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Spermatids do it differently! Paip2a--the essential regulator of spermiogenesis？

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Asian Journal of Andrology 2011年第1期13卷 122-124页

作者： e.le.n a mclaughlin Gary R Hime ARC Centre of excellence in Biotechnology and Development Callaghan NSW 2308 Australia School of environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Cell Biology University of Melbourne Parkville VIC 3010 Australia

The mechanisms underpinning the latter stages of spermiogenesis are poorly understood and male germ cells have been presumed to extensively employ post-tran- scriptional regulatory machinery,

关键词： Spermatids Paip2a-the essential

Opioid growth factor and the treatment of human pancreatic cancer:A review

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World Journal of Gastroenterology 2014年第9期20卷 2218-2223页

作者： Ian S Zagon Patricia J mclaughlin Department of neural and Behavioral Sciences Pennsylvania State University College of Medicine Hershey PA 17033 United States

Opioid growth factor (OGF), chemically termed [Met5]-enkephalin, and its receptor, OGF receptor (OGFr), form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia. Modulation of the OGF-OGFr pathway mediates the course of pancreatic cancer, with exogenous OGF or upregulation of OGFr repressing growth of human pancreatic cancer cells in culture and in nude mice. OGF therapy alone or in combination with standard chemotherapies such as gemcitabine and 5-fluorouracil results in enhanced inhibition of DnA synthesis and tumor growth. Molecular manipulation of OGFr confirms that the receptor is specific for OGF’s inhibitory action. Preclinical studies have warranted Phase I and Phase II clinical trials using OGF infusions as a treatment for patients with advanced, unresectable pancreatic cancers. OGF, an endogenous neuropeptide, is a safe, non-toxic, and effective biotherapy that utilizes the OGF-OGFr axis to mediate pancreatic tumor progression.

关键词： enkephalins DnA synthesis Pancreatic adenocarcinoma Opioids nude mice Receptor transfection

Advancements in assessing soil health through functional traits and energy flow analysis of soil

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Soil ecology letters 2024年第2期6卷 21-30页

作者： Jingnan Zhang Shiyu Li elly Morrien neil B.mclaughlin Shixiu Zhang School of Life Sciences Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and AgroecologyChineseAcademy of SciencesChangchun 130012China Key Laboratory of Mollisols Agroecology Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130012China Institute of Biodiversity and ecosystem Dynamics(IBeD-eLD) Department of Ecosystem and Landscape DynamicsUniversity of AmsterdamScience Park 9041098 XHA msterdamThe Netherlands Ottawa Research and Development Centre Agriculture and Agri-Food CanadaOttawa K1AoC6Canada University of Chinese Academy of Sciences Bejing 100049China

We examined the development of soil nematodes ecological indices from the perspective off *** found that soil nematode energy flow analyses based on multiple functional traits quantify the dynamics of energy flow across multipletrophic levels to provide a more comprehensive *** conducted comparative analyses of the sensitivities of nMF and energy flow to verify that the energy flow analyses are more sensitive and have greater potential to reveal soil health and ecosystem *** in-depth studies of functional traits and energy flow analysis can help us achieve informed soil management practices,sustainable agriculture,*** Tess CT nematode ecological index based on functional traits:MI el,S,BI,C1 nMF Bongen.1990 Ferrisetal,2001 Ferris,2010 energs low analysis of soil nematodes Compare thecological index(nMf)and Bacterivores(Ba)Functional traits energy flux Fungihores(Fn)rahn Soilnematodes latitude Lindicator Plant-parasites(PP)PF energflus Soilhealth Omnivores-predators(oP)latitude energy flow analysis of soil nematodes:By quantifying energy fux among trophic groups Barbes et al.,2014,2018 This paper examines the development of ecological indices for soil nematodes from the perspective of functional *** emphasizes the increasing significance of integrating multiple functional traits to achieve a more accurate assessment of soil *** indices based on life history strategies,feeding habits,and body size provide useful tools for assessing soil ***,these indices do not fully capture the dynamics ofenergyflow across multiple-trophic levels inthesoil foodweb,which is critical fora deeperunderstanding of the intrinsic properties of soil *** combining functional traits such as functional group,body size,feeding preference and metabolic rate,nematode energy flow analyses provide a more comprehensive *** approach establishes a direct correlation between changes

关键词： soil nematodes soil health nematodefoodweb functional traits energyflux

Progress on waveguide-based holographic video(Invited Paper)

