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Genes & Diseases 2023年第3期10卷 864-876页

作者： Zicai Dong Chuan Yang Jiulin Tan ce Dou Yueqi Chen Department of Biome.ical Materials Science Army Medical UniversityChongqing 400038China Department of Orthopedics Southwest HospitalArmy Medical UniversityChongqing 400038China

The skeletal system is a dynamically balanced system, which undergoes continuous bone resorption and formation to maintain bone matrix homeostasis. As an important ADP-ribosylase and NAD+-dependent deacylase, SIRT6 (SIR2-like protein 6) is widely expressed on various kinds of bone cells, such as chondrocytes, osteoblasts, osteoclasts. The aberration of SIRT6 impairs gene expression (e.g., NF-κB and Wnt target genes) and cellular functions (e.g., DNA repair, glucose and lipid metabolism, telomeric maintenance), which disturbs the dynamic balance and ultimately leads to several bone-related diseases. In this review, we summarize the critical roles of SIRT6 in the onset and progression of bone-related diseases including osteoporosis, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration, as well as the relevant signaling pathways. In addition, we discuss the advances in the development of SIRT6 activators and elucidate their pharmacological profiles, which may provide novel treatment strategies for these skeletal diseases.

关键词： Intervertebral disc degeneration(IDD) Osteoarthritis(OA) Osteoporosis(OP) Rheumatoid arthritis(RA) SIRT6(SIR2-Like protein 6) SIRT6 activator

Temporal sequence Object-based CNN(TS-OCNN) for crop classification from fine resolution remote sensing image time-series

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The Crop Journal 2022年第5期10卷 1507-1516页

作者： Huapeng Li Yajun Tian ce Zhang Shuqing Zhang Peter MAtkinson Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130012JilinChina Lancaster environment centre Lancaster UniversityLancaster LA14YQUK Faculty of Science and Technology Lancaster UniversityLancaster LA14YRUK

Accurate crop distribution mapping is required for crop yield prediction and field management. Due to rapid progress in remote sensing technology, fine spatial resolution(FSR) remotely sensed imagery now offers great opportunities for mapping crop types in great detail. However, within-class variance.can hamper attempts to discriminate crop classes at fine resolutions. Multi-temporal FSR remotely sensed imagery provides a means of increasing crop classification from FSR imagery, although current methods do not exploit the available information fully. In this research, a novel Temporal Sequence Object-based Convolutional Neural Network(TS-OCNN) was proposed to classify agricultural crop type from FSR image time-series. An object-based CNN(OCNN) model was adopted in the TS-OCNN to classify images at the object level(i.e., segmented objects or crop parcels), thus, maintaining the precise boundary information of crop parcels. The combination of image time-series was first utilized as the input to the OCNN model to produce an ‘original’ or baseline classification. Then the single-date images were fed automatically into the deep learning model scene-by-scene in order of image acquisition date to increase successively the crop classification accuracy. By doing so, the joint information in the FSR multi-temporal observations and the unique individual information from the single-date images were exploited comprehensively for crop classification. The effectiveness of the proposed approach was investigated using multitemporal SAR and optical imagery, respectively, over two heterogeneous agricultural areas. The experimental results demonstrated that the newly proposed TS-OCNN approach consistently increased crop classification accuracy, and achieved the greatest accuracies(82.68% and 87.40%) in comparison with state-of-the-art benchmark methods, including the object-based CNN(OCNN)(81.63% and85.88%), object-based image analysis(OBIA)(78.21% and 84.83%), and standard pixel-wise

关键词： Convolutional neural network Multi-temporal imagery Object-based image analysis(OBIA) Crop classification Fine spatial resolution imagery

ResLNet:deep residual LSTM network with longer input for action recognition

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Frontiers of Computer Science 2022年第6期16卷 41-49页

作者： Tian WANG Jiakun LI Huai-Ning WU ce LI Hichem SNOUSSI Yang WU Institute of Artificial Intelligence Beihang UniversityBeijing100191China School of Automation Science and electrical engineering Beihang UniversityBeijing100191China College of electrical and Information engineering Lanzhou University of TechnologyLanzhou730050China Institute Charles Delaunay-LM2S FRe CNRS 2019 University of Technology of TroyesTroyes10010France Institute for Research Initiatives Nara Institute of Science and TechnologyNara630-0192Japan

Action recognition is an important research topic in video analysis that remains very *** recognition relies on learning a good representation of both spatial information(for appearance)and temporal information(for motion).These two kinds of information are highly correlated but have quite different properties,leading to unsatisfying results of both connecting independent models(e.g.,CNN-LSTM)and direct unbiased co-modeling(e.g.,3DCNN).Besides,a long-lasting tradition on this task with deep learning models is to just use 8 or 16 consecutive frames as input,making it hard to extract discriminative motion *** this work,we propose a novel network structure called ResLNet(Deep Residual LSTM network),which can take longer inputs(e.g.,of 64 frames)and have convolutions collaborate with LSTM more effectively under the residual structure to learn better spatial-temporal representations than ever without the cost of extra computations with the proposed embedded variable stride *** superiority of this proposal and its ablation study are shown on the three most popular benchmark datasets:Kinetics,HMDB51,and *** proposed network could be adopted for various features,such as RGB and optical *** to the limitation of the computation power of our experiment equipment and the real-time requirement,the proposed network is tested on the RGB only and shows great performance.

