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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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In-port-plug transmission line design of the ITeR plasma position reflectometer

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Plasma Science and Technology 2020年第6期22卷 15-20页

作者： j MARTÍNeZ-FeRNÁNDeZ ÁCAPPA A SIMONeTTO T eSTRADA e De LA LUNA e.j blanco Laboratorio Nacional de Fusión.CIeMAT Avda Complutense 40.Madrid 28040Spain CNR-ISTP via Cozzi 5320125 MilanoItaly

This work describes the microwave design of the transmission line housed in the in-port-plug region of the ITeR plasma position reflectometer(PPR).The design of the components of the inport-plug reflectometers(located in equatorial port-plug 10(ePP10) and in upper-port-plug 01(UPP01)) is *** a 3 D ray tracing code, the spatial position and optimum orientation angles of each set of emission and detection antennas were determined.A feasible path was then created from the obtained antenna positions and orientations to the primary vacuum *** tall waveguides were chosen to reduce ohmic *** to space constraints in the ITeR crowded environment, bends in oversized waveguides were unavoidable, and thus mode conversion was *** keep mode conversion losses at bay, hyperbolic secant curvature bends had to be used whenever ***, e-plane bends in tall waveguides proved to be especially critical, making it necessary to employ other approaches when higher bending angles were *** conversion results were obtained by evaluating the mode coupling *** losses have also been computed and their results compared with commercial simulators, obtaining a perfect agreement.

关键词： reflectometry microwave technology ITeR diagnostic

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Spectral signatures of hydrilla from a tank and field setting

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Frontiers of earth Science 2012年第4期6卷 453-460页

作者： Alfonso blanco john j. QU William e. ROPeR George Mason University College of Science Department of Geography and Geoinforrnation Sciences 4400 University Drive Fairfax VA 22030 USA

The invasion of hydrilla in many waterways has caused significant problems resulting in high main- tenance costs for eradicating this invasive aquatic weed. Present identification methods employed for detecting hydrilla invasions such as aerial photography and videos are difficult, costly, and time consuming. Remote sensing has been used for assessing wetlands and other aquatic vegetation, but very little information is available for detecting hydrilla invasions in coastal estuaries and other water bodies. The objective of this study is to construct a library of spectral signatures for identifying and classifying hydrilla invasions. Spectral signatures of hydrilla were collected from an experimental tank and field locations in a coastal estuary in the upper Chesapeake Bay. These measurements collected from the experimental tank, resulted in spectral signatures with an average peak surface reflectance in the near-infrared （NIR） region of 16% at a wavelength of 818 nm. However, the spectral measure- ments, collected in the estuary, resulted in a very different spectral signature with two surface reflectance peaks of 6% at wavelengths of 725 nm and 818 nm. The difference in spectral signatures between sites are a result of the components in the water column in the estuary because of increased turbidity （e.g., nutrients, dissolved matter and suspended matter）, and canopy being lower （submerged） in the water column. Spectral signatures of hydrilla observed in the tank and the field had similar characteristics with low reflectance in visible region of the spectrum from 400 to 700 nm, but high in the NIR region from 700 to 900 nm.

关键词： Chesapeake Bay hydrilla spectral library spectral signatures near-infrared NDVI

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Consumer willingness to pay for plastic bags levy and willingness to accept eco-friendly alternatives in Botswana

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Chinese.journal of Population,Resources and environment 2017年第3期15卷 255-261页

作者： Patricia K.Madigele Goemeone e.j Mogomotsi Mavis Kolobe Okavango Research Institute University of Botswana Department of Legal Services Office of the Vice ChancellorUniversity of Botswana Department of economics Faculty of Social Sciences University of Botswana

Plastic bags, though commonly used for packaging of goods, are highly durable and non- biodegradable. Plastic bag litter serves as a negative environmental externality detrimental to animal health and natural beauty of the environment. In an effort to curtail the excessive use of plastic bags in Botswana, the government introduced a plastic levy targeted at consumers at retail points. This study uses primary data collected from 367 respondents randomly selected from six geospatially and purposively selected shopping malls to determine the consumers＇ willingness to pay （WTP） for continued plastic bag usage and their willingness to accept （WTA） to shift to eco-friendly alternatives. The results of the study revealed that open dumping and burning of plastic litter are more common in Maun than in Gaborone, It also showed that there is a significant relationship between the level of education and W＇FP. Further, there is a significant variation in income and education in respect to environmental awareness. The government should improve its efforts of sensitizing the public about the improper disposal of plastic bags.