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Chinese Optics letters 2016年第1期14卷 7-11页

作者： S. mclaughlin C. leach S. Gneiting V. M. Bove, Jr. S. Jolly D. e. Smalley 1electroholography Group Brigham Young University 459 Clyde Building Provo Utah 84602 USA MIT Media Laboratory Massachusetts Institute of Technology 77 Mass. Ave Cambridge Massachusetts 02139 USA

This paper presents progress on the characterization of guided-wave light modulators for use in a low-cost holographic video monitor based on the MIT scanned-aperture architecture. A custom-built characterization apparatus was used to study device bandwidth, RGB operation, and linearity in an effort to identify optimal parameters for high bandwidth, GPU-driven, full-color holographic display.

关键词： mode Progress on waveguide-based holographic video Invited Paper

Scent of a human:The mosquito olfactory system defies dogma to ensure attraction to humans

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四川生理科学杂志 2022年第8期44卷 1496-1496页

作者： Colleen n mclaughlin Howard Hughes Medical Institute Department of Biology Stanford University Stanford CA 94305 USA

Mosquitoes are strongly attracted to humans,and their bites not only cause intense itch but can beget severe *** this issue of Cell,Herre et *** that non-canonical olfactory circuit organization and coding likely endo... 详细信息

关键词： al. likely intense

Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases

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World Journal of Gastroenterology 2013年第1期19卷 115-121页

作者： Ana Paula Oppenheimer Christopher Koh Mary mclaughlin John C Williamson Thomas D norton Jennifer Laudadio Theo Heller David e Kleiner Kevin P High Caryn G Morse Section of Infectious Diseases Department of MedicineWake Forest School of MedicineWinston-SalemNC 27109-7205United States Liver Diseases Branch National Institute of DiabetesDigestive and Kidney DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Laboratory of Immunoregulation National Institute of Allergy and Infectious DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Division of Infectious Diseases and Immunology Department of MedicineNew York University School of MedicineNew YorkNY 10016United States Laboratory of Pathology Wake Forest School of MedicineWinston-SalemNC 27109-7205United States Laboratory of Pathology National Cancer InstituteNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Department of Critical Care Medicine National Institutes of Health Clinical CenterBethesdaMD 20892-1403United States

Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to *** in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not *** date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected *** report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated *** includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis *** HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral *** was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other *** HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes.

关键词： Human immunodeficiency virus Antiretroviral therapy Vanishing bile duct syndrome Ductopenia Liver biopsy

The Opioid Growth Factor Inhibits established Ovarian Cancer in nude Mice and Can Be Combined with Taxol or Cisplatin to enhance Growth Inhibition

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Journal of Cancer Therapy 2011年第2期2卷 110-124页

作者： Renee n. Donahue Ian S. Zagon Patricia J. mclaughlin Department of neural and Behavioral Sciences The Pennsylvania State University College of Medicine Hershey PA

Ovarian cancer is the 5th leading cause of cancer-related mortality in women. Seventy-five percent of ovarian cancer patients present in advanced stages, and receive cytoreductive surgery and adjuvant chemotherapy. However, within 2 years 65% of these patients relapse and thereafter only receive palliative care. novel therapies based on the biology of these cancers are urgently needed. The opioid growth factor (OGF)-OGF receptor (OGFr) axis is an endogenous opioid system known to inhibit proliferation of human ovarian cancer cells in tissue culture, but does not affect cell survival. The present study determined whether OGF in combination with standard of care chemotherapy, provides an inhibitory effect on the growth of human ovarian cancer cells in vitro. In addition, this investigation assessed whether OGF biotherapy, alone or in combination with taxol or cisplatin, inhibits tumor growth in mice with xenografts of ovarian cancer. The combination of OGF (10–6 M) with taxol (10–9 M or 10–10 M) or cisplatin (0.01 ug/ml or 0.001 ug/ml) markedly reduced cell number and DnA synthesis in vitro to a greater extent than individual compounds. OGF, but not taxol or cisplatin, altered growth in an opioid receptor mediated and reversible manner. Female nu/nu mice inoculated subcutaneously with SKOV-3 cells, and treated with OGF (10 mg/kg) for 5 weeks commencing at the time tumors became measurable, had tumor volumes and weight that were reduced by up to 50% from animals receiving saline. The combination of OGF with taxol (3 mg/kg, weekly) or cisplatin (4 mg/kg, weekly for 2 weeks) for 37 days reduced tumor volumes and weight in contrast to mice receiving individual agents alone. Moreover, OGF treatment in mice receiving cisplatin provided protection against the weight loss associated with cisplatin alone. All treatments suppressed DnA synthesis and angiogenesis, whereas exposure to taxol or cisplatin, but not OGF, induced apoptosis. Additive inhibitory effects on DnA synthesis

