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Fault on-off versus strain rate and earthquakes energy

Geoscience Frontiers 2015年第2期6卷 265-276页

作者： C.Doglioni S.Barba e.carminati F.Riguzzi Dipartimento di Scienze della Terra Università Sapienza Istituto di Geologia Ambientale e Geoingegneria CNR Istituto Nazionale di Geofisica e Vulcanologia

We propose that the brittle-ductile transition （BDT） controls the seismic cycle. In particular, the movements detected by space geodesy record the steady state deformation in the ductile lower crust, whereas the stick-slip behavior of the brittle upper crust is constrained by its larger friction. GPS data allow analyzing the strain rate along active plate boundaries. In all tectonic settings, we propose that earthquakes primarily occur along active fault segments characterized by relative minima of strain rate, segments which are locked or slowly creeping. We discuss regional examples where large earthquakes happened in areas of relative low strain rate. Regardless the tectonic style, the interseismic stress and strain pattern inverts during the coseismic stage. Where a dilated band formed during the interseismic stage, this will be shortened at the coseismic stage, and vice-versa what was previously shortened, it will be dilated. The interseismic energy accumulation and the coseismic expenditure rather depend on the tectonic setting （extensional, contractional, or strike-slip）. The gravitational potential energy dominates along normal faults, whereas the elastic energy prevails for thrust earthquakes and performs work against the gravity force. The energy budget in strike-slip tectonic setting is also primarily due elastic energy. Therefore, precursors may be different as a function of the tectonic setting. In this model, with a given displacement, the magnitude of an earthquake results from the coseismic slip of the deformed volume above the BDT rather than only on the fault length, and it also depends on the fault kinematics.

关键词： earthquake generation mode Strain rate Brittle-ductile transition earthquake energy

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Fault on-off versus coseismic fluids reaction

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Geoscience Frontiers 2014年第6期5卷 767-780页

作者： C.Doglioni S.Barba e.carminati F.Riguzzi Dipartimento di Scienze della Terra Università SapienzaRomaItaly Istituto di Geologia Ambientale e Geoingegneria CNRRomaItaly Istituto Nazionale di Geofisica e Vulcanologia RomaItaly

The fault activation （fault on） interrupts the enduring fault locking （fault off） and marks the end of a seismic cycle in which the brittle-ductile transition （BDT） acts as a sort of switch. We suggest that the fluid flow rates differ during the different periods of the seismic cycle （interseismic, pre-seismic, coseismic and post-seismic） and in particular as a function of the tectonic style. Regional examples indicate that tectonic-related fluids anomalies depend on the stage of the tectonic cycle and the tectonic style. Although it is difficult to model an increasing permeability with depth and several BDT transitions plus independent acquicludes may occur in the crust, we devised the simplest numerical model of a fault constantly shearing in the ductile deeper crust while being locked in the brittle shallow layer, with variable homogeneous permeabilities. The results indicate different behaviors in the three main tectonic settings. In tensional tectonics, a stretched band antithetic to the normal fault forms above the BDT during the interseismic period. Fractures close and fluids are expellecl during the coseismic stage. The mechanism reverses in compressional tectonics. During the interseismic stage, an over-compressed band forms above the BDT. The band dilates while rebounding in the coseismic stage and attracts fluids locally. At the tip lines along strike-slip faults, two couples of subvertical bancls show different behavior, one in dilationJcompression and one in compressionJdilation. This deformation pattern inverts during the coseismic stage. Sometimes a pre-seismic stage in which fluids start moving may be observed and could potentially become a precursor.

关键词： Fault activation BritUe-ductile transition earthquakeFluids response

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日本海沟俯冲带热结构与深源地震

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地球物理学报 2014年第10期57卷 3208-3217页

作者：张晨张双喜 e.carminati 高冰玉武汉大学测绘学院武汉430079 武汉大学地球空间环境与大地测量教育部重点实验室武汉430079 Department of earth Sciences University of Roma‘La Sapienza’Italy

本文利用有限差分方法,计算了全地幔对流模式和双层地幔对流模式下日本海沟俯冲带热结构、浮力及P波速度异常分布,基于亚稳态橄榄石相变模型推测亚稳态橄榄石的存在范围,同时分析了热传导系数、热膨胀系数和热源对俯冲带热结构的影响,... 详细信息

本文利用有限差分方法,计算了全地幔对流模式和双层地幔对流模式下日本海沟俯冲带热结构、浮力及P波速度异常分布,基于亚稳态橄榄石相变模型推测亚稳态橄榄石的存在范围,同时分析了热传导系数、热膨胀系数和热源对俯冲带热结构的影响,以及俯冲带所受浮力与俯冲带形态的关系.结果表明,双层地幔对流模式下模拟的P波速度异常分布与层析成像结果更为相符,也与深源地震的分布有较好的相关性.板块内部亚稳态橄榄石的存在范围随热传导系数和热膨胀系数的减小而增大,同时忽略相变潜热和剪切生热的影响也会造成模型所预测的亚稳态橄榄石范围偏大.俯冲带所受负浮力在400km深度附近达到最大值,亚稳态橄榄石的存在使负浮力逐渐减小,甚至在板块内部产生正浮力,不利于俯冲带穿透660km相变界面.

