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experimental measurements of gamma-photon production and estimation of electron/positron production on the PeTAL laser facility

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Matter and Radiation at extremes 2024年第5期9卷 32-47页

作者： f.Brun L.Ribotte G.Boutoux X.Davoine P.e.Masson-Laborde Y.Sentoku N.Iwata N.Blanchot D.Batani I.Lantuéjoul L.Lecherbourg B.Rosse C.Rousseaux B.Vauzour D.Raffestin e.D’Humières X.Ribeyre Centre Lasers Intenses et Applications UMR 5107Universitéde Bordeaux-CNRS-CEA33405 TalenceFrance CeA DAMCESTAF-33116 Le BarpFrance CeA DAMDIFF-91297 ArpajonFrance CeA LMCEUniversitéParis-Saclay91680 Bruyères-le-ChâtelFrance Institute of Laser engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan

This article reports the first measurements of high-energy photons produced with the high-intensity PeTawatt Aquitaine Laser(PeTAL)*** experiments were performed during the commissioning of the *** laser had an energy of about 400 J,an intensity of 8×10^(18)W cm^(−2),and a pulse duration of 660 fs(fWHM).It was shot at a 2 mm-thick solid tungsten *** high-energy photons were produced mainly from the bremsstrahlung process for relativistic electrons accelerated inside a plasma generated on the front side of the *** paper reports measurements of electrons,protons and *** electrons up to35 MeV with a few-MeV temperature were recorded by a spectrometer,called SeSAMe(SpectreÉlectronS Angulaire MoyenneÉnergie).K-and L-shells were clearly detected by a photon spectrometer called SPeCTIX(Spectromètre PetalàCristal en TransmIssion pour le rayonnnement X).High-energy photons were diagnosed by CRACC-X(Cassette de RAdiographie Centre Chambre-rayonnement X),a bremsstrahlung *** cannon analysis is strongly dependent on the hypothesis adopted for the spectral *** shapes can exhibit similar reproductions of the experimental *** eliminate dependence on the shape hypothesis and to facilitate analysis of the data,simulations of the interaction were *** model the mechanisms involved,a simulation chain including hydrodynamic,particle-in-cell,and Monte Carlo simulations was *** simulations model the preplasma generated at the front of the target by the PeTAL laser prepulse,the acceleration of electrons inside the plasma,the generation of MeV-range photons from these electrons,and the response of the detector impacted by the energetic photon *** this work enabled reproduction of the experimental *** high-energy photons produced have a large emission angle and an exponential distribution *** addition to the analysis of the photon spectra,positron production was also ***,if high

关键词： process positron hypothesis

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Chromomagnetic dipole moments of light quarks in the bestest little Higgs model

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Chinese Physics C 2024年第10期48卷 125-136页

作者： T.Cisneros-Pérez e.Cruz-Albaro A.Y.Ojeda-Castañeda S.e.Solís-Núñez Unidad Académica de Ciencias Químicas Universidad Autónoma de ZacatecasApartado Postal C-58598060 ZacatecasMexico facultad de física Universidad Autónoma de ZacatecasApartado Postal C-58098060 ZacatecasMexico

In this study,we investigated the anomalous Chromomagnetic Dipole Moment(CMDM),denoted as μ_(q)^(BLHM),of light quarks q=(u,c,d,s,b) within the framework of the Bestest Little Higgs Model(BLHM)as an extension of the Standard Model(SM).Our investigation encompassed novel interactions among the light quarks,heavy quark B,and heavy bosons (W'^(±),H^(±),φ^(±),η^(±))incorporating the extended Cabibbo-Kobayashi-Maskawa(CKM)matrix characteristic of the *** thoroughly explored the permissible parameter space,yielding a spectrum of CMDM values ranging from 10^(-10) to 10^(-3).

