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Integrated fluid inclusion studies and source rock parameters in constraining hydrocarbon potential in offshore Lamu Basin, Kenya

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energy Geoscience 2023年第3期4卷 26-47页

作者： G.A.Osukuku O.O.Osinowo W.A.Sonibare e.W.Makhanu C.Orora Pan African University for Life and earth Sciences Institute(Including Health and Agriculture) PAULESIUniversity of IbadanNigeria Schlumberger Offshore Service Limited the Netherlands National Oil Corporation of Kenya(NOCK) Kenya

Fluid inclusion signal strength and visual inclusion abundance are generally lower along migration pathways than in charged reservoirs from the same area. A zone that displays strong fluid inclusion stratigraphy (FIS) hydrocarbon indications and high visualized petroleum inclusion abundance, indicates paleo-charge or in some cases a migration pathway, e.g, where inclusion abundance is enhanced by extensive microfracturing. In this study, fluid inclusion data are interpreted in seven offshore wells of the Lamu Basin to enhance the understanding of hydrocarbon generation, migration and migration pathways. The study also examines the interrelationship among rock texture, rock composition and trapped fluid distribution in the study area. The studies were based on FIS analyzed data courtesy of Fluid Inclusion Technologies (FIT) Inc. in USA laboratories. FIT conducted analysis on 391 samples from the Paleocene to Upper Jurassic (Kiboko-1 well), 249 from the Paleoecene to Campanian (Kubwa-1 well), 106 from the Maastrichtian to Turonian (Mbawa-1 well), 59 from the eocene to Campanian (Pomboo-1 well), 26 form the Lower eocene to Maastrichtian (Simba-1 well), 16 from the eocene to Maastrichtian (Kipini-1 well) and 11 from the Maastrichtian to Campanian (Kofia-1 well). It also made analysis on sidewall core sample plates, with 44 from the Maastrichtian to Campanian (Kubwa-1 well), 108 from the Campanian to Upper Jurassic (Kiboko-1 well) and 8 from the Campanian (Pomboo-1 well) for petrographic evaluation. For photomicroscopy, thin sections were examined under a petrographic microscope using Ultra Violet (UV) fluorescence and microthermometry, in order to verify the presence of petroleum bearing inclusions in the rock samples and to explore textural relationships that may yield additional information on the timing of hydrocarbon migration or generation. Gas shows in Mbawa-1 well is a result of generated hydrocarbons from the carbonate interbeds in the Upper Cretaceous. Gas show

关键词： Fluid inclusion stratigraphy(FIS) Petroleum inclusion Vitrinite reflectance Photomicr osCopy Lamu basin

Linear endoscopic ultrasound:Current uses and future perspectives in mediastinal examination

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World Journal of Gastroenterology 2024年第33期30卷 3803-3809页

作者： eyad Gadour Sarah Al Ghamdi Bogdan Miutescu Hossam e Shaaban Zeinab Hassan Aymen Almuhaidb Hussein H Okasha Department of Gastroenterology and Hepatology King Abdulaziz National Guard HospitalAhsa 36428Saudi Arabia Department of Internal Medicine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan Department of Medicine Division of GastroenterologyKing Abdulaziz UniversityJeddah 3646Saudi Arabia Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Department of Internal Medicine and Gastroenterology NhtmriCairo 11796Egypt Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Department of Gastroenterology King Faisal Specialist Hospital and Research CenterRiyadh 11211Saudi Arabia Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

This editorial elaborates on the current and future applications of linear endoscopic ultrasound(eUS),a substantial diagnostic and therapeutic modality for various anatomical *** scope of endosonographic assessment is broad and,among other factors,allows for the evaluation of the mediastinal anatomy and related pathologies,such as mediastinal lymphadenopathy and the staging of central malignant lung ***,eUS assessment has proven more accurate in detecting small lesions missed by standard imaging examinations,such as computed tomography or magnetic resonance *** focus on its current uses in the mediastinum,including lung and esophageal cancer staging,as well as evaluating mediastinal lymphadenopathy and submucosal *** editorial also explores future perspectives of eUS in mediastinal examination,including ultrasound-guided therapies,artificial intelligence integration,advancements in mediastinal modalities,and improved diagnostic approaches for various mediastinal lesions.

关键词： Linear endoscopic ultrasound Mediastinal examination Lung cancer Computed tomography Magnetic resonance imaging

Molecular Therapy and Prevention of Liver Diseases

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Virologica Sinica 2008年第2期23卷 81-92页

作者： Hubert e. Blum Department of Medicine II University Hospital

Molecular analyses have become an integral part of biomedical research as well as clinical medicine. The definition of the genetic basis of many human diseases has led to a better understanding of their pathogenesis and has in addition offered new perspectives for their diagnosis, therapy and prevention. Genetically, human diseases can be classified as hereditary monogenic, acquired monogenic and polygenic diseases. Based on this classification, gene therapy is based on six concepts: (1) gene repair, (2) gene substitution, (3) cell therapy, (4) block of gene expression or function, (5) DNA vaccination and (6) gene augmentation. While major advances have been made in all areas of gene therapy during the last years, various delivery, targeting and safety issues need to be addressed before these strategies will enter clinical practice. Nevertheless, gene therapy will eventually become part of the management of patients with various liver diseases, complementing or replacing existing therapeutic and preventive strategies.

