检索结果-南通市图书馆

对疼痛线索的晚期注视偏向预测慢性疼痛的维持:来自眼动的证据

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

心理学报 2024年第1期56卷 44-60页

作者：杨周朱嘉雯苏琳熊明洁 todd Jackson 西南大学心理学部认知与教育部重点实验室西南大学医院重庆400715 澳门大学心理学院中国澳门999078

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研... 详细信息

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研究发现,点探测视觉任务中,慢性疼痛患者在前3个时间窗上(0~500 ms、500~1000 ms、1000~1500 ms)对疼痛线索的注视偏向显著高于对中性线索的注视偏向,但在第四个时间窗上(1500~2000ms)不存在差异;融入真实疼痛刺激的视觉任务中,慢性疼痛患者在4个时间窗上对疼痛线索的注视偏向均显著高于对中性线索的注视偏向。分层标准多元回归模型和机器学习回归模型均发现,慢性疼痛患者在两个任务中对疼痛线索的晚期注视偏向(1000~1500ms、1500~2000ms两个时间窗),均可以独立预测6个月后慢性疼痛强度和功能损伤的维持。研究结果表明,尽管慢性疼痛患者对疼痛线索从注意早期就表现出注视偏向,但是只有晚期的注视偏向能够预测慢性疼痛的维持。

关键词：慢性疼痛疼痛强度功能损伤注视偏向眼动追踪

Successful endoscopic treatment of colonic gallstone ileus using electrohydraulic lithotripsy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2010年第12期16卷 1533-1536页

作者： Martin D Zielinski Lincoln e Ferreira todd H Baron Division of Trauma Critical Care and General Surgery Department of Medicine Federal University of Juiz de Fora Department of gastroenterology and Hepatology

The surgical management of gallstone ileus is complex and potentially highly *** management requires enterolithotomy and is generally followed by fistula resection at a later *** have been reports of gallstone extraction using various endoscopic modalities to relieve the obstruction,however,to date,there has never been a published case of endoscopic stone extraction from the colon using electrohydraulic *** this report,we present the technique employed to successfully perform an electrohydraulic lithotripsy for removal of a large gallstone impacted in the sigmoid colon.A cavity was excavated in an obstructing 4.1 cm lamellated stone in the sigmoid colon using electrohydraulic lithotripsy.A screw stent retractor and stent extractor bored a larger lumen which allowed for guidewire advancement and stone fracture via serial pneumatic balloon *** stone fragments were *** lithotripsy is a safe and effective method to treat colonic obstruction in the setting of gallstone ileus.

关键词： gallstone ileus endoscopy electrohydraulic lithotripsy Bowel obstruction Colon

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States gangarosa Department of environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKgROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTg edgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

general synthesis of silica-based yolk/shell hybrid nanomaterials and in vivo tumor vasculature targeting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2018年第9期11卷 4890-4904页

作者： Feng Chen Shreya goel Sixiang Shi todd e. Barnhart Xiaoli Lan Weibo Cai Department of Radiology University of Wisconsin-Madison W153705 USA Materials Science Program University of Wisconsin-Madison W153705 USA Department of Medical Physics University of Wisconsin-Madison WI 53705 USA Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China University of Wisconsin Carbone Cancer Center Madison W153705 USA

Multifunctional yolk/shell-structured hybrid nanomaterials have attracted increasing interest as theranostic nanoplatforms for cancer imaging and therapy. However, because of the lack of suitable surface engineering and tumor targeting strategies, previous research has focused mainly on nanostructure design and synthesis with few successful examples showing active tumor targeting after systemic administration. In this study, we report the general synthetic strategy of chelator-free zirconium-89 （89Zr）-radiolabeled, TRC105 antibody-conjugated, silica-based yolk/sheU hybrid nanopartides for in vivo tumor vasculature targeting. Three types of inorganic nanoparticles with varying morphologies and sizes were selected as the internal cores, which were encapsulated into single hollow mesoporous silica nanosheUs to form the yolk/sheU-structured hybrid nanopartides. As a proof-of-concept, we demonstrated successful surface functionalization of the nanoparticles with polyethylene glycol, TRC105 antibody （specific for CD105/endoglin）, and ~Zr （a positron-emitting radioisotope）, and enhanced in vivo tumor vasculature-targeted positron emission tomography imaging in 4T1 murine breast tumor-bearing mice. This strategy could be applied to the synthesis of other types of yolk/shell theranostic nanoparticles for tumor- targeted imaging and drug delivery.