关键词： Cell Proliferation [Met5]-enkephalin Opioid Growth Factor OGFr Ovarian Cancer

Overexpression of OGFr Downregulates Ovarian Cancer Cell Proliferation <i>In Vitro</i>and Inhibits Tumorigenesis

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Journal of Cancer Therapy 2011年第4期2卷 579-594页

作者： Renee n. Donahue Patricia J. mclaughlin Ian S. Zagon 不详

The opioid growth factor (OGF) and its receptor (OGFr) regulate human ovarian cancer cell proliferation through a tonically active inhibitory axis. We investigated the effect of OGFr overexpression on ovarian tumorigenesis. Clonal cell lines of SKOV-3 human ovarian cancer were established to stably overexpress OGFr. shRnA constructs were evaluated for antitumor activity in vitro, as well as in vivo using mouse models of s.c. and i.p. tumor transplantation. The 5 clonal cell lines were characterized by increases in OGFr protein (62% to 245%) and binding capacity (51% - 154%), and decreases (36% - 185%) in cell number, relative to untransfected wild-type (WT) cells and empty vector (eV) transfected clones. nude mice receiving s.c. injection of 2 overexpressing OGFr cell lines (OGFr-3 and OGFr-22) had reduced tumor incidence, delayed tumor appearance (up to 12 days), and decreased tumor volume (up to 87%) relative to WT and eV controls. Mice injected i.p. with these clonal lines displayed reduced formation of tumor nodules (up to 95%), and depressed tumor weights (up to 99%) compared to WT and eV groups. DnA synthesis, but not cell survival, was depressed in cells and s.c. tumors overexpressing OGFr in comparison to the WT and eV groups. Angiogenesis was reduced up to 86% in clonal tumors compared to WT and eV groups. This preclinical evidence demonstrates that OGFr expression is a molecular determinant of ovarian cancer progression, and has important relevance to understanding the pathogenesis and treatment of this deadly disease.

关键词： Cell Proliferation Opioids [Met5]-enkephalin OGF OGFr Ovarian Cancer

利用稳定性^65Cu稀释技术测定长期施用有机肥土壤中不同pH条件下铜的e-值及L-值

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化学学报 2011年第4期69卷 459-465页

作者：陈世宝马义兵 enzo,Lombi Mike,J.mclaughlin 中国农科院农业资源与区划研究所农业部植物营养与养分循环重点实验室北京100081 中国科学院南京土壤研究所土壤与农业可持续发展国家重点实验室南京210008 Division of Land & Water CSIRO PMB 2 Glen Osmond 5064 Australia

准确评价铜的有效性对预测长期施用有机肥土壤中铜的生态风险及其环境质量标准的修订具有十分重要意义.根据稳定性65Cu稀释原理,利用黑麦草和蚯蚓为供试生物,对长期施用有机肥土壤中铜的同位素可交换性(e-值)、生物有效性(L-值)及pH变化... 详细信息

准确评价铜的有效性对预测长期施用有机肥土壤中铜的生态风险及其环境质量标准的修订具有十分重要意义.根据稳定性65Cu稀释原理,利用黑麦草和蚯蚓为供试生物,对长期施用有机肥土壤中铜的同位素可交换性(e-值)、生物有效性(L-值)及pH变化对e-值、L-值的影响进行了研究.试验结果表明,以黑麦草测定的铜的L-值与铜的e-值基本相等,二者间有很高的正相关关系(R2=0.98),不同pH处理土壤中铜的L-值占土壤全铜含量变化为15.9%～21.6%,土壤中铜的L-值、e-值随pH的上升而显著下降;而利用蚯蚓测定铜的L-值小于土壤中铜的e-值和蚯蚓肠溶物中铜的e-值;蚯蚓的活动明显增加了土壤中铜的迁移、转化特性,调节土壤pH状况可以有效控制土壤中铜的生物有效性从而降低其向食物链的迁移转化.

关键词： ^65Cu 同位素稀释技术 e-值 L-值生物有效性