关键词：日本海沟俯冲带地幔对流模式热结构负浮力波速异常

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Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara e Agko Marina N Kouliou Konstantinos e Koumarelas Dimitris Zacharoulis Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIe)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIe include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIe’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIe.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

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Tectonically asymmetric earth:From net rotation to polarized westward drift of the lithosphere

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Geoscience Frontiers 2015年第3期6卷 401-418页

作者： Carlo Doglioni eugenio carminati Mattia Crespi Marco Cuffaro Mattia Penati Federica Riguzzi Dipartimento di Scienze della Terra Sapienza Universita di Roma DITS-Area di Geodesia e Geomatica Sapienza Universita di Roma Istituto di Geologia Ambientale e Geoingegneria CNR MOX-Dipartimento di Matematica Politecnico di Milano Istituto Nazionale di Geofisica e Vulcanologia Sez.CNTRomeItaly

The possibility of a net rotation of the lithosphere with respect to the mantle is generally overlooked since it depends on the adopted mantle reference frames, which are arbitrary. We review the geological and geophysical signatures of plate boundaries, and show that they are markedly asymmetric worldwide. Then we compare available reference frames of plate motions relative to the mantle and discuss which is at best able to fit global tectonic data. Different assumptions about the depths of hotspot sources （below or within the asthenosphere, which decouples the lithosphere from the deep mantle） predict different rates of net rotation of the lithosphere relative to the mantle. The widely used no-net-rotation （NNR） reference frame, and low （〈0.2°-0.4°/Ma） net rotation rates （deep hotspots source） predict an average net rotation in which some plates move eastward relative to the mantle （e.g., Nazca）. With fast （〉1°/Ma） net rotation （shallow hotspots source）, all plates, albeit at different velocity, move westerly along a curved trajectory, with a tectonic equator tilted about 30° relative to the geographic equator. This is consistent with the observed global tectonic asymmetries.

关键词： Asymmetric plate tectonics Plate motions Westward drift Mantle convection

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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

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Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

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Unscrambling light-automatically undoing strong mixing between modes

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Light(Science & Applications) 2017年第1期6卷 342-351页

作者： Andrea Annoni emanuele Guglielmi Marco carminati Giorgio Ferrari Marco Sampietro David AB Miller Andrea Melloni Francesco Morichetti Dipartimento di elettronica Informazione e BioingegneriaPolitecnico di MilanoMilano 20133Italy Ginzton Laboratory Stanford UniversitySpilker BuildingStanfordCA 94305USA

Propagation of light beams through scattering or multimode systems may lead to the randomization of the spatial coherence of the *** information is not lost,its recovery requires a coherent interferometric reconstruction of the original signals,which have been scrambled into the modes of the scattering *** we show that we can automatically unscramble optical beams that have been arbitrarily mixed in a multimode waveguide,undoing the scattering and mixing between the spatial modes through a mesh of silicon photonics tuneable beam *** light detectors integrated in a photonic chip are used to directly monitor the evolution of each mode along the mesh,allowing sequential tuning and adaptive individual feedback control of each beam *** entire mesh self-configures automatically through a progressive tuning algorithm and resets itself after significantly perturbing the mixing,without turning off the *** demonstrate information recovery by the simultaneous unscrambling,sorting and tracking of four mixed modes,with residual cross-talk of−20 dB between the *** partitioning assisted by transparent detectors enables scalability to meshes with a higher port count and to a higher number of modes without a proportionate increase in the control *** principle of self-configuring and self-resetting in optical systems should be applicable in a wide range of optical applications.

关键词： optical processing photonic integrated circuits silicon photonics tuneable photonic devices

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Forging an easier path through graduation:Improving the patient transition from paediatric to adult critical care

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World Journal of Critical Care Medicine 2025年第1期14卷 82-90页

作者： Stephen Warrillow Ben Gelbart Jess Stevens Gordon Baikie Mark e Howard Department of Intensive Care Austin HealthHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneParkville 3010VictoriaAustralia Department of Intensive Care Royal Children’s HospitalParkville 3010VictoriaAustralia Living with Disability Research Centre La Trobe UniversityBundoora 3086VictoriaAustralia Department of Neurodevelopment&Disability Royal Children’s HospitalParkville 3010VictoriaAustralia Department of Paediatrics The University of MelbourneParkville 3010VictoriaAustralia Department of Respiratory and Sleep Medicine Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine Austin HealthThe University of MelbourneHeidelberg 3084VictoriaAustralia

Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing *** normal experiences are potentially magnified for teenagers living with chronic illness or disability and their *** in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing *** those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of *** the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general *** there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive *** patients may encounter considerable challenges during this *** may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric *** addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health *** challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.

关键词： Paediatric intensive care Disability Adult intensive care Transition Critical care

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