关键词： Gene therapy Gene repair Gene replacement Gene expression or function Immune therapy Liver Diseases

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290K下0.1～600MPa水的Raman光谱原位研究

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光谱学与光谱分析 2004年第8期24卷 963-965页

作者：孙樯郑海飞谢鸿森徐济安 Hines e 北京大学地球与空间科学学院北京100871 中国科学院地球化学研究所贵州贵阳550002 Carnegie Institute of Washington Charles and Colvard

在 2 90K和 0 0 1～ 6 0 0MPa条件下 ,就压力对液态水对称伸缩振动的影响进行了原位Raman散射光谱研究。表明 :( 1)在 0 1～ 2 0 0MPa范围内 ,(ν1) max随着压力升高而减小 ;( 2 )在 2 0 0～ 4 0 0MPa范围内 ,压力升高导致 (ν1) max... 详细信息

在 2 90K和 0 0 1～ 6 0 0MPa条件下 ,就压力对液态水对称伸缩振动的影响进行了原位Raman散射光谱研究。表明 :( 1)在 0 1～ 2 0 0MPa范围内 ,(ν1) max随着压力升高而减小 ;( 2 )在 2 0 0～ 4 0 0MPa范围内 ,压力升高导致 (ν1) max增大 ,并在 4 0 0MPa时达到最大值 ;( 3) (ν1) max随着压力的进一步升高 ( >4 0 0MPa)而降低。这表明在 2 0 0和 4 0 0MPa时 ,液态水结构的变化是不连续的 ,这也与在该压力范围内rOO 的变化特征是一致的。可认为与冰Ⅰh→冰Ⅲ→冰Ⅴ的相变相类似。

关键词：液态水压力对称伸缩振动原位Raman散射光谱相变氢键

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A General Algorithm for Calculating Irreducible Brillouin Zones

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Communications in Computational Physics 2022年第2期31卷 495-515页

作者： Jeremy J.Jorgensen John e.Christensen Tyler J.Jarvis Gus L.W.Hart Department of Physics and Astronomy Brigham Young UniversityProvoUtah84602USA Department ofMathematics BrighamYoungUniversityProvoUtah84602USA

Calculations of properties of materials require performing numerical integrals over the Brillouin zone(BZ).Integration points in density functional theory codes are uniformly spread over the BZ(despite integration error being concentrated in small regions of the BZ)and preserve symmetry to improve computational *** points over an irreducible Brillouin zone(IBZ),a rotationally distinct region of the BZ,do not have to preserve crystal symmetry for greater *** freedom allows the use of adaptive meshes with higher concentrations of points at locations of large error,resulting in improved algorithmic *** have created an algorithm for constructing an IBZ of any crystal structure in 2D and *** algorithmuses convex hull and half-space representations for the BZ and IBZ to make many aspects of construction and symmetry reduction of the BZ *** algorithm is simple,general,and available as open-source software.

关键词： Brillouin zone irreducible Brillouin zone

Automated ex-situ detection of pitting corrosion and its effect on the mechanical integrity of rare earth magnesium alloy-We43

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Bioactive Materials 2022年第2期7卷 545-558页

作者： Kerstin van Gaalen Felix Gremse Felix Benn Peter e.McHugh Alexander Kopp Ted J.Vaughan Biomechanics Research Centre(BioMeC) Biomedical EngineeringSchool of EngineeringCollege of Science and EngineeringNational University of Ireland GalwayGalwayIreland Meotec GmbH AachenGermany Institute for experimental Molecular Imaging RWTH Aachen UniversityAachenGermany School of Mechanical and Aerospace engineering Queen’s University BelfastBelfastUnited Kingdom

This study develops a three-dimensional automated detection framework(PitScan)that systematically evaluates the severity and phenomenology of pitting *** framework uses a python-based algorithm to analyse microcomputer-tomography scans(μCT)of cylindrical specimens undergoing *** approach systematically identifies several surface-based corrosion features,enabling full spatial characterisation of pitting parameters,including pit density,pit size,pit depth as well as pitting factor according to ASTM ***,it is used to evaluate pitting formation in tensile specimens of a Rare earth Magnesium alloy undergoing corrosion,and relationships between key pitting parameters and mechanical performance are *** demonstrated that several of the parameters described in ASTM G46-94,including pit number,pit density and pitting factor,showed little correlation to mechanical ***,this study did identify that other parameters showed strong correlations with the ultimate tensile strength and these tended to be directly linked to the reduction of the cross-sectional area of the ***,our results indicate,that parameters directly linked to the loss of the cross-sectional area(*** material width),are parameters that are most suited to provide an indication of a specimen’s mechanical *** automated detection framework developed in this study has the potential to provide a basis to standardise measurements of pitting corrosion across a range of metals and future prediction of mechanical strength over degradation time.

