检索结果-南通市图书馆

Pancreatic ductal adenocarcinoma screening:New perspectives

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第36期18卷 4973-4977页

作者： Raffaele Pezzilli Dario fabbri Andrea Imbrogno Department of Digestive Diseases and Internal Medicine Sant'OrsolaMalpighi Hospital40138 BolognaItaly

Pancreatic ductal adenocarcinoma accounts for more than 90% of all pancreatic cancers and its incidence has increased significantly *** with pancreatic ductal adenocarcinoma have a poor outcome and more than 95% of the people affected die from the disease within 12 mo after *** is the first-line treatment in the case of resectable neoplasm,but only 20% of patients are candidates for this *** of the reasons there are few candidates for surgery is that,during the early phases of the disease,the symptoms are poor or *** diagnosis is of crucial importance to improve patient outcome;therefore,we are looking for a good screening *** screening test must identify the disease in an early stage in order to be effective;having said this,a need exists to introduce the concept of "early" ductal *** has been reported that at least five additional years after the occurrence of the initiating mutation are required for the acquisition of metastatic ability of pancreatic adenocarcinoma and patients die an average of two years *** have reviewed the most recent literature in order to evaluate the present and future perspectives of screening programs of this deadly disease.

关键词： Pancreatic neoplasms Study population Prevention Therapeutics

MicroRNAs and drug modulation in cancer:an intertwined new story

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Biology 2011年第5期6卷 351-356页

作者： Francesca FANINI Ivan VANNINI Muller fabbri Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola47014Italy Department of Molecular Virology Immunologyand Medical Genetics and Comprehensive Cancer CenterOhio State UniversityColumbusOH 43210USA

MicroRNAs(miRNAs)are endogenous small non-coding RNAs(ncRNAs)which play important regulatory roles in physiological processes such as cellular differentiation,proliferation,development,apoptosis and stem cell *** increasing number of papers have clearly claimed their involvement in cancer,providing,in some cases,also the molecular mechanisms *** studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer *** particular,miRNAs can be effectively used to overcome drug resistance,one of the main factors responsible for anticancer treatment *** of the main questions remains how to modulate the expression of miRNAs in cancer ***,a few studies have shown that the expression of miRNAs is affected by drugs(including some drugs currently used as anticancer agents),therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and,in turn,can affect drug sensitivity of cancer cells.

关键词： miRNAs cancer multidrug resistance transcription factor chemotherapy

Vascular injury during laparoscopic cholecystectomy:An oftenoverlooked complication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2023年第3期15卷 338-345页

作者： Antonio Pesce Nicolò fabbri Carlo Vittorio Feo Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraLagosanto 44023FerraraItaly

Laparoscopic cholecystectomy is one of the most frequently performed procedures in gastrointestinal surgery *** complications due to vascular injuries represent an important cause of morbidity and mortality,especially when facing major bleeding during laparoscopy,where bleeding control can be technically challenging in inexperienced ***,the reported incidence rate of conversion to open surgery due to vascular lesions is approximately 0%-1.9%,with a mortality rate of approximately 0.02%.The primary aim of this article was to perform an up-to-date overview regarding the incidence and surgical management of vascular injuries during laparoscopic cholecystectomy according to the available scientific evidence.

关键词： Laparoscopic cholecystectomy Vascular injury Vascular anomalies Surgical management Specialized hepatobiliary centers

Parallel pathways:A chronicle of evolution in rectal and breast cancer surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1091-1096页

作者： Antonio Pesce Nicolòfabbri Diletta Iovino Carlo Vittorio Feo Unit of General Surgery University of FerraraAzienda USL of FerraraFerrara 44023LagosantoItaly

In this editorial,we have analyzed the historical evolution of rectal and breast cancer surgery,focusing on the progressive reduction of demolitive approaches and the increasing use of more conservative strategies,accompanied by a growing emphasis on perioperative treatments aimed at enhancing surgical *** of these changes have been made possible due to an increased awareness and understanding of oncological diseases and improved perioperative treatments.