关键词： beyond standard model flavor physics chromomagnetic dipole light quarks

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Burden of gallstone disease in the United States population:Prepandemic rates and trends

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1130-1148页

作者： Aynur Unalp-Arida Constance e Ruhl National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of HealthBethesdaMD 20892-5458United States Social&Scientific Systems Inc.DLH Holdings Corp CompanySilver SpringMD 20910United States

BACKGROUND Gallstone disease is one of the most common digestive disorders in the United States and leads to significant morbidity,mortality,and health care *** To expand on earlier findings and investigate prepandemic rates and trends in the gallstone disease burden in the United States using national survey and claims *** The National Ambulatory Medical Care Survey,National Inpatient Sample,Nationwide emergency Department Sample,Nationwide Ambulatory Surgery Sample,Vital Statistics of the United States,Optum Clinformatics®Data Mart,and Centers for Medicare and Medicaid Services Medicare 5%Sample and Medicaid files were used to estimate claims-based prevalence,medical care including cholecystectomy,and mortality with a primary or other gallstone *** were age-adjusted(for national databases)and shown per 100000 *** Gallstone disease prevalence(claims-based,2019)was 0.70%among commercial insurance enrollees,1.03%among Medicaid beneficiaries,and 2.09%among Medicare beneficiaries and rose over the previous ***,in the United States population,gallstone disease contributed to approximately 2.2 million ambulatory care visits,1.2 million emergency department visits,625000 hospital discharges,and 2000 deaths *** had higher medical care rates with a gallstone disease diagnosis,but mortality rates were higher among *** had higher ambulatory care visit and hospital discharge rates compared with Whites,but not mortality *** had lower ambulatory care visit and mortality rates,but similar hospital discharge rates compared with *** the study period,ambulatory care and emergency department visit rates with a gallstone disease diagnosis rose,while hospital discharge and mortality rates *** commercial insurance enrollees,rates were higher compared with national data for ambulatory care visits and hospitalizations,but lower for emergency department ***

关键词： Gallstone disease Burden Cholecystectomy Mortality Health care use Cholelithiasis Gallstones epidemiology

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Assembly structures of coastal woody species of eastern South America:Patterns and drivers

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Plant Diversity 2024年第5期46卷 611-620页

作者： eduardo Vinícius da Silva Oliveira Myrna friederichs Landim Sidney f.Gouveia Graduate Program in ecology and Conservation Federal University of SergipeSão CristovãoSergipeBrazil National Institute of Science and technology ecology Evolution and Conservation of Biodiversity(INCT-EECBio)GoiâniaGoiasBrazil Department of Biology Federal University of SergipeSão CristóvãoSergipeBrazil Department of ecology Federal University of SergipeSão CristóvãoSergipeBrazil

Tropical regions have provided new insights into how ecological communities are *** dry coastal communities,water stress has been hypothesized to determine plant assembly structure by favoring preadapted lineages from neighboring ecosystems,consistent with functional ***,it is unclear whether this hypothesis is sufficient to explain how coastal communities in tropical ecosystems are ***,we test whether water stress or other factors drive community assembly in woody plant communities across the coastal zone of Brazil,a tropical *** characterized functional and phylogenetic structures of these communities and determined the underlying environmental factors(e.g.,water stress,historical climate stability,edaphic constraints,and habitat heterogeneity)that drive their community *** of coastal woody species show geographically varied patterns,including stochastic arrangements,clustering,and overdispersion of species relative to their traits and phylogenetic *** complexity,water vapor pressure,and soil nutrient availability best explained the gradient in the functional *** deficit,water vapor pressure,and soil organic carbon were the best predictors of variation in phylogenetic *** results support the water-stress conservatism hypothesis on functional and phylogenetic structure,as well as the effect of habitat heterogeneity on functional structure and edaphic constraints on functional and phylogenetic *** effects are associated with increased phenotypic and phylogenetic divergence of woody plant assemblages,which is likely mediated by abiotic filtering and niche opportunities,suggesting a complex pattern of ecological assembly.

关键词： Brazil Completeness Clustering Restinga vegetation Water constraints

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Tracking the Ti^(4+)substitution in phlogopite by spectroscopic imaging:A tool for unravelling the growth of micas at HP-HT conditions

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Geoscience frontiers 2024年第3期15卷 1-13页

作者： G.Della Ventura N.el Moutaouakkil B.Boukili S.Bernardini A.Sodo L.Pronti M.Cestelli-Guidi f.Holtz f.Lucci Dipartimento di Scienze UniversitàRoma TreRomaItaly INfN-LNf via Fermi 200040 FrascatiRomaItaly IngV Via di Vigna Murata 60500143 RomaItaly Laboratory of Géosciences Water and Environment.Department of Earth Sciences.Faculty of SciencesUniversity Mohammed VRabatMorocco Leibnitz Universität Hannover Institute of MineralogyCallinstr 330167 HannoverGermany Dipartimento di Scienze della terra e Geoambientali Universitàdi Bari“Aldo Moro”BariItaly

