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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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Ranking environmental and edaphic attributes driving soil microbial community structure and activity with special attention to spatial and temporal scales

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mLife 2024年第1期3卷 21-41页

作者： vadakattu v.S.R.Gupta James M.Tiedje CSIRO Agriculture&Food UrrbraeSouth AustraliaAustralia Centre for Microbial ecology Michigan State UniversityEast LansingMichiganUSA

The incredibly complex soil microbial communities at small scales make their analysis and identification of reasons for the observed structures *** community structure is mainly a result of the inoculum(dispersal),the selective advantages of those organisms under the habitat-based environmental attributes,and the ability of those colonizers to sustain themselves over *** soil is protective,and its microbial inhabitants have long adapted to varied soil conditions,significant portions of the soil microbial community structure are likely ***,a substantial portion of the community will not correlate to often measured soil *** suggest that the drivers be ranked on the basis of their importance to the fundamental needs of the microbes:(i)those that supply energy,i.e.,organic carbon and electron acceptors;(i)environmental effectors or stressors,i.e.,pH,salt,drought,and toxic chemicals;(ii)macro-organism associations,i.e.,plants and their seasonality,animals and their fecal matter,and soil fauna;and(iv)nutrients,in order,N,P,and probably of lesser importance,other micronutrients,and *** relevance of drivers also varies with spatial and time scales,for example,aggregate to field to regional,and persistent to dynamic populations to transcripts,and with the extent of phylogenetic difference,hence phenotypic differences in organismal *** present a summary matrix to provide guidance on which drivers are important for particular studies,with special emphasis on a wide range of spatial and temporal scales,and illustrate this with genomic and population(rRNA gene)data from selected studies.

关键词： abundance community structure diversity functional microbiome microorganisms

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Storylines of family medicine Ⅷ:clinical approaches

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Family Medicine and Community Health 2024年第S3期12卷 70-78页

作者： William B ventres Leslie A Stone Lauren e Gibson-Oliver elizabeth Kyle Meehan Mari A Ricker David Loxterkamp Stacy A Ogbeide Frank v deGruy Megan R Mahoney Steven Lin Clare MacRae Stewart W Mercer Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Community Medicine The University of Arizona College of Medicine-TucsonTucsonArizonaUSA Bucksport Regional Health Center BucksportMaineUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA eugene S.Farley Jr.Health Policy CenterUniversity of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Division of Primary Care and Population Health Stanford MedicinePalo AltoCaliforniaUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅷ:clinical approaches’,authors address the following themes:‘evaluation,diagnosis and managementⅠ—toward a working diagnosis’,‘evaluation,diagnosis and managementⅡ—process steps’,‘Interweaving integrative medicine and family medicine’,‘Halfway—the art of clinical judgment’,‘Seamless integration in family medicine—team-based care’,‘Technology—uncovering stories from noise’and‘Caring for patients with multiple long-term conditions’.May readers recognise in these essays the uniqueness of a family medicine approach to care.

关键词： uniqueness dimensions illustration

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2024 Adult Compendium of Physical Activities:A third update of the energy costs of human activities

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Journal of Sport and Health Science 2024年第1期13卷 6-12页

作者： Stephen D.Herrmann erik A.Willis Barbara e.Ainsworth Tiago v.Barreira Mary Hastert Chelsea L.Kracht John M.Schuna Jr. Zhenghui Cai Minghui Quan Catrine Tudor-Locke Melicia C.Whitt-Glover David R. Jacobs Jr. Kansas Center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of exercise and Health Shanghai University of SportShanghai 200438China exercise Science Department Syracuse UniversitySyracuseNY 13244USA Clinical Sciences Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of exercise and Sport Science Oregon State UniversityCorvallisOR 97331USA College of Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA Gramercy Research Group KnightdaleNC 27545USA Division of epidemiology and Community Health School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Background:The Compendium of Physical Activities was published in 1993 to improve the comparability of energy expenditure values assigned to self-reported physical activity(PA)across *** original version was updated in 2000,and again in 2011,and has been widely used to support PA research,practice,and public health ***:This 2024 update was tailored for adults 19-59 years of age by removing data from those≥60 *** a systematic review and supplementary searches,we identified new activities and their associated measured metabolic equivalent(MeT)values(using indirect calorimetry)published since *** replaced estimated MeTs with measured values when ***:We screened 32,173 abstracts and 1507 full-text papers and extracted 2356 PA energy expenditure values from 701 *** added303 new PAs and adjusted 176 existing MeT values and descriptions to reflect the addition of new data and removal of MeTs for older *** added a Major Heading(video Games).The 2024 Adult Compendium includes 1114 PAs(912 with measured and 202 with estimated values)across 22 Major ***:This comprehensive update and refinement led to the creation of The 2024 Adult Compendium,which has utility across research,public health,education,and healthcare domains,as well as in the development of consumer health *** new website with the complete lists of PAs and supporting resources is available at https://***.

关键词： Adults energy expenditure exercise MeT Physical Activities

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Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3147-3149页

作者： Leonard e.van Dyck Frank Bremmer Katharina Dobs Department of Psychology Justus Liebig University GiessenGiessenGermany Max Planck Institute for Human Cognitive and Brain Sciences LeipzigGermany Center for Mind Brain and BehaviorUniversities of MarburgGiessenand DarmstadtMarburgGermany Department of Neurophysics Philipps-Universitat MarburgMarburgGermany

In a recent study published in Cell,Marin vargas and Bisi et al.1 present an innovative approach to unravel the computational principles underlying proprioceptive processing in non-human *** findings showcase the utility of task-driven modeling in advancing neuroscience and offer translational potential by providing seminal insights into the goals and mechanisms by which the brain encodes body position and movements.

