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Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium

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International Journal of Ophthalmology(english edition) 2024年第4期17卷 646-652页

作者： Xuan Liu Ming Liu Meng ji Bo Ma Yu-Cen Hou Xin-Yue Yao Qiao-Chu Cheng Li Chen Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an 710000Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(eMT)in retinal pigment epithelium(RPe).MeTHODS:Adult retinal pigment epithelial cell line(ARPe-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)*** cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell *** eMT-related indexes and BMP-6 protein levels were detected by Western ***,a BMP-6 overexpression plasmid was constructed and RPe cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression *** eMT-related indexes and extracellular regulated protein kinases(eRK)protein levels were ***:Compared with the control group,the migration of RPe cells in the TGF-β_(2) group was significantly ***-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of e-cadherin and BMP-6(Pe migration of RPe cells in the BMP-6 siRNA group was also significantly ***-6 siRNA increased the protein expression levels ofα-SMA,fibronectin and vimentin but significantly decreased the protein expression levels of e-cadherin(Perexpression of BMP-6 inhibited the migration of RPe cells induced by TGF-β_(2) and prevented TGF-β_(2) from affecting eMT-related biomarkers(Pevents the eMT in RPe cells induced by TGF-β_(2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.

关键词： bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration

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以高质量发展为导向的医院精细化绩效管理实践

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卫生经济研究 2024年第9期41卷 83-86页

作者：刘冀钟琼娥武汉市第四医院湖北武汉430033

当前,公立医院的绩效管理普遍存在体系建设不完善、分配模式落后、指标设置不科学、信息数据碎片化等问题。样本医院以高质量发展为导向,结合自身实际,制定了精细化绩效管理方案,包括调研与方案、沟通与考核、分析与反馈、优化与调整等... 详细信息

当前,公立医院的绩效管理普遍存在体系建设不完善、分配模式落后、指标设置不科学、信息数据碎片化等问题。样本医院以高质量发展为导向,结合自身实际,制定了精细化绩效管理方案,包括调研与方案、沟通与考核、分析与反馈、优化与调整等实现路径;新的绩效方案运行后,医院运营效率和医务人员满意度得以提升,绩效管理的真正价值得以体现。

关键词：高质量发展绩效管理运营效率

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Crowdsourcing intelligence for improving disaster forecasts

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The Innovation 2024年第4期5卷 13-14页

作者： Xiaohui Wang Fuhai Dao Yatai ji Sihang Qiu Xian Zhu We.jie Dong Huizan Wang Weimin Zhang Xiaolong Zheng College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China School of Atmospheric Science Sun Yat-sen UniversityZhuhai 519082China College of Systems engineering National University of Defense TechnologyChangsha 410073China The School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 101408China The State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

*** disasters,including floods,storms,and tsunamis,pose a great threat to human societies.A recent study highlighted this concern,revealing that billions of people globally were exposed to flood hazards.1 In 2023,Super Typhoon Doksuri caused devasting floods in Be.jing and Hebei areas,resulting in massive casualties and huge economic ***,there is a need for a precise understanding of disaster processes,reliable forecasting of disaster effects,and timely warning of risks to prevent and mitigate major disasters.2 Numerical modeling stands as the predominant approach to meet these ***,the predictive accuracy of such numerical models could be degraded because of various factors:oversimplification of real processes,computational errors,fluctuations of complex environments(e.g.,terrains,precipitations,buildings,and plants),and the influence of human activities(e.g.,evacuation and rescue)during disasters.

关键词： disaster floods storm

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Dual-species biofilms of escherichia coli and Pseudomonas promote temperature-dependent cross-contamination on meat surfaces

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Food Science and Human Wellness 2024年

作者： Yangyang Yuan Junke.ji Chen Zhang Yu Cheng Wenzheng Liu Yun jiang School of Food Science and Pharmaceutical engineering， Nanjing Normal University

Temperature and contact surfaces are critical factors influencing biofilm formation of microbial communities derived from both lab and natural environments. However， there is limited understanding regarding how different temperatures impact transfer dynamics of individual microbial species between meat surfaces in dual-species biofilms. In this study， we evaluated the biofilm-forming capabilities of various meat-derived escherichia coli and Pseudomonas strains on pork surfaces at 15 ℃ and 25 ℃. The results revealed that lower temperature had a significantly negative effect on the growth fitness of e. coli compared to Pseudomonas. Two robust biofilm-forming strains， e. coli C-13 and P. fluorescens S1-23， were selected under both temperature conditions to further explore their interactions in dual-species biofilms on meat surfaces. Outcome showed that e. coli exhibited a competitive growth advantage at 25 ℃， while Pseudomonas displayed enhanced growth at 15 ℃， indicating temperature-dependent competition patterns. Additionally， three established mathematical models were utilized to simulate the transfer dynamics of the two strains within mono- and dual-species biofilms. As anticipated， the numbers of transferred cells progressively declined with increased imprinting reactions between the meat surfaces. Interestingly， the transfer rates of both strains markedly improved in dual-species versus mono-species biofilms at 15 ℃， highlighting the influential role of inter-species interactions on transfer dynamics of microbes that may cross-contaminate meats. Our findings advance current understanding of mono- and dual-species biofilm development on meat surfaces under different temperature conditions. They also offer scientific evidence to support strategies for controlling microbial cross-contamination during meat processing to ensure product safety.

