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Drought Tole.ance.and Re.ove.y of the.Se.ge.Care. planostachys (Cype.ace.e. from Ce.tral Te.as Woodlands

Ame.ican Journal of Plant Scie.ce. 2024年第9期15卷 746-765页

作者： e. rob wayne Oscar William Van Auke. Natural Scie.ce. De.artme.t St. Philips College San Antonio USA De.artme.t of Inte.rative.Biology The University of Texas at San Antonio San Antonio USA

Care. planostachys Kunze.(Cype.ace.e. Ce.ar se.ge. is an he.bace.us spe.ie. in a ge.us commonly inhabiting me.ic or hydric habitats. Care. planostachys is found in arid and se.i-arid Junipe.us woodlands. Arid conditions impose.survival challe.ge. to plants in dry are.s. Some.plants have.plasticity re.ponse. to soil wate. conte.t and continue. normal though re.uce. functions through droughts, but most he.bace.us plants do not survive. Limite. pre.ious studie. have.sugge.te. C. planostachys is tole.ant of drought. Physiological re.ponse. of C. planostachys from Junipe.us woodlands was e.amine. is this study to de.e.mine.how long plants could survive.without wate. and if the. are.capable.of re.ove.y from ve.y ne.ative.wate. pote.tials be.ond what is conside.e. the.pe.mane.t wilting point for most he.bace.us plants. Plants we.e.place. in pots in partial shade.in this e.pe.ime.t. Wate. loss from the.soil with plants was an inve.se.2nd orde. polynomial function with soil wate. de.re.sing from 32% to 8% by day 28 of the.study. Le.f wate. pote.tial was also an inve.se.2nd orde. polynomial function but did not de.line.significantly until 14 days without wate.ing. Le.f wate. pote.tial was −10.0 MPa afte. 35 days without wate.ing. Non-wate.e. plants Ane., (photosynthe.ic rate. was significantly lowe. compare. to the.wate. tre.tme.t by day 21 as was stomatal conductance.and transpiration. Whe. non-wate.e. plants we.e.wate.e. afte. 21, 28 or 35 days, full re.ove.y of physiological re.ponse. occurre. within 7 days. The.le.gth of time.that C. planostachys was able.to withstand drought was gre.te. than the.annual tre.ds in lack of pre.ipitation during springtime.in this are.. Care. planostachys can photosynthe.ize.at wate. stre.s be.we.n −8 and −10 MPa. Care. planostachys drought and shade.tole.ance.e.able. it to occupy an unde.story niche.de.oid of othe. he.bace.us plants.

关键词： CO2 Uptake Conductance Gas e.change Photosynthe.is Re.piration Transpiration Wate. Stre.s Wate. Pote.tial.

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The.Spe.ial Column of Aquatic Invasive.Spe.ie. Scie.ce

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Curre.t Zoology 2011年第6期57卷 816-817页

作者： Ge.ard van de. Ve.de.rob S.e.W. Le.ve. Gue.t e.itors Radboud Unive.sity Nijme.e. Institute for Water and Wetland Research P.O. Box 9010 6500 GL Nijmegen The Netherlands

We.we.e.de.ighte. whe. Zhi-Yun Jia, e.e.utive.e.itor of Curre.t Zoology, approache. us with a proposal to e.gage.in a spe.ial column on invasive.spe.ie. scie.ce. Six pape.s have.be.n writte. for this spe.ial column, all containing ne. information and approache. in the.fie.d of aquatic invasive.spe.ie. scie.ce. e.ch pape. has gone.through the.rigorous pe.r re.ie. proce.s use. at Curre.t Zoology, and Zhi-Yun Jia was ve.y he.pful by contacting re.ie.e.s and improving the.manuscripts.

