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Whole-exome sequencing and microRNA profiling reveal PI3K/AKT pathway＇s involvement in juvenile myelomonocytic leukemia

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Frontiers of electrical and electronic engineering in China 2018年第1期6卷 85-97页

作者： Saad M Khan Jason e Denney Michael X Wang Dong Xu Informatics Institute and C. S. Bond Life Sciences Center Universitv of Missouri. Columbia. MO 65211 USA Department of Pathology and Anatomical Sciences University of Missouri Columbia MO 65211 USA Department of computer Science University of Missouri Columbia MO 65211 USA

Background： Clinical studies and genetic analyses have revealed that juvenile myelomonocytic leukemia （JMML） is caused by somatic and/or germline mutations of genes involved in the RAS/MAPK signalling pathway. Given the vastly different clinical prognosis among individual patients that have had this disease, mutations in genes of other pathways may be involved. Methods： In this study, we conducted whole-exome and cancer-panel sequencing analyses on a bone marrow sample from a 2-year old juvenile myelomonocytic leukemia patient. We also measured the microRNA profile of the same patient＇s bone marrow sample and the results were compared with the normal mature monocytic cells from the pooled peripheral blood. Results： We identified additional novel mutations in the Pi3K/AKT pathway and verified with a cancer panel targeted sequencing. We have confirmed the previously tested PTPNII gene mutation （exon 3 181G〉T） in the same sample and identified new nonsynonymous mutations in NTRKI, HMGA2, MLH3, MYH9 and AKT1 genes. Many of the microRNAs found to be differentially expressed are known to act as oncogenic MicroRNAs （onco^MicroRNAs or oncomiRs）, whose target genes are enriched in the PI3K/AKT signalling pathway. Conclusions： Our study suggests an alternative mechanism for JMML pathogenesis in addition to RAS/MAPK pathway. This discovery may provide new genetic markers for diagnosis and new therapeutic targets for JMML patients in the future.

关键词： single-cell RNA-Seq differential expression

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P-Lite: A study of parallel coordinate plot literacy

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Visual Informatics 2022年第3期6卷 81-99页

作者： elif e.Firat Alena Denisova Max L.Wilson Robert S.Laramee School of Computer Science University of NottinghamUK Department of Computer Science University of YorkUK

Visualization literacy,the ability to interpret and comprehend visual designs,is recognized as an essential skill by the visualization *** identify and investigate barriers to comprehending parallel coordinates plots(PCPs),one of the.advanced graphical representations for the display of multivariate and high-dimensional *** develop a parallel coordinates literacy test with diverse images generated using popular PCP software *** test improves PCP literacy and evaluates the user’s literacy *** introduce an interactive educational tool that assists the teaching and learning of parallel coordinates by offering a more active learning *** this pedagogical tool,we aim to advance novice users’parallel coordinates literacy *** on the hypothesis that an interactive tool that links traditional Cartesian Coordinates with PCPs interactively will enhance PCP literacy further than static slides,we compare the learning experience using traditional slides with our novel software tool and investigate the efficiency of the educational software with an online,crowdsourced ***-study results show that our pedagogical tool positively impacts a user’s PCP comprehension.

关键词： Human-centered computing Visualization systems and tool empirical studies in visualization

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effect of an environmental Contaminant, Diisopropyl Methylphosphonate, on the Blood Pressure of the Mallard

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Biomedical and environmental Sciences 1992年第4期5卷 314-320页

作者： ROSS e.JONeS KATHY S.HOWeLL ROBeRTK.RINGeR DVM 8424 S. Kings Cove Dr. Salt Lake CityMichigan State University DABT Texas Instruments P.O. Box 655303 M/S 8308 Dallas TX 75265 UT 84121 E. Lansing MI 48824

