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mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-David m.gothié Timothy e.Kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

A Proposed Feature Selection Particle Swarm Optimization Adaptation for Intelligent Logistics--A Supply Chain Backlog elimination Framework

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Computers, materials & Continua 2024年第6期79卷 4081-4105页

作者： Yasser Hachaichi Ayman e.Khedr Amira m.Idrees College of Computing and Information Technology at Khulais Department of Information SystemsUniversity of JeddahJeddah21959Saudi Arabia Faculty of Computers and Information Technology Future University in EgyptCairo11835Egypt

The diversity of data sources resulted in seeking effective manipulation and *** challenge that arises from the increasing dimensionality has a negative effect on the computation performance,efficiency,and stability of *** of the most successful optimization algorithms is Particle Swarm Optimization(PSO)which has proved its effectiveness in exploring the highest influencing features in the search space based on its fast convergence and the ability to utilize a small set of parameters in the search *** research proposes an effective enhancement of PSO that tackles the challenge of randomness search which directly enhances PSO *** the other hand,this research proposes a generic intelligent framework for early prediction of orders delay and eliminate orders backlogs which could be considered as an efficient potential solution for raising the supply chain *** proposed adapted algorithm has been applied to a supply chain dataset which minimized the features set from twenty-one features to ten significant *** confirm the proposed algorithm results,the updated data has been examined by eight of the well-known classification algorithms which reached a minimum accuracy percentage equal to 94.3%for random forest and a maximum of 99.0 for Naïve ***,the proposed algorithm adaptation has been compared with other proposed adaptations of PSO from the literature over different *** proposed PSO adaptation reached a higher accuracy compared with the literature ranging from 97.8 to 99.36 which also proved the advancement of the current research.

关键词： Optimization particle swarm optimization algorithm feature selection logistics supply chain management backlogs

Commentary on “Does light-intensity physical activity moderate the relationship between sitting time and adiposity markers in adolescents?”

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Journal of Sport and Health Science 2024年第4期13卷 453-454页

作者： Barbara e.Ainsworth Amanda m.Ferland School of exercise and Health Shanghai University of SportShanghai 200433China Department of Orthopedics Tongji UniversityShanghai 200092China

In the September 2022 issue of the Journal of Sport and Health Science,Ayala et al.1 published results from a cross-sectional study where they tested the hypothesis that light intensity physical activity(LIPA,1.6-2.9 metabolic equivalents(meTs))moderates the relationship between sitting time and adiposity in 219 Australian adolescents aged 14±1.6 years(mean±SD).

关键词： metabolic light

Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest ecosystems 2024年第1期11卷 24-31页

作者： goran Ståhl Terje gobakken Svetlana Saarela Henrik J.Persson magnus ekstrom Sean P.Healey Zhiqiang Yang Johan Holmgren eva Lindberg Kenneth Nystrom emanuele Papucci Patrik Ulvdal Hans OleØrka erik Næsset Zhengyang Hou Håkan Olsson Ronald e.mcRoberts Department of Forest Resource management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of environmental Sciences and Natural Resource management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of ministry of education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias model-based inference Design-based inference

Transfer learning applications for autoencoder-based anomaly detection in wind turbines

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energy and AI 2024年第3期17卷 1-10页

作者： Cyriana m.A.Roelofs Christian gück Stefan Faulstich Fraunhofer Iee Joseph-Beuys-Straße 834117 KasselGermany

Anomaly detection in wind turbines typically involves using normal behaviour models to detect faults *** behaviour models are often implemented through the use of neural networks,of which autoencoders are particularly popular in this ***,training autoencoder models for each turbine is time-consuming and resource ***,transfer learning becomes essential for wind turbines with limited data or applications with limited computational *** study examines how cross-turbine transfer learning can be applied to autoencoder-based anomaly ***,autoencoders are combined with constant thresholds for the reconstruction error to determine if input data contains an *** models are initially trained on one year’s worth of data from one or more source wind *** are then fine-tuned using small amounts of data from the target wind *** methods for fine-tuning are investigated:adjusting the entire autoencoder,only the decoder,or only the threshold of the *** performance of the transfer learning models is compared to baseline models that were trained on one year’s worth of data from the target wind *** results of the tests conducted in this study indicate that models trained on data of multiple wind turbines do not improve the anomaly detection capability compared to models trained on data of one source wind *** addition,modifying the model’s threshold can lead to comparable or even superior performance compared to the baseline,whereas fine-tuning the decoder or autoencoder further enhances the models’performance.