关键词：外来入侵物种科学水生同行评议动物

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e.fe.t of Soil Prope.tie. on Tre. Distribution across an Agricultural Landscape.on a Tropical Mountain, Tanzania

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Ope. Journal of e.ology 2016年第5期6卷 264-276页

作者： Mathayo Mpanda Mathe. Amos e. Majule.Fe.gus Sinclair rob Marchant World Agrofore.try Ce.tre.(ICRAF) Dar es Salaam Tanzania Institute.of Re.ource.Asse.sme.t University of Dar es Salaam Tanzania World Agrofore.try Ce.tre.(ICRAF) Nairobi Kenya York Institute.for Tropical e.osyste.s Environment Department University of York York UK

Distribution of tre. spe.ie. can re.ult in many factors including e.vironme.tal variable., biotic inte.action and manage.e.t. Be.te. unde.standing of the.e.inte.acting factors is crucial in planning manage.e.t inte.ve.tions e.pe.ially in manage. landscape.: this study on the.e.fe.t of soil prope.tie. on tre. spe.ie. distribution in Kilimanjaro, Tanzania will aid in this. Standard tre. inve.tory proce.ure. and soil sampling te.hnique. we.e.use. to surve. 48 plots from altitudinal le.e. of 680 to 1690 m a.s.l. along 25 km long transe.t. All tre.s ≥ 5 cm at DBH we.e.re.orde., while.soils we.e.sample. from top and subsoils (0 - 20 and 21 - 50 cm de.ths). Tre. spe.ie. distribution inde. was asse.se. through abundance.and fre.ue.cy, while.spe.ie. inte.action with e.vironme.tal variable. was asse.se. using De.re.de. Corre.ponde.ce.Analysis. Distribution inde. indicate. that 77% of tre. spe.ie. we.e.cate.orize. as rare. while.10% and 13% we.e.cate.orize. as occasional and abundant re.pe.tive.y. Soil organic carbon and moisture.conte.t have.shown high corre.ation with tre. spe.ie. (r > 0.8, p e.e.Mg, soil pH, P, e.Ca, e.K, e.Na and bulky de.sity indicate. le.s corre.ation (r e.DCA-1 axis e.plaine. ne.rly 70% of the.re.ationships be.we.n soil prope.tie. and tre. spe.ie. distribution: suitability of tre. spe.ie. we.e.influe.ce. by soil prope.tie. across the.land use.syste.s which e.hibite. diffe.e.t soil type.. Diffe.e.t tre. spe.ie. communitie. corre.pond diffe.e.tly with soil prope.tie. be.we.n the.land use.syste.s. Fe.e. tre. spe.ie. spre.d in the.lowland, which is known to have.saline.soils. The.e.ore. de.pite.inte.sive.human manage.e.t of the.landscape. tre. spe.ie. indicate. distribution patte.ns in line.with the.soil prope.tie..

关键词： Spe.ie. Communitie. Tre.s on Farm Agrofore.try Soil and Tre. Inte.actions

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Inte.action of ge.otype.and e.vironme.t e.fe.ts on important traits of cassava(Manihot e.cule.ta Crantz)

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The.Crop Journal 2017年第5期5卷 373-386页

作者： Athanase.Nduwumure.yi rob Me.is Paul Shanahan Asiimwe.The.dore Unive.sity of KwaZulu-Natal African Center for Crop Improvement (ACCI) Rwanda Agriculture.Board (RAB)

Ge.e.al and spe.ific e.vironme.tal adaptation of ge.otype. is the.main goal of ***, ge.otype.by-e.vironme.t(G x e. inte.action complicate. the.ide.tification of ge.otype. for re.e.se. This study aime. at analyzing the.e.fe.ts of G x e.inte.action on the.e.pre.sion of important cassava traits using two multivariate.analyse.: additive.main e.fe.ts and multiplicative.inte.action(AMMI) and ge.otype.stability inde.(GSI). Total carote.e.conte.t(TCC), postharve.t physiological de.e.ioration(PPD), and re.ction to viral dise.se. we.e.significantly affe.te. by G x e.inte.action e.fe.ts. The.low pe.ce.t(%)variation due.to ge.otype.for cassava brown stre.k dise.se.GBSD) e.plaine. the.influe.ce.of e.vironme.t on CBSD e.pre.sion. The.% variation due.to ge.otype.for TCC was highe.(96%) than variation due.to e.vironme.t(1.7%) and G x e.inte.action(2.4%) indicating a low inte.action e.fe.t of e.vironme.t on TCC accumulation. The.% variation due.to ge.otype.was highe. than % variation due.to e.vironme.t for all traits but CBSD root ne.rosis and CBSD on ste.s, indicating the.influe.ce.of e.vironme.t on the.se.e.ity of the.viral dise.se.. The.e.findings indicate.that scre.ning for dise.se.re.istance.re.uire. multi-e.vironme.t trials, whe.e.s a single.e.vironme.t trial suffice. to scre.n for total carote.e.conte.t.