Phlogopite solid-solutions have a wide pressure-temperature(P-T)stability field and are ubiquitous in a wide variety of geological settings,from deep lithosphere magmatic environments to upper crust metamorphic *** composition represents therefore a valuable physical-chemical archive and may provide important information regarding its crystallization and the petrogenesis of the *** this paper we examine the phlogopite phenocrysts from the well-known fort Regent mica-bearing lamprophyre minette from ***(Island of Jersey,UK).Phlogopite phenocrystals from lamprophyres generally show normal-step and continuous compositional zoning,however those from the fort Regent minette show a peculiar texture characterized by dark brown high-Ti(average TiO_(2)≈8.5 wt.%)cores enveloped by euhedral low-to mid-amplitude zonation due to oscillatory contents in Ti,fe and ***-barometry modelling based on biotite-only composition yields relatively high P-T estimates(T≈970±54℃at P≈0.73±0.13 GPa)for cores whereas lower values(T≈790±54℃at P≈0.29±0.13 GPa)are obtained for the outer *** temperatures(T≈1075±54℃)but extremely high and anomalous pressure values(P≈1.82±0.13 GPa)are obtained for the yellowish inner *** combination of electron micro probe(eMP)analysis and single-crystal infra-red(fTIR)imaging in the OH-stretching region shows that the exceptional and oscillatory Ti contents are due to the Ti-vacancy substitution,typical of crystallization and growth processes of HP/HT *** imaging provides additional insight for this process,confirming the dominant dioctahedral nature for the Ti-fe-rich cores and outer *** of thermobaric estimates obtained from the phlogopite compositiononly model,based on the fine-scale compositional evolution,shows that pressure-temperature values from low-Ti high-Mg domains should be carefully evaluated because the substitution mechanisms during the dark mica growth are not univocal

关键词： Ti-phlogopite Jersey minette(UK) Ti-substitution fTIR imaging Raman imaging Thermobarometric modelling

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Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3147-3149页

作者： Leonard e.van Dyck frank Bremmer Katharina Dobs Department of Psychology Justus Liebig University GiessenGiessenGermany Max Planck Institute for Human Cognitive and Brain Sciences LeipzigGermany Center for Mind Brain and BehaviorUniversities of MarburgGiessenand DarmstadtMarburgGermany Department of Neurophysics Philipps-Universitat MarburgMarburgGermany

In a recent study published in Cell,Marin Vargas and Bisi et al.1 present an innovative approach to unravel the computational principles underlying proprioceptive processing in non-human *** findings showcase the utility of task-driven modeling in advancing neuroscience and offer translational potential by providing seminal insights into the goals and mechanisms by which the brain encodes body position and movements.

关键词： networks neural principles

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WRKY11 up-regulated dirigent expression to enhance lignin/lignans accumulation in Lilium regale Wilson during response to fusarium wilt

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Journal of Integrative Agriculture 2024年第8期23卷 2703-2722页

作者： Jie Deng Zi’e Wang Wenyun Li Xiaohua Chen Diqiu Liu faculty of Life Science and technology Kunming University of Science and TechnologyKunming 650500China

Lilium are highly economically valuable ornamental plants that are susceptible to fusarium wilt caused by fusarium *** regale Wilson,a wild lily native to China,is highly resistant to *** this study,a WRKY transcription factor,WRKY11,was isolated from ***,and its function during the interaction between *** and *** was *** ectopic expression of LrWRKY11 in tobacco increased the resistance to f oxysporum,moreover,the transcriptome sequencing and UHPLC-MS/MS analysis indicated that the methyl salicylate and methyl jasmonate levels rose in LrWRKY11 transgenic tobacco,meanwhile,the expression of lignin/lignans biosynthesis-related genes including a dirigent(DiR)was *** lignin/lignans contents in LrWRKY11-transgenic tobacco also significantly increased compared with the wild-type *** addition,the resistance of *** scales in which LrWRKY11 expression was silenced by RNAi evidently decreased,and additionally,the expression of lignin/lignans biosynthesis-related genes including LrDIR1 was significantly ***,LrDIR1 and its promoter(PLrDIR1)sequence containing the W-box element were isolated from *** interaction assay indicated that LrWRKY11 specifically bound to the W-box element in PLrDIR1 and activated LrDIR1 ***,β-glucuronidase activity in the transgenic tobacco co-expressing LrWRKY11/PLrDIR1-β-glucuronidase was higher than that in transgenic tobacco expressing PLrDIR1-β-glucuronidase ***,the ectopic expression of LrDIR1 in tobacco enhanced the resistance to *** and increased the lignin/lignans *** brief,this study revealed that LrWRKY11 positively regulated *** resistance to *** through interaction with salicylic acid/jasmonic acid signaling pathways and modulating LrDIR1 expression to accumulate lignin/lignans.