关键词： Condition monitoring Transfer learning Autoencoder Anomaly detecti on Wind turbines Fault detection

Immunotherapy of gastric cancer:Present status and future perspectives

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World Journal of gastroenterology 2024年第8期30卷 779-793页

作者： John K Triantafillidis manousos m Konstadoulakis Apostolos e Papalois Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Second Department of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Research and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this editorial,we comment on the article entitled“Advances and key focus areas in gastric cancer immunotherapy:A comprehensive scientometric and clinical trial review(1999-2023),”which was published in the recent issue of the World Journal of *** focused on the results of the authors’bibliometric analysis concerning gastric cancer immunotherapy,which they analyzed in depth by compiling the relevant publications of the last 20 *** that,we briefly describe the most recent data concerning the epidemiological parameters of gastric cancer(gC)in different countries,attempting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the *** then briefly discuss the conservative treatment(chemotherapy)of the various forms of this malignant *** describe the treatment of resectable tumors,locally advanced neoplasms,and unresectable(advanced)*** attention is given to modern therapeutic approaches with emphasis on immunotherapy,which seems to be the future of gC treatment,especially in combination with *** is also a thorough analysis of the results of the study under review in terms of the number of scientific publications,the countries in which the studies were conducted,the authors,and the scientific centers of origin,as well as the clinical studies in ***,an attempt is made to draw some conclusions and to point out possible future directions.

关键词： gastric cancer Chemotherapy Immunotherapy Immune checkpoint inhibitors Bibliometrics Scientometrics

exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1820-1831页

作者： Aakilah S.Hernandez gabriel A.Zayas eduardo e.Rodriguez Kaitlyn m.Sarlo Davila Fahad Rafiq Andrea N.Nunez Cristiane goncalves Titto Raluca g.mateescu Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Animal Sciences University of FloridaGainesvilleFLUSA. Ruminant Diseases and Immunology Research Unit National Animal Disease CentersUnited States Department of Agriculture1920 Dayton AvenueAmesIA 50010USA. Department of Animal Science Iowa StateAmesIAUSA School of Animal Sciences and Food engineering University of Sao PauloAv Duque de Caxias Norte 225PirassunungaSao Paulo 13635‑900Brazil

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around$369 million being lost annually due to reduced *** stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production *** utilize various physiological mechanisms such as sweating to regulate internal *** in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater *** This study used 2,401 Brangus cattle from two commercial ranches in *** phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area,sweat gland depth,and sweat gland *** animals were genotyped with the Bovine ggP F250K,and BLUPF90 software was used to estimate genetic parameters and for genome Wide Association *** Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics,allowing producers the ability to select for favorable sweat gland properties.A weighted single-step gWAS using sliding 10 kb windows identified multiple quantitative trait loci(QTLs)explaining a significant amount of genetic *** located on BTA7 and BTA12 explained over 1.0%of genetic variance and overlap the ADgRV1 and CCDC168 genes,*** variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat *** of Origin Alleles(BOA)were predicted using local ancestry in admixed populations(LAmP-LD),allowing for identification of markers'origin from either Brahman or Angus ancestry.A BOA gWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland pheno

关键词： gWAS Heritability Skin Thermotolerance

effect of biochar on the metabolome of soybean seedlings

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Oil Crop Science 2024年第1期9卷 60-68页

作者： Nathalia e.Silva mariana g.Aguilar Osania e.Ferreira gleicia m.Paulino Jaqueline C.L.Carvalho Lúcia P.S.Pimenta Alan R.T.machado Programa de Pos-graduaçao em Ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de Ciencias exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(SCB300),400℃(SCB400)and 600℃(SCB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear magnetic *** Relative germination,Relative Average Radicle growth and germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for SCB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： germination metabolomics 1H NmR Pyrolysis Sugarcane bagasse

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben g.marshall David Hancock Tim Wallis Julian Downward Rob m.ewing Donna e.Davies mark g.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(emT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces emT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and mRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce emT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk emT LKB1 Pulmonary fibrosis