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Virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li Juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu Jiajia Liu Shikun Xu Lihua Guan Dong huang Qibing wang Juying Qian Zexin Zhao Yabin Wei Junbo Ge Xiao huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the hamilton Anxiety Rating Scale(hAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of hAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,ph follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

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Photothermal properties of Cu@polycarbonate composites with strong localized surface plasmon resonances

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Nano Research 2024年第9期17卷 8513-8520页

作者： Fengyi wang Jiangling he Junshan hu Zhihui Chen Yumeng Shi Qing-hua Xu SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore College of Materials Science and engineering Sichuan UniversityChengdu 610065China

Copper is relatively low cost and highly abundant compared with the well-studied noble metals such as gold and ***,the poor plasmonic and high susceptibility towards oxidation limit the study of its optical properties and applications as ***,copper nanoparticles@polycarbonate(Cu@PC)composites were prepared by using a facile one-step solvothermal *** Cu@PC composites have strong localized surface plasmon resonances(LSPR)due to that the PC shell can induce the particles to form many-particles system with different particle numbers,which not only lead to overlap and hybridize of the LSPR modes,but also shift the LSPR away from the interband transitions,and the PC layer also prevents the oxidation of Cu *** photothermal conversion efficiency of Cu@PC composites reaches 41.1%under 808 nm continuous wave(CW)laser irradiation which is higher than previously reported Cu nanomaterials that have been ***,the composites also have high photothermal ***,interfacial evaporator is prepared by assembling the Cu@PC composites on scouring sponge as light absorption layer which has>92.8%absorption in entire solar spectrum *** seawater evaporation rate is 3.177 kg·m^(-2)·h^(-1)with a e_(evaporator)/e_(water)of *** high evaporation rate interfacial evaporator with low cost,simple,and scalable approach shows great application value in the field of photothermal evaporation.

关键词： Cu nanoparticles localized surface plasmon resonances(LSPR) photothermal interfacial evaporation

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Two-dimensional C_(2)N-based single-atom catalyst with complex microenvironment for enhanced electrochemical nitrogen reduction:A descriptor-based design

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Journal of energy Chemistry 2024年第10期97卷 110-119,I0003页

作者： enduo Dai Wei An Ruixian Guo Xugen Shi Yunyi Li Yibo wang Mingming Liu College of Chemistry and Chemical engineering.Shanghai University of engineering Science Shanghai 201620China

The catalytic descriptor with operational feasibility is highly desired towards rational design of high-performance catalyst especially the electrode/electrolyte solution interface working under mild ***,we demonstrate that the descriptorΩparameterized by readily accessible intrinsic properties of metal center and coordination is highly operational and efficient in rational design of single-atom catalyst(SAC)for driving electrochemical nitrogen reduction(NRR).Using twodimensional metal(M)-B_(x)P_(y)S_(z)N_m@C_(2)N as prototype SAC models,we reveal that^(*)N_(2)+(h~++e~-)→^(*)N_(2)h acts predominantly as the potential-limiting step(PLS)of NRR on M-B_(2)P_(2)S_(2)@C_(2)N and M-B_(1)P_(1)S_(1)N_(3)@C_(2)N regardless of the distinction in coordination *** the 28 screened M active sites,withΩvalues close to the optimal 4,M-B_(2)P_(2)S_(2)@C_(2)N(M=V(Ω=3.53),Mo(Ω=5.12),and W(Ω=3.92))and M-B_(1)P_(1)S_(1)N_(3)@C_(2)N(M=V(Ω=3.00),Mo(Ω=4.34),and W(Ω=3.32))yield the lowered limiting potential(U_(L))as-0.45,-0.54.-0.36,-0.58,-0.25,and-0.24 V,respectively,thus making them the promising NRR *** importantly,these SACs are located around the top of volcano-shape plot of U_(L) versusΩ,re-validatingΩas an effective descriptor for accurately predicting the high-activity NRR SACs even with complex *** study unravels the relationship between active-site structure and NRR performance via the descriptorΩ,which can be applied to other important sustainable electrocatalytic reactions involving activation of small molecules viaσ-donation andπ^(*)-backdonation mechanism.