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A novel low molecular weight compound polysaccharides from Chinese herbal medicines: purification， characterization and anti-tumor activities in vitro and in vivo

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Food Science and Human Wellness 2024年

作者： Xu Yang Dongli Cao Haiyu ji Huijing Xu Mengjie Xu Anjun Liu Key Laboratory of Food Nutrition and Safety， Ministry of education， School of Food Science and engineering， Tianjin University of Science and Technology National Center of Inspection and Testing for Processed Food Quality， Tianjin Institute for Food Safety Inspection Technology

A novel low molecular weight polysaccharide (LMW-CPS) was identified from a specific combination of Chinese herb ingredients. The monosaccharide composition of LMW-CPS was consisted of single arabinose， which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa. NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of →5)-α-L-Araf-(1→ with α-L-Araf-(1→ as the terminal residue. In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase. In vivo experiments showed that it protected immune organs such as the thymus and spleen， enhanced immune cell activities， stimulated cytokine release， augmented the abundance of CD8， CD3， CD4， and CD19 positive lymphocytes， and markedly impeded solid hepatocellular carcinoma progression in mice. H&e staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis. These findings indicated its promising potential for the treatment of hepatocellular carcinoma.

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Pectin methylesterase inhibitors GhPMeI53 and AtPMeI19 improve seed germination by modulating cell wall plasticity in cotton and Arabidopsis

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Journal of Integrative Agriculture 2024年第10期23卷 3487-3505页

作者： Yayue Pei Yakong Wang Zhenzhen Wei ji Liu Yonghui Li Shuya Ma Ye Wang Fuguang Li Jun Peng Zhi Wang Zhengzhou Research Base State Key Laboratory of Cotton Bio-breeding and Integrated UtilizationZhengzhou UniversityZhengzhou 450001China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China National Key Laboratory of Cotton Bio-breeding and Integrated Utilization/Institute of Cotton Research Chinese Academy ofAgricultural SciencesAnyang 455000China

The germination process of seeds is influenced by the interplay between two opposing factors,pectin methylesterase(PMe)and pectin methylesterase inhibitor(PMeI),which collectively regulate patterns of pectin *** the recognized importance of pectin methylesterification in seed germination,the specific mechanisms that govern this process remain *** this study,we demonstrated that the overexpression of GhPMeI53is associated with a decrease in PMe activity and an increase in pectin *** leads to seed cell wall softening,which positively regulates cotton seed ***19,the homologue in Arabidopsis thaliana,plays a similar role in seed germination to GhPMeI53,indicating a conserved function and mechanism of PMeI in seed germination *** studies revealed that GhPMeI53 and AtPMeI19 directly contribute to promoting radicle protrusion and seed germination by inducing cell wall softening and reducing mechanical ***,the pathways of abscicic acid(ABA)and gibberellin(GA)in the transgenic materials showed significant changes,suggesting that GhPMeI53/AtPMeI19-mediated pectin methylesterification serves as a regulatory signal for the related phytohormones involved in seed *** summary,GhPMeI53 and its homologs alter the mechanical properties of cell walls,which influence the mechanical resistance of the endosperm or ***,they impact cellular phytohormone pathways(e.g.,ABA and GA)to regulate seed *** findings enhance our understanding of pectin methylesterification in cellular morphological dynamics and signaling transduction,and contribute to a more comprehensive understanding of the PMe/PMeI gene superfamily in plants.

关键词： cotton seed germination cell wall pectin demethylesterification PMeI ABA

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Multimodal Omics Approaches to Aging and Age‑Related Diseases

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Phenomics 2024年第1期4卷 56-71页

作者： Qianzhao ji Xiaoyu jiang Minxian Wang Zijuan Xin Weiqi Zhang jing Qu Guang‑Hui Liu State Key Laboratory of Membrane Biology Instituteof ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and ReproductiveBiology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academyof Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academyof SciencesBeijing 100101China Be.jing Institute for Stem Cell and Regenerative Medicine Beijing 100101China School of Future Technology University of ChineseAcademy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for GeriatricDisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Centerfor Aging and CancerXuanwu HospitalCapital MedicalUniversityBeijing 100053China

Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated *** increasing body of experimental evidence shows that aging is a complex biological process coordinately regulated by multiple factors at diferent molecular ***,it is difcult to delineate the overall systematic aging changes based on single-layer ***,multimodal omics approaches,in which data are acquired and analyzed using complementary omics technologies,such as genomics,transcriptomics,and epigenomics,are needed for gaining insights into the precise molecular regulatory mechanisms that trigger *** recent years,multimodal omics sequencing technologies that can reveal complex regulatory networks and specifc phenotypic changes have been developed and widely applied to decode aging and age-related *** review summarizes the classifcation and progress of multimodal omics approaches,as well as the rapidly growing number of articles reporting on their application in the feld of aging research,and outlines new developments in the clinical treatment of age-related diseases based on omics technologies.

