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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POr)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POr quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural regeneration research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Investigating the use of an ionic liquid for rare earth mineral flotation

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Journal of rare earths 2021年第7期39卷 866-874,I0004页

作者： r.li C.Marion e.r.l.espirtu r.Multani Xiaoqi Sun K.e.Waters Department of Mining and Materials engineering McGill University3610 Rue University.MontrealQuebecH3A 0C5Canada Vale Ontario Operations(Base Metals)18 Rink St.Copper CliffOntario POM 1N0Canada Fujian Institute of research on the Structure of Matter Chinese Academy of Sciences155 Yangqiao Road WestFuzhou 350002China

Common collectors for rare earth mineral(reM) flotation,which include carboxylates and hydroxamates,face problems such as being non-selective and sensitive to impurity ions.A type of ionic liquid(Il),tetraethylammonium mono-(2-ethylhexyl)2-ethylhexyl phosphonate([N_(2222)][eHeHP]),has been investigated previously for rare earth elements(ree) solvent extraction,and was proven to be selective and *** this work,[N_(2222)][eHeHP] was evaluated as a collector in bastnasite(a primary reM source for ree production) flotation for the first *** results were compared with quartz and hematite,two common gangue minerals in reM *** potential measurements and Fouriertransform infrared spectroscopy(FT-Ir) were completed to investigate the surface chemical properties involved in the flotation of these minerals using this *** findings were compared with microflotation ***-Ir and zeta potential measurements suggest adsorption of the collector’s phosphonate group onto bastnäsite and hematite,likely through chemisorption;whereas for quartz,the minimum micro flotation recovery is likely due to no adsorption of Il on its *** flotation re sults show higher collectability of [N_(2222)] [eHeHP] for hematite than bastnasite,the latter only shows appreciable recovery at pH 5 with elevated dosage of Il(500 g/t).To achieve better separation,a two-stage flotation scheme was designed and evaluated by bench scale flotation on a synthetic mineral *** concentrates and tails were analyzed by magnetic separation,and it is found that bastnasite recovery over 90% with maximum upgrade ratio 1.7 can be achieved with elevated collector dosage.

关键词： Ionic liquid rare earth Bastnasite Flotation FT-Ir Zeta potential

Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAr Gamma： A Potential Therapeutic Target in Gliomas

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Neuroscience Bulletin 2018年第3期34卷 573-588页

作者： AlexANDre Vallée Yves lecarpentier rémy Guillevin Jean-Noёl Vallée laboratory of Mathematics and Applications Unites Mixtes de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 7348 University of Poitiers PoitiersFrance Delegation a la recherche Clinique et a l'Innovation (DrCI) Hopital Foch Suresnes France Centre de recherche Clinique Grand Hopital de l'EstFrancilien Meaux France DACTIM UMR CNRS 7348 University of Poitiers et CHU de Poitiers Poitiers France CHU Amiens Picardie University of Picardie Jules VerneAmiens France

In gliomas, the canonical Wingless/Int（WNT）/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma（PPAr-c） is *** two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAr-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAr-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAr-c and thus appear to provide an interesting therapeutic approach for ***（TMZ） is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas.

关键词： WNT/beta-catenin pathway PPAr gamma Glioma STAT3 pathway PI3K/Akt pathway NSAID Curcumin

Metal separations of interest to the Chinese metallurgical industry

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Journal of rare earths 2010年第S1期28卷 22-29页

作者： S.r.Izatt N.e.Izatt r.l.Bruening IBC Advanced Technologies Inc.856 E.Utah Valley DriveAmerican ForkUT 84003U.S.A.

IBC Advanced Technologies’ Molecular recognition Technology(MrT) Superlig products selectively and rapidly bind with target species enabling their selective removal from *** MrT process can produce a high purity separation product of maximum added value at a competitive *** products have high selectivity for many target species which can include metal ions,anions,and neutral *** operation,the Superlig product is first placed in a packed column.A solution containing a mixture of the target species and other chemical species is then passed through the *** target species is removed selectively by the Superlig product,the column is washed to remove residual feed solution,and the target species is recovered by a minimal quantity of *** result is a pure and concentrated species that can be kept for its value or disposed of *** process is environmentally and ecologically friendly with no organic solvents being *** paper provides a review of some examples of applications of MrT to separations of interest to the Chinese metallurgical *** are several applications of MrT,including Pd separations from Pt metal refinery streams and low-grade spent catalyst wastes,rh recovery from spent auto catalyst and other feeds,re removal from selected impurity ions,Cd removal from Co electrolyte,Bi removal from Cu electrolyte,In and Ge separations from difficult matrices,and removal of bivalent first transition series and other metal ions from acid mine drainage(Berkeley Pit,Montana).Finally,the potential application of MrT to separations involving the recovery of rare earth metals and li from low-level waste solutions and end-of-life products is discussed.