关键词： electrocatalysis N_(2) reduction Single-atom catalyst Descriptor DFT

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Phase-stable wide-bandgap perovskites enabled by suppressed ion migration

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Journal of energy Chemistry 2024年第9期96卷 120-128页

作者： Zhiyu Gao Yu Zhu Jingwei Zhu Cong Chen Zongjin Yi Yi Luo Yuliang Xu Kai Wu Tianshu Ma Fangfang Cao Zijun Chen Fang Yao Juncheng wang Wenwu wang Chuanxiao Xiao hao huang hongxiang Li Qianqian Lin Pei Cheng Changlei wang Xia hao Guanggen Zeng Dewei Zhao College of Materials Science and engineering&Institute of New energy and Low-Carbon Technology&engineering Research Center of Alternative energy Materials and Devices Ministry of EducationSichuan UniversityChengdu 610065SichuanChina School of Optoelectronic Science and engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of ChinaSoochow UniversitySuzhou 215006JiangsuChina Ningbo Institute of Materials Technology and engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina Ningbo New Materials Testing and evaluation Center Co.Ltd Ningbo 315201ZhejiangChina State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structure&School of Resources Environment and MaterialsGuangxi UniversityNanning 530004GuangxiChina Key Lab of Artificial Micro-and Nano-Structures of Ministry of education of China School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina College of Polymer Science and engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina

Wide-bandgap(>1.7 eV)perovskites suffer from severe light-induced phase segregation due to high bromine content,causing irreversible damage to devices ***,the strategies of suppressing photoinduced phase segregation and related mechanisms have not been fully ***,we report a new passivation agent 4-aminotetrahydrothiopyran hydrochloride(4-ATphCl)with multifunctional groups for the interface treatment of a 1.77-eV wide-bandgap perovskite film.4-ATph^(+)impeded halogen ion migration by anchoring on the perovskite surface,leading to the inhibition of phase segregation and thus the passivation of defects,which is ascribed to the interaction of 4-ATph^(+)with perovskite and the formation of low-dimensional ***,the champion device achieved an efficiency of 19.32%with an open-circuit voltage(V_(OC))of 1.314 V and a fill factor of 83.32%.Moreover,4-ATphCl modified device exhibited significant improved stability as compared with control *** target device maintained 80%of its initial efficiency after 519 h of maximum power output(MPP)tracking under 1 sun illumination,however,the control device showed a rapid decrease in efficiency after 267 ***,an efficiency of 27.38%of the champion 4-terminal all-perovskite tandem solar cell was achieved by mechanically stacking this wide-bandgap top subcell with a 1.25-eV low-bandgap perovskite bottom subcell.

关键词： Wide-bandgap perovskite Phase segregation lon migration Interface post-treatment All-perovskite tandems

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evaluation of the seismic behavior of reinforced concrete structures with flat slab-column gravity frame and shear walls through nonlinear analysis methods

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earthquake engineering and engineering Vibration 2024年第3期23卷 713-726页

作者： M.A.Najafgholipour S.heidarian Radbakhsh e.erfani Department of Civil and environmental engineering Shiraz University of TechnologyShiraz ***Iran Department of Building Civiland Environmental EngineeringConcordia UniversityMontréal H3G 1M8Canada

This paper presents an investigation of the seismic behavior of reinforced concrete(RC)structures in which shear walls are the main lateral load-resisting elements and the participation of flat slab floor systems is not considered in the seismic design *** this regard,the behavior of six prototype structures(with different heights and plan layouts)is investigated through nonlinear static and time history analyses,implemented in the OpenSees *** results of the analyses are presented in terms of the behavior of the slab-column connections and their mode of failure at different loading ***,the global response of the buildings is discussed in terms of some parameters,such as lateral overstrength due to the gravity flat slab-column *** to the nonlinear static analyses,in structures in which the slab-column connections were designed only for gravity loads,the slab-column connections exhibited a punching mode of failure even in the early stages of ***,the punching failure was eliminated in structures in which a minimum transverse reinforcement recommended in ACI 318(2019)was provided in the slabs at joint ***,despite neglecting the contribution of gravity flat slab-column frames in the lateral load resistance of the structures,a relatively significant overstrength was imposed on the structures by the gravity frames.