关键词： Rectal cancer History Breast surgery Demolitive treatment Conservative surgery

Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第7期12卷 916-931页

作者： Marco Infante Martina Leoni Massimiliano Caprio Andrea fabbri UniCamillus Saint Camillus International University of Health SciencesRome 00131Italy Diabetes Research Institute Federation(DRIF) Division of Endocrinology and DiabetesCTO Alesini HospitalDepartment of Systems MedicineUniversity of Rome Tor VergataRome 00145Italy Network of Immunity in Infection Malignancy and Autoimmunity(NIIMA)Universal Scientific Education and Research Network(USERN)Rome 00145Italy Department of Human Sciences and Promotion of the Quality of Life San Raffaele Roma Open UniversityRome 00166Italy Laboratory of Cardiovascular endocrinology IRCCS San Raffaele PisanaRome 00166Italy

To date,metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy ***,metformin is the most widely used oral insulinsensitizing agent,being prescribed to more than 100 million people worldwide,including patients with prediabetes,insulin resistance,and polycystic ovary ***,over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 *** note,evidence suggests that long-term and high-dose metformin therapy impairs vitamin B12 *** B12(also referred to as cobalamin)is a water-soluble vitamin that is mainly obtained from animal-sourced *** the cellular level,vitamin B12 acts as a cofactor for enzymes that play a critical role in DNA synthesis and ***,vitamin B12 deficiency can lead to a number of clinical consequences that include hematologic abnormalities(e.g.,megaloblastic anemia and formation of hypersegmented neutrophils),progressive axonal demyelination and peripheral ***,no definite guidelines are currently available for vitamin B12 deficiency screening in patients on metformin therapy,and vitamin B12 deficiency remains frequently unrecognized in such ***,in this“field of vision”article we propose a list of criteria for a cost-effective vitamin B12 deficiency screening in metformin-treated patients,which could serve as a practical guide for identifying individuals at high risk for this ***,we discuss additional relevant topics related to this field,including:(1)The lack of consensus about the exact definition of vitamin B12 deficiency;(2)The definition of reliable biomarkers of vitamin B12 status;(3)Causes of vitamin B12 deficiency other than metformin therapy that should be identified promptly in metformin-treated pat

关键词： Metformin Vitamin B12 deficiency Metformin-induced cobalamin deficiency Diabetes Type 2 diabetes Prediabetes Screening criteria Neuropathy Anemia

Risk, Contract Management, and Financing of the Gotthard Base Tunnel in Switzerland

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

engineering 2019年第3期5卷 379-383页

作者： Davide fabbri Lombardi engineering Ltd. Minusio 6648 Switzerland

1. Introduction With the opening ceremony of the Gotthard Base Tunnel on 1 June 2016, a new world record was established: the commissioning of the longest railway tunnel in the world. Many challenges have been overcome and many technical innovations have been developed and considered in this project. As of 11 December 2016, the Gotthard Base Tunnel has been an integral part of the new timetable of the Swiss Federal Railways (SBB-CFF-FFS), and is in full operation. With a total length of 57 km and a cruising speed of 200 km·h^-1 for passenger trains, the Gotthard Base Tunnel reduces the journey time through the Alps by 40 min, significantly reducing the distance between the south and north of europe.

关键词： Risk Contract Management Financing Gotthard Base Tunnel Switzerland

Time-Resolved Oxidation State Changes Are Key to elucidating the Bifunctionality of Perovskite Catalysts for Oxygen evolution and Reduction

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

energy & environmental Materials 2024年第5期7卷 292-300页

作者： Casey e.Beall e.iliana fabbri Adam H.Clark Vivian Meier Nur Sena Yüzbasi Benjamin H.Sj∅lin Ivano e.Castelli Dino Aegerter Thomas Graule Thomas J.Schmidt Paul Scherrer Institute(PSI) 5232Villigen PSISwitzerland Institute for Physical Molecular Science ETH Zürich8093ZürichSwitzerland empa 8600DübendorfSwitzerland Department of energy Conversion and Storage Technical University of DenmarkDK-2800Kgs.LyngbyDenmark

