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Supplementation of vitamin e or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia V.Silva‑Guillen Consuelo Arellano Jeffrey Wiegert R.Dean Boyd Gabriela e.martinez eric van Heugten Department of Animal Science North Carolina State UniversityRaleighNC 27695USA Department of Statistics North Carolina State UniversityRaleighNC 27695USA Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Animal Nutrition Research LLCAlvatonKY 42122USA.

Background Heat stress has severe negative consequences on performance and health of pigs,leading to significant economic *** objective of this study was to investigate the effects of supplemental vitamin e and a botanical extract in feed or drinking water on growth performance,intestinal health,and oxidative and immune status in grow-ing pigs housed under heat stress *** Duplicate experiments were conducted,each using 64 crossbred pigs with an initial body weight of 50.7±3.8 and 43.9±3.6 kg and age of 13-week and 12-week,***(n=128)were housed individually and assigned within weight blocks and sex to a 2×4 factorial arrangement consisting of 2 environments(thermo-neutral(21.2℃)or heat-stressed(30.9℃))and 4 supplementation treatments(control diet;control+100 IU/L of D-α-tocopherol in water;control+200 IU/kg of DL-α-tocopheryl-acetate in feed;or control+400 mg/kg of a botanical extract in feed).Results Heat stress for 28 d reduced(P≤0.001)final body weight,average daily gain,and average daily feed intake(-7.4 kg,-26.7%,and-25.4%,respectively)but no effects of supplementation were detected(P>0.05).Serum vitamin e increased(Pe supplementation in water and in feed(1.64 vs.3.59 and 1.64 vs.3.24),but not for the botanical extract(1.64 vs.1.67 mg/kg)and was greater when supplemented in water ***(P=0.002).Liver vitamin e increased(Pe supplementations in water(3.9 vs.31.8)and feed(3.9 vs.18.0),but not with the botanical extract(3.9 vs.4.9 mg/kg).Serum malondialdehyde was reduced with heat stress on d 2,but increased on d 28(interaction,Peater(Pementation compared to *** proliferation was reduced(P=0.037)in the jejunum under heat stress,but increased in the ileum when vitamin e was supplemented in feed and water under heat stress(interaction,P=0.04).Tumor necrosis factor-αin jejunum and ileum mucosa decreased by heat stress(Pe

关键词： Botanical extract Growing pigs Heat stress Immune status Oxidative status Tocopherol Water

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On q-n-gonal Klein Surfaces

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Acta Mathematica Sinica,english Series 2007年第10期23卷 1833-1844页

作者： B.eSTRADA R.A.HIDALGO e.martinez Departamento de Matemáticas Fundamentales UNEDPaseo Senda del Rey 928040 MadridSpain Departamento de Matemática Universidad Técnica Federico Santa MaríaCasilla 110-V ValparaisoChile

We consider proper Klein surfaces X of algebraic genus p ≥ 2, having an automorphism φ of prime order n with quotient space X/（φ） of algebraic genus q. These Klein surfaces axe called q-n-gonal surfaces and they are n-sheeted covers of surfaces of algebraic genus q. In this paper we extend the results of the already studied cases n ≤ 3 to this more general situation. Given p ≥ 2, we obtain, for each prime n, the （admissible） values q for which there exists a q-n-gonal surface of algebraic genus p. Furthermore, for each p and for each admissible q, it is possible to check all topological types of q-n-gonal surfaces with algebraic genus p. Several examples are given： q-pentagonal surfaces and q-n-gonal bordered surfaces with topological genus g = 0, 1.

关键词： Klein surfaces Riemann surfaces automorphism groups non-euclidean crystallographic groups

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Microstructures and Hardness Properties for β-Phase Ti-24Nb-4Zr-7.9Sn Alloy Fabricated by electron Beam Melting

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Journal of Materials Science & Technology 2013年第11期29卷 1011-1017页

作者： J.Hernandez S.J.Li e.martinez L.e.Murr X.M.Pan K.N.Amato X.Y.Cheng F.Yang C.A.Terrazas S.M.Gaytan Y.L.Hao R.Yang F.Medina R.B.Wicker Department of Metallurgical and Materials engineering The University of Texas at El Paso Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences School of Materials Science and engineering Dalian University of Technology W.M.Keck Center for 3D Innovation The University of Texas at E1 Paso

Atomized, pre-alloyed Ti-24Nb-4Zr-7.9Sn （wt%） powder was used to fabricate solid, prototype components by electron beam melting （eBM）. Vickers microindentation hardness values were observed to average 2 GPa for the precursor powder and 2.5 GPa for the solid, eBM-fabricated products. The powder and solid product microstructures were examined by optical and electron microscopy. X-ray diffraction analyses showed that they had bcc β-phase microstructure. However, it was found by transmission electron microscopy that the eBM-fabricated product had plate morphology with space -100-200 nm. Although the corresponding selected area diffraction patterns can be indexed by β-phase plus α＂-martensite with orthorhombic crystal structure, the dark-field analyses failed to observe the α＂-martensite. Such phenomenon was also found in deformed gum metals and explained by stress-induced diffusion scattering due to phonon softening.