关键词： Lilium regale fusarium oxysporum WRKY transcription factor dirigent

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BaTiO_(3)solid solutions co-doped with Gd^(3+)and eu^(3+):Synthesis,structural evolution and dielectric properties

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Journal of Rare earths 2024年第10期42卷 1920-1926页

作者： R.Martínez-López M.Pérez-Labra J.A.Romero-Serrano f.R.Barrientos-Hernández M.Reyes-Pérez M.I.Valenzuela-Carrillo G.Urbano-Reyes V.e.Reyes-Cruz G.I.Dávila-Pulido Academic Area of earth Sciences and Materials Autonomous University of Hidalgo StateRoad Pachuca-Tulancingo Km 4.5 Mineral de La Reforma.Hidalgo42184Mexico Metallurgy and Materials Department ESIQIE-IPNUPALMZacatencoCiudad de Mexico07738Mexico Autonomous University of Coahuila Boulevard Adolfo López Mateos S/nNueva RositaCoahuila26800Mexico

In this paper,the synthesis,structural evolution,and dielectric properties of BaTiO_(3)solid solutions codoped with rare earth elements(Gd^(3+)and eu^(3+))prepared using the solid-state reaction method are *** pure precursor powders of BaCl_3,TiO_(2),Gd_(2)O_(3),and eu_(2)O_(3)were mixed in stoichiometric proportions,ground in an agate mortar before being uniaxially pressed at 250 MPa and sintered at 1300℃in air atmosphere for 6 h to obtain Ba_(1-3x)Gd_(2x)Ti_(1-3x)eu_(4x)O_(3)(x=0,0.0015,0.01 and0.1).X-ray diffraction(XRD)and Rietveld's refinement results reveal the crystal phase ferroelectric tetragonal BaTiO_(3)for the samples with x=0,0.0015 and 0.01,as well as a consistent increment in the lattice parameters caused by the *** solubility limit of Gd^(3+)and eu^(3+)in the BaTiO_(3)structure is reached for the sample with x>0.01,and the orthorhombic eu_2TiO_(5)and monoclinic BaTi_(2)O_(5)secondary phases were *** Raman results show the characteristic peaks of ferroelectric tetragonal BaTiO_(3)around 716 cm^(-1)(LO of A1 symmetry),515 cm^(-1)(TO of A1 symmetry),and 305 cm^(-1)(B1).The maximum relative permittivity measured at 1 kHz was recorded to be 6151.8 for the sample with x=0.0015,and a decrease in the Curie temperature to 105℃with respect to the undoped sample was *** punctual microanalysis for the samples with x=0.0015,0.01,and 0.1 reveals grains composed of Ba,Ti,O,Gd,and eu homogeneously distributed in the BaTiO_(3)*** Ba/Ti ratios for samples with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for samples with x=0.0015 and 0.01 and a substitution at the Ba site for the sample with x=0.1.

关键词： BaTiO_(3) Doping Gadolinium europium Synthesis Rare earths

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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks María f Mascardi Adrián Gadano Sebastián Marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-Consejo Nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease Non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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New trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： efstathios T Pavlidis Ioannis N Galanis Theodoros e Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(CT),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase CT angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PeT)-CT or ^(18)f-fDG PeT-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(T1a)to extended resections and including extended cholecystectomy(T1b),with wide lymph node resection in every case or IV-V segmentectomy(T2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(T3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointestinal malignancies

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