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A MeMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

Microsystems & Nanoengineering 2019年第1期5卷 356-366页

作者： Jungpyo Lee Kyungmin ko Hyogeun Shin Soo-Jin Oh CJustin Lee Namsun Chou Nakwon Choi Min Tack Oh Byung Chul Lee Seong Chan Jun il-Joo Cho Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Mechanical engineering Yonsei UniversitySeoul 03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Convergence Research Center for Diagnosis Treatmentand Care System of DementiaKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Center for Glia-Neuron interaction Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KiST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and TechnologyUSTYuseong-guDaejeon 34113Republic of Korea

Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain *** there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound *** addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still *** determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular ***,we introduce a new MeMS ultrasound stimulation system for modulating neurons or brain slices with high spatial *** piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural *** designed the ultrasound transducer as an array structure to enable localized modulation in the target *** addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain *** this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied *** also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer.

关键词： neural stimulation system

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influence of night duty on endoscopic therapy for bile duct stones

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World Journal of Gastroenterology 2016年第42期22卷 9387-9393页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki konno Hiroyuki Asama ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine Department of endoscopy Fukushima Medical University Hospital

AiM To examine the influence of night duty(ND) on endoscopic therapy for biliary duct *** The subjects consisted of 133 patients who received initial endoscopic therapy for biliary duct stones performed by eight endoscopists after they had been on(ND group, n = 34 patients) or not [day duty(DD) group, n = 99 patients]. Patient characteristics(age, gender, history of abdominal surgery, transverse diameter of the largest stone, number of stones), years of experience of the endoscopists, endoscopic procedures [sphincterotomy, papillary balloon dilation(ePBD), papillary large balloon dilation(ePLBD)], and outcomes of initial endoscopy(procedure time; rate of stone removal by the first endoscopist; proceduresuccess rate by the first endoscopist: removal of stones or endoscopic retrograde biliary drainage; rate of final stone removal; final procedure success rate; complications; hospitalization after the procedure) were compared retrospectively between the two groups. History of abdominal surgery and treatment outcomes were also compared between the groups for each of the four endoscopists who performed most of the procedures in the ND *** There were no significant differences regarding the number of treatments performed by each endoscopist or the years of experience between the ND and DD groups. The frequency of endoscopic retrograde cholangiopancreatography procedures did not differ significantly between the groups. There were also no significant differences regarding patient characteristics: age, gender, history of abdominal surgery(ND 7: Billroth ii 4, R-Y 3; DD 18: double tract reconstruction 1, Billroth i 3, Billroth ii 6, R-Y 7, duodenoduodenostomy for annular pancreas 1), transverse diameter of largest stone, and number of stones between the two groups. Among the treatment procedures, the endoscopic s p h i n c t e r o t o m y a n d e P B D r a t e s d i d n o t d i f f e r significantly between the groups. However, ePLBD was performed more fr

关键词： Night duty endoscopic therap Bile duct stone Removal of stones Procedure time

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Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3834-3848页

作者： Thuy Giang Nguyen Cao Ji Hee Kang Su Jin Kang Quan Truong Hoang Han Chang Kang Won Jong Rhee Yu Shrike Zhang Young Tag ko Min Suk Shim Division of Bioengineering Incheon National UniversityIncheon 22012Republic of Korea College of Pharmacy Gachon UniversityIncheon 21936Republic of Korea Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciencesand BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future PharmacyCollege of Pharmacythe Catholic University of KoreaGyeonggi-do 14662Republic of Korea Research Center for Bio Materials&Process Development Incheon National UniversityIncheon 22012Republic of Korea Division of engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Glioblastoma(GBM)is the most aggressive malignant brain tumor and has a high mortality *** therapy(PDT)has emerged as a promising approach for the treatment of malignant brain ***,the use of PDT for the treatment of GBM has been limited by its low blood-brain barrier(BBB)permeability and lack of cancer-targeting ***,brain endothelial cell-derived extracellular vesicles(beVs)were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the *** enhance PDT efficacy,the photosensitizer chlorin e6(Ce6)was linked to mitochondria-targeting triphenylphosphonium(TPP)and entrapped into *** Ce6(TPP-Ce6)selectively accumulated in the mitochondria,which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light ***,the encapsulation of TPP-Ce6 into b eVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6,leading to significantly enhanced PDT efficacy in U87MG GBM *** in vivo biodistribution study using orthotopic GBM-xenografted mice showed that b eVs containing TPP-Ce6[b eV(TPP-Ce6)]substantially accumulated in brain tumors after BBB penetration via transferrin receptor-mediated *** such,b eV(TPP-Ce6)-mediated PDT considerably inhibited the growth of GBM without causing adverse systemic toxicity,suggesting that mitochondria are an effective target for photodynamic GBM therapy.

