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Impact of Ve.tically-Suspe.de. e.