关键词： Multimodal omics approaches Aging Genome epigenome

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Oxidation behavior of Ni-based superalloy GH4738 under tensile stress

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Rare Metals 2024年第8期43卷 3913-3920页

作者： ji-Chong Hu Hai-Liang Huang Chong-Chong Wu Xiao-Yu Sun jie Wang Yan-Hong Yang jing-Long Qu Liang jiang jin-He Dou Yang Chen Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China Department of Management and engineering Linkoping University58183LinkopingSweden Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Gaona Aero Material Co. LtdBeijing 100081China College of Artificial Intelligence and Big Data Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117China

Revealing the oxidation behavior of superalloys is crucial for optimizing material properties and extending service *** study investigated the oxidation behavior of superalloy GH4738 under stress states at 850℃.High-throughput specimens were fabricated to withstand different stresses at the same *** oxidation s amples were analyzed using the mass gain method to obtain oxidation kinetic *** results show that the external stress below 200 MPa could improve the oxidation resistance of the *** tensile stress increasing,the oxide layer becomes thinner,denser and more complete,while internal oxidation *** tensile stress alters the structure of the external oxide layer from a two-layer to a threelayer *** Cr_(2)O_(3) oxide layer inhibits the outward diffusion of Ti,leading to Ti enrichment at the oxide-matrix interface and altering the oxidation mechanism of GH4738.

关键词： Ni-based Superalloy Oxidation behavior Tensile stress Oxide layer

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Bazi Bushen alleviates reproductive aging in aged male mice

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Chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing ZHANG Shaolan ZHANG Yaping jiANG Yuning ji Chuanyuan NIU Kunxu LI Hongrong HOU Yunlong WeI Cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional Chinese Medicine·College of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional Chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse *** study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural ***,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive *** was achieved by assessing sex hormone production,testicular histomorphology,and *** to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged ***,spermatogenesis was *** analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory *** these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular *** contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid ***,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional Chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

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青藏高原高寒植物对生长季偶发性霜冻事件表现出深度过冷却现象

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Journal of Plant ecology 2024年第3期17卷 84-94页

作者： ji Suonan Wangwang Lü Aimée TClassen Wenying Wang Ben La Xuwei Lu Cuo Songzha Chenghao Chen Qi Miao Fanghui Sun Lhamo Tsering Shiping Wang College of Life Sciences Qinghai Normal UniversityXining 810016China Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province Xining 810016China State Key Laboratory of Tibetan Plateau earth System Resources and EnvironmentInstitute of Tibetan Plateau ResearchBeijing 100101China Department of ecology and evolutionary Biology University of MichiganMI 48109USA

气候变暖促进了植物的春季物候,打破了气候与植物生长之间原有的平衡。随着极端气候事件出现更加频繁,气候与植物生长之间的不匹配性会影响植物的生存、生长和繁殖。为了防止生长季节在细胞内结冰,植物会采用过冷却策略。然而,气候事件... 详细信息

气候变暖促进了植物的春季物候,打破了气候与植物生长之间原有的平衡。随着极端气候事件出现更加频繁,气候与植物生长之间的不匹配性会影响植物的生存、生长和繁殖。为了防止生长季节在细胞内结冰,植物会采用过冷却策略。然而,气候事件的严重程度和物候期可能会影响植物在霜冻事件后的恢复。本研究通过实验探究了4种不同严重程度的极端霜冻事件如何影响青藏高原上两种优势物种钉柱委陵菜(Potentilla saundersiana,仲夏开花)和小龙胆(Gentiana parvula,夏末开花)的过冷却点和枯黄期。探讨了物候期如何影响钉柱委陵菜对霜冻事件的反应。结果发现,两个物种在遭受霜冻损害时都表现出过冷现象。钉柱委陵菜的平均过冷却点为−6.9℃,并受最低温度、持续时间和物候期的影响,而小龙胆的平均过冷却点为−4.8℃,最低温度和持续时间对其过冷却点影响不显著。此外,两个物种在最低温度(−10℃)处理持续4小时后均快速枯黄。本研究首次探索并定量了青藏高原高寒植物的过冷却点。鉴于高寒植物遭遇霜冻事件的概率不断增加,上述结果对了解高寒植物的生长和生存如何应对极端气候的不利影响具有重要意义。

关键词：气候变化极端霜冻事件过冷却现象物候期枯黄

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