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Animal models of hepatitis e infection: Advances and challenges

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze Xiang Xiang-Lin He Chuan-Wu Zhu Jia-Jia Yang Lan Huang Chun Jiang Jian Wu Chinese Consortium for the Study of Hepatitis e(CCSHe) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

Hepatitis e virus(HeV)is one of the leading causes of acute viral hepatitis *** most of HeV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and *** infection may become chronic in immunosuppressed *** addition,HeV infection can also cause several extrahepatic *** exists in a wide range of hosts in nature and can be transmitted across ***,animals susceptible to HeV can be used as *** establishment of animal models is of great significance for studying HeV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis *** review summarized the animal models of HeV,including pigs,monkeys,rabbits,mice,rats,and other *** each animal species,we provided a concise summary of the HeV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HeV *** advantages and disadvantages of these animal models were also *** review offers new perspectives to enhance the current understanding of the research landscape surrounding HeV animal models.

关键词： Hepatitis e virus Animal models Pathogenesis Prevention Treatment

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Jigsaw-Sketch: a fast and accurate algorithm for finding top-k elephant flows in high-speed networks

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Science China(Information Sciences) 2024年第4期67卷 113-130页

作者： Boyu ZHANG He HUANG Yu-e SUN Yang DU Dan WANG School of Computer Science and Technology Soochow University School of rail Transportation Soochow University

Finding top-k elephant flows in high-speed networks is one of the most fundamental network measurement tasks. It is more challenging than per-flow size estimation since the IDs and sizes of top-k flows must be tracked simultaneously. Most existing studies only record the IDs of a small number of elephant flows to fit their estimators in the extremely limited high-speed on-chip memory. However, these solutions need too many memory accesses when a packet arrives to track the elephant flows with high accuracy, which limits their practicability. Therefore, this paper proposes Jigsaw-Sketch, a new algorithm to find the top-k elephant flows with much fewer memory accesses while achieving high memory efficiency and accuracy. In this design, we propose a novel two-stage jigsaw storage scheme, which can capture the candidate top-k flows from massive network steams efficiently, and further find the top-k elephant flows with high memory efficiency and only a few memory accesses for each packet. extensive experimental results based on real network traces show that Jigsaw-Sketch improves the packet processing throughput by at least 86%, while achieving smaller memory footprints and higher accuracy compared to the SOTA.

关键词： sketch top-$k$ network measurement elephant flow high-speed networks

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2024 Wheelchair Compendium of Physical Activities:An update of activity codes and energy expenditure values

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Journal of Sport and Health Science 2024年第1期13卷 18-23页

作者： Scott A.Conger Stephen D.Herrmann erik A.Willis Tom e.Nightingale Joseph R.Sherman Barbara e.Ainsworth Department of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of exercise and Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an update of the 2011 Wheelchair Compendium of Physical Activities designed for wheelchair users and is referred to as the 2024 Wheelchair *** Wheelchair Compendium aims to curate existing knowledge of the energy expenditure for wheelchair physical activities(PAs).Methods:A systematic review of the published energy expenditure of PA for wheelchair users was completed between 2011 and May *** added these data to the 2011 Wheelchair Compendium data that was compiled previously in a systematic review through ***:A total of 47 studies were included,and 124 different wheelchair PA reported energy expenditure values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nordic sit skiing).Conclusion:In introducing the updated 2024 Wheelchair Compendium,we hope to bridge the resource gap and challenge the prevailing narratives that inadvertently exclude wheelchair users from physical fitness and health PAs.

关键词： Disability exercise MeT Mobility

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Mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-David M.Gothié Timothy e.Kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

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New insights into the role of the endoplasmic reticulum in microglia

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Neural Regeneration Research 2024年第7期19卷 1397-1398页

作者： Veronika e.Neubrand M.Rosario Sepúlveda Department of Cell Biology Faculty of SciencesUniversity of GranadaGranadaSpain

Microglial cells are the only resident immune cells in the central nervous system and constitute its frontline *** are extremely reactive against infections,trauma,or toxins,but are also responsible for mediating inflammation,taking part in the pathogenic course of many neuropathologies(Sierra et al.,2019).Cell-specific staining,ultrastructural analysis by transmission electron microscopy(TeM),or two-photonmicroscopy imaging have been relevant for the characterization of microglia as well as their cell-cell interactions。

关键词： inflammation reticulum

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Translating Difference:Reflections on the Interface between Novelistic Discourse and World Literature

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Journal of Foreign Languages and Cultures 2024年第1期8卷 16-30页

作者： e.V.raMAKRISHNAN Central University of Gujarat

The present essay examines two moments from the evolution of the modern Malayalam novel,in relation to the reception of two classics in world literature,namely Victor Hugo's Les Miserables translated into Malayalam between 1925 and 1927 and Garcia Marquez's One Hundred Years of Solitude translated in *** translation of Hugo's novel energized the scene of Malayalam fiction by infusing new modes of representation and widening the intellectual horizons of writers in general,and novelists in *** echoes of Les Miserables could be heard in Malayalam fiction well into the *** struggles against colonial and feudal authorities in Kerala,provided a fertile context for the imaginative interpretation of Hugo's humanist *** paper illustrates this point through close readings of critical essays,autobiographical narratives and debates on the nature of *** fascination of Malayali readers with Garcia Marquez has resulted in the translation of his entire corpus into *** realism as pioneered by Garcia Marquez liberated the Malayalam novelistic narrative from social realist and modernist *** colonial disruption of oral narratives,the consequent cultural amnesia and the struggle to reclaim one's forgotten past are themes that struck a chord in Malayalam writers of *** a detailed discussion of the novel,Moustache by ***,the interface between novelistic discourse and world literature is mapped in the latter part of the essay.