During a toxicological test using diisopropyl methylphosphonate (DIMP) on mallards, an anaesthesia-like response was noted after oral dosing. In order to further elucidate these effects, arterial blood pressures were determined both pre-and post-dosing on adit male and female mallards by cannulation of the left carotid artery. A significant decrease in systolic, diastolic, and mean blood pressure was noted after the oral administration of DIMP. There was no significant difference in response between males and females. During the first 30 min after dosing, systolic pressure fell from an average of 158 mmHg, to 94 mmHg, diastolic decreased from 127 mmHg to 63 mmHg, and mean blood pressure dropped from 138 mmHg to 75 mmHg. However, there was no significant effect on pulse pressure, heart rate, or respiratory rate. These results are compared to physiological data cited in the literature for various CNS-acting drugs on mallards.

关键词： on the Blood Pressure of the Mallard effect of an environmental Contaminant Diisopropyl Methylphosphonate

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Time-Harmonic Acoustic Scattering in a Complex Flow:A Full Coupling Between Acoustics and Hydrodynamics

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Communications in Computational Physics 2012年第2期11卷 555-572页

作者： ***-Ben Dhia J.F.Mercier F.Millot *** e.Peynaud POeMS CNRS-INRIA-ENSTA UMR 723132 Boulevard Victor75015 ParisFrance CeRFACS 42Avenue Gaspard Coriolis31057 Toulouse Cedex 01France

For the numerical simulation of time harmonic acoustic scattering in a complex geometry,in presence of an arbitrary mean flow,the main difficulty is the coexistence and the coupling of two very different phenomena:acoustic propagation and convection of *** consider a linearized formulation coupling an augmented Galbrun equation(for the perturbation of displacement)with a time harmonic convection equation(for the vortices).We first establish the well-posedness of this time harmonic convection equation in the appropriatemathematical *** the complete problem,with Perfectly Matched Layers at the artificial boundaries,is proved to be coercive+compact,and a hybrid numerical method for the solution is proposed,coupling finite elements for the Galbrun equation and a Discontinuous Galerkin scheme for the convection *** a 2D numerical result shows the efficiency of the method.

关键词： Aeroacoustics scattering of sound in flows Galbrun equation advection equation finite elements discontinuous Galerkin method

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Catalytic feasibility of Ce-doped LaCoO_(3) systems for chlorobenzene oxidation:An analysis of synthesis method

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Journal of Rare earths 2022年第6期40卷 897-905,I0002页

作者： Héctor Acosta Pérez Carlos A.López Luis e.Cadús Fabiola N.Agüero Chemical Technology Research Institute(INTeQUI) UNSL-CONICETFaculty of Biochemical Chemistry and Pharmacy(UNSL)Almirante Brown 14555700San LuisArgentina

A family of Ce-doped LaCoO_(3) perovskites are presented as possible catalysts for Cl-VOCs *** materials with different contents of Ce were obtained through the citrate and the reactive grinding *** insertion of Ce in the original perovskite structure favours the presence of Co^(2+)/Co^(3+) and Ce^(3+)/Ce^(4+) redox pairs and a higher content of oxygen vacancies that enhances the catalytic performance in chlorobenzene combustion based on differential kinetics *** family obtained by the grinding method presents a performance as high as that synthesized by citrate ***,the reactive grinding is a feasible green chemistry alternative to obtain a catalyst with the same performance as that obtained from traditional ***,the stability of samples was evaluated under total combustion reaction conditions showing an excellent activity during 45 h time on stream.

关键词： Cl-VOCs Perovskites Chlorobenzene Cerium Cobalt Rare earths

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Managing international collaboration for the development and application of environmental technologies: opportunities for China & other Asia Pacific countries

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Journal of environmental Sciences 1999年第4期11卷 432-442页

作者： Turlough F. Guerin (1691 e Green Briars Dr., Suite 3821, Schaumburg, Illinois 60173,U.S. A. e\|mail: turloughg@***) 1691 e Green Brianrs Dr 美国

Increased international cooperation in the field of contaminated site management has resulted in the formation of numerous networks and fora. The key benefits of increased co\|operation are perceived to be in the reduction of duplication in efforts, particularly related to industry, in the co\|ordination of contaminated site research, policy development and information dissemination. The paper introduces and briefly discusses key networks and collaborative projects currently in operation throughout the world relating to contaminated site management. The experience shared within these groups should prove useful to the application of such environmental problems in China and the Asia\|Pacific region.

