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Bayesian Optimization for Field-Scale Geological Carbon Storage

engineering 2022年第11期18卷 96-104页

作者： Xueying Lu Kirk e.Jordan Mary F.Wheeler edward O.Pyzer-Knapp Matthew Benatan Center for Subsurface Modeling Oden Institute for Computational Engineering and SciencesThe University of Texas at AustinAustinTX 78712USA IBM Research United Kingdom Warrington WA44ADUK

We present a framework that couples a high-fidelity compositional reservoir simulator with Bayesian optimization(BO)for injection well scheduling optimization in geological carbon *** work represents one of the first at tempts to apply BO and high-fidelity physics models to geological carbon *** implicit parallel accurate reservoir simulator(IPARS)is utilized to accurately capture the underlying physical processes during CO_(2)*** provides a framework for several flow and mechanics models and thus supports both stand-alone and coupled *** this work,we use the compositional flow module to simulate the geological carbon storage *** compositional flow model,which includes a hysteretic three-phase relative permeability model,accounts for three major CO_(2)trapping mechanisms:structural trapping,residual gas trapping,and solubility ***,IPARS is coupled to the International Business Machines(IBM)Corporation Bayesian Optimization Accelerator(BOA)for parallel optimizations of CO_(2)injection strategies during field-scale CO_(2)*** builds a probabilistic surrogate for the objective function using a Bayesian machine learning algorithm-the Gaussian process regression,and then uses an acquisition function that leverages the uncertainty in the surrogate to decide where to *** IBM BOA addresses the three weaknesses of standard BO that limits its scalability in that IBM BOA supports parallel(batch)executions,scales better for high-dimensional problems,and is more robust to *** demonstrate these merits by applying the algorithm in the optimization of the CO_(2)injection schedule in the Cranfield site in Mississippi,USA,using field *** optimized injection schedule achieves 16%more gas storage volume and 56%less water/surfactant usage compared with the *** performance of BO is compared with that of a genetic algorithm(GA)and a covariance matrix adaptation(CMA)-e

关键词： Compositional flow Bayesian optimization Geological carbon storage CCUS Machine learning AI for science

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美洲大蠊鲜虫提取物的抗炎作用研究

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中药药理与临床 2024年第8期40卷 60-64页

作者：田朝娥高洁沈咏梅刘彬马秀英李利民陈思敏耿福能成都中医药大学药学院成都611137 药用美洲大蠊四川省重点实验室成都610000 四川省中医药科学院成都610041

目的:研究美洲大蠊鲜虫提取物的抗炎作用。方法:用美洲大蠊鲜虫提取物处理不同炎症模型,检测其对相关指标的影响。用脂多糖(LPS)刺激小鼠巨噬细胞RAW264.7造体外炎症模型,检测一氧化氮(NO)、白细胞介素6(IL-6)的释放。用二甲苯、巴豆油... 详细信息

目的:研究美洲大蠊鲜虫提取物的抗炎作用。方法:用美洲大蠊鲜虫提取物处理不同炎症模型,检测其对相关指标的影响。用脂多糖(LPS)刺激小鼠巨噬细胞RAW264.7造体外炎症模型,检测一氧化氮(NO)、白细胞介素6(IL-6)的释放。用二甲苯、巴豆油、角叉菜胶造动物急性炎症模型,分别检测血管通透性、耳廓肿胀度和足肿胀度;用棉球接种于小鼠腋下造慢性炎症模型,称肉芽干质量。角叉菜胶足趾肿胀试验中用酶联免疫法检测大鼠血清中IL-6和前列腺素e2(PGe2)的含量。结果:美洲大蠊鲜虫提取物可显著抑制LPS诱导的RAW264.7细胞释放NO和IL-6(P<0.01);抑制二甲苯致小鼠皮肤毛细血管通透性增高(P<0.01);减轻巴豆油致小鼠耳廓肿胀度(P<0.01)、减轻慢性炎症模型小鼠的肉芽肿干质量(P<0.01)、减轻角叉菜胶致大鼠足肿胀度(P<0.05或P<0.01),显著降低大鼠血清中IL-6含量(P<0.05)。结论:美洲大蠊鲜虫提取物具有明显的抗炎作用。

关键词：美洲大蠊鲜虫提取物炎症

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糖尿病高危足患者风险分级管理的证据总结

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中华现代护理杂志 2024年第30期30卷 4089-4095页

作者：孙晓娜解子为吴金局刘春娥大连大学护理学院大连116000 大连大学附属新华医院护理部大连116021

目的检索、评价糖尿病高危足患者风险分级管理的相关证据,为糖尿病足的管理提供参考。方法按照循证资源"6S"金字塔模型,检索Web of Science、UpToDate、Cochrane Library、PubMed、中国知网、万方数据库、维普数据库等数据库,指南网站... 详细信息

