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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Bone research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander rauch Molecular endocrinology Laboratory(KMeB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems research(IMSr)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and receptors(COMPAre) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on rNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLr1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5Ar1),somatostatin receptor 2(SSTr2),and free fatty acid receptor 4(FFAr4/GPr120).Activating C5Ar1 enhanced osteoclast formation,while activating SSTr2 decreased the resorptive activity of mature osteoclasts,and activating FFAr4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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初次手术切缘阳性的乳腺癌病人残存病灶的乳腺MrI研究

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国际医学放射学杂志 2018年第1期 115-116页

作者： J.Krammer e.r.price M.S.Jochelson e.Watson M.P.Murray S.O.Schoenberg 汤若微 Institute of Clinical radiology and Nuclear Medicine University Medical Center MannheimMedical Faculty MannheimUniversity of Heidelberg

摘要目的探讨术后MrI预测女性乳腺癌病人手术切缘阳性残存病灶的准确性,确定准确界定残留病灶大小阈值的价值。方法该回顾性研究经伦理委员会批准并符合

关键词： MrI 切缘阳性乳腺癌

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Acetabular cup size trends in total hip arthroplasty

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World Journal of Orthopedics 2024年第1期15卷 39-44页

作者： Daniel Patrick McKenna Alex price Timothy McAleese Darren Dahly Paul McKenna May Cleary Department of Trauma and Orthopaedics University Hospital WaterfordWaterford X91 ER8EIreland Department of epidemiology and Public Health University College CorkCork T12 XF62Ireland

BACKGrOUND Total hip arthroplasty(THA)is a common procedure for end stage *** learning curve for THA is complex and *** of the most difficult skills to master is acetabular *** wish to identify if experience in arthroplasty leads to preservation of more bone *** To investigate if increasing surgeon experience will predict an ever decreasing acetabular cup *** A retrospective case series of four attending orthopaedic surgeons was *** uncemented elective total hip arthroplasties since appointment were selected for *** size of acetabular cup used was noted and logistic regression was used to identify if a trend to smaller cups *** A total of 1614 subjects were included with a mean age of 64 *** cups were on average 0.18mm smaller per year(95%confidence interval-0.25 to-0.11,Prgeon trends showed cup sizes to decrease 0.27 mm/year for surgeon A,0.02 mm/year for surgeon B,0.15 mm/year for surgeon C and 0.29 mm/year for surgeon *** of the four surgeons had a more pronounced trend to smaller cups for male subjects than their female *** We found increasing surgeon experience to be associated with an ever-decreasing acetabular cup *** acetabular cup size may act as a surrogate marker of surgical proficiency by virtue of decreased acetabular reaming.

关键词： Hip Arthroplasty Acetabulum Cup Learning

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加利福尼亚乳腺密度信息小组对乳腺密度、乳腺癌风险及乳腺密度告知立法的协作

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国际医学放射学杂志 2014年第1期 80-81页

作者： e.r.price J.Hargreaves J.A.Lipson e.A.Sickles r.J.Brenner K.K.Lindfors 车东东杨迎迎 Department of radiology Stanford University School of Medicine Advanced Medicine Center 875 Blake Wilbur Dr Room CC2239 Stanford Calif

为使加利福尼亚州乳腺密度告知立法,即告知乳腺X线检查中乳腺密度显著增高及不均匀增高女性的风险水平,放射学专家及乳腺癌风险专家成立了工作组来建立其

关键词：乳腺密度乳腺癌乳腺肿瘤乳腺组织加利福尼亚美国

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定性放射基因组学:Oncotype DX检测复发风险评分与BI-rADS乳腺X线摄影和乳腺Mr成像特征的相关性

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国际医学放射学杂志 2018年第2期 213-213页

作者： G.A.Woodard K.M.ray B.N.Joe e.r.price 郝彩仙 Department of radiology and Biomedical Imaging Division of Breast ImagingUniversity of California

摘要目的评价行Oncotype DX检测雌激素受体阳性的乳腺癌病人的乳腺影像报告和数据系统(BI-rADS)乳腺X线摄影和MrI特征与乳腺癌复发风险的相关性。材料与方

关键词： BI-rADS Mr 相关性

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Assessing display variability in wild brown anoles Anolis sagrei using a mechanical lizard model

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Current Zoology 2011年第2期57卷 140-152页

作者： Sarah r. PArTAN Peter OTOVIC Virginia L. price Scott e. BrOWN School of Cognitive Science Hampshire College Amherst MA 01002 USA Department of Psychology University of South Florida St. Petersburg FL 33701 USA

Signals used for species identity ought to be highly stereotyped so as to facilitate immediate recognition by con-specifics. It is surprising therefore to find variability in putative species signature displays. The brown anoleAnolis sagreihas a high degree of variability in its signature bobbing display. In this study we collected descriptive data on variability in the temporal structure of wild brown anole bobbing patterns, finding that no two displays analyzed had the same temporal structure, and we also tested whether wild brown anoles prefer the signature display over an alternate display pattern by using mechanical robot playbacks in the field. As a response metric we assessed whether or not the lizards showed social responses (pushup, dewlap extension, or head-nod) in response to the robotic presentations. We found that the lizards responded slightly more to the signature than to the alternate pattern, providing support for the idea that despite the variability seen in displays, the signature pattern is meaningful to them. We tested two other independent variables: speed of the display and elevation of the robot during its display, neither of which was significant. Dewlap extensions were given predominantly by adult males and were more likely to be given in the breeding season than the nonbreeding season. Pushups and head-nods were given equally by males and a combined class of females and juveniles, and were not seasonal. Head-nods increased after the robot turned off, suggesting that they may be used in a conversational turn-taking style during communication.