关键词： extracellular vesicle Chlorin e6 Triphenylphosphonium Mitochondria-targeting photosensitizer Photodynamic therapy Blood-brain barrier Glioblastoma Transferrin receptor

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evolving networks: from topology to dynamics

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控制理论与应用(英文版) 2004年第1期2卷 60-64页

作者： Zhengping FAN Guanrong CHeN King Tim ko Deparment of electronic engineering City University of Hong KongHong Kong SAgChina

A multi-local-world model is introduced to describe the evolving networks that have a localization property such as the internet. Based on this model, we show that the traffic load defined by 'betweenness centrality' on the multi-local-world scale-free networks' model also follows a power law form. in this kind of network, a few vertices have heavier loads and so play more important roles than the others in the network.

关键词： evolving network Multi-local-world model Betweenness centrality

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The HiV’s Transmission from the Mother to the Child at the Community Hospital Center of Bangui (Central African Republic)

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Open Journal of Obstetrics and Gynecology 2020年第6期10卷 802-808页

作者： N. R. Ngbale C. e. Gaunefet A. koïrokpi G. D. kossa-ko-Ouakoua S. Matoulou-Mbala-Wa-Ngogbe S. Ouapou A. Manirakiza L. kobangue A. Sepou Gynaecology-Obstetrics Service of the Bangui Community Hospital Bangui Central African Republic Department of Public Health of the University of Bangui Bangui Central African Republic Dermatology-Venerology Service of the CNHU of Bangui Bangui Central African Republic

Objective: Assess the impact of B + option on mother-to-child HiV’s transmission at the community university hospital center after 4 years of use. Patients and methods: This was a retrospective and analytical study f... 详细信息

Objective: Assess the impact of B + option on mother-to-child HIV’s transmission at the community university hospital center after 4 years of use. Patients and methods: This was a retrospective and analytical study from January 1st 2015 to December 31st 2018 i>i.e.i> 4 years. The population’s study was on HIV-positive mothers and their infants care in the service. Results:e="font-family:Verdana;">e="font-family:Verdana;">e="font-family:Verdana;

关键词： Transmission HiV Community Hospital

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模拟生活垃圾填埋反应器堆体底部抽气对污染气体排放的控制

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环境工程学报 2020年第11期14卷 3182-3191页

作者：杜越 ko Jae Hac 黄丹丹王前向静雅徐期勇北京大学深圳研究生院环境与能源学院深圳518055 济州国立大学海洋科学学院济州岛63243韩国

在填埋作业期间,生活垃圾填埋场由于缺少覆盖材料和集气系统,导致填埋气排放缺乏有效控制。为探究垃圾堆体抽气操作对填埋气的减排作用,搭建了3个模拟反应器,包括不抽气的对照组(C)、低抽气量组(e1)和高抽气量组(e2)。在为期171 d的实验... 详细信息

在填埋作业期间,生活垃圾填埋场由于缺少覆盖材料和集气系统,导致填埋气排放缺乏有效控制。为探究垃圾堆体抽气操作对填埋气的减排作用,搭建了3个模拟反应器,包括不抽气的对照组(C)、低抽气量组(e1)和高抽气量组(e2)。在为期171 d的实验中,垃圾分3层填埋,使用静态通量箱法,探究了3个反应器中二氧化碳、甲烷及含硫恶臭气体(甲硫醇、二硫化碳、甲硫醚、乙硫醚和二甲二硫醚)排放通量随反应器运行时间和垃圾堆体抽气操作强度的变化情况。结果表明:e2组比C组更早产生甲烷,但其抽气后减排率可达100%;而e1一直未检测到甲烷,可能是因为甲烷化过程并未建立,或是其中甲烷被覆土中的甲烷氧化菌氧化。此外,与自身抽气前相比,e1和e2对5种硫化物具有不同程度的减排效果,但e2的效果更好。上述研究结果可为填埋场的温室气体和含硫恶臭气体减排策略的制定提供参考。