关键词： Willingness to pay willingness to accept plasticbags plastic bag levy environmental externality

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Community participation in cultural heritage and environmental policy formulation in Botswana

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Chinese.journal of Population,Resources and environment 2018年第2期16卷 171-180页

作者： Goemeone e.j Mogomotsi Patricia K Mogomotsi Reniko Gondo Tshenolo j Madigele Department of Legal Services Office of the Vice Chancellor University of Botswana Okavango Research Institute University of Botswana Department of Theology and Religious Studies University of Botswana

Cultural heritage does not have direct economic benefits. However, if properly managed it can stimulate social cohesions, improving the environment and have beneficial economic spin offs for the local communities. This paper discusses the role of communities in the formulation of the policies concerning their local environment. It argues that community engagement by policy makers is important in giving legitimacy and ownership of the policies. Furthermore, this paper discusses the potential of cultural heritage in diversifying the economy in Botswana. This paper recommends for the re-assessment of the relationship between the state and local communities which is critical in resuscitating the seemingly ailing community business organizations. In conclusion, it argues for the sustainable management of cultural heritage as a social and economic resource in the next 50 years of Botswana's independence.

关键词： Cultural heritage sustainable economic growth local communities policy formulation

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3D printing of patient-specific 316L–stainless–steel medical implants using fused filament fabrication technology: two veterinary case studies

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Bio-Design and Manufacturing 2022年第4期5卷 808-815页

作者： j.M.Chacón P.j.Núñez M.A.Caminero e.García-Plaza j.Vallejo M.blanco escuela Técnica Superior de Ingeniería Industrial Universidad de Castilla-La ManchaAvdaCamilo JoséCela213071 Ciudad RealSpain Protresde Ingeniería y Soluciones C/Solana 60nave 313005 Ciudad RealSpain

Biomedical fracture fixation implants have complex sculptured geometries to adapt perfectly to fractured bones,making them difficult and expensive to manufacture with conventional machining methods. Fused filament fabrication(FFF) is a very popular Additive Manufacturing technology that simplifies the manufacture of parts with complex geometries, making it ideal for the manufacture of customized medical implants.

关键词： steel fracture fused

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Surgeon＇s Innovation Lets a Girl Breathe Normally--one tough cookie of a patient defies odds

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空中英语教室（高级版．彭蒙惠英语） 2016年第12期 24-25,44,45页

作者： e.j, Smith III

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eDB中微米单颗粒振荡特性

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化工学报 2004年第6期55卷 902-906页

作者：冯昭华朱家骅杨雪峰夏素兰关国强 Davis e.j 四川大学化学工程学院四川成都610065 华盛顿大学化工系

改进了Davis关于微米单颗粒在eDB(electrodynamicbalance)中悬浮的两区理论 ,通过引入Oseen曳力公式和非齐次项 ,建立了振荡条件下颗粒完整的运动微分方程 ,并对其运动轨迹进行了数值模拟 .从理论上证实了颗粒在eDB中存在稳定的阻尼振... 详细信息

改进了Davis关于微米单颗粒在eDB(electrodynamicbalance)中悬浮的两区理论 ,通过引入Oseen曳力公式和非齐次项 ,建立了振荡条件下颗粒完整的运动微分方程 ,并对其运动轨迹进行了数值模拟 .从理论上证实了颗粒在eDB中存在稳定的阻尼振荡过渡区 ,给出了不同于Davis理论的三区状态图 (δ β图 ) ,从而构建了振荡条件下颗粒eDB研究的理论基础 .这些理论结果的可靠性通过实验也得到了很好的验证 .

关键词： eDB 微米单颗粒振荡特性运动轨迹数值模拟

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epithelial-mesenchymal transition in prostate cancer： providing new targets for therapy

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Asian journal of Andrology 2011年第2期13卷 179-180页

作者： Andrew j Armstrong Stephen，Freedland Mariano Garcia-blanco Duke Cancer Institute Departments of Medicine and Surgery Duke Prostate Center Duke University Durham NC 27710 USA Section of Urology Durham VA Medical Center Duke Prostate Center Division of Urologic Surgery Departments of Surgery and Pathology Duke University Medical Center Durham NC 27710 USA Department of Molecular Genetics and Microbiology Department ol Medicine Center for RNA Biology Duke Universit＇ Medical Center NC 27710 USA

The ability of epithelial cells to undergo phenotypic transitions during embryo-genesis, wound healing and malignant pro- gression is now widely accepted as a core biological process termed epithelialmesenchymal transition （eMT）. During cancer progression, the process of eMT has been associated with the acquisition of stemness properties, treatment resistance and metastatic progression, hallmarks of malig- nancy.

关键词： Cells Lymphocytes Associations Cancer (genus) Neoplasms Processing Models Crossing over Proteins Castration

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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