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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Rice e3 Ligase-Like Protein OsPIAL1 Positively Regulated the Drought Stress Response but Negatively Regulated the Salt Stress Response

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Phyton-International journal of experimental Botany 2023年第7期92卷 2017-2034页

作者： Sang ik Song Department of Bioscience and Bioinformatics Myongji UniversityYongin17058Korea

Small ubiquitin-like modifier(SUMO)e3 ligases that facilitate the conjugation of SUMO proteins to target substrates contain an SP-RING domain which is like the RING domain found in ubiquitin e3 *** this study,we isolated and characterized the Oryza sativa protein inhibitor of activated STAT like1(OsPIAL1)containing SP-RING domains,as the rice homolog of Arabidopsis ***1 interacts with OsSUMO proteins but does not interact with rice SUMO-conjugating enzymes(OsSCes).An analysis of transgenic rice plant shows that OsPIAL1 is involved in SUMO conjugation to SCes but not in SUMO conjugation to *** addition,this OsPIAL1 activity requires drought stress *** profiles show that the OsPIAL1 gene is induced by only drought stress in the leaves,whereas it is repressed by ABA and abiotic stresses in the *** stress leads to the fastest decrease in OsPIAL1 transcripts in the ***,the stress experiments indicate that the transgenic rice plants overexpressing OsPIAL1 exhibit a drought stress-tolerant phenotype but a salt stress hypersensitive *** results and those from Arabidopsis pial mutants suggest that PIALs act as a positive regulator in the drought stress response but as a negative regulator in the salt stress response.

关键词： Drought stress high-salinity stress Oryza sativa OsPIAL1 SUMO

energy estimate for the Type-Ⅱ Superconducting Film

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Acta Mathematica Sinica,english Series 2008年第1期24卷 75-86页

作者： Kwang ik KIM Zu Han LIU Department of Mathematics Pohang University of Science and Technology Pohang 790-784 Republic of Korea Department of Mathematics Xuzhou Normal University Xuzhou 221116 P. R. China

We study the minimizers of the Ginzburg-Landau model for variable thickness, superconducting, thin films with high k, placed in an applied magnetic field hex, when hex is of the order of the ＂first critical field＂, i.e. of the order of ｜lnε｜. We obtain the asymptotic estimates of minimal energy and describe the possible locations of the vortices.

关键词： superconductivity Ginzburg-Landau functional free boundary problem

China Regional Income Convergence:Using Spatial Panel data

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清华大学学报（哲学社会科学版） 2009年第S1期24卷 73-80页

作者： Moon ik joon School of economics and Management Tsinghua University

This paper uses spatial panel data models to analyze regional growth in *** for fixed-effects allows us to disentangle the effect of spatial dependence from that of spatial heterogeneity and omitted variable to invest... 详细信息

关键词： Spatial panel data models Regional ConvergenceAbout the Author: Moon ik joon,School of economics and Management,Tsinghua University,Ph.D.Candidate,research direction: spatial econometrics

Development and experimental evaluation of Strip Shape Prediction Model for Sendzimir Rolling Mills

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journal of Iron and Steel Research International 2013年第12期20卷 25-32页

作者： SHIN jong-min HAN Seong-ik KIM jong-shik School of Mechanical engineering Pusan National University School of electrical engineering Pusan National University

It is difficult to obtain the desired strip shape using Sendzimir rolling mills because small diameter work rolls can be easily deformed by the roiling force. To control the strip shape effectively, it is important to understand the relationship between the behavior of the shape actuator and the variation of the strip shape. A numerical model based on the contact element method was proposed for the prediction of strip shape. In this numerical model, the re- lationships between the actuating forces, the roll deflections, the thickness profiles of the entry and exit sides, and the strip shape were considered. The proposed numerical model for strip shape prediction was evaluated by computer simulation and experiment with respect to various AS-U roll and first intermediate roll positions.

关键词： Sendzimir rollingmill double acting AS-U roll strip shape prediction model contact element method

Improvement of Shape Recognition Performance of Sendzimir Mill Control Systems Using echo State Neural Networks

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journal of Iron and Steel Research International 2014年第3期21卷 321-327页

作者： jung-hyun PARK Seong-ik HAN jong-shik KIM School of Mechanical engineering Pusan National University School of electrical engineering Pusan National University

High rigidity twenty-high Sendzimir mills （ZRMs） are widely used for rolling stainless steels, silicon sheets, etc. A ZRM uses a small diameter work roll to produce massive rolling forces. Since a work roll with a small diameter can be bent easily, strips often have complex shapes with mixed quarter and deep edge waves in the shape of plates. In order to solve this problem, fuzzy neural network controls are generally used for shape： recognition in ZRM control systems. Among various neural network types, the multi-layer perceptron （MLP） is typically used in current ZRMs. However, an MLP causes the loss of a large amount of shape recognition data. To improve the shape recognition per- formance of ZRM control systems, echo state networks （eSNs） are proposed to be used. Through simulation re- sults, it is found that shape recognition performance could be improved using the proposed eSN method.