关键词：生活垃圾填埋场抽气气体排放控制温室气体含硫气体

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A novel apolipoprotein e mutation (***150Cys)in a Chinese patient with lipoprotein glomerulopathy

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Chinese Medical Journal 2019年第2期132卷 237-239页

作者： Ming ko Cai Tao An-An Zhou Yuan Cheng Qi-Jun Wan Depatment of Nephrology the First Affiliated Hospital of Shenzhen UniversityShenzhenGuangdong 518035China Department of Nephrology Shenzhen Second People's HospitalClinical Medicine College of Anhui Medical UniversityShenzhenGuangdong 518035China Shenzhen Chi Biology Technology Co. UdShenzhenGuangdong 518000China

To the editor:Lipoprotein glomerulopathy (LPG) is an uncommon inherited renal disease characterized by lipoprotein thrombi in the markedly dilated capillary lumina of affected glomeruli, high plasma concentrations of apolipoprotein e (apoe), and proteinuria.[1] it mainly affects people of Japanese and Chinese origin, and approximately 117 cases have been reported to date.[2,3] Several genetic studies have demonstrated that APOe gene mutations may lead to the development of LPG;[4,5,6] however, conflicting published evidence has found that some patients with APOe variants were unaffected.[7] Thus, further studies are needed to examine the role of APOe mutations in the pathogenesis of *** study investigated a novel point mutation in the APOe gene in a family with one LPG patient and an asymptomatic carrier of the same APOe variant.

关键词： Lipoprotein glomerulopathy lipoprotein however

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Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： Young Jae Park Jaeho Shim Joo Song Lee Kyu Seung Lee Ji-Yeon Kim Kang Bok ko Sang-Youp Yim Seongjun Kim Hoon-Kyu Shin Donghee Park Yong Ju Yun Dong ick Son institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of energy and environment(KU-KiST Green School) Korea UniversitySeoul 02841Republic of Korea KiST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical ***,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm *** resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS *** also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative *** modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent ***,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum *** study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

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Plant ABC Transporters enable Many Unique Aspects of a Terrestrial Plant＇s Lifestyle

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Molecular Plant 2016年第3期9卷 338-355页

作者： Jae-Ung Hwang Won-Yong Song Daewoong Hong Donghwi ko Yasuyo Yamaoka Sunghoon Jang Sojeong Yim eunjung Lee Deepa Khare Kyungyoon Kim Michael Palmgren Hwan Su Yoon enrico Martinoia Youngsook Lee Department of Life Science Pohang University of Science and Technology (POSTECH) Pohang 37673 Korea Division of integrative Bioscience and Biotechnology POSTECH Pohang 37673 Korea Center for Membrane Pumps in Cells and Disease - PUMPKiN Danish National Research Foundation Department of Plant and Environmental Science University of Copenhagen 1871 Frederiksberg Denmark Department of Biological Sciences Sungkyunkwan University Suwon 16419 Korea Department of Plant and Microbial Biology University Zurich Zurich 8008 Zurich Switzerland

Terrestrial plants have two to four times more ATP-binding cassette （ABC） transporter genes than other organisms, including their ancestral microalgae. Recent studies found that plants harboring mutations in these transporters exhibit dramatic phenotypes, many of which are related to developmental processes and functions necessary for life on dry land. These results suggest that ABC transporters multiplied during evolution and assumed novel functions that allowed plants to adapt to terrestrial environmental conditions. examining the literature on plant ABC transporters from this viewpoint led us to propose that diverse ABC transporters enabled many unique and essential aspects of a terrestrial plant＇s lifestyle, by transporting various compounds across specific membranes of the plant.

关键词： abscisic acid transporter adaptation to dry (and ATP-binding cassette transporters evolution lifestyle of plants

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鲜花十字架

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作者： (俄罗斯)叶莲娜·科利亚金娜(eлeна koлядинa)

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