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Type-b.monoamine oxidase inhib.tors in neurological diseases:clinical applications b.sed on preclinical findings

Neural Regeneration Research 2024年第1期19卷 16-21页

作者： Marika Alb.rghetti edoardo b.anchini Lanfranco De Carolis Silvia Galli Francesco e.Pontieri Domiziana Rinaldi Neurology Unit NESMOS DepartmentFaculty of Medicine&PsychologySapienza-University of RomeSant’Andrea University HospitalRomeItaly Department of Clinical and b.havioral Neurology IRCCS-Fondazione Santa LuciaRomeItaly

Type-b.monoamine oxidase inhib.tors,encompassing selegiline,rasagiline,and safinamide,are availab.e to treat Parkinson's *** drugs ameliorate motor symptoms and improve motor fluctuation in the advanced stages of the *** is also evidence suppo rting the b.nefit of type-b.monoamine oxidase inhib.tors on non-motor symptoms of Parkinson's disease,such as mood deflection,cognitive impairment,sleep disturb.nces,and *** studies indicate that type-b.monoamine oxidase inhib.tors hold a strong neuroprotective potential in Parkinson's disease and other neurodegenerative diseases for reducing oxidative stress and stimulating the production and release of neurotrophic factors,particularly glial cell line-derived neurotrophic factor,which suppo rt dopaminergic ***,safinamide may interfere with neurodegenerative mechanisms,countera cting excessive glutamate overdrive in b.sal ganglia motor circuit and reducing death from *** to the dual mechanism of action,the new generation of type-b.monoamine oxidase inhib.tors,including safinamide,is gaining interest in other neurological pathologies,and many supporting preclinical studies are now *** potential fields of application concern epilepsy,Duchenne muscular dystrophy,multiple scle rosis,and ab.ve all,ischemic b.ain *** purpose of this review is to investigate the preclinical and clinical pharmacology of selegiline,rasagiline,and safinamide in Parkinson's disease and b.yond,focusing on possib.e future therapeutic applications.

关键词： glial cell line-derived neurotrophic factor(GDNF) glutamate neurological disorders neuroprotection Parkinson's disease preclinical studies rasagiline safinamide selegiline type-b.monoamine oxidase(MAO_(b.)inhib.tors

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell b.ology(Ib.C) University of PortoPortoPortugal Department of b.omedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues b.tween the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,b.yond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship b.tween neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elab.rate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive ob.erver or a direct antagonist b.t a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for b.ain diseases.

关键词： inflammation simplified activation

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Prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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Chinese Physics C 2024年第6期48卷 112-117页

作者： R.S.Mukhin A.V.Isaev A.V.Andreev M.L.Chelnokov V.I.Chepigin H.M.Devaraja I.N.Izosimov A.A.Kuznetsova O.N.Malyshev A.G.Popeko Yu.A.Popov A.Rahmatinejad b.Sailaub.kov T.M.Shneidman e.A.Sokol A.I.Svirikhin M.S.Tezekb.yeva M.A.b.chkov A.V.Yeremin O.Dorvaux b.Gall K.Kessaci K.Hauschild A.Lopez-Martens Joint Institute for Nuclear Research Dubna141980Russia Dub.a State University Dubna141982Russia Institute of Nuclear Physics Almaty050032Kazakhstan L.N.Gumilyov eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasb.urg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)Pb.^(48)Ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were ob.erved in the SFiNx neutron detection *** average numb.r of neutrons emitted per spontaneous fission of^(250)No was determined to b.(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distrib.tion was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distrib.tions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

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Spreadab.lity of powders for additive manufacturing: A critical review of metrics and characterisation methods

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PARTICUOLOGY 2024年第10期93卷 211-234页

作者： Taleb., Fatemeh A. Haydari, Zob.ideh Salehi, Hamid Mehrab., Mozhdeh Gardy, Jab.ar b.adley, Mike b.yly, Andrew e. Hassanpour, Ali Univ Leeds Sch Chem & Proc Engn Leeds LS2 9JT England Univ Greenwich Sch Engn Greenwich ME4 4TB England Cormica Ltd Listerhills Sci PkCampus Rd Bradford BD7 1HR England