目的检索、评价糖尿病高危足患者风险分级管理的相关证据,为糖尿病足的管理提供参考。方法按照循证资源"6S"金字塔模型,检索Web of Science、UpToDate、Cochrane Library、PubMed、中国知网、万方数据库、维普数据库等数据库,指南网站以及专业协会网站中与糖尿病高危足患者风险分级管理相关的证据,检索时限均为建库至2024年1月1日。结果共纳入11篇文献,其中指南8篇、系统评价1篇、专家共识1篇、专家意见1篇,总结出关于糖尿病高危足患者分级管理最佳证据24条,涵盖了关于风险评估、风险分级、建立档案、筛查频率、健康教育、足部处理、运动管理以及转诊8个方面的内容。结论该研究汇总了糖尿病高危足患者风险分级管理的最佳证据,为临床护理人员开展循证实践提供参考依据。

关键词：糖尿病足糖尿病高危足风险分级分级管理证据总结

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菌斑可视化干预对成人正畸伴牙周炎患者牙周组织健康的影响

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北京口腔医学 2024年第1期32卷 44-49页

作者：张玉革刘均娥刘宇赵福云首都医科大学护理学院、首都医科大学口腔医学院护理部北京100050 首都医科大学护理学院

目的探讨菌斑可视化干预对成人正畸伴牙周炎患者牙周组织健康的影响。方法采用类实验研究设计,便利抽样法选取2022年8月-2023年4月在北京市某三级甲等口腔专科医院正畸科符合纳入排除标准的患者64例。每周一、三、五入组者为试验组,... 详细信息

目的探讨菌斑可视化干预对成人正畸伴牙周炎患者牙周组织健康的影响。方法采用类实验研究设计,便利抽样法选取2022年8月-2023年4月在北京市某三级甲等口腔专科医院正畸科符合纳入排除标准的患者64例。每周一、三、五入组者为试验组,每周二、四、六入组者为对照组,试验组采用菌斑可视化干预方案进行干预,对照组采用常规干预。比较戴矫治器当日(T0期)、戴矫治器1个月(T1期)、戴矫治器3个月(T2期)、戴矫治器6个月(T3期),两组患者在临床依从性、正畸菌斑指数、龈沟出血指数、牙龈指数、牙周探诊深度的差异。结果重复测量方差结果分析显示,两组患者在临床依从性、正畸菌斑指数、龈沟出血指数、牙龈指数、牙周探诊深度时间方面均存在显著性差异(P <0.05)。结论菌斑可视化干预可提高患者口腔卫生、复诊时间及矫治器维护的依从性,降低成人正畸伴牙周炎患者牙周指数,改善口腔卫生状况,降低正畸治疗过程中牙周病的发生率。

关键词：可视化成人正畸牙周炎干预性研究

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Old nest material functions as an informative cue in making nest-site selection decisions in the european Kestrel(Falco tinnunculus)

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Avian Research 2019年第4期10卷 423-430页

作者： Mingju e Tuo Wang Shangyu Wang Ye Gong Jiangping Yu Lin Wang Wei Ou Haitao Wang Jilin engineering Laboratory for Avian ecology and Conservation Genetics School of Life SciencesNortheast Normal UniversityChangchun 130024China Northeast Normal University Natural History Museum Northeast Normal UniversityChangchun 130024China School of Life Sciences Jilin UniversityChangchun 130012China Ministry of education Key Laboratory of Vegetation ecology School of Life SciencesNortheast Normal UniversityChangchun 130024China Key Laboratory of Wetland ecology and environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China Jilin Academy of Agricultural Sciences Changchun 130033China Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization School of Life SciencesNortheast Normal UniversityChangchun 130024China