关键词： Biomedical titanium alloy β-Martensite electron beam melting Hardness Optical and electron microscopy

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钢水二次精炼和凝固时CaS的形成

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电工钢 1996年第8期 32-36页

作者：Ｅ．Ｍａｒｔｉｎｅｚ

钢水二次精炼和凝固时ＣａＳ的形成［英］Ｅ．Ｍａｒｔｉｎｅｚ等１前言非金属夹杂物的控制是很复杂的，特别是对钢的质量越来越高时尤其如此。非金属夹杂物的范围包括析出的ＣａＳ颗粒。在二次精炼和连铸中ＣａＳ颗粒的形成取决于钢液... 详细信息

钢水二次精炼和凝固时ＣａＳ的形成［英］Ｅ．Ｍａｒｔｉｎｅｚ等１前言非金属夹杂物的控制是很复杂的，特别是对钢的质量越来越高时尤其如此。非金属夹杂物的范围包括析出的ＣａＳ颗粒。在二次精炼和连铸中ＣａＳ颗粒的形成取决于钢液中硫、铝、钙的含量。但是其它一些基...

关键词：非金属夹杂物碱度钢中液相线连铸二次精炼出钢连续铸造 CaS 钢包炉钢水熔融金属

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MicroRNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment

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Neural Regeneration Research 2024年第7期19卷 1523-1531页

作者： Bridget martinez Philip V.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Chara cterized by positive symptoms(such as changes in behavior or thoughts,including delusions and hallu cinations),negative symptoms(such as apathy,anhedonia,and social withdrawal),and cognitive impairments,schizophrenia is a chro nic,severe,and disabling mental disorder with late adolescence or early adulthood onset,Antipsychotics are the most commonly used drugs to treat schizophrenia,but those currently in use do not fully reverse all three types of symptoms characte rizing this *** is frequently misdiagnosed,resulting in a delay of or inappropriate *** expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of *** recent studies reviewed included microRNA profiling in blood-and urine-based materials and nervous tissue mate *** the studies that had validated the preliminary findings,potential candidate biomarkers for schizophrenia in adults could be miR-22-3p,-30e-5p,-92a-3p,-148b-5p,-181a-3p,-181a-5p,-181b-5p,-199 b-5p,-137 in whole blood,and miR-130b,-193a-3p in blood *** treatment of schizophrenia patients was found to modulate the expression of certain microRNAs including miR-130b,-193a-3p,-132,-195,-30e,-432 in blood *** studies are warranted with adolescents and young adults having schizophrenia and consideration should be given to using animal models of the disorder to investigate the effect of suppressing or overexpressing specific microRNAs.

关键词： antipsychotics biomarkers blood exosomes blood plasma brain tissue exosomes brain tissues leukocytes microRNAs neural stem cells olfactory neuroepithelium schizophrenia whole blood

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MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder

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Neural Regeneration Research 2024年第3期19卷 557-562页

作者： Bridget martinez Philip V.Peplow Department of Pharmacology University of Nevada-RenoRenoUSA Department of Medicine University of Nevada-RenoRenoUSA Department of Anatomy University of OtagoDunedinNew Zealand

Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric *** cognitive function and learning ability of children with attention deficit hyperactivity disorder are affected,and these symptoms may persist to adulthood if they are not *** diagnosis of attention deficit hyperactivity disorder is only based on symptoms and objective tests for attention deficit hyperactivity disorder are *** for attention deficit hyperactivity disorder in children include medications,behavior therapy,counseling,and education services which can relieve many of the symptoms of attention deficit hyperactivity disorder but cannot cure *** is a need for a molecular biomarker to distinguish attention deficit hyperactivity disorder from healthy subjects and other neurological conditions,which would allow for an earlier and more accurate diagnosis and appropriate treatment to be *** expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of attention deficit hyperactivity *** recent studies reviewed had performed microRNA profiling in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactivity disorder.A large number of microRNAs were dysregulated when compared to healthy controls and with some overlap between individual *** the studies that had included a validation set of patients and controls,potential candidate biomarkers for attention deficit hyperactivity disorder in children could be miR-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood *** studies are warranted with children and adults with attention deficit hyperactivity disorder,and

关键词： adults attention deficit hyperactivity disorder biomarkers blood plasma blood serum children microRNA total white blood cells whole blood