关键词：显示模式模型评估棕色野生蜥蜴变异机械非繁殖季节

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.r. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony e. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce e. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan r. Astalos S. Atashi r.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.r. Bailey J.T. Baines L. Baines O.K. Baker e. Bakos D. Bakshi Gupta V. Balakrishnan r. Balasubramanian e.M. Baldin P. Balek e. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz e. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat e.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JeT QUArK GLUON TAGGING

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SOLITON SOLUTIONS OF A CLASS OF GeNerALIZeD NONLINeAr SCHrODINGer eQUATIONS

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Applied Mathematics(A Journal of Chinese Universities) 1997年第4期12卷 389-398页

作者： CAOQINGJIe ZHANGTIANDe K.DJIDJeLI G.W.price e.H.TWIZeLL DepartmentofMathematicsandPhysics ShangdongUniversityofTechnologyJinan.Chlna250061 DepartmentoFMathematicsandPhysics ShangdongUniver.~ityo~Tecl~nologyJinan.China250061 DepartmentofShipScience UniversityofSouthamptonSouthamptonSo171BJEngland. DepartmentofShipScience UniversityofSouthamptonSouthamptonSO171BJEngland DepartmentofMathematicsandStatistics BrunelUniversityUxbridgeMiddlesexUB83PHEngland.

Soliton solutions of a class of generalized nonlinear evolution equations are discussed analytically and numerically. This is done by using a travelling wave method to formulate one soliton solution and the finite difference method to the numerical solutions and the interactions between the solitons for the generalized nonlinear Schrdinger equations. The characteristic behavior of the nonlinearity admitted in the system has been investigated and the soliton states of the system in the limit when α→0 and α→∞ have been studied. The results presented show that the soliton phenomenon is characteristics associated with the nonlinearities of the dynamical systems.

关键词： Generalized nonlinear Schrodinger equation Soliton solution Weighted six-point scheme

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Drosophila seizure disorders： genetic suppression of seizure susceptibility

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Frontiers in Biology 2016年第2期11卷 96-108页

作者： Arunesh Saras Laura e. Simon Harlan J. Brawer richard e. price Mark A. Tanouye Division of Organismal Biology Department of Environmental Science Policy and Management University of California Berkeley CA 94720 USA Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA

Various Drosophila models of human disease have recently received increased interest. The main goal is to uncover the fundamental biological basis for human pathology taking advantage of the power of Drosophila genetics. This review examines a set of Drosophila seizure-sensitive mutations that model human seizure disorders, especially epilepsy. Also described is a novel set of mutations that act as seizure-suppressors that ameliorate epilepsy phenotypes in double mutant combinations.

关键词： Drosophila epilepsy seizure disorders sodium channel seizttre-suppressor genes

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科技期刊的作者分类方法及作者群建设策略——以《服装学报》为例

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中国科技期刊研究 2024年第1期35卷 130-136页

作者：沈天琦梁惠娥潘如如江南大学《服装学报》编辑部江苏省无锡市号214122 江南大学纺织科学与工程学院江苏省无锡市号214122 江南大学设计学院江苏省无锡市号214122 无锡学院传媒与艺术学院江苏省无锡市214105

【目的】针对不同类型的作者提出分类建设策略,以提升稿源质量,实现纺织服装类科技期刊的良性、可持续发展。【方法】以《服装学报》作者为例,根据普赖斯定律、指数计算法、混合选取法,定量分析2016—2022年《服装学报》所有作者的发文... 详细信息

【目的】针对不同类型的作者提出分类建设策略,以提升稿源质量,实现纺织服装类科技期刊的良性、可持续发展。【方法】以《服装学报》作者为例,根据普赖斯定律、指数计算法、混合选取法,定量分析2016—2022年《服装学报》所有作者的发文量和对期刊的影响力,并将其分为核心作者、进取型作者、潜力作者、成长型作者4类,有针对性地提出分类建设策略。【结果】发文量≥3篇、影响力指数≥5的作者为《服装学报》的核心作者;发文量≥3篇、影响力指数≤-5的作者为进取型作者;发文量为1篇、影响力指数≥5的作者为潜力作者;发文量为1篇、影响力指数≤-5的作者为成长型作者。编辑通过维系核心作者、服务进取型作者、拓展潜力作者、培养成长型作者,进行作者群分类建设,提升稿源质量。【结论】作者群分类建设是科技期刊培养作者队伍、提升论文质量的重要策略,也是推进期刊高质量发展的重要环节。纺织服装类科技期刊需注重作者队伍建设,树牢期刊发展的根基,以增强在行业内的学术引领能力。

关键词：科技期刊纺织服装作者分类作者群建设

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