Background:For secondary cavity-nesting bird species that do not add lining materials to nests,the presence of old nest material or organic remains that have accumulated within nest cavities from previous breeding events may be a cue of nest-site *** materials potentially contain information about past breeding success in con-and heterospecifics and may improve the thermal insulation of eggs during ***,few studies have addressed whether the presence of old nest materials serves as a cue for cavity-nesting raptors when choosing specific nest ***:We conducted a 9-year nest box experiment to test whether old nest materials from con-and heterospecifics serve as informative cues to the european Kestrel(Falco tinnunculus)when making nest selection decisions,as this species uses nest boxes without adding nesting ***:The presence of old nest materials and entrance size best discriminated nest boxes occupied by european Kestrels from unoccupied *** boxes containing conspecific organic remains,artificial dry leaf and branch material,and material left behind by Great Tits(Parus major)were reused at higher rates,especially those containing conspecific nest material,than nest boxes containing true or simulated nest materials from *** 2010,no single nest box was occupied by the same banded individual that occupied the box in the previous year(10 females and 2 males were banded in 2009).Conclusions:european Kestrels preferred nest boxes containing old nest material over empty boxes,which is consistent with previous findings that they exploit con-and heterospecific cues when deciding where to settle and breed,as old nest or organic material provides substrate for incubating *** may be able to assess the predation risks associated with a specific nest site based on experience or the presence of prey *** repeated use of nest boxes across breeding seasons by kestrels cannot be entirely ascribed to phi

关键词： european Kestrel Informative cue Nest box Nest materials

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ecological correlates of invasion impact for Burmese pythons in Florida

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Integrative Zoology 2012年第3期7卷 254-270页

作者： Robert N.ReeD John D.WILLSON Gordon H.RODDA Michael e.DORCAS US Geological Survey Fort Collins Science CenterFort CollinsColorado Department of Fish and Wildlife Conservation Virginia TechBlacksburgVirginia Department of Biology Davidson CollegeDavidsonNorth CarolinaUSA

An invasive population of Burmese pythons(Python molurus bivittatus)is established across several thousand square kilometers of southern Florida and appears to have caused precipitous population declines among several species of native *** has this giant snake had such great success as an invasive species when many established reptiles have failed to spread?We scored the Burmese python for each of 15 literature-based attributes relative to predefined comparison groups from a diverse range of taxa and provide a review of the natural history and ecology of Burmese pythons relevant to each *** focused on attributes linked to spread and magnitude of impacts rather than establishment *** results suggest that attributes related to body size and generalism appeared to be particularly applicable to the Burmese python’s success in *** attributes with the highest scores were:high reproductive potential,low vulnerability to predation,large adult body size,large offspring size and high dietary ***,attributes of ectotherms in general and pythons in particular(including predatory mode,energetic efficiency and social interactions)might have also contributed to invasion *** establishment risk assessments are an important initial step in prevention of new establishments,evaluating species in terms of their potential for spreading widely and negatively impacting ecosystems might become part of the means by which resource managers prioritize control efforts in environments with large numbers of introduced species.

关键词： body size Burmese python Florida invasive species Python molurus

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Histone Acetylation, VeRNALIZATION INSeNSITIVe 3, FLOWeRING LOCUS C, and the Vernalization Response

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Molecular Plant 2009年第4期2卷 724-737页

作者： Donna M. Bond elizabeth S. Dennis Barry J. Pogson e. Jean Finnegan CSIRO Plant Industry Canberra Australia ARC Centre of excellence in Plant energy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The quantitative induction of VIN3 by low temperatures is required for PRC2 repression of FLC and promotion of flowering （vernalization） in Arabidopsis. Histone acetylation, a chromatin modification commonly associated with gene transcription, increased on VIN3 chromatin in two spatially and temporally distinct phases in response to low temperatures. During short-term cold exposure, histone H3 acetylation at the transcription start site rapidly increased, implying that it is required for VlN3 induction. Subsequent changes in histone H3 and H4 acetylation occurred following continued VIN3 transcription during prolonged cold exposure. Members of the SAGA-like transcriptional adaptor complex, including the histone acetyltransferase GCNS, which induces expression of the cold acclimation pathway genes, do not regulate VlN3 induction during cold exposure, indicating that the cold acclimation pathway and the cold-induction of VlN3 are regulated by different transcriptional mechanisms. Mutations in the other 11 histone acetyltransferase genes did not affect VlN3 induction. However, nicotinamide, a histone deacetyiase inhibitor, induced VIN3 and altered histone acetylation at the VIN3 locus. VIN3 induction was proportional to the length of nicotinamide treatment, which was associated with an early-flowering phenotype and repression of FLC. However, unlike vernalization, the repression of FLC was independent of VIN3 activity. Nicotinamide treatment did not cause a change in the expression of any genes in the autonomous pathway or members of the PRC2 complex, the well characterized repressors of FLC. Our data suggest that FLC is repressed via a novel pathway involving the SIR2 class of histone deacetylases.

关键词： Cold acclimation histone acetyltransferase histone deacetylase SIR2 nicotinamide.