关键词： action recognition deep learning neural network

Degradation of Rhodamine B by MnFe-LDH/PMS/O_(3) three-phase catalytic system: performance, mechanism and ecotoxicity studies

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Frontiers of environmental Science & engineering 2024年第1期18卷 111-127页

作者： Ying Han Ying Yang Weibao Liu Yilong Hou ce Wang Jiangwei Shang Xiuwen Cheng Key Laboratory of Pollutant Chemistry and environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China Key Laboratory for environmental Pollution Prediction and Control of Gansu Province College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

This study developed a novel MnFe-LDH/PMS/O3 three-phase catalytic system to degrade the organic dye RhB, which was used to address the drawbacks of persulfate oxidation and ozonation techniques. The structure, ionic and elemental composition, specific surface area, and magnetic properties of the LDHs were investigated using a variety of physicoche.ical characterization tools. The results showed that MnFe-LDH had a large specific surface area, a rich crystalline phase composition, and a functional group structure. The RhB degradation rate of MnFe-LDH/PMS/O3 was 0.34 min−1, which was much higher than that of other comparative systems. RhB could be completely degraded in 10 min after optimization and had a significant effect on TOC removal. The system was found to be effective over a wide pH range. Common anions were largely unaffected and humic acid acted as an inhibitor. At the same time, the system had generally effective degradation performance for different dyes. Combined with quenching experiments and ePR, it was found that SO4•−, •OH, O_(2)•−, and 1O_(2) all participated in the reaction, and •OH contributed more. The degradation pathway of RhB was derived by LC-MS, and the T.e.S.T. evaluation found that the toxicity of the intermediate product was significantly reduced. Finally, the stability and availability of LDHs were verified using cycling experiments and metal ion leaching. This work provides a theore.ical basis and data support for the synergistic catalysis of PMS/O3 and the deep treatment of dye wastewater.

关键词： Rhodamine B Layered double hydroxides Peroxymonosulfate Ozonation

Music stimulus has a positive eff ect on survival and development of the larvae in swimming crab Portunus trituberculatus

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Journal of Oceanology and Limnology 2022年第3期40卷 1277-1285页

作者： Zhiming ReN Jiechi WANG Chunlin WANG Changkao MU Yangfang Ye ce SHI Key Laboratory of Applied Marine Biotechnology Ningbo UniversityChinese Ministry of EducationNingbo 315211China Collaborative Innovation center for Zhejiang Marine High-effi ciency and Healthy Aquaculture Ningbo 315211China

The sound stimulus has a signifi cant impact on marine ***,many studies have focused on the negative impacts of sound on marine *** positive impacts of sound on marine animals,especially on marine invertebrates,were rarely *** the present study,we evaluated the eff ects of music on the survival and development of an economically important marine invertebrate,swimming crab Portunus *** pieces of classical music and a control group,i.e.,eine Kleine Nachtmusik by Mozart(eK),Bach-Violin Concerto No.1(BV),Anonymous Romanza by Anonymous(AR),and environmental sound(eN)were *** sound pressure received were 163-dB root mean square(RMS)re 1μPa for eK,166-dB RMS re 1μPa for BV,165-dB RMS re 1μPa for AR,44-dB RMS re 1μPa for eN,*** larvae were subject to 3-h classical music transmission every day during the entire larval development *** result showed that BV and AR signifi cantly elevated the cumulative survival rate of the larva from 3.42%±1.77%(eN)to 10.65%±1.69%(BV)and 7.12%±1.37%(AR)respectively(Pect the cumulative development time of larvae from ZoeaⅠto ZoeaⅣ,it signifi cantly increased the molting rate of megalopa from 24.00%±11.78%(eN)to 44.00%±13.06%(AR)and 46.67%±10.50%(BV)(Pical exposure during critical growth intervals may contribute to the survival and development of larval *** an application point of view,music intervention is much economically *** observed music eff ects imply that music could further enhance growth,welfare,and production.

关键词： swimming crab Portunus trituberculatus sound classical music oxygen consumption

An efficient synthesis of novel benzo[b]pyrido[3',2':4,5]thieno[2,3-e][1,6]naphthy-ridine-8-ones

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Chinese Che.ical Letters 2015年第9期26卷 1109-1112页

作者： Dao-Lin Wang Yong-Yang Wang Xiao-ce Shi Jian Ma College of Chemistry and Che.ical engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bohai University

An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.

关键词： 4-Bromomethylquinoline-2-one 3-Cyanopyridine-2-thione Benzo[b]pyrido[3' 2':4 5 ]thieno[23-e][1 6] naphthyridine-8-one Thorpe-Ziegler reaction Pictet-Spengler reaction

Synthesis of novel benzo[b]pyrimido[4',5':5,4]thieno[2,3-e][1,6]naphthyridine-8-ones via Pictet–Spengler cyclization

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Chinese Che.ical Letters 2016年第2期27卷 261-264页

作者： Dao-Lin Wang Xiao-ce Shi Yong-Yang Wang Jian Ma College of Chemistry and Che.ical engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bohai University

An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thieno-2-yl）quinoline-2-ones, which could be obtained from Thorpe-Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine,with aromatic aldehydes in the presence of BF3·Oet2 gives pyrimidothieno[1,6]naphthyridines in good yields.