关键词： contaminated sites technology transfer soil remediation contaminated soil risk assessment

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Analysis of antisym metric cross-ply laminates using high-order shear deformation theories:a meshless approach

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Acta Mechanica Sinica 2020年第5期36卷 1078-1098,I0003页

作者： D.e.S.Rodrigues J.Belinha L.M.J.S.Dinis R.M.Natal Jorge Institute of Science and Innovation in Mechanical and Industrial engineering 4200-465 PortoPortugal Department of Mechanical engineering School of EngineeringPolytechnic of Porto(ISEP)4200-072 PortoPortugal Department of Mechanical engineering Faculty of EngineeringUniversity of Porto(FEUP)4200-465 PortoPortugal

For many years finite element method(FeM)was the chosen numerical method for the analysis of composite ***,in the last 20 years,the scientific community has witnessed the birth and development of several meshless methods,which are more flexible and equally accurate numerical *** meshless method used in this work is the natural neighbour radial point interpolation method(NNRPIM).In order to discretize the problem domain,the NNRPIM only requires an unstructured nodal ***,using the Voronoi mathematical concept,it enforces the nodal connectivity and constructs the background integration *** NNRPIM shape functions are constructed using the radial point interpolation *** this work,the displacement field of composite laminated plates is defined by high-order shear deformation *** the end,several antisymmetric cross-ply laminates were analysed and the NNRPIM solutions were compared with the *** obtained results show the efficiency and accuracy of the NNRPIM formulation.

关键词： Antisymmetric cross-ply laminates High-order shear deformation theories Meshless methods Naturalneighbour radial point interpolation method(NNRPIM)

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The production of carbon nanotubes from carbon dioxide:challenges and opportunities

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Journal of Natural Gas Chemistry 2010年第5期19卷 453-460页

作者： Geoffrey S.Simate Sunny e.Iyuke Sehliselo Ndlovu Clarence S.Yah Lubinda F.Walubita School of Chemical and Metallurgical engineering University of the Witwatersrand TTI-Texas A&M University System College Station

Recent advances in the production of carbon nanotubes （CNTs） are reviewed with an emphasis on the use of carbon dioxide （CO2） as a sole source of carbon. Compared to the most widely used carbon precursors such as graphite, methane, acetylene, ethanol, ethylene, and coal-derived hydrocarbons, CO2 is competitively cheaper with relatively high carbon yield content. However, CNT synthesis from CO2 is a newly emerging technology, and hence it needs to be ex- plored further. A theoretical and analytical comparison of the cur- rently existing CNT-CO2 synthesis techniques is given including a review of some of the process parameters （i.e., temperature, pres- sure, catalyst, etc.） that affect the CO2 reduction rate. Such analysis indicates that there is still a fundamental need to further explore the following aspects so as to realize the full potential of CO2 based CNT technology：（1） the CNT-CO2 synthesis and formation mechanism, （2） catalytic effects of transitional metals and mechanisms, （3） uti- lization of metallocenes in the CNT-CO2 reactions, （4） applicability of ferrite-organometallic compounds in the CNT-CO2 synthesis reactions, and （5） the effects of process parameters such as temperature, etc.

