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Metabolic profile of Guge Fengtong tablet in rat urine and bile after oral administration,using high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry

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Chinese Journal of Natural Medicines 2015年第12期13卷 954-960页

作者： ZeNG Su-Ling LI Ping LIU e-Hu State Key Laboratory of Natural Medicines China Pharmaceutical University

In the present study, we developed and validated a rapid analytical method using high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry(HPLC-Q-TOF/MS) to investigate the metabolic profile of Guge Fengtong tablet(GGFTT), a traditional Chinese medicine. The urine and bile samples were collected with 24 h after oral administration of GGFTT. A total of 34 compounds, including 11 parent compounds and 23 metabolites were unambiguously or tentatively identified. Our results indicated that glucuronidation, oxidation and methylation were the major metabolic pathways of the constituents in GGFTT. In addition, the results of this work also demonstrated the feasibility of HPLC-eSI-Q-TOF/MS for reliable characterization of the in vivo metabolites from herbal preparations.

关键词： Guge Fengtong tablet HPLC-Q-TOF/MS Urine Bile Metabolite

Dark halos acting as chaos controllers in asymmetric triaxial galaxy models

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Research in Astronomy and Astrophysics 2011年第7期11卷 811-823页

作者： Nicolaos D.Caranicolas euaggelos e.Zotos Department of Physics Section of AstrophysicsAstronomy and MechanicsAristotle University of Thessaloniki 541 24ThessalonikiGreece

We study the regular or chaotic character of orbits in a 3D dynamical model,describing a triaxial galaxy surrounded by a spherical dark halo *** numerical experiments suggest that the percentage of chaotic orbits decreases exponentially as the mass of the dark halo increases.A linear increase of the percentage of the chaotic orbits was observed as the scale length of the halo component increases. In order to distinguish between regular and chaotic motion,we chose to use the total angular momentum Ltot of the 3D orbits as a new *** with other,previously used,dynamical indicators,such as the Lyapunov Characteristic exponent or the P（f） spectral method,shows that the Ltot indicator gives very fast and reliable results for characterizing the nature of orbits in galactic dynamical models.

关键词： galaxies:kinematics and dynamics—dynamical indicators

Contactins in the central nervous system: role in health and disease

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Neural Regeneration Research 2019年第2期14卷 206-216页

作者： Madhurima Chatterjee Detlev Schild Charlotte e.Teunissen Amsterdam UMC VU University Medical Center Department of Clinical Chemistry Amsterdam Neuroscience Institute of Neurophysiology and Cellular Biophysics University of G?ttingen DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) University of G?ttingen DFG excellence Cluster 171 University of G?ttingen

Contactins are a group of cell adhesion molecules that are mainly expressed in the brain and play pivotal roles in the organization of axonal domains, axonal guidance, neuritogenesis, neuronal development, synapse formation and plasticity, axo-glia interactions and neural regeneration. Contactins comprise a family of six members. Their absence leads to malformed axons and impaired nerve conduction. Contactin mediated protein complex formation is critical for the organization of the axon in early central nervous system development. Mutations and differential expression of contactins have been identified in neuro-developmental or neurological disorders. Taken together, contactins are extensively studied in the context of nervous system development. This review summarizes the physiological roles of all six members of the Contactin family in neurodevelopment as well as their involvement in neurological/neurodevelopmental disorders.

关键词： cell adhesion molecule Contactins axonal domain,neurogenesis synaptogenesis autism spectrum disorder neuro-developmental disorder neurological disease

阿司匹林联合硫酸氢氯吡格雷治疗脑梗死的效果分析

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中外医疗 2024年第22期43卷 79-82页

作者：张畅夏许静田凤娥单县中心医院药剂科山东菏泽274300

目的探讨阿司匹林联合硫酸氢氯吡格雷治疗脑梗死患者的应用价值。方法方便选取2022年2月—2023年10月单县中心医院收治的116例脑梗死患者为研究对象,根据不同的治疗方案将其分为对照组(n=58,阿司匹林)与研究组(n=58,阿司匹林+硫酸氢氯... 详细信息