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重晶石浮选新工艺的研究

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国外金属矿选矿 1976年第Z3期 24-27页

作者： e.martinez 简火根

研究的样品含BaSO大约16％,并且80％-325目。以前的浮选重晶石的方法,未能得到满意的品位和重晶石的回收率,其原因是给矿品位低,此外还含有6％的方解石。混合添加新的长碳链磺化丁酰胺捕收剂与高浓度的硅酸钠并采用简单的粗选-精选流程... 详细信息

研究的样品含BaSO大约16％,并且80％-325目。以前的浮选重晶石的方法,未能得到满意的品位和重晶石的回收率,其原因是给矿品位低,此外还含有6％的方解石。混合添加新的长碳链磺化丁酰胺捕收剂与高浓度的硅酸钠并采用简单的粗选-精选流程,所得到的重晶石精矿可达到油钻泥浆(oil-drilling mud)的需要。磨细的矿石并可不需脱泥。得到的重晶石回收率超过80％,精矿产品的比重大于4.3。在研究工作的过程中,应用了红外线(IR)分光光度计对试样中的重晶石,方解石,石英和长石进行了半定量的分析,还用热天平分析了方解石的含量。这些仪器能迅速地进行矿物分析。实验证明:使用这些仪器对指导浮选研究有很大的帮助。

关键词：方解石回收率实收率硫酸盐矿物重晶石架状硅酸盐矿物长石重晶石精矿粗精矿硅氧矿物石英品位

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Quality evaluation of Nothofagus pumilio seeds linked to forest management and climatic events

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ecological Processes 2024年第1期13卷 98-107页

作者： Julian Rodríguez-Souilla Jimena e.Chaves María Vanessa Lencinas Juan Manuel Cellini Fidel A.Roig Pablo L.Peri Guillermo martinez Pastur Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de la Plata (UNLP) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IAN-IGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background Forest ecosystems undergo significant transformations due to harvesting and climate fluctuations, emphasizing the critical role of seeding in natural regeneration and long-term structural preservation. Climate change further amplifies these dynamics, affecting phenology across species and regions. In Tierra del Fuego(Argentina), Nothofagus pumilio(lenga) forests represent the most important timber resource, and it is managed through different silvicultural strategies. This species demonstrates notable post-disturbance regeneration, yet seed fall exhibits signifi-cant variability, leading to variations in seed quality(e.g., viability). This study aims to assess fluctuations in N. pumilio seed quality, determine how it varies concerning forest management strategies, annual productivity, and the co-occurrence of climatic phenomena including el Ni?o-Southern Oscillation(eNSO) and the Southern Annular Mode(SAM).Results Viable seeds represented 18.4% of the total, notably higher in unharvested than in managed areas. Con-versely, empty seeds were more prevalent in harvested areas(> 75%). Seed quality exhibited significant differences across silvicultural treatments, except for insect-predated seeds, which had similar proportions across all areas, though dispersed retention showed higher predation. When considering years with varying production levels, high-production years favoured full and viable seeds, particularly in unharvested forests and aggregated retention, while low-production years saw reduced viability across all treatments. Quadratic models revealed that viability increased with seed production, where unharvested forests achieved the highest values. Climate variability influenced seed proportions, where eNSO+/SAM+ promoting more full and viable seeds, while eNSO–/SAM+ favoured non-predated seeds, especially in unharvested *** Seed quality varies among treatments and years with different levels of seeding. Variations in seed qual-ity, l

关键词： Forest management Seeding Climate change extreme event Patagonia

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On the Use of Monotonicity-Preserving Interpolatory Techniques in Multilevel Schemes for Balance Laws

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1319-1341页

作者： Antonio Baeza Rosa Donat Anna martinez-Gavara Department de Matematiques Universitat de ValenciaDr.Moliner5046100 BurjassotValenciaSpain Department d'estadistica i Investigacio Operativa Universitat de ValenciaDr.Moliner5046100BurjassotValenciaSpain

Cost-effective multilevel techniques for homogeneous hyperbolic conservation laws are very successful in reducing the computational cost associated to high resolution shock capturing numerical *** they do not involve any special data structure,and do not induce savings in memory requirements,they are easily implemented on existing codes and are recommended for 1D and 2D simulations when intensive testing is *** multilevel technique can also be applied to balance laws,but in this case,numerical errors may be induced by the *** present a series of numerical tests that point out that the use of monotonicity-preserving interpolatory techniques eliminates the numerical errors observed when using the usual 4-point centered Lagrange interpolation,and leads to a more robust multilevel code for balance laws,while maintaining the efficiency rates observed forhyperbolic conservation laws.

关键词： Hyperbolic balance laws Well-balanced schemes Multilevel schemes Harten's multiresolution

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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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