Ce. population.A gre.te. proportion of patie.ts with Ce. pe.ce.ve. an incre.se. risk of contracting COVID-19 whe. compare. to infe.tions in ge.e.al due.to the.r Ce.(56.1%vs 26.7%,Pe.ue.tly,34.8%re.orte. taking e.tra COVID-19 pre.autions as a re.ult of the.r *** of ce.iac associations we.e.le.s like.y to pe.ce.ve.an incre.se. risk of COVID-19 whe. compare. to non-me.be.s(49.5%vs 57.4%,Pe. age.aOR:0.99;95%CI:0.99 to 0.99,Pe.se.(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adhe.e.ce.to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)we.e.associate.

关键词： Ce.iac dise.se Glute. Risk Infe.tion Knowle.ge Pe.ce.tion Coronavirus COVID-19

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e.aluation of the.prognostic value.of live. stiffne.s in patie.ts with he.atitis C virus tre.te. with triple.or dual antiviral the.apy:A prospe.tive.pilot study

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World Journal of Gastroe.te.ology 2015年第10期21卷 3013-3019页

作者： Cristina Stasi Ale.sia Piluso Umbe.to Are.a e.e.a Salomoni Paolo Montalto Monica Monti Barbara Boldrini Giampaolo Corti Fabio Marra giacomo Laffi Ste.ano Milani Anna Linda Zigne.o De.artme.t of e.pe.ime.tal and Clinical Me.icine University of Florence He.lth Age.cy of Tuscany Gastrointe.tinal e.doscopy Unit Ospedale SS Cosma e Damiano De.artme.t of Biome.ical Experimental and Clinical sciencesUniversity of Florence

AIM:To e.aluate.the.association be.we.n live. stiffne.s(LS) prior to the.initiation of dual/triple.the.apy and viral ***:LS was me.sure. in all patie.ts be.ore.tre.tme.t was *** the.ape.tic approach was base. on he.atic,virological,and immunological e.aluations and conside.e. the.fact that patie.ts with se.e.e.fibrosis(F3)or compe.sate. cirrhosis(F4)in Child-Pugh class A are.the.primary candidate. for triple.*** total,65 he.atitis C virus(HCV)patie.ts we.e.tre.te. with Pe.-inte.fe.on/ribavirin(Pe.-IFN/RBV);24patie.ts we.e.classifie. as ge.otype. 1/4(36.92%),and41 patie.ts we.e.classifie. as ge.otype. 2/3(63.08%)(dual the.apy).In addition,20 HCV tre.tme.t-e.pe.ie.ce. ge.otype.1 patie.ts we.e.tre.te. with Pe. IFN-RBV and boce.re.ir(triple.the.apy).Wilcoxon rank-sum te.ts we.e.use. to compare.the.***:LS significantly diffe.e. be.we.n dual the.apy and triple.the.apy(P=0.002).The.me.n LS value.be.ore.dual the.apy tre.tme.t was 8.61±5.79k Pa and was significantly diffe.e.t be.we.n patie.ts achie.ing a sustaine. virologic re.ponse.SVR)24we.ks afte. the.apy and those.who did not(7.23±5.18 k Pa vs 11.72±5.99 k Pa,re.pe.tive.y,P=0.0003).The.re.ative.risk of non-re.ponse.to the.apy was 4.45(95%CI:2.32-8.55).The.attributable.risk of non-re.ponse.to the.apy was 49%.The.me.n LSvalue.be.ore.triple.the.apy tre.tme.t was 13.29±8.57k Pa and was significantly diffe.e.t be.we.n patie.ts achie.ing and not achie.ing SVR24(9.41±5.05 vs19.11±9.74,re.pe.tive.y;P=0.008).The.re.ative.risk of non-re.ponse.to the.apy was 5.57%(95%CI:1.50-20.65).The.attributable.risk of non-re.ponse.to the.apy(70%)was incre.se. compare. with dual the.apy ***-tre.tme.t stiffne.s>12 k Pa was significantly associate. with non-SVR(Pe.tre.tme.t live. stiffne.s may be.use.ul for pre.icting the.re.ponse.to tre.tme.t in patie.ts tre.te. with e.the. dual or triple.anti-HCV the.apy.

关键词： Antiviral the.apy Chronic he.atitis C Fibrosis Liv

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