In a unified regenerative fuel cell(URFC)or reversible fuel cell,the oxygen bifunctional catalyst must switch reversibly between the oxygen reduction reaction(ORR),fuel cell mode,and the oxygen evolution reaction(OeR),electrolyzer ***,it is often unclear what effect alternating between ORR and OeR has on the electrochemical behavior and physiochemical properties of the ***,operando X-ray absorption spectroscopy(XAS)is utilized to monitor the continuous and dynamic evolution of the Co,Mn,and Fe oxidation states of perovskite catalysts Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)(BSCF)and La_(0.4)Sr_(0.6)MnO_(3-δ)(LSM),while the potential is oscillated between reducing and oxidizing potentials with cyclic *** results reveal the importance of investigating bifunctional catalysts by alternating between fuel cell and electrolyzer operation and highlight the limitations and challenges of bifunctional *** is shown that the requirements for ORR and OeR performance are divergent and that the oxidative potentials of OeR are detrimental to ORR *** findings are used to give guidelines for future bifunctional catalyst ***,it is demonstrated how sunlight can be used to reactivate the ORR activity of LSM after rigorous cycling.

关键词： BSCF LSM OeR ORR XAS

Diet and nutrition against inflammatory bowel disease: Trick or treat(ment)?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of experimental Medicine 2022年第5期12卷 104-107页

作者： Salvatore Greco Beatrice Bonsi Nicolòfabbri Department of Translational Medicine University of FerraraFerrara 44100Italy Department of Internal Medicine Azienda UnitàSanitaria Locale Di FerraraOspedale del DeltaAzienda UnitàSanitaria Locale di FerraraFerrara 44100Italy Unit of General Surgery Azienda UnitàSanitaria Locale di FerraraOspedale del DeltaAzienda UnitàSanitaria Locale di FerraraFerrara 44100Italy

even if the relationships between nutrition and inflammatory bowel disease(IBD)remain underexplored,the current literature is providing,day by day,much more evidence on the effects of various diets in both prevention and treatment of such *** dietary habits,together with other environmental factors such as pollution,breastfeeding,smoke,and/or antibiotics,are among the theoretical pathogenetic causes of IBD,whose multifactorial aetiology has been already *** some of these risk factors are potentially reversible,some others cannot be avoided,and efficient treatments become necessary to prevent IBD spread or ***,the drugs currently available for treatment of such disease provide low-to-no effect against the symptoms,making the illnesses still strongly *** nutrition and specific diets will prove to effectively interrupt the course of IBD has still to be clarified and,in this sense,further research concerning the applications of such dietary interventions is still needed.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Diet Nutrition Treatment

Asthma and gastroesophageal reflux disease: effect of long-term pantoprazole therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第48期11卷 7657-7660页

作者： Calabrese Carlo fabbri Anna Areni Alessandra Scialpi Carlo Zahlane Desiree Di Febo Giulio Department of Internal Medicine and Gastroenterology

AIM： To define the prevalence of gastroesophageal reflux disease （GeRD） in mild persistent asthma and to value the effect of pantoprazole therapy on asthmatic ***： Seven of thirty-four asthmatic patients without GeRD served as the non-GeRD control group. Twenty-seven of thirty-four asthmatic patients had GeRD （7/27 also had erosive esophagitis, sixteen of them presented GeRD symptoms. An upper gastrointestinal endoscopy was performed in all the subjects to obtain five biopsy specimens from the lower 5 cm of the esophagus. Patients were considered to have GeRD when they had a dilation of intercellular space （DIS）〉0.74 μm at transmission electron microscopy. Patients with GeRD were treated with pantoprazole, 80 mg/day. Forced expiratory volume in one second （FeV1） was performed at entry and after 6 mo of treatment. Asthmatic symptoms were recorded. The required frequency of inhaling rapid acting β2-agonists was self-recorded in the patients＇ ***： Seven symptomatic patients presented erosive esophagitis. Among the 18 asymptomatic patients, 11 presented DIS, while all symptomatic patients showed ultrastructural esophageal damage. Seven asymptomatic patients did not present DIS. At entry the mean of FeV1 was 1.91 L in symptomatic GeRD patients and 1.88 L in asymptomatic GeRD patients. After the treatment, 25 patients had a complete recovery of DIS and reflux symptoms. Twenty-three patients presented a regression of asthmatic symptoms with normalization of FeV1. Four patients reported a significant improvement of symptoms and their FeV1 was over 80%.CONCLUSION： GeRD is a highly prevalent condition in asthma patients. Treatment with pantoprazole （80 mg/day） determines their improvement and complete regression.

关键词： Asthma Gastroesophageal reflux disease Pantoprazole NeRD eRD Dilated intercellular spaces TeN