关键词： Sendzimir mill neural network multi-layer perceptron echo state network shape recognition

Systematic study of(MoTa)_(x)NbTiZr medium-and high-entropy alloys for biomedical implants-In vivo biocompatibility examination

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journal of Materials Science & Technology 2021年第19期78卷 183-191页

作者： Muhammad Akmal Ahtesham Hussain Muhammad Afzal Young ik Lee Ho jin Ryu Department of Materials Science and engineering KAISTYuseongDaejeon 34141South Korea Lee's Biotech Co. Ltd.#415C-Dong13 Techno-4-roYuseong-guDaejeon34013South Korea Department of Mechanical engineering KAISTYuseongDaejeon34141South Korea Department of Nuclear and Quantum engineering KAISTYuseongDaejeon 34141South Korea

In this study,the application of medium-and high-entropy(Mo Ta)_(x)Nb Ti Zr alloys in biomedical implants was systematically *** alloy with the best combination of mechanical properties was selected and characterized for in vitro and in vivo response for the first time to examine its biomedical properties.A logarithmic increase in the hardness and the yield strength was observed as a function of the Mo and Ta *** with up to 0.4 mol fraction of Mo and Ta showed a plastic strain of more than 30%under *** nanoindentation results showed that the addition of Mo and Ta increased the elastic modulus of the system *** was surmised that the addition of Ta and Mo above a critical concentration(mole fraction=0.4)was unfavorable from a biomedical perspective as it increased the brittleness and elastic modulus and decreased the ductility of the ***,the(Mo Ta)_(0.2)Nb Ti Zr alloy is a potential structural material for biomedical implants because of its excellent strength and *** developed alloy was investigated for its corrosion properties and compared with commercial biomedical ***,the biocompatibility of the alloy was examined using an in vivo *** alloy was implanted in the skeletal muscles of mice for four weeks and the histology of the surrounding tissue was *** alloy exhibited strong passive behavior in a phosphate buffer solution and non-toxic soft tissue response.

关键词： High-entropy alloys Medium-entropy alloys Biomedical applications In vivo Biocompatibility

Hybrid silicon modulators

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Chinese Optics Letters 2009年第4期7卷 280-285页

作者： j.e.Bowers Department of electrical and Computer engineering University of California Santa Barbara

A number of active elements have been demonstrated using the hybrid silicon evanescent platform, including lasers, amplifiers, and detectors. In this letter, two types of hybrid silicon modulators, flflfilling the building blocks in optical communication on this platform, are presented. A hybrid silicon electroabsorp- tion modulator, suitable for high speed interconnects, with 10-dB extinction ratio at -5 V and 16-GHz modulation bandwidth is demonstrated. In addition, a hybrid silicon Mach-Zehnder modulator utilizing carrier depletion in multiple quantum wells is proved with 2 *** voltage-length product, 150-nm optical bandwidth, and a large signal modulation up to 10 Gb/s.

关键词： Bandwidth electroabsorption modulators Modulation Modulators Optical communication Quantum well lasers Semiconducting indium compounds Semiconductor quantum wells Silicon Silicon detectors

Approximate ballistics formulas for spherical pellets in free flight

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Defence Technology（防务技术） 2018年第1期14卷 1-11页

作者： e.j.Allen Department of Mathematics and Statistics Texas Tech University

The ballistics equations for spherical pellets in free flight are simplified through appropriate scaling of the pellet velocity and pellet distance. Two different drag coefficient curves are averaged to yield a single curve applicable to shot pellets and round balls. The resulting S-shaped drag coefficient curve is approximated by three straight-line segments. The scaled ballistics equations are then solved exactly and simple formulas are found for the velocity and flight time with respect to trajectory distance. The formulas are applicable to spherical shot pellets and round balls of any composition under any atmospheric conditions. The formulas are amenable to quick and easy computation and may also serve as an aid in understanding and comparing black-box ballistics calculators. For shotshell ballistics, an important assumption in the present investigation is that the pellets are moving as single, free spheres and not as a dense cloud or in a shot column, in particular, the pellets are not interacting during flight. Therefore, the formulas are most appropriate for single round balls, for large shot sizes, and for pellets of small shot size fired from open chokes. The formulas are clear and accessible, and can be implemented by military or law enforcement personnel as well as hunters and shooters. This work differs from previous investigations in that accurate ballistics formulas are derived for spherical projectiles of shotguns and muzzleloaders using realistic drag coefficients.

关键词： Ballistics Sphere Drag Shotgun Muzzleloader Nondimensionalization