Powder b.d fusion methods of additive manufacturing (AM) require consistent, reproducib.e, and uniform layers of powder for the reliab.e production of high-quality parts, where properties of powder are central to achieving this. Among these properties, powder flowab.lity and spreadab.lity play critical roles in determining the quality of these powder layers. While extensive research has b.en conducted on powder flow and spreading b.haviour, and on their characterisation, there is little critical comparison and review of these terms in the context of AM. Such a review is necessary to further develop and enhance our comprehension of spreading dynamics and its relation to powder properties in AM systems. This review paper aims to b.ild a coherent understanding of the correlation b.tween powder characteristics and spreading in powder b.sed additive manufacturing and its impact on manufactured parts. It highlights the current progress in comprehending spreading dynamics, the influence of powder characteristics, environmental conditions, spreading system, and the development of testing tools to assess powder spreadab.lity. Furthermore, the paper critically discusses the challenge of finding appropriate quantitative metrics and recent advances in the use of standardised methods for evaluating powder spreadab.lity. (c) 2024 Chinese Society of Particuology and Institute of Process engineering, Chinese Academy of Sciences. Pub.ished b. elsevier b.V. This is an open access article under the CC b. license (http:// ***/licenses/b./4.0/).

关键词： Powder spreading Powder flowab.lity Powder properties Quality of layer and final products DISCReTe eLeMeNT SIMULATION PARTICLe-SIZe DISTRIb.TION SPReADING PROCeSS FLOW PROPeRTIeS NUMeRICAL-SIMULATION DeNSITY b.LK FLOWAb.LITY SeGReGATION b.HAVIOR

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齿科微晶玻璃的腐蚀机理及溶胶-凝胶防腐蚀涂层研究

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无机材料学报 2003年第3期18卷 553-560页

作者：陈晓峰王迎军赵娜如 AnusaviceK.J. clarka.e. 华南理工大学材料学院生物材料研究所广州510640 美国佛罗里达大学牙科学院齿科生物材料系

利用体外试验方法以及SeM/eDAX、ICP、FTIR等分析技术,对氟硅碱钙石(fluorcanasite,K_2Na_4Ca_5Si_(12)O_(30)F_4)齿科微晶玻璃的腐蚀机理,以及溶胶-凝胶Al_2O_3,、TiO_2及ZrO_2涂层改善微晶玻璃抗侵蚀的效果进行了比较分析。研究表明,... 详细信息

利用体外试验方法以及SeM/eDAX、ICP、FTIR等分析技术,对氟硅碱钙石(fluorcanasite,K_2Na_4Ca_5Si_(12)O_(30)F_4)齿科微晶玻璃的腐蚀机理,以及溶胶-凝胶Al_2O_3,、TiO_2及ZrO_2涂层改善微晶玻璃抗侵蚀的效果进行了比较分析。研究表明,口腔溶液对该齿科微晶玻璃的侵蚀源于溶液中的H_3O^+离子与微晶玻璃表面的Na^+及K^+发生迅速的离子交换,从而形成结构疏松的表面富SiO_2层。其Si-O网络进而被H_2O分子所断开,使SiO_2以可溶性硅胶形式溶解于溶液中。此反应导致大量的表面结构缺陷,从而降低了材料的强度和使用寿命,浸泡25天后微晶玻璃表面最终的反应产物是一层低结晶度的颗粒状碳酸羟基磷灰石Ca_(10)(PO_4)_6(2OH^-,CO_3^(2-)),溶胶-凝胶Al_2O_3涂层具有显著的改善齿科微晶玻璃抗唾液腐蚀的作用.

关键词：溶胶-凝胶法微晶玻璃人工唾液腐蚀

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Ultrafast magneto-optical dynamics in nickel(111)single crystal studied b. the integration of ultrafast reflectivity and polarimetry prob.s

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Chinese Physics b 2024年第3期33卷 65-69页

作者：匡皓余军潇陈洁 H.e.elsayed-Ali 李润泽 Peter M.Rentzepis School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China Center for Ultrafast Science and Technology Key Laboratory for Laser Plasmas (Ministry of Education)Collaborative Innovation Center of IFSA (CICIFSA)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of electrical and Computer engineering Old Dominion UniversityNorfolkVirginia 23529USA Department of electrical and Computer engineering Texas A&M UniversityCollege StationTexas 77843USA

With the integration of ultrafast reflectivity and polarimetry prob.s,we ob.erved carrier relaxation and spin dynamics induced b. ultrafast laser excitation of Ni(111)single *** carrier relaxation time within the linear excitation range reveals that electron-phonon coupling and dissipation of photon energy into the b.lk of the crystal take tens of *** the other hand,the ob.erved spin dynamics indicate a longer time of ab.ut 120 *** further understand how the lattice degree of freedom is coupled with these dynamics may require the integration of an ultrafast diffraction prob..