关键词： supercritical CO2 CO2 reduction chemical vapour decomposition(CVD) carbon nanotubes ferrite catalysts

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Retinal vessel diameter changes induced by transient high perfusion pressure

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International Journal of Ophthalmology(english edition) 2014年第4期7卷 602-607页

作者： Yin-Ying Zhao Ping-Jun Chang Fang Yu Yun-e Zhao School of Ophthalmology and Optometry Wenzhou Medical University Affiliated eye Hospital Wenzhou Medical University

·AIM: To investigate the effects of transient high perfusion pressure on the retinal vessel diameter and retinal ganglion cells.·MeTHODS: The animals were divided into four groups according to different infusion pressure and infusion time(60 mm Hg-3min, 60 mm Hg-5min, 100 mm Hg-3min, 100 mm Hg-5min). each group consisted of six rabbits. The left eye was used as the experimental eye and the right as a control. Retinal vascular diameters were evaluated before, during infusion, immediately after infusion, 5min, 10 min and 30 min after infusion based on the fundus photographs. Blood pressure was monitored during infusion. The eyes were removed after 24 *** to retinal ganglion cell(RGC) was analyzed by histology.·ReSULTS: Retina became whiten and papilla optic was pale during perfusion. Measurements showed significant decrease in retinal artery and vein diameter during perfusion in all of the four groups at the proximal of the edge of the optic disc. The changes were significant in the 100 mm Hg-3min group and 100 mm Hg-5min group compared with 60 mm Hg-3min group(P 1=0.025, P 2=0.000).The diameters in all the groups recovered completely after 30 min of reperfusion. The number of RGC)showed no significant changes at the IOP in 100 mm Hg with5 min compared with contralateral untreated eye(P >0.05).·CONCLUSION: Transient fluctuations during infusion lead to temporal changes of retinal vessels, which could affect the retinal blood circulation. The RGCs were not affected by this transient fluctuation. Further studies are necessary to evaluate the effect of pressure during realtime phacoemusification on retinal blood circulation.

关键词： ocular perfusion pressure retinal ischemia retinal ganglion cells animals

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Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles

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Journal of environmental Sciences 2022年第7期34卷 46-57页

作者： Andressa Gonsioroski Mary Laws Vasiliki e.Mourikes Alison Neff Jenny Drnevich Michael J.Plewa Jodi A.Flaws Department of Comparative Biosciences University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy J.Carver Biotechnology Center University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Department of Crop Sciences and the Safe Global Water Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoacetic acid(IAA) is an unregulated water disinfection byproduct that is an ovarian toxicant. However, the mechanisms of action underlying IAA toxicity in ovarian follicles remain unclear. Thus, we determined whether IAA alters gene expression in ovarian follicles in mice. adult female mice were dosed with water or IAA(10 or 500 mg/L) in the water for 35-40 days. Antral follicles were collected for RNA-sequencing analysis and sera were collected to measure estradiol. RNA-sequencing analysis identified 1063 differentially expressed genes(DeGs) in the 10 and 500 mg/L IAA groups(false discovery rate FDR espectively, compared to controls. Gene Ontology enrichment analysis showed that DeGs were involved with RNA processing and regulation of angiogenesis(10 mg/L) and the cell cycle and cell division(500 mg/L). Pathway enrichment analysis showed that DeGs were involved in the phosphatidylinositol 3-kinase and protein kinase B(PI3K-Akt), gonadotropin-releasing hormone(Gn RH), estrogen, and insulin signaling pathways(10 mg/L). Pathway enrichment analysis showed that DeGs were involved in the oocyte meiosis, Gn RH, and oxytocin signaling pathways(500 mg/L). RNA-sequencing analysis identified 809 DeGs when comparing the 500 and 10 mg/L IAA groups(FDR eGs were related to ribosome, translation, m RNA processing, oxidative phosphorylation, chromosome, cell cycle, cell division, protein folding, and the oxytocin signaling pathway. Moreover, IAA exposure significantly decreased estradiol levels(500 mg/L) compared to control. This study identified key candidate genes and pathways involved in IAA toxicity and can help to further understand the molecular mechanisms of IAA toxicity in ovarian follicles.

关键词： Disinfection byproducts Iodoacetic acid Ovary Ovarian follicles Steroidogenesis endocrine disruptors

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