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extraction and isolation of the salidroside-type metabolite from zinc(Zn) and cadmium(Cd) hyperaccumulator Sedum alfredii Hance

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第10期13卷 839-845页

作者： Yan XING Hong-yun PeNG Xia LI Meng-xi ZHANG Ling-ling GAO Xiao-e YANG Ministry of education Key Laboratory of environmental Remedia-tion and ecological Health College of Environmental and ResourceSciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Hydrology-Water Resources and Hydraulicengineering Hohai UniversityNanjing 210098China

The active metabolite in the post-harvested biomass of zinc(Zn) and cadmium(Cd) hyperaccumulator Sedum alfredii Hance from phytoextraction is of great interest in *** current study demonstrates that a salidroside-type metabolite can be yielded from the Zn/Cd hyperaccumulator *** biomass by means of sonication/ethanol extraction and macroporous resin column(AB-8 type) *** concentrations of Zn and Cd in the salidroside-type metabolite were below the limitation of the national standards.

关键词： Salidroside-type metabolite Isolation Hyperaccumulator Sedum alfredii Hance

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AGe-0 SILVeR CARP AND GIZZARD SHAD DAILY GROWTH AND HATCH TIMING IN THe MIDDLe MISSISSIPPI RIVeR

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水生生物学报 2018年第6期42卷 1084-1088页

作者： WOLF Michael C. HAUPT Kevin PHeLPS Quinton e. Department of Natural Resources Fish and Wildlife Division204 Main Street East BaudetteMinnesota 56623USA U.S.Fish and Wildlife Service Carterville Fish and Wildlife Conservation Office 9053 Rt.148 Suite A MarionIllinois 62959USA West Virginia University Division of Forestry and Natural Resources307C Percival HallMorgantownWest Virginia 26505USA

The establishment of a highly efficient planktivore, Silver carp(Hypophthalmichthys molitrix), in the Mississippi River Basin has been documented as having negative impacts on native planktivore populations. Silver carp have the potential, to alter the trophic food web through negative interactions with native planktivores in large river systems. Due to increasing Silver carp ranges, interactions between Silver carp and other native planktivores is likely to increase. One abundant native planktivore that is often found in similar habitats as Silver carp is Gizzard shad(Dorosoma cepedianum). Potential competition for resources exists because of overlapping habitat use and forage. Given the similarities between these two planktivores, we sought to evaluate daily growth rates and determine hatch dates of age-0 Silver carp and Gizzard shad in the Middle Mississippi River. Silver carp and Gizzard shad were collected from the Middle Mississippi River using an electrified surface trawl from June through September with sizes ranging from 21—65 mm total length for Gizzard shad and 24—85 mm total length for Silver carp. A sample of age-0 fish(n=697) was collected at the end of the growing season including 292 Gizzard shad and 405 Silver carp. Size structure(total length in mm) of Silver carp(49.05±0.41; ± Se) was significantly greater(T= –16.43, df=695, Pes were similar between Silver carp(July 26 th to August 18 th) and Gizzard shad(July 28 th to August 19 th). Growth of Silver carp(2.24 mm per day) was significantly greater(Per day). Mortality was similar between Silver carp(28.1%)and Gizzard shad(25.1%) at this early life stage. The faster growth rates in Silver carp result in Silver carp entering the winter season larger in size with likely an increased capacity to consume plankton and decreased predation ultimately leading to higher recruitment. Knowing that there exists

关键词： Dorosoma cepedianum Silver carp

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Theoretical Analysis of Solidly Mounted Film Bulk Acoustic Resonator with Nanocrystalline Diamond as High Impedance Material of Bragg Reflector

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Journal of Harbin Institute of Technology(New Series) 2021年第2期28卷 1-7页

作者： Yujia e Sen Zhang Bing Dai Jiaqi Zhu Jiecai Han Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150080China

In this paper,a solidly mounted resonator(SMR)was designed with nanocrystalline diamond(NCD)as the high acoustic impedance material of Bragg reflector to improve the *** used Mathcad to investigate the effect of the Bragg reflector on the performance of the SMR,as well as the influence of different materials and the number of layers of Bragg reflector on the quality factor *** show that the Bragg reflector could reduce energy loss effectively,and the higher the impedance of the high acoustic impedance layer,the better the *** parasitic factors of the SMR using two high acoustic impedance materials,tungsten(W)and NCD,were also simulated by an Advanced Design System(ADS)using the Mason *** was found that the parasitic effect caused by metal would significantly decrease the Q factor of the *** the frequency range below 6 GHz,within which the SMR works normally,NCD performed better than ***,NCD is a better choice of high acoustic impedance material in the design of the SMR,with improved quality at high frequency and low *** optimum number of layers of Bragg reflector is 6.

关键词： solidly mounted resonator(SMR) nanocrystalline diamond(NCD) Bragg reflector quality factor(Q) parasitic effect

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