关键词： RC flat slab-column frames seismic behavior nonlinear analysis time history analysis

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In silico off-target profiling for enhanced drug safety assessment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2927-2941页

作者： Jin Liu Yike Gui Jingxin Rao Jingjing Sun Gang wang Qun Ren Ning Qu Buying Niu Zhiyi Chene Xia Sheng Yitian wang Mingyue Zheng Xutong Li College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Nanjing University of Chinese Medicine Nanjing 210023China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyHangzhou 330106China

ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent ***,the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is *** off-target interactions,along with the adverse drug reactions they induce,are significant factors affecting drug *** assess the liability of candidate drugs,we developed an artificial intelligence model for the precise prediction of compound off-target interactions,leveraging multi-task graph neural *** outcomes of off-target predictions can serve as representations for compounds,enabling the differentiation of drugs under various ATC codes and the classification of compound ***,the predicted off-target profiles are employed in adverse drug reaction(ADR)enrichment analysis,facilitating the inference of potential ADRs for a *** the withdrawn drug Pergolide as an example,we elucidate the mechanisms underlying ADRs at the target level,contributing to the exploration of the potential clinical relevance of newly predicted off-target ***,our work facilitates the early assessment of compound safety/toxicity based on off-target identification,deduces potential ADRs of drugs,and ultimately promotes the secure development of drugs.

关键词： Drug safety Off-target prediction Adverse drug reactions Toxicity Molecular representation Artificial intelligence

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Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-ChAT

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2716-2725页

作者： Tian hong Qinghua Luo haiyun Ma Xin wang Xinqiong Li Chongrong Shen Jie Pang Yan wang Yuejia Chen Changbin Zhang Zhaoming Su haohao Dong Xiaodi Tang Department of Laboratory Medicine State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina Frontiers Medical Center Tianfu Jincheng LaboratoryWest China HospitalSichuan UniversityChengduChina

CRISPR‒Cas7-11 is a Type Ⅲ-e CRISPR-associated nuclease that functions as a potent RNA editing ***-peptide repeat fused with Cas/heF1-associated signal transducer(TPR-ChAT)acts as a regulatory protein that interacts with CRISPR RNA(crRNA)-bound Cas7-11 to form a CRISPR-guided caspase complex(Craspase).however,the precise modulation of Cas7-11’s nuclease activity by TPR-ChAT to enhance its utility requires further ***,we report cryo-electron microscopy(cryo-eM)structures of Desulfonema ishimotonii(Di)Cas7-11-crRNA,complexed with or without the full length or the N-terminus of *** structures unveil the molecular features of the Craspase *** analysis,combined with in vitro nuclease assay and electrophoretic mobility shift assay,reveals that DiTPR-ChAT negatively regulates the activity of DiCas7-11 by preventing target RNA from binding through the N-terminal 65 amino acids of DiTPR-ChAT(DiTPR-ChAT_(NTD)).Our work demonstrates that DiTPRChAT_(NTD) can function as a small unit of DiCas7-11 regulator,potentially enabling safe applications to prevent overcutting and offtarget effects of the CRISPR‒Cas7-11 system.

关键词： CRISPR crRNA TPR

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A Compact Filtering Antenna System with Wide-Angle Scanning Capability for V2I Communication

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Chinese Journal of electronics 2024年第2期33卷 516-526页

作者： Chuang hAN Tong LI Zhaolin ZhANG Ling wang Guangwei YANG School of electronics and Information Northwestern Polytechnical University School of electronic engineering and Computer Science Queen Mary University of London

A compact filtering antenna system with wide-angle scanning is proposed for vehicle to infrastructure(V2I) communication which would handle complex communication scenarios. In this work, a wide beam filtering antenna is realized by using some inductive resistance structures such as metal pins and pillars, and capacitive structures such as slots, parasitical patches to produce the radiation nulls at two sides of the operating frequency band and improve the impedance matching in the passband. Meanwhile, the wide beam capability is also realized by the above structure. Furthermore, two h-and e-plane linear arrays are designed for the beam scanning capability with filtering characteristics based on the proposed antenna. To verify the proposed design concept, a prototype is fabricated and measured. The measurement and simulation agree well, demonstrating an excellent filtering characteristic with the operating frequency band from 3.18 to 3.45 Ghz(about 8.1%), the high total efficiency of about 88%, and 3-d B-beamwidth of more than 100° and 120° in the above two arrays, respectively. Additionally, the proposed arrays can realize the beam scanning up to the coverage of 112° and 120° with a lower gain reduction and a good filtering characteristic, respectively.