目的探讨阿司匹林联合硫酸氢氯吡格雷治疗脑梗死患者的应用价值。方法方便选取2022年2月—2023年10月单县中心医院收治的116例脑梗死患者为研究对象,根据不同的治疗方案将其分为对照组(n=58,阿司匹林)与研究组(n=58,阿司匹林+硫酸氢氯吡格雷),对比两组的治疗有效率、神经功能缺损、认知及日常生活能力评分、炎性因子水平、凝血功能。结果研究组的治疗总有效率为94.83%(55/58),高于对照组的81.03%(47/58),差异有统计学意义(χ^(2)=5.199,P<0.05)。研究组神经功能缺损评分较对照组低,认知功能评分、日常生活能力评分较对照组高,差异有统计学意义(P均<0.05)。研究组白细胞介素-6、C反应蛋白、肿瘤坏死因子-α水平低于对照组,差异有统计学意义(P均<0.05)。研究组纤维蛋白原较对照组低,凝血酶时间、凝血酶原时间、活化部分凝血酶时间较对照组高,差异有统计学意义(P均<0.05)。结论脑梗死的治疗中联合使用阿司匹林和硫酸氢氯吡格雷可提高临床疗效,降低炎症反应,改善血流动力学与凝血功能,减轻神经功能缺损情况,对改善其认知功能、提高生活能力有积极的影响。

关键词：脑梗死阿司匹林硫酸氢氯吡格雷神经功能缺损

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Covering Your Bases： Inheritance of DNA Methylation in Plant Genomes

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Molecular Plant 2014年第3期7卷 472-480页

作者： Chad e. Niederhuth Robert J. Schmitz Department of Genetics University of Georgia Athens GA 30602 USA

Cytosine methylation is an important base modification that is inherited across mitotic and meiotic cell divisions in plant genomes. Heritable methylation variants can contribute to within-species phenotypic variation. Few methylation variants were known until recently, making it possible to begin to address major unanswered questions： the extent of natural methylation variation within plant genomes, its effects on phenotypic variation, its degree of depend- ence on genotype, and how it fits into an evolutionary context. Techniques like whole-genome bisulfite sequencing （WGBS） make it possible to determine cytosine methylation states at single-base resolution across entire genomes and populations. Application of this method to natural and novel experimental populations is revealing answers to these long-standing questions about the role of DNA methylation in plant genomes.

关键词： DNA methylation epigenetics epiallele whole-genome bisulfite sequencing.

Antioxidant defense system induced by cysteinestabilized peptide fraction of aqueous extract of Morinda lucida leaf in selected tissues of Plasmodium berghei-infected mice

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Journal of Integrative Medicine 2017年第5期15卷 388-397页

作者： Kayode e.Adewole Joseph O.Adebayo Department of Biochemistry Faculty of Life SciencesUniversity of ilorinilorin 24003Nigeria

OBJeCTIve： This study evaluated the responses of some antioxidant parameters in selected tissues of Plasmodium berghei-infected mice treated with cysteine-stabilized peptide fraction（CSPF） of aqueous extract of Morinda lucida ***：Fifty-six mice were randomly divided into seven *** A（normal control）was uninfected and received 5%dimethyl sulfoxide（DMSO）.Mice in Groups B（negative control）,C,D,e and F were inoculated with *** NK65 and were administered with 5%DMSO and 15.63,31.25,61.5 and 125 mg/kg body weight of CSPF *** G animals,were also inoculated with *** NK65,and received 20 mg/kg body weight of *** administration lasted for three days,after which malondialdehyde（MDA）concentration and various antioxidant parameters in selected tissues of mice were determined on days 4 and 8 ***：The results revealed that MDA concentration was significantly increased（P〈0.05）in the tissues of the negative control and chloroquine-treated *** increased MDA concentration was reduced by CSPF in a dose-dependent manner,which was significant（P〈0.05）at higher *** activities of superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glutathioneS-transferase and the concentration of reduced glutathione were significantly reduced（P〈0.05）in the tissues of the negative control animals compared to the normal *** observed reduction in the negative control animals was reverted in a dose-dependent manner in infected animals given CSPF,even to the range of the normal controls at highest dose,as did ***：The results suggest that CSPF of *** leaf extract may induce the antioxidant defense system in vivo against Plasmodium species infection.