关键词： networks neural principles

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Thermoluminescence characterization of natural and synthetic irradiated Ce-monazites

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Journal of Rare earths 2024年第4期42卷 643-650页

作者： v.Correcher C.Boronat J.Garcia-Guinea J.F.Benavente T.Rivera-Montalvo CIeMAT Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of synthetic and natural Ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic CePO_(4):Nd_(0.20),La_(0.25)).The main differences appreciated in these complex TL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthetic monazite relies only on Nd and La).The behavior of the dose response in the range of 1-8 Gy is similar for both samples;the TL intensity increases linearly as the dose increases without changes in the position of the maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,Ce3+?Ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODCs or NBOHCs).

关键词： Thermoluminescence Kineticparameters Phosphate Ce-monazite Defects Rare earths

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Ballistic performance of titanium-based layered composites made using blended elemental powder metallurgy and hot isostatic pressing

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Defence Technology（防务技术） 2024年第9期39卷 1-14页

作者： Pavlo Markovsky Jacek Janiszewski Dmytro Savvakin Oleksandr Stasyuk Bartosz Fikus victor Samarov vianey ellison Sergey v.Prikhodko G.v.Kurdyumov Institute for Metal Physics of N.A.S.of Ukraine 36Academician Vernadsky BoulevardUA-03142 KyivUkraine Jarosław Dabrowski Military University of Technology 2Gen.Sylwester Kaliski Str.00e908 Warsaw 46Poland Synertech Inc. 11711 Monarch Street Garden GroveLos AngelesCA 92841USA Department of Materials Science and engineering University of California Los AngelesLos AngelesCA 90095USA

Metal matrix composites tiles based on Ti-6Al-4v(Ti64)alloy,reinforced with 10,20,and 40(vol%)of either TiC or TiB particles were made using press-and-sinter blended elemental powder metallurgy(BePM)and then bonded together into 3-layer laminated plates using hot isostatic pressing(HIP).The laminates were ballistically tested and demonstrated superior *** microstructure and properties of the laminates were analyzed to determine the effect of the BePM and HIP processing on the ballistic properties of the layered *** effect of porosity in sintered composites on further diffusion bonding of the plates during HIP is analyzed to understand the bonding features at the interfaces between different adjacent layers in the *** ballistic performance of fabricated structures was explained by a significant reduction in the residual porosity of the BePM products by their additional processing using HIP,which provides an unprecedented increase in the hardness of the layered *** is argued that the combination of the used two technologies,BePM and HIP is principally complimentary for the materials in question with the abilities to solve the essential problems of each used individually.

关键词： Metal matrix composites Powder metallurgy Titanium hydride powder Master alloy Titanium carbide Titanium boride Hot isostatic pressing Ballistic tests

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New trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： efstathios T Pavlidis Ioannis N Galanis Theodoros e Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(CT),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase CT angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PeT)-CT or ^(18)F-FDG PeT-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(T1a)to extended resections and including extended cholecystectomy(T1b),with wide lymph node resection in every case or Iv-v segmentectomy(T2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(T3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointestinal malignancies

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Stereoscopic spatial graphical method of Mueller matrix:Global‑Polarization Stokes ellipsoid

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Frontiers of Optoelectronics 2024年第3期17卷 113-128页

作者： Xinxian Zhang Jiawei Song Jiahao Fan Nan Zeng Honghui He valery v.Tuchin Hui Ma Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China School of Teacher education Nanjing Normal UniversityNanjing 210097China Institute of Physics Saratov State UniversitySaratov 410012Russia Department of Physics Tsinghua UniversityBeijing 100084China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China

A Mueller matrix covers all the polarization information of the measured sample,however the combination of its 16 elements is sometimes not intuitive enough to describe and identify the key characteristics of polarization *** the Poincarésphere system,this study achieves a spatial representation of the Mueller matrix:the Global-Polarization Stokes ellipsoid(GPSe).With the help of Monte Carlo simulations combined with anisotropic tissue models,three basic characteristic parameters of GPSe are proposed and explained,where the v parameter represents polarization maintenance ability,and the e and D†parameters represent the degree of ***,based on GPSe system,a dynamic analysis of skeletal muscle dehydration process demonstrates the monitoring efect of GPSe from an application perspective,while confrming its robustness and accuracy.

关键词： Full polarization Mueller matrix Tissue characterization Optical measurement

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Liquid crystal immunosensors for the selective detection of escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO C.OLIveIRA MARIA S.SOAReS BÁRBARA v.GONÇALveS ANDReIA C.M.RODRIGUeS AMADeU M.v.M.SOAReS RITA G.SOBRAL NUNO F.SANTOS JAN NeDOMA PeDRO L.ALMeIDA CARLOS MARQUeS CICeCO-Aveiro Institute of Materials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CeSAM-Centre for environmental and Marine Studies and Department of Biology University of Aveiro3810-193 AveiroPortugal Department of Telecommunications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CeNIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRe ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious illnesses,and traditional methods to detect escherichia coli are still associated with long waiting times and high costs given the necessity to transport samples to specialized *** is a need to develop new technologies that allow cheap,fast,and direct monitoring at the site of ***,in this work,we developed optical immunosensors for the selective detection of ***,based on liquid crystal technology,whose molecules can align in different manners depending on the boundary conditions (such as substrates) as well as the environment that they *** glass substrate was functionalized with *** antibody using cysteamine as an intermediate,and a vertical alignment was imposed on the liquid crystal molecules by using DMOAP during *** presence of bacteria disrupts the alignment of the liquid crystal molecules,changing the intensity of light emerging between cross polarizers,measured using a polarized optical microscope and a *** was possible to detect *** in suspensions in the concentration range from 2.8 cells/mL to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contaminated water samples.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instruments.

关键词： crystal alignment analysis

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