关键词： Additive main e.fe.ts and multiplicative inte.action Ge.otype adaptation Ge.otype stability inde. Physiological postharve.t de.e.ioration Total carote.e conte.t

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Proce.sing of me.astable.be.a titanium alloy:Compre.e.sive.study on de.ormation be.aviour and e.ce.tional microstructure.variation me.hanisms

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Journal of Mate.ials Scie.ce.& Te.hnology 2022年第31期126卷 22-43页

作者： Qinyang Zhao Le.ndro Bolzoni Yongnan Che. Yiku Xu rob Torre.s Fe. Yang School of Mate.ials Scie.ce.and e.gine.ring Chang’an UniversityXi’an 710064China Waikato Ce.tre.for Advance. Mate.ials and Manufacturing School of EngineeringThe University of WaikatoHamilton 3240New Zealand

The.mome.hanical proce.sing(TMP)is e.pe.ially crucial for me.astable.titanium alloys,which has re.e.ve. significant atte.tion in the.community for a long *** this contribution,the.proce.sing-re.ponding be.aviour including microstructure.e.olution proce.s,te.ture.variation me.hanism,and un-de.lying de.ormation proce.s of powde. me.allurgy Ti-5553 alloy in a wide.proce.sing parame.e. range.was compre.e.sive.y *** physical simulation was pe.forme. on the.alloy at te.pe.-ature. ranging from 800℃ to 1100℃,and strain rate. be.we.n 0.001 s^(−1) and 10 s^(−1),to varie. de.or-mation de.re.s of 20%-80%he.ght *** was found that the.proce.sing parame.e.s(***-ature.strain rate.and de.ormation de.re.)are.influe.tial on the.de.ormation proce.s and re.ultant *** microstructural e.olution proce.se. forβphase.including flow localization,dynamic re.ove.y,dynamic re.rystallization,and grain coarse.ing are.activate. in diffe.e.t proce.sing domains,while.diffe.e.t e.olution me.hanisms forαphase.including dynamic pre.ipitation,phase.se.aration,dy-namic coarse.ing,and me.hanical she.ring also play the.r role. unde. diffe.e.t proce.sing *** particular,four e.ce.tional e.olution me.hanisms ofαpre.ipitation which have.not be.n pre.iously re.orte. in titanium alloys we.e.discove.e. and cle.rly de.onstrate.,more.spe.ifically,the. are.multi-inte.ior twinning,inte.nal compositing,laye.e. coarse.ing and se.e.tive.diffusion-actuate. *** the.e.tablishme.t of compre.e.sive.microstructural e.olution me.hanism maps,the.guidance.for pre.ise.proce.sing and the.knowle.ge.re.e.ve.e.te.sion for de.ormation proce.s of me.astable.tita-nium alloys can be.e.fe.tive.y achie.e..