关键词： 4-Bromomethylquinoline-2-one 5-Cyano-6-thioxopyrimidine Pyrimido[4′,5′:5,4]thieno[2-3e]naphthyridine Thorpe-Ziegler reaction Pictet-Spengler reaction

Understanding and designing magnetoelectric heterostructures guided by computation:progresses,remaining questions,and perspectives

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npj Computational Materials 2017年第1期3卷 304-324页

作者： Jia-Mian Hu Chun-Gang Duan ce-Wen Nan Long-Qing Chen Department of Materials Science and engineering Pennsylvania State UniversityUniversity ParkPA 16802USA Key Laboratory of Polar Materials and Devices Ministry of EducationEast China Normal UniversityShanghaiChina School of Materials Science and engineering and State Key Lab of New Ceramics and Fine ProcessingTsinghua UniversityBeijing 100084China

Magnetoelectric composites and heterostructures integrate magnetic and dielectric materials to produce new functionalities,e.g.,magnetoelectric responses that are absent in each of the constituent materials but emerge through the coupling between magnetic order in the magnetic material and electric order in the dielectric *** magnetoelectric coupling in these composites and heterostructures is typically achieved through the exchange of magnetic,electric,or/and elastic energy across the interfaces between the different constituent materials,and the coupling effect is measured by the degree of conversion between magnetic and electric energy in the absence of an electric *** strength of magnetoelectric coupling can be tailored by choosing suited materials for each constituent and by geometrical and microstructural *** this article,we discuss recent progresses on the understanding of magnetoelectric coupling mechanisms and the design of magnetoelectric heterostructures guided by theory and *** outline a number of unsolved issues concerning magnetoelectric *** compile a relatively comprehensive experimental dataset on the magnetoelecric coupling coefficients in both bulk and thin-film magnetoelectric composites and offer a perspective on the data-driven computational design of magnetoelectric composites at the mesoscale microstructure level.

关键词： composites material coupling

A stereotaxic method and apparatus for the Gekko gecko

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Chinese Science Bulletin 2008年第7期53卷 1107-1112页

作者： WANG WenBo DAI ZhenDong TAN Hua GUO ce SUN JiuRong Institute of Bioinspired Structure and Surface engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China College of Life Sciences Peking University Beijing 100871 China

To study the modulation mechanism of the middle brain of the Gekko to the locomotion, we introduced a stereotaxic method first in literature and developed an apparatus suitable for Gekko gecko, the big-gest wall and ceiling climber in nature. We defined the bregma and nasal points as reference points, selected the bilateral infraorbital margin and top point of the maxillary tooth for locating and fixing, and set up the line passing through the bregma and paralleling to a line connecting the bilateral infraorbital margin as x axis. Then, we defined a horizontal plane in the stereotaxic instrument, passing through x axis and the certain point which is 4.8 mm exactly above the nasal point, as the XOY plane; the sagittal plane, i.e. the YOZ plane, is the plane which is perpendicular to x axis and passes through the bregma; the plane, i.e. the XOZ plane, which passes through x axis and is perpendicular to the horizontal plane is the coronal plane. We designed a set of head holder which includes three parts: bilateral infraorbital margin clamps, a gecko adaptor holding the rostral side of the upper jaw. The allocation and operation of the head holder is accurate and simple, and the device is low in cost and compatible with standard stereotaxic instrument.

关键词：立体器械爬山虎攀缘植物双向性

Development of Shallow Footing Anti-Ram Bollard System Through Modeling and Testing

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Transactions of Tianjin University 2006年第B9期12卷 46-50页

作者： CRAWFORD John e Karogozian & case 2550 N.Hollywood WaySuite 500BurbankCA 91505USA

In past terrorist attacks, vehicle borne improvised explosive devices (VBIeD) have been the primary manner of attacking buildings and infrastructures. Preventing unauthorized vehicles from approaching a protected area with anti-ram systems would maintain an established standoff distance against moving and stationary vehicles and consequently reduce blast and debris threats. This strategy has been considered the first line of defence against terrorists. Several types of anti-ram devices have been developed in accordance with U. S. Department of State K-rating criteria, for example, wedge barriers, rising beams, sliding/swing gates, and drop arms. However, these devices typically need a deep foundation for installation and can't be implemented into many locations where a depth of excavation is limited in order to protect utility lines of buildings and infrastructures. This paper presents a recent development of a series of shallow footing anti-ram bollard systems (SFABS) that can satisfy K-12 rating with only five-inch thick footing. A high-fidelity physics based finite element technique with a vehicle crash model is used for predicting anti-ram capacity and determining design parameters of the SFABS. Full-scale vehicle crash tests of the developed SFABS systems have been carried out to validate the design and analysis.

关键词： anti-ram bollard shallow footing crash testing finite element analysis