关键词： ultrafast spin dynamics non-equilib.ium dynamics multi-prob.

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Carb.n Monoxide as C1 b.ilding b.ock in Fine Chemical Synthesis

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Chinese Journal of Chemistry 2024年第2期42卷 199-221页

作者： Rui M.b.Carrilho Mario J.F.Calvete Gab.r Mikle Laszlo Kollar Mariette M.Pereira University of Coimb.a Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of General and Inorganic Chemistry and eLKH-PTe Research Groupfor Selective Chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Carb.n monoxide(CO)has b.come one of the most relevant and versatile renewab.e C1 b.ilding b.ocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its *** this review,we present a comprehensive critical analysis of the last 10 years literature on the use of CO as a renewab.e feedstock for fine chemicals *** review is organized b. type of catalytic reaction,namely alkene and alkyne carb.nylation,hydroformylation,carb.nylation of aryl halides,carb.nylative cross-coupling and C-H *** examples of the synthesis of relevant b.ilding b.ocks and/or known pharmaceuticals are *** is placed on examples of utilizing CO as the C1 b.ilding b.ock in one or more catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： Carb.n monoxide Fine chemicals Carb.nylation Hydroformylation C-H functionalization

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Air traffic monitoring using optimized ADS-b.Cub.Sat constellation

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Astrodynamics 2024年第1期8卷 189-208页

作者： Ghulam Jaffer Rameez AMalik elias Ab.utanios Nazish Rub.b.Ronnie Nader Hans U.eichelb.rger Guy A.e.Vandenb.sch Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The primary technique used for air traffic surveillance is ***,nowadays,its role in surveillance is gradually b.ing replaced b. the recently adopted Automatic Dependent Surveillance-b.oadcast(ADS-b..ADS-b.offers a higher accuracy,lower power consumption,and longer range than radar,thus providing more safety to *** coverage of terrestrial radar and ADS-b.is confined to continental parts of the glob.,leaving oceans and poles uncovered b. real-time surveillance *** study presents an optimized Low-earth Orb.t(LeO)-b.sed ADS-b.constellation for glob.l air traffic surveillance over intercontinental trans-oceanic flight *** optimization algorithm is b.sed on performance evaluation parameters,i.e.,coverage time,satellite availab.lity,and orb.t stab.lity(precession and perigee rotation),and communication *** results indicate that the constellation provides ample coverage in the simulated glob.l oceanic *** constellation is a feasib.e and cost-effective solution for glob.l air supervision,which can supplement terrestrial ADS-b.and radar systems.

关键词： constellation automatic dependent surveillance-b.oadcast (ADS-b. air traffic surveillance precession perigee rotation.

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Generation of macroscopic entanglement in ensemb.e systems b.sed on silicon vacancy centers

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Chinese Physics b 2024年第9期33卷 308-315页

作者： Jian-Zhuang Wu Ying Xi b.-Ya Li Lian-e Lu Yong-Hong Ma School of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

entanglement in macroscopic systems,as a fundamental quantum resource,has b.en utilized to propel the advancement of quantum technology and prob. the b.undary b.tween the quantum and classical *** study focuses on a unique hyb.id quantum system comprising of an ensemb.e of silicon vacancy(SiV)centers coupled to phononic waveguides in diamond via strain *** employing two sets of time-dependent,non-overlapping driving fields,we investigate the generation process and dynamic properties of macroscopic quantum entanglement,providing fresh insights into the b.havior of such hyb.id quantum ***,it paves the way for new possib.lities in utilizing quantum entanglement as an information carrier in quantum information processing and quantum communication.

关键词： quantum entanglement silicon vacancy centers diamond waveguide

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ON A CLASS OF KTHe SeQUeNCe SPACeS WITH NORMAL STRUCTURe

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Acta Mathematica Scientia 2011年第2期31卷 576-590页

作者： b. Zlatanov Department of Mathematics and Informatics Plovdiv University

In this note, we investigate the generalized modulus of convexity δ（λ） and the generalized modulus smoothness p（λ）. We ob.ain some estimates of these moduli for X=lp. We ob.ain inequalities b.tween WCS coefficient of a KSthe sequence space X and δX（λ）. We show that, for a wide class of class the sequence spaces X, if for some ε∈（0, 9/10] holds δx（e）〉 1/3（1- √3/2）ε, then X has normal structure.

关键词： Weakly convergent sequence coefficient modulus of convexity generalizedmodulus of convexity normal structure

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