关键词： Malayalam literature translation difference world literature magic realism caste resistance

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enhanced quantum resources via two distant atom-cavity systems under the influence of atomic dissipation

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Communications in Theoretical Physics 2024年第2期76卷 62-73页

作者： M Setodeh Kheirabady M K Tavassoly M rafeie e Ghasemian Laser and Optics Group Faculty of PhysicsYazd UniversityYazd 89195-741Iran Department of electrical engineering Faculty of Intelligent Systems Engineering and Data SciencePersian Gulf UniversityBushehrIran

Quantum resources such as entanglement and coherence are the holy grail for modern quantum technologies. Although the unwanted environmental effects tackle quantum information processing tasks, suprisingly these key quantum resources may be protected and even enhanced by the implementation of some special hybrid open quantum systems. Here, we aim to show how a dissipative atom-cavity-system can be accomplished to generate enhanced quantum *** do so, we consider a couple of dissipative cavities, where each one contains two effective two-level atoms interacting with a single-mode cavity field. In practical applications, a classical laser field may be applied to drive each atomic subsystem. After driving the system, a Bell-state measurement is performed on the output of the system to quantify the entanglement and coherence. The obtained results reveal that the remote entanglement and coherence between the atoms existing inside the two distant cavities are not only enhanced, but can be stabilized, even under the action of dissipation. In contrast, the local entanglement between two atoms inside each dissipative cavity attenuates due to the presence of unwanted environmental ***, the local coherence may show the same behavior as the remote ***, the system provides the steady state entanglement in various interaction regimes,particularly in the strong atom-cavity coupling and with relatively large detuning. More interestingly, our numerical analyses demonstrate that the system may show a memory effect due to the fact that the death and revival of the entanglement take place during the interaction. Our proposed model may find potential applications for the implementation of long distance quantum networks. In particular, it facilitates the distribution of quantum resources between the nodes of large-scale quantum networks for secure communication.

关键词： remote entanglement and coherence atomic dissipation steady state entanglement Bell-statemeasurement

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Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings

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Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： Marcello Serra Nicola Simola Alexia e.Pollack Giulia Costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

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A novel method for modeling the phase change of iron ore particles in the cohesive zone of a blast furnace

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Particuology 2024年第3期86卷 252-261页

作者： Dianyu e Yingming Wen Jiayun Dan Youyuan Jiang Guangchao Wei Jiaxin Cui Jiangxi Provincial Key Laboratory for Simulation and Modelling of Particulate Systems Jiangxi University of Science and TechnologyNanchang330013China International Institute for Innovation Jiangxi University of Science and TechnologyNanchang330013China Ironmaking Plant Xiangtan Iron and Steel Corporation of Hunan HualingXiangtan411101China Schoolof Transportation and Vehicle enginering Shandong University of TechnologyZibo255000China

Cohesive zone plays a vital role in the stable operation of a blast furnace(BF),yet the complex phase change process of iron ore particles in this zone is still not well *** this study,a novel one-dimensional(1D)unsteady phase change model was developed to elucidate the heat transfer and melting mechanisms of iron ore *** model validation,the effects of several key operating parameters(e.g.,particle diameter,gas velocity,initial temperature)on the phase change behavior of iron ore particles were analyzed,and the joint effect of multiple parameters was *** results show that larger-sized iron ore particles possess lower specific surface areas,which in turn reduces their convective heat absorption ***,the distance from the solid-liquid phase interface to the particle surface increases,thereby slowing down the movement of the phase interface and pro-longing the melting duration of the *** the gas velocity and the initial temperature does not have a significant impact on reducing the duration of the complete melting *** the specified conditions,it is observed that increasing the gas velocity by 3-fold and 9-fold results in a reduction of the melting duration by 2.4%and 8.3%,*** the initial temperature of iron ore particles results in a decrease in the core-to-surface temperature difference,a slower heating rate,and a shorter duration to achieve *** the factors affecting the melting process,the particle diameter is found to be the most significant in terms of the liquid phase precipitation,mushy zone thickness,and core-to-surface temperature difference of iron ore particles.

关键词： Blast furnace Iron ore melting Cohesive zone Heat transfer Phase change

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Chromomagnetic dipole moments of light quarks in the bestest little Higgs model

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Chinese Physics C 2024年第10期48卷 125-136页

作者： T.Cisneros-Pérez e.Cruz-Albaro A.Y.Ojeda-Castañeda S.e.Solís-Núñez Unidad Académica de Ciencias Químicas Universidad Autónoma de ZacatecasApartado Postal C-58598060 ZacatecasMexico Facultad de Física Universidad Autónoma de ZacatecasApartado Postal C-58098060 ZacatecasMexico

In this study,we investigated the anomalous Chromomagnetic Dipole Moment(CMDM),denoted as μ_(q)^(BLHM),of light quarks q=(u,c,d,s,b) within the framework of the Bestest Little Higgs Model(BLHM)as an extension of the Standard Model(SM).Our investigation encompassed novel interactions among the light quarks,heavy quark B,and heavy bosons (W'^(±),H^(±),φ^(±),η^(±))incorporating the extended Cabibbo-Kobayashi-Maskawa(CKM)matrix characteristic of the *** thoroughly explored the permissible parameter space,yielding a spectrum of CMDM values ranging from 10^(-10) to 10^(-3).

关键词： beyond standard model flavor physics chromomagnetic dipole light quarks

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