关键词： selective and environmentally friendly metal separations molecular recognition technology Superlig platinum group metals minor metals transition series metals rhenium cadmium indium germanium bismuth rare earth metals lithium

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal University Institute of Acoustics Tongji University l.V.Kirensky Institute of Physics Department of Mechanical engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to Δl-4,whereΔl embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Prediction of environment variables in precision agriculture using a sparse model as data fusion strategy

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Information Processing in Agriculture 2022年第2期9卷 171-183页

作者： l.Mancipe-Castro r.e.Gutierrez-Carvajal Multimedia engineering Program/Universidad Militar Nueva Granada Bogota 110111Colombia

Precision agriculture seeks to optimize production processes by monitoring and analyzingenvironmental variables. For example, establishing farming actions on the crop requiresanalyzing variables such as temperature, ambient humidity, soil moisture, solar irradiance,and rainfall. Although these signals might contain valuable information, it is vital to mixup the monitored signals and analyze them as a whole to provide more accurate information than analyzing the signals separately. Unfortunately, monitoring all these variablesresults in high costs. Hence it is necessary to establish an appropriate method that allowsthe infer variables behavior without the direct measurement of all of *** paper introduces a multi-sensor data fusion technique, based on a sparse representation, to find the most straightforward and complete linear equation to predict and understand a particular variable behavior based on other monitored environmental variablesmeasurements. Moreover, this approach aims to provide an interpretable model that allowsunderstanding how these variables are combined to achieve such results. The fusion strategy explained in this manuscript follows a four-step process that includes 1. data cleaning,2. redundant variable detection, 3. dictionary generation, and 4. sparse regression. Thealgorithm requires a target variable and two highly correlated signals. It is essential to pointout that the developed method has no restrictions to specific variables. Consequently, it ispossible to replicate this method for the semiautomatic prediction of multiple critical environmental *** a case study, this work used the SMl2010 data set of the UCI machine learning repository to predicted the humidity’s derivative trend function with an error rate lower than 17%and a mean absolute error lower than 6%. The experiment results show that even thoughsparse model predictions might not be the most accurate compared to those of linearregression (lr), support vector m

关键词： Precision agriculture Multi-sensor data fusion Sparse representation Inference of variables Humidity

Getting physical with medical education:exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal Michele l Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy exercise Online learning

Flotation behavior and electronic simulations of rare earth minerals in the presence of dolomite supernatant using sodium oleate collector

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Journal of rare earths 2019年第1期37卷 101-112,M0005页

作者： e.r.l.e.piritu G.r.da Silva D.Azizi F.larachi K.e.Waters Department of Mining and Materials engineering McGill University Department of Chemical engineering Université Laval

Common rare earth(re) minerals, such as bastnasite and monazite, may be formed in deposits associated with carbonate gangue, such as calcite and dolomite. Sodium oleate is a widely used collector for the flotation of both re and gangue minerals, which might, therefore, be an inefficient process due to the lack of selectivity of this collector. Since these minerals are also sparingly soluble in solution, they could release their constituent ions into the solution, which could affect the floatability of other minerals. In this study, the interactions of sodium oleate with bastnasite and monazite in the presence of dissolved dolomite species have been investigated. Microflotation tests were carried out to explore the effects of these dissolved species on the floatability of the re minerals. Zeta potential measurements and XPS characterization were carried out to understand how the species affect the collector adsorption. To complement these characterizations, density functional theory(DFT) simulations were conducted to investigate the collector-mineral and collector-adsorbed species(on the mineral surface) *** results show that collector-dolomite interaction energy is greater than that of collector-adsorbed species, but lower than collector-monazite interaction energy, explaining the decrease in the minerals' recovery upon exposure to the dissolved mineral species. It is also shown that oleate ions(OI^-) have the strongest interaction with the minerals compared to other oleate species such as acid soap(HOI_2^-) and oleate dimer(OI_2^(2-)). The behavior(strength and selectivity) of sodium oleate towards re minerals and dolomite, as compared to other re mineral collectors(such as aromatic hydroxamate), is attributed mainly to the collector's and the minerals' structure. The long hydrocarbon chain of sodium oleate which imparts hydrophobic characteristic to the minerals, makes it stronger collector than ***, sodium oleate(with linear str

关键词： rare earth minerals Bastnsite Monazite Dolomite Sodium oleate DFT simulation