关键词： Magnesium Corrosion Degradation Micro-computer-tomography Pit detection Automatization Mechanical integrity

Current and future perspectives on acute-on-chronic liver failure: Challenges of transplantation, machine perfusion, and beyond

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World Journal of Gastroenterology 2022年第48期28卷 6922-6934页

作者： Bianca Della Guardia Amanda P C S Boteon Celso e L Matielo Guilherme Felga Yuri L Boteon Liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de ensino e Pesquisa Albert einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

Acute-on-chronic liver failure(ACLF)is a syndrome that occurs in patients with chronic liver disease and is characterized by acute decompensation,organ failure and high short-term *** due to the lack of universal diagnostic criteria,the actual ACLF prevalence remains unclear;nevertheless,it is expected to be a highly prevalent condition *** transplantation is an effective protective measure for selected ACLF *** liver transplantation,diagnosing and treating precipitant events and providing supportive treatment for organ failures are currently the cornerstone of ACLF *** new clinical specific therapies have been researched,more studies are necessary to assess safety and ***,future ACLF management strategies must consider measures to improve access to liver transplantation because the time window for this life-saving therapy is frequently ***,an urgent and global discussion about allocation and prioritization for transplantation in critically ill ACLF patients is needed because there is evidence suggesting that the current model may not portray their waitlist *** addition,while donor organ quality is meant to be a prognostic factor in the ACLF setting,recent evidence suggests that machine perfusion of the liver may be a safe tool to improve the donor organ pool and expedite liver transplantation in this scenario.

关键词： Acute-on-chronic liver failure Liver cirrhosis Liver transplantation Machine perfusion Hypothermic oxygenated machine perfusion

Intestinal Ca2+ absorption revisited: A molecular and clinical approach

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World Journal of Gastroenterology 2020年第24期26卷 3344-3364页

作者： Vanessa A Areco Romina Kohan Germán Talamoni Nori G Tolosa de Talamoni María e Peralta López Laboratorio“Dr.Fernando Canas” Cátedra de Bioquímica y Biología MolecularFacultad de Ciencias MédicasINICSA(CONICET-Universidad Nacional de Córdoba)Córdoba 5000Argentina

Ca2+has an important role in the maintenance of the skeleton and is involved in the main physiological *** homeostasis is controlled by the intestine,kidney,bone and parathyroid *** intestinal Ca2+absorption occurs mainly via the paracellular and the transcellular *** proteins involved in both ways are regulated by calcitriol and other hormones as well as dietary *** growth factor 23(FGF-23)is a strong antagonist of vitamin D *** of the intestinal Ca2+movement seems to be vitamin D *** Ca2+absorption changes according to different physiological *** is promoted under high Ca2+demands such as growth,pregnancy,lactation,dietary Ca2+deficiency and high physical *** contrast,the intestinal Ca2+transport decreases with *** stress inhibits the intestinal Ca2+absorption whereas the antioxidants counteract the effects of prooxidants leading to the normalization of this physiological *** pathologies such as celiac disease,inflammatory bowel diseases,Turner syndrome and others occur with inhibition of intestinal Ca2+absorption,some hypercalciurias show Ca2+hyperabsorption,most of these alterations are related to the vitamin D endocrine *** research work should be accomplished in order not only to know more molecular details but also to detect possible therapeutic targets to ameliorate or avoid the consequences of altered intestinal Ca2+absorption.

关键词： Ca2+absorption Transcellular pathway Paracellular pathway Hormones Dietary calcium Physiological conditions Pathological alterations

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药物治疗阿尔茨海默病的新进展

中国心理卫生杂志 1999年第5期13卷 280-282页

作者： B.e.Leonar Pharmacology Department National University of Ireland Galway

对阿尔茨海默病在治疗策略上可以分为两类 :对症治疗与预防性治疗。在确凿的临床证据表明胆碱酯酶抑制剂对该病的早期患者有一定程度的暂时缓解 ,预防性治疗则需要逆转神经元与突触不断丢失的进程 ,而这进程正是认知功能衰退的基础。因... 详细信息

对阿尔茨海默病在治疗策略上可以分为两类 :对症治疗与预防性治疗。在确凿的临床证据表明胆碱酯酶抑制剂对该病的早期患者有一定程度的暂时缓解 ,预防性治疗则需要逆转神经元与突触不断丢失的进程 ,而这进程正是认知功能衰退的基础。因此 ,任何开发某种治疗措施以改变治疗进程的尝试 ,都应建立在对病因学的了解 (例如 β淀粉样蛋白沉积的形成 )及寻求保持神经元活力的基础之上 (如神经生长因子 )。在治疗上除了要考虑对认知功能失调的对症或预防性措施之外 ,还要考虑到对阿尔茨海默病常常伴随非认知性或行为缺陷的治疗。阿尔茨海默病病人常常伴有激越、抑郁及精神病性症状 ,而这些症状都可以为标准的抗抑郁剂和神经阻滞剂所缓解。但是当使用这些药物时切记要在这些药物对非认知性症状的疗效与它们所引起的副作用之间仔细权衡。

关键词：老年性痴呆药物疗法胆碱酯酶抑制剂

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