关键词： Morinda lucida peptide extract Plasmodium berghei antioxidant oxidative stress

Non-equilibrium ignition criterion for magnetized deuterium–tritium fuel

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Nuclear Science and Techniques 2019年第4期30卷 132-142页

作者： e.Ghorbanpour A.Ghasemizad S.Khoshbinfar Department of Physics Faculty of Science University of Guilan

In this paper, non-equilibrium ignition conditions for magnetized cylindrical deuterium–tritium plasma in the presence of an axial magnetic field have been investigated. It is expected that temperature imbalance between ions and electrons as well as the axial magnetic field will relax the threshold of ignition ***, ignition conditions for this model are derived numerically involving the energy balance equation at the stagnation point. It has been derived using parametric space including electron and ion temperature(T_e, T_i), areal density(q R), and seed magnetic field-dependent free parameters of B/q, mB, and BR. For B/ρ e minimum fuel areal density exceeds between ρR >0.002 g cm^(-2), ρR> 0.25 g cm^(-2), and ρR > 0.02 g cm^(-2),respectively. The practical equilibrium conditions also addressed which is in good agreement with the corresponding one-temperature magnetized mode proposed in previous studies. Moreover, it has been shown that the typical criterion of BR ≥(6.13–4.64) × 10~5 G cm would be expectable. It is also confirmed that the minimum product of areal density times fuel temperature in equilibrium model is located in the range of T = 6–8 kev for all these free parameters, depending on the magnitude of the magnetic field. This is the entry point for the non-equilibrium model consistent with equilibrium model.

关键词： Magnetized plasma Two-temperature model Ion-electron non-equilibrium Axial magnetic field Ignition criteria

Citizen science reporting indicates geographic and phenotypic drivers of road use and mortality in a threatened rattlesnake

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Current Zoology 2023年第3期69卷 264-276页

作者： Chaz Rhodes Willard Haunfelder Bradley e.Carlson Department of Biology Wabash CollegeCrawfordsvilleIN 47933USA

Roads may influence the selection of phenotypic traits of *** particular,the likelihood of vehicle collisions with wildlife may vary depending on body coloration in contrast to the road,which may be exaggerated by cultural attitudes toward the *** timber rattlesnake Crotalus horridus is a threatened species that varies widely in coloration,and their color pattern could influence thermoregulatory use of roads and visibility to ***,better-camouflaged snakes may have higher road mortality in areas where environmental interest is lower and,perhaps,negative attitudes toward wildlife are more *** used citizen scientist observations of timber rattlesnakes from iNaturalist and categorized for each rattlesnake the surface they were on,its color pattern,and whether they were *** combined iNaturalist data with Google Trends data to characterize regional variation in environmental *** discovered that lighter-colored snakes were more likely to be found on roads,as were snakes further south,west,and on warmer *** on a road,coloration did not influence survival regardless of road type or environmental ***,snakes on asphalt roads or on southern roads were more likely to be found *** higher likelihood of lighter-colored snakes being found on roads suggests that they are at a greater overall risk of road death,potentially selecting for darker *** scientist behavior may at least partly underlie the influence of latitude on the results,however,and further work in the application of citizen science data to such research questions is warranted.

关键词： google Trends iNaturalist reptiles roadkill selection snakes

乳腺癌化疗患者构建经济毒性预警模型的价值分析

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河北医药 2024年第17期46卷 2614-2617页

作者：李珊许月娥李娟朱姝江苏省淮安市第二人民医院(徐州医科大学附属淮安医院)肿瘤内科 223022 江苏省淮安市第二人民医院(徐州医科大学附属淮安医院)老年科 223022 江苏省淮安市第二人民医院(徐州医科大学附属淮安医院)甲乳外科 223022

目的通过构建经济毒性预警模型并制定相应干预措施,探讨其对乳腺癌化疗患者应对方式、心理弹性和生存质量的影响。方法将2021至2022年收治的90例接受乳腺癌化疗治疗的患者随机分为对照组和预警组,每组45例。对照组给予常规化疗相关护理... 详细信息

目的通过构建经济毒性预警模型并制定相应干预措施,探讨其对乳腺癌化疗患者应对方式、心理弹性和生存质量的影响。方法将2021至2022年收治的90例接受乳腺癌化疗治疗的患者随机分为对照组和预警组,每组45例。对照组给予常规化疗相关护理,预警组通过构建经济毒性预警模型给予相应护理干预,比较2组患者干预前和干预4周后的应对方式、心理弹性和生存质量变化情况。结果2组患者干预前应对方式、心理弹性和生存质量各维度得分比较差异无统计学意义(P>0.05)。2组患者干预后的屈服和回避应对方式评分低于干预前,而面对应对方式、自强、乐观、坚韧、心理弹性总分、躯体、角色、社会、认知、情绪和总体健康评分高于干预前,预警组的各维度水平变化趋势更明显,组间和组内各维度得分比较差异均有统计学意义(P<0.05)。结论对乳腺癌化疗患者构建经济毒性预警模型并制定针对性干预措施可明显提高患者面对疾病的积极性,改善其心理弹性水平和生存质量。

关键词：乳腺癌化疗经济毒性预警模型