关键词： yolk/shelLintrinsic radiolabeling vasculature targeting positron emission tomography zirconium-89

Seasonal influence and local factors affecting macroinvertebrate structure in a high-altitude Andean stream

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2020年第6期17卷 1374-1386页

作者： SCHeIBLeR erica e FeRNáNDeZ CAMPóN Florencia LAgOS SILNIK Susana WeLLNITZ todd Laboratorio de entomologia IADIZACCT CONICET MendozaAvenida Ruiz Leal s/nParque Gral.San MartinCC 5075500MendozaArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICeT) Avenida Rivadavia 1917C1033AAJCABAArgentina Facultad de Ciencias exactas y Naturales Universidad Nacional de CuyoPadre Jorge Contreras 1300M5502JMA MendozaArgentina Biology Department University o f Wisconsin-Eau Claire105 Garfield Avenue54701Eau ClaireWisconsinUSA

Small water bodies are critical for maintaining freshwater biodiversity,but are among the least investigated aquatic *** examined physical and chemical variables at two reaches in Arroyo Tambillos,a small,high-elevation Andean stream,in NW Mendoza province,Argentina,across four seasons to examine how local factors and seasonality affected the structure of the macroinvertebrate *** Arroyo Tambillos community was numerically dominated by ephemeropterans(mainly Massartellopsis irarrazavali)while the dipteran Chironomidae were the most species *** macroinvertebrate abundance was highest in summer,driven mainly by taxa that were secondary in dominance(Austrelmis *** Andesiops peruvianus),while richness did not differ between ***,benthic composition was different in Fall 2013(March)compared to other seasons,largely because of the increased abundance of *** correspondence analysis discriminated Chironomidae species distributions in Fall 2013 by substrate type(i.e.,big and small boulder substrate).By contrast,discharge,velocity,and depth were the variables which most affected the macroinvertebrate abundance and *** to our expectations,most community changes observed occurred in fall instead of ***-kryal stream communities like the one described here have become increasingly important for conserving mountain stream biodiversity as anthropogentic impacts and climate change increasingly impact lower stream ***,monitoring high-altitude streams like the Arroyo Tambillos may be critical for preventing the future loss of unique and sensitive stream biota.

关键词： ephemeroptera dominance Chironomidae richness Mountain small stream Physical variables Biodiversity ecosystem

Analysis of trace dicyandiamide in stream water using solid phase extraction and liquid chromatography UV spectrometry

在线全文

学校读者我要写书评

暂无评论

Journal of environmental Sciences 2015年第9期27卷 38-42页

作者： Huidong Qiu Dongdi Sun Sameera R.gunatilake Jinyan She todd e.Mlsna Department of Chemistry and Chemical engineering Chongqing University of Science and Technology Department of Chemistry Mississippi State University

An improved method for trace level quantification of dicyandiamide in stream water has been developed. This method includes sample pretreatment using solid phase *** extraction procedure（including loading, washing, and eluting） used a flow rate of1.0 m L/min, and dicyandiamide was eluted with 20 m L of a methanol/acetonitrile mixture（V/V = 2：3）, followed by pre-concentration using nitrogen evaporation and analysis with high performance liquid chromatography–ultraviolet spectroscopy（HPLC–UV）. Sample extraction was carried out using a Waters Sep-Pak AC-2 Cartridge（with activated carbon）.Separation was achieved on a ZIC-Hydrophilic Interaction Liquid Chromatography（ZIC-HILIC）（50 mm × 2.1 mm, 3.5 μm） chromatography column and quantification was accomplished based on UV absorbance. A reliable linear relationship was obtained for the calibration curve using standard solutions（R^2〉 0.999）. Recoveries for dicyandiamide ranged from 84.6% to 96.8%, and the relative standard deviations（RSDs, n = 3） were below 6.1% with a detection limit of 5.0 ng/m L for stream water samples.