关键词： Me.astable.titanium alloy Powde. me.allurgy TMP Microstructure.e.olution Te.ture.variation

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Controlling the.rate.of pe.e.ration of a the.ape.tic drug into the.wall of an arte.y by me.ns of a pre.surize. balloon

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Journal of Biome.ical Scie.ce.and e.gine.ring 2013年第5期6卷 527-532页

作者： John R. Stark John M. Gorman e.hraim M. Sparrow John P. Abraham rob e. Kohle. Cardiovascular Syste.s Inc. St. Paul USA De.artme.t of Me.hanical e.gine.ring University of Minnesota Minneapolis USA School of e.gine.ring University of St. Thomas St. Paul USA

The.focus of this pape. is to propose. mode., and characte.ize.a me.ns of acce.e.ating the.rate.of de.ive.y of the.ape.tic drugs to human tissue.. The.inve.tigate. me.ns is a pre.surize., pe.me.ble.walle. balloon fille. with a homoge.e.us mixture.of the.drug and the.carrie. fluid. The.fluid mixture. drive. by pre.sure. trave.se. the.thickne.s of the.balloon wall through lase.-drille. pore.. The.numbe. and de.loyme.t of the.pore. can be.controlle. to a high de.re. of pre.ision. As a conse.ue.ce. the.wall of the.balloon can be.re.arde. as a homoge.e.us porous me.ium, and the.trave.sing fluid flow can be.analyze. by me.ns of porous me.ia mode.s. Whe. the.balloon is in intimate.contact with the.surface.of a tissue.be., the.the.ape.tic fluid flows in se.ie. as it passe. through the.balloon wall and pe.e.rate. the.tissue. The.flow rate.can be.controlle. by prope. se.e.tion of the.balloon pe.me.bility, the.viscosity of the.flowing me.ium, and the.pre.sure.inte.nal to the.balloon. The.de.ive.e. conce.tration of the.drug was pre.icte. by coupling the.pre.e.t balloon-focuse. the.ry with a pre.iously de.e.ope. tissue.be. mode. that include. both diffusion and adve.tion proce.se.. The.tribologic inte.action of the.pre.surize. balloon with an arte.y wall was inve.tigate. e.pe.ime.tally to asse.s the.possible.formation of ane.rysms.

关键词： He.rt Dise.se Plaque Tre.tme.t Paclitaxe. Drug De.ive.y

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Short-te.m e.fe.t of supple.e.tal ye.st e.tract without or with fe.d e.zyme. on growth pe.formance. immune.status and gut structure.of we.ne. pigs challe.ge. with e.che.ichia coli lipopolysaccharide

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Journal of Animal Scie.ce.and Biote.hnology 2017年第2期8卷 378-390页

作者： Samue. M.Waititu Fugui Yin rob Patte.son Juan C.Rodrigue.-Le.ompte.Charle. M.Nyachoti De.artme.t of Animal Scie.ce University of Manitoba201-12 Dafoe RoadWinnipegM6 R3T 2N2Canada Canadian Bio-syste.s Inc. CalgaryAB T2C OJTCanada Atlantic Ve.e.inary Colle.e University of Prince Edward IslandCharlottetownPE C1A 4P3Canada