关键词： Antenna measurements Radio frequency Resistance Slot antennas Filtering Communication systems Vehicle-to-infrastructure

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Precisely Control Relationship between Sulfur Vacancy and h Absorption for Boosting hydrogen evolution Reaction

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Nano-Micro Letters 2024年第4期16卷 14-24页

作者： Jing Jin Xinyao wang Yang hu Zhuang Zhang hongbo Liu Jie Yin Pinxian Xi College of Chemistry and Chemical engineering Frontiers Science Center for Rare IsotopesState Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000People’s Republic of China

ef fective and robust catalyst is the core of water splitting to produce ***, we report an anionic etching method to tailor the sulfur vacancy(VS) of NiS_(2) to further enhance the electrocatalytic performance for hydrogen evolution reaction(heR). With the VS concentration change from 2.4% to 8.5%, the h* adsorption strength on S sites changed and NiS_(2)-VS 5.9% shows the most optimized h* adsorption for heR with an ultralow onset potential(68 m V) and has long-term stability for 100 h in 1 M KOh media. In situ attenuated-total-reflection Fourier transform infrared spectroscopy(ATR-FTIRS) measurements are usually used to monitor the adsorption of intermediates. The S-h* peak of the Ni S_(2)-VS 5.9% appears at a very low voltage, which is favorable for the heR in alkaline media. Density functional theory calculations also demonstrate the Ni S_(2)-VS 5.9% has the optimal |ΔG^(h*)| of 0.17 e V. This work offers a simple and promising pathway to enhance catalytic activity via precise vacancies strategy.

关键词： hydrogen evolution reaction S vacancies Nanosheet h Adsorption

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Geochemical Characteristics and hydrocarbon Generation Modeling of the Paleocene Source Rocks in the Jiaojiang Sag,east China Sea Basin

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Journal of earth Science 2024年第2期35卷 642-654页

作者： Chuang Lei Shiyan Yin Jiaren Ye Jingfu Wu Zhaosheng wang Bin Gao Collaborative Innovation Center of Green Development and ecological Restoration of Mineral Resources North China University of Science and TechnologyTangshan063210China Key Laboratory of Tectonics and Petroleum Resources China University of GeosciencesMinistry of EducationWuhan430074China CNOOC Research Institute Ltd Beijing100028China

Jiaojiang sag in the east China Sea Basin is at the earlier exploration stage,where characterizing hydrocarbon generation of source rocks is important to understand oil-gas exploration *** geochemical and basin modeling analysis,hydrocarbon generation capacity and process of the Paleocene e_(1)y,e_(1)l and e_(1)m formations were *** show that e_(1)y and e_(1)l mudstones are high-quality source rocks with Type Ⅱ kerogen,which is dominated by both aquatic organisms and terrestrial higher plants deposited in sub-reduced environment.e_(1)m mudstone interbedded with thin carbonaceous mudstone and coal is poor-quality source rock with Type Ⅲ kerogen,whose organic matter was originated from terrestrial higher plants under oxidized *** by burial and maturity histories,e_(1)y and e_(1)l source rocks experienced two hydrocarbon generation stages,which took place in the Late Paleocene and in the Middle to Late eocene,respectively,and had high hydrocarbon generation capacity with cumulative hydrocarbon volume of 363 and 328 mg/g,respectively.e_(1)m source rock only had one hydrocarbon generation process in the Late eocene,which had low hydrocarbon generation capacity with cumulative hydrocarbon volume of only 24 mg/*** future oil-gas exploration in the Jiaojiang sag should focus on hydrocarbon generation center and select targets in the central uplift formed before the Miocene with high-quality traps.

关键词： east China Sea Basin Jiaojiang sag source rock geochemical characteristics hydrocarbon generation basin modeling petroleum geology

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