关键词： Dicyandiamide Solid phase extraction Stream water samples High performance liquid chromatography–ultraviolet spectrometry

The acceleration of a high-charge electron bunch to 10 geV in a 10-cm nanoparticle-assisted wakefield accelerator

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at extremes 2024年第1期9卷 15-24页

作者： Constantin Aniculaesei Thanh Ha Samuel Yoffe Lance Labun Stephen Milton edward McCary Michael M.Spinks Hernan J.Quevedo Ou Z.Labun Ritwik Sain Andrea Hannasch Rafal Zgadzaj Isabella Pagano Jose A.Franco-Altamirano Martin L.Ringuette erhart gaul Scott V.Luedtke ganesh Tiwari Bernhard ersfeld enrico Brunetti Hartmut Ruhl todd Ditmire Sandra Bruce Michael e.Donovan Michael C.Downer Dino A.Jaroszynski Bjorn Manuel Hegelich University of Texas at Austin AustinTexas 78712USA SUPA Department of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Systems Inc.AustinTexas 78701USA Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Brookhaven National Laboratory UptonNew York 11973USA Ludwig-Maximilians-Universität MunichGermany

An intense laser pulse focused onto a plasma can excite nonlinear plasma *** appropriate conditions,electrons from the background plasma are trapped in the plasma wave and accelerated to ultra-relativistic *** scheme is called a laser wakefield *** this work,we present results from a laser wakefield acceleration experiment using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the *** find that a 10-cm-long,nanoparticle-assisted laser wakefield accelerator can generate 340 pC,10±1.86 geV electron bunches with a 3.4 geV rms convolved energy spread and a 0.9 mrad rms *** can also produce bunches with lower energies in the 4–6 geV range.

关键词： acceleration nanoparticle charge

Recent developments in the detection of melamine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第7期13卷 525-532页

作者： Yuan LIU ewen e.D.todd Qiang ZHANg Jiang-rong SHI Xian-jin LIU Key Laboratoy.of Food Quality and Safety of Jiangsu Province Nanjing 210014China Michigan State Universities East Lansing 48824-1212USA

In recent years,there were two reported outbreaks of food borne illness associated with *** presence of melamine and its related compounds in milk,feed,and other foods has resulted in the need for reliable methods for the detection and accurate quantification of this class of *** sample pretreatment for melamine in a complex matrix usually involves a liquid extraction by a polar solvent,followed by a further clean-up with solid phase *** of melamine and related compounds are commonly carried out by liquid or gas chromatographic methods conjugated with mass *** innovative screening methods,which use antibodies,molecularly imprinted polymers,capillary electrophoresis,and gold nanoparticles,are also used to develop assays and biosensors to ***,many of these methods have been hindered by matrix effects,the solubility of melamine-cyanuric acid complex,and background *** article reviews recent developments for detecting melamine and discusses future directions.

关键词： Melamine Detection Confirmation methods Screening methods Sample pretreatment

Upper bounds on a two-term exponential sum

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2001年第8期44卷 1003-1015页

作者： todd COCHRANe 郑志勇 Department of Mathematics Kansas State University Manhattan KS 66506 USA Department of Mathematics Tsinghua University Beijing 100084 China

We obtain upper bounds for mixed exponential sums of the type $S(\chi ,f,p^m ) = \sum\nolimits_{x = 1}^{p^n } {\chi (x)e} _{p^m } (ax^n + bx)$ where pm is a prime power with m? 2 and X is a multiplicative character (mod pm). If X is primitive or p?(a, b) then we obtain |S(χ,f,p m)| ?2np 2/3 m . If X is of conductor p and p?( a, b) then we get the stronger bound |S(χ,f,p m)|?np m/2.

关键词： exponential sums primitive character weil’sbound