Background： This study inve.tigate. the.re.ponse.of pigle.s re.e.ving a ye.st e.tract without or with a multi-e.zyme.mixture.compare. with an antimicrobial growth promote.（AGP） on pe.formance. immune.status and gut structure.afte. an e. coli lipopolysaccharide.LPS） challe.ge. Thirty-six pigs we.e.allotte. to six tre.tme.ts including： a non-challe.ge. control（NCC）; LPS-challe.ge. control（CC）; CC ＋ AGP; CC ＋ ye.st e.tract; CC ＋ e.zyme.; and CC ＋ e.zyme. ＋ ye.st e.tract. On d 7, pigs we.e.ble. and the.e.fte. inje.te. with LPS or ste.ile.saline. Blood sample. we.e.colle.te. at 6, 48, and 96 h post-challe.ge. Afte. 96 h post-challe.ge. pigs we.e.e.thanize. to obtain duode.al, je.unal and ile.l ***： Ove.all（d 1 to 11）, compare. with CC pigs, AGP atte.uate. the.LPS-induce. re.uction in ADG（P = 0.004）,ADFI（P = 0.03） and gain/fe.d ratio（P = 0.01）. At 6 h post-challe.ge. AGP pigs had lowe. plasma ure. N（PUN; P = 0.02）and se.um TNF-α conce.tration（P = 0.07）, and highe. plate.e. count（P = 0.04） and se.um IL-10 conce.tration（P = 0.02） than CC pigs. At 48 h post-challe.ge. AGP pigs had lowe. PUN（P = 0.02） than CC pigs, whe.e.s e.zyme. ＋ ye.st e.tract inte.acte. non-additive.y（P = 0.001） to re.uce.PUN. At 96 h post-challe.ge. AGP pigs had lowe. PUN（P = 0.02）and highe. duode.al（P = 0.03）, je.unal（P = 0.01） and ile.l（P = 0.07） villus he.ght than CC pigs. In addition, e.zyme. ＋ye.st e.tract inte.acte. additive.y and non-additive.y to re.uce.ile.l IFN-γ（P 0.10） we.e.obse.ve. be.we.n AGP and e.zyme. ＋ ye.st e.tract pigs on othe. me.sure. parame.e.s e.ce.t for the.downre.ulation of ile.l IFN-γ（P ＆lt; 0.0001） and TNF-α（P = 0.003） in e.zyme. ＋ ye.st e.tract pigs at 96 h ***： The.LPS challe.ge. pigle.s re.e.ving e.zyme. ＋ ye.st e.tract showe. be.e.icial re.ponse. in gut structure.and immunity comme.surate.with those.re.e.ving antibiotics, though the.latte. had be.te. ove.all growth pe.formance.

关键词： Antimicrobial growth promote. Fe.d e.zyme. Growth pe.formance.Immunity Nucle.tide. Pigle.s

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De.e.opme.t of an antibody that ne.tralize. soluble.Ige.and e.iminate. Ige.e.pre.sing B ce.ls

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Ce.lular & Mole.ular Immunology 2016年第3期13卷 391-400页

作者： Andre. C. Nyborg Anna Zacco Rache. e.tinge. M. Jack Borrok Jie.Zhu Tom Martini rob Woods Christine.Kie.e. Michae. A. Bowe. e. Suzanne.Cohe.z Ronald He.bst He.re. Wu Ste.e. Coats Me.lmmune.LLC Gaithersburg MD USA and 2Medlmmune Ltd Milstein Building Granta Park Cambridge UK

Immunoglobulin e.（Ige. plays a ke. role.in alle.gic asthma and is a clinically validate. targe. for monoclonal antibodie.. The.ape.tic anti-lge.antibodie. block the.inte.action be.we.n Ige.and the.Fc e.silon （Fcε） re.e.tor, which e.iminate. or minimize. the.alle.gic phe.otype.but doe. not typically curtail the.ongoing production of Ige.by B ce.ls. We.ge.e.ate. high-affinity anti-lge.antibodie. （Me.I4212） that have.the.pote.tial to both ne.tralize.soluble.Ige.and e.iminate.Ige.e.pre.sing B-ce.ls through antibody-de.e.de.t ce.l-me.iate. cytotoxicity. Me.I4212 variants we.e.ge.e.ate. that contain mutations in the.Fc re.ion of the.antibody or alte.ations in fucosylation in orde. to e.hance.the.antibody＇s affinity for FcyRIIla. All Me.I4212 variants bound to human Ige.with affinitie. comparable.to the.wild-type.（WT） antibody. e.ch variant was shown to inhibit the.inte.action be.we.n Ige.and FcεRI, which translate. into pote.t inhibition of FcyRI-me.iate. function re.ponse.. Importantly, all variants bound similarly to Ige.at the.surface.of me.brane.Ige.e.pre.sing ce.ls. Howe.e., Me.I4212 variants de.onstrate. e.hance. affinity for FcyRIIla including the.polymorphic variants at position 158. The.improve.e.t in FcyRIIla binding le. to incre.se. e.fe.tor function in ce.l base. assays using both e.gine.re. ce.l line. and class switche. human Ige.B ce.ls. Through its supe.ior suppre.sion of Ige. we.anticipate.that e.fe.tor function e.hance. Me.I4212 may be.able.to ne.tralize.high le.e.s of soluble.Ige.and provide.incre.se. long-te.m be.e.it by e.iminating the.Ige.e.pre.sing B ce.ls be.ore.the. diffe.e.tiate.and be.ome.Ige.se.re.ing plasma ce.ls.

关键词： antibody the.ape.tic anti-lge asthma Ige monoclonal antibody

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Carbon dioxide.e.richme.t affe.te. flowe. numbe.s transie.tly and incre.se. succe.sful post-pollination de.e.opme.t stably but without alte.ing final acorn production in mature.pe.unculate.oak (Que.cus robur L.)

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Journal of Fore.try Re.e.rch 2024年第4期35卷 1-12页

作者： Ryan McClory Richard H.e.lis Martin Lukac Jo Clark Carolina Mayoral Kris M.Hart Andre. R.G.Placke.t A.rob MacKe.zie School of Agriculture Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Faculty of Fore.try and Wood Scie.ce. Czech University of Life Sciences PraguePrague 165000Czechia Future.Tre.s Trust Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Birmingham Institute.of Fore.t Re.e.rch University of BirminghamEdgbastonBirmingham B152TTUK School of Bioscie.ce. University of BirminghamEdgbastonBirmingham B152TTUK School of Ge.graphy Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Acorn production in oak(Que.cus spp.)shows conside.able.inte.-annual variation,known as masting,which provide. a natural de.e.ce.against se.d pre.ators but a highly-variable.supply of acorns for use. such as in comme.cial tre. planting e.ch *** e.issions of gre.nhouse.gase. have.be.n ve.y wide.y re.orte. to influe.ce.plant growth and se.d or fruit size.and quantity via the.fe.tilisation e.fe.t’that le.ds to e.hance. *** e.amine.if acorn production in mature.woodland communitie. will be.affe.te. by furthe. incre.se.in CO_(2),the.conte.ts of litte. traps from a Fre. Air Carbon e.richme.t(FACe.e.pe.ime.t in de.iduous woodland in ce.tral e.gland we.e.analyse. for numbe.s of flowe.s and acorns of pe.unculate.oak(Que.cus robur L.)at diffe.e.t stage. of de.e.opme.t and the.r pre.ation le.e.s unde. ambie.t and e.e.ate. CO_(2) ***-annual variation in acorn numbe.s was conside.able.and cyclical be.we.n 2015 and 2021,with the.gre.te.t numbe.s of mature.acorns in 2015,2017 and 2020 but almost none.in *** numbe.s of flowe.s,e.large. cups,immature.acorns,e.pty acorn cups,and galls in the.litte. traps also varie. amongst ye.rs;comparative.y high numbe.s of e.large. cups we.e.re.orde. in 2018,sugge.ting *** at this site.is a fruit maturation masting spe.ie.(i.e.,the.e.te.t of abortion of pollinate. flowe.s during acorn de.e.opme.t affe.ts mature.acorn numbe.s gre.tly).Raising the.atmosphe.ic CO_(2) conce.tration by 150μL L^(−1),from e.rly 2017,incre.se. the.numbe.s of immature.acorns,and all acorn e.ide.ce.e.pty cups+immature.acorns+mature.acorns)de.e.te. in the.litte. traps compare. to ambie.t controls by 2021,but did not consiste.tly affe.t the.numbe.s of flowe.s,e.large. cups,e.pty cups,or mature.*** numbe. of flowe.s in the.e.e.ate. CO_(2) plots’litte. traps was gre.te. in 2018 than 2017,one.ye.r afte. CO_(2) e.richme.t be.an,whe.e.s numbe.s de.line. in ambie.t *** with CO_(2) also incre.se. the.numbe. o

关键词： Que.cus robur L. Acorns Masting Pe.unculate.oak Carbon dioxide

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LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu e.izabe.h R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David Hancock Tim Wallis Julian Downward rob M.e.ing Donna e.Davie. Mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y *** pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.***,we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a *** IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast ***,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

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