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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

A CONJUGATe GRADIeNT MeTHOD FOR DISCReTe-TIMe OUTPUT FeeDBACK CONTROL DeSIGN

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Journal of Computational Mathematics 2012年第3期30卷 279-297页

作者： e1-Sayed M.e. Mostafa Department of Mathematics Faculty of Science Alexandria University Alexandria Egypt

In this paper, the discrete-time static output feedback control design problem is con- sidered. A nonlinear conjugate gradient method is analyzed and studied for solving an unconstrained matrix optimization problem that results from this optimal control prob- lem. In addition, through certain parametrization to the optimization problem an initial stabilizing static output feedback gain matrix is not required to start the conjugate gradi- ent method. Finally, the proposed algorithms are tested numerically through several test problems from the benchmark collection.

关键词： Output feedback control Nonlinear conjugate gradient methods Nonlinearprogramming.

Constrained bilinear control problem： Application to a cancer chemotherapy model

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International Journal of Biomathematics 2017年第4期10卷 189-209页

作者： e1 Hassan Zerrik Nihale.e1 Boukhari MA CS Team Faculty of Sciences Moulay Ismail University Meknes Morocco

The aim of this paper is to investigate the optimal control problem for finite-dimensional bilinear systems and its application to a chemotherapy model. We characterize an opti- mal control that minimizes a quadratic cost functional in two cases of constrained admis- sible controls, then we give sufficient conditions for the uniqueness of such a control, and we derive useful algorithms for the computation of the optimal control. The established results are applied to a cancer chemotherapy bilinear model in order to simulate the opti- mal treatment protocol using two different approaches： one based on a limited instant toxicity, and the other on a limited cumulative toxicity along the therapy session.

关键词： Bilinear systems optimal control chemotherapy instant toxicity cumulativetoxicity.

Pyrolysis of olive residue/low density polyethylene mixture：Part Ⅰ Thermogravimetric kinetics

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燃料化学学报 2008年第6期36卷 672-678页

作者： ABOULKAS A e1 HARFI K el BOUADILI A Laboratoire de Recherche sur la Reactivites des Materiaux et l Optimisation des Procedes ＂ReMATOP＂ Departement de chimie Faculte des Sciences Semlalia Universite Cadi Ayyad BP 2390 40001 Marrakech Maroc Departement de chimie Faculte polydisciplinaire de Beni-Mellal Universite Sultan Moulay Slimane BP 592 23000 Beni-Mellal Maroc Laboratoire de Chimie Organique et Analytique Departement de chimie Faculte des Sciences et Techniques de Beni-Mellal Universite Sultan Moulay Slimane BP 523 23000 Beni-Mellal Maroc

This paper demonstrates the thermal pyrolysis of olive residue,low density polyethylene(LDPe) and olive residue/LDPe mixture in an inert atmosphere of N2 using thermogravimetric analysis(TGA).Measurements were carried out in the temperature range 300K^973K at heating rates of 2K/min,10K/min,20K/min and 50K/*** on the results obtained,three temperature regimes were selected for studying the non-isothermal kinetics of olive residue/LDPe *** first two were dominated by the olive residue pyrolysis,while the third was linked to the LDPe pyrolysis,which occurred at much higher *** between the experimental and calculated TG/DTG profiles were considered as a measurement of the extent of interactions occurring on *** maximum degradation temperatures of each component in the mixture were higher than those the individual components;thus an increase in thermal stability was *** kinetic parameters associated with thermal degradation were determined using Friedman isoconversional method.

关键词：高温分解反应低密度聚乙烯动力学 LDPe

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI H.GHANDVAR e.JUMAeV S.KHATIR T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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A TRUST-ReGION ALGORITHM FOR SOLVING MINI-MAX PROBLeM

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Journal of Computational Mathematics 2018年第6期36卷 776-791页

作者： Bothina e1-Sobky Abdallah Abotahoun Department of Mathematics Alexandria University Alexandria Egypt

In this paper, we propose an algorithm for solving inequality constrained mini-max optimization problem. In this algorithm, an active set strategy is used together with mul- tiplier method to convert the inequality constrained mini-max optimization problem into unconstrained optimization problem. A trust-region method is a well-accepted technique in constrained optimization to assure global convergence and is more robust when they deal with rounding errors. One of the advantages of trust-region method is that it does not require the objective function of the model to be convex. A global convergence analysis for the proposed algorithm is presented under some conditions. To show the efficiency of the algorithm numerical results for a number of test problems are reported.

关键词： Mini-max problem Active-set Multiplier method Trust-region Global con-vergence

Occurrence mechanism of silicate and aluminosilicate minerals in Sarcheshmeh copper flotation concentrate

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 494-499页

作者： H.R.Barkhordari1 e.Jorjani1 A.eslami M.Noaparast Mining engineering Department Science and Research BranchIslamic Azad UniversityPoonakHesarakTehranIran R&D Division-Sarcheshmeh Copper Complex RafsanjanIran School of Mining engineering University College of EngineeringUniversity of TehranTehranIran

The Sarcheshmeh copper flotation circuit is producing 5× 10^4 t copper concentrate per month with an averaging grade of 28% Cu in rougher, cleaner and recleaner stages. In recent years, with the increase in the open pit depth, the content of aluminosilicate minerals increased in plant feed and subsequently in flotation concentrate. It can motivate some problems, such as unwanted consumption of reagents, decreasing of the copper concentrate grade, increasing of Al2O3 and SiO2 in the copper concentrate, and needing a higher temperature in the smelting process. The evaluation of the composite samples related to the most critical working period of the plant shows that quartz, illite, biotite, chlorite, orthoclase, albeit, muscovite, and kaolinite are the major Al2O3 and SiO2 beating minerals that accompany chalcopyrite, chalcocite, and covellite minerals in the plant feed. The severe alteration to clay minerals was a general rule in all thin sections that were prepared from the plant feed. Sieve analysis of the flotation concentrate shows that Al2O3 and SiO2 bearing minerals in the flotation concentrate can be decreased by promoting the size reduction from 53 to 38 μm. Interlocking of the Al2O3 and SiO2 bearing minerals with chalcopyrite and chalcocite is the occurrence mechanism of silicate and aluminosilicate minerals in the flotation concentrate. The dispersed form of interlocking is predominant.

关键词： copper aluminosilicate silicate flotation