检索结果-南通市图书馆

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** eMBASe,Ovid MeDLINe,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for english language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-english language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Methods for a blind analysis of isobar data collected by the STAR collaboration

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第5期32卷 43-50页

作者： J.Adam L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin e.c.aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.c.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.caines M.calderon de la Barca Sanchez D.cebra I.chakaberia P.chaloupka B.K.chan F-H.chang Z.chang N.chankova-Bunzarova A.chatterjee D.chen J.chen J.H.chen X.chen Z.chen J.cheng M.cherney M.chevalier S.choudhury W.christie X.chu H.J.crawford M.csanad M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.c.Dunlop T.edmonds N.elsey J.engelage G.eppley S.esumi O.evdokimov A.ewigleben O.eyser R.Fatemi S.Fazio P.Federic J.Fedorisin c.J.Feng Y.Feng P.Filip e.Finch Y.Fisyak A.Francisco L.Fulek c.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal X.Gou D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He Y.He S.Heppelmann S.Heppelmann N.Herrmann e.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs c.Jena A.Jentsch Y.Ji J.Jia K.Jiang S.Jowzaee X.Ju e.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła c.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung c.Li c.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis c.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Md.Nasim K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonak christian University AbileneTX 796992 AGH University of Science and Technology FPACSCracow 30-059Poland Alikhanov Institute for Theoretical and experimental Physics NRc"Kurchatov Institute" MoscowRussia 117218 Argonne National Laboratory ArgonneIL 60439 American University of cairo New CairoNew Cairo 11835Egypt Brookhaven National Laboratory UptonNY 11973 University of california BerkeleyCA 94720 University of california DavisCA 95616 University of california Los AngelesCA 90095 University of california RiversideCA 92521 central china Normal University Wuhan 430079 University of Illinois at chicago ChicagoIL 60607 creighton University OmahaNE 68178 czech Technical University in Prague FNSPEPrague 11519Czech Republic Technische Universitat Darmstadt Darmstadt 64289Germany eLTe eotvos Lorand University Budapest 1117Hungary Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg 69120 HeidelbergGermany University of Houston HoustonTX 77204 Huzhou University Huzhou 313000 Indian Institute of Science education and Research(IISeR) Berhampur 760010India Indian Institute of Science education and Research(IISeR)Tirupati Tirupati 517507India Indian Institute Technology PatnaBihar 801106India Indiana University BloomingtonIN 47408 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research DubnaRussia 141980 Kent State University KentOH 44242 University of Kentucky LexingtonKY 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCA 94720 Lehigh University BethlehemPA 18015 Max-Planck-Institut fur Physik 80805 MunichGermany Michigan State University East LansingMI 48824 National Research Nuclear University MePhI MoscowRussia 115409 National Institute of Science education and Research HBNIJatni 752050India National cheng Kung University Tainan 70101 Nuclear Physics Institute of the cAS Rez 25068Czech Republic Ohio State University

In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of *** isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)*** order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,STAR developed a three-step blind analysis *** are initially provided a"reference sample"of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run *** tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking *** this sample,species-specific information is disguised,but individual output files contain data from a single isobar *** run-by-run corrections and code alteration subsequent to these corrections are allowed at this *** these modifications,the"frozen"code is passed over the fully un-blind data,completing the blind *** a check of the feasibility of the blind analysis procedure,analysts completed a"mock data challenge,"analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in *** Au+Au data were prepared in the same manner intended for the isobar blind *** details of the blind analysis procedure and results from the mock data challenge are presented.

关键词： Blind analysis chiral magnetic effect Heavy-ion collisions

Measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV

在线全文

学校读者我要写书评

暂无评论

chinese Physics c 2020年第10期44卷 59-67页

作者： L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin e.c.aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.c.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.caines M.calderón de la Barca Sánchez D.cebra I.chakaberia P.chaloupka B.K.chan F-H.chang Z.chang N.chankova-Bunzarova A.chatterjee D.chen J.H.chen X.chen Z.chen J.cheng M.cherney M.chevalier S.choudhury W.christie X.chu H.J.crawford M.csanád M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.c.Dunlop T.edmonds N.elsey J.engelage G.eppley S.esumi O.evdokimov A.ewigleben O.eyser R.Fatemi S.Fazio P.Federic J.Fedorisin c.J.Feng Y.Feng P.Filip e.Finch Y.Fisyak A.Francisco L.Fulek c.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He S.Heppelmann S.Heppelmann N.Herrmann e.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs c.Jena A.Jentsch Y.JI J.Jia K.Jiang S.Jowzaee X.Ju e.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła c.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung c.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis c.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Nasim Md K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonaka A.S.Nunes G.Odyniec A.Ogawa Abilene christian University AbileneTexas 79699 AGH University of Science and Technology FPACSCracow 30-059Poland Alikhanov Institute for Theoretical and experimental Physics NRc"Kurchatov Institute" Moscow 117218Russia Argonne National Laboratory ArgonneIllinois 60439 American University of cairo New Cairo 11835New CairoEgypt Brookhaven National Laboratory UptonNew York 11973 University of california BerkeleyCalifornia 94720 University of california DavisCalifornia 95616 University of california Los AngelesCalifornia 90095 University of california RiversideCalifornia 92521 central china Normal University WuhanHubei 430079 University of Illinois at chicago ChicagoIllinois 60607 creighton University OmahaNebraska 68178 czech Technical University in Prague FNSPEPrague 11519Czech Republic Technische Universität Darmstadt Darmstadt 64289Germany eLTe eötvös Loránd University BudapestHungary H-1117 Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg Heidelberg 69120Germany University of Houston HoustonTexas 77204 Huzhou University HuzhouZhejiang 313000 Indian Institute of Science education and Research(IISeR) Berhampur 760010India Indian Institute of Science education and Research(IISeR)Tirupati Tirupati 517507India Indian Institute Technology PatnaBihar 801106India Indiana University BloomingtonIndiana 47408 Institute of Modern Physics Chinese Academy of SciencesLanzhouGansu 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna 141980Russia Kent State University KentOhio 44242 University of Kentucky LexingtonKentucky 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Lehigh University BethlehemPennsylvania 18015 Max-Planck-Institut für Physik Munich 80805Germany Michigan State University East LansingMichigan 48824 National Research Nuclear University MePhI Moscow 115409Russia National Institute of Science education and Research HBNIJatni 752050Indi

High transverse momentum(pT)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion *** of energy at low-to-modest pT has been difficult to measure,owing to large anisotropic *** report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the STAR *** correlation shapes,for trigger particles pT>3GeV/c and various associated particle pT ranges within 0.5eV/c,are consistent with Gaussians,and their widths increase with *** results indicate jet broadening in the medium created in central heavy-ion collisions.

关键词： di-hadron correlations jet heavy-ion

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

enhancing perianal disease management with integrated physical and psychological approaches

在线全文

学校读者我要写书评

暂无评论

World Journal of clinical cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

Dynamics of air transport networks：A review from a complex systems perspective

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Aeronautics 2017年第2期30卷 469-478页

作者： Luis e.c.Rocha Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Mathematics University of Namur 5000 Belgium

Air transport systems are highly dynamic at temporal scales from minutes to *** dynamic behavior not only characterizes the evolution of the system but also affect the system＇s *** the evolutionary mechanisms is thus fundamental in order to better design optimal air transport networks that benefits companies,passengers and the *** this review,we briefly present and discuss the state-of-the-art on time-evolving air transport *** distinguish the structural analysis of sequences of network snapshots,ideal for long-term network evolution（*** evolution）,and temporal paths,preferred for short-term dynamics（*** evolution）.We emphasize that most previous research focused on the first modeling approach（***-term） whereas only a few studies look at high-resolution temporal *** conclude the review highlighting that much research remains to be done,both to apply already available methods and to develop new measures for temporal paths on air transport *** particular,we identify that the study of delays,network resilience and optimization of resources（aircraft and crew） are critical topics.

关键词： Air transport Airport network complex network Dynamic network Temporal network

NecAB family of neuronal calcium-binding proteins in health and disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NecAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NecAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NecAB2 interacts with predominantly striatal G-protein-coupled receptors, while NecAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NecAB proteins exhibit distinct subcellular localizations: NecAB1 is found in the nucleus and cytosol, NecAB2 resides in endosomes and the plasma membrane, and NecAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NecAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NecAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Alternative fuels—a new field for mine surveying

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2005年第S1期15卷 289-293页

作者： A. Preuβe c. Herzog Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANYInstitute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANY

Due to the public’s increased interest in renewable energies and the “erneuerbare energien Gesetz” (eeG) from February 2000, geothermal energy and other alternative or renewable energies gain more and more importance. As far as Germany is concerned, geothermal energy and coal bed/mine methane are considered as mineral resources according to the German mining law. This demands the participation of mine surveyors/mineral resources managers from the planning to the production stage and even beyond it. The main tasks that have to be fulfilled are, among others, applications for exploration and production licences as well as the evaluation of the resource’s potential. This paper indicates the tasks of mine surveyors/mineral resources managers in the wide area of the renewable energies in Germany, especially concerning the use of geothermal energy and methane.

关键词： mine surveying mineral resources management renewable energies geothermal energy methane

effect of particle Froude number on sub-grid effective drag,filtered and residual stresses in fluidized gas-particle flows

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第12期95卷 36-48页

作者： christian c.Milioli Fernando e.Milioli Department of Mechanical engineering School of Engineering of São CarlosUniversity of São Paulo13566-590São CarlosSPBrazil

Sub-grid effective drag,filtered and residual stresses in the meso-scale of gas-particle fluidized flows are intrinsically affected by underlying micro-scale conditions as well as non-local effects related to macro-scale *** this work we applied microscopic two-fluid modeling to experiment with particle Froude number in order to evaluate the impact of this micro-scale condition over the concerning meso-scale derived sub-grid *** performed highly resolved simulations in periodic domains for particle Froude numbers from 12.21 to 799.22,for a wide range of macro-scale *** were filtered and classified by ranges of meso-scale markers for the various particle Froude *** particle Froude number was found to considerably affect the structural refinement of the heterogeneous flow fields thereby directly impacting effective drag,filtered and residual *** of those parameters showed systematic behaviors in relation to particle Froude number,thereby providing sound data for new sub-grid modeling propositions.

关键词： Fluidization Gas-particle flows Two-fluid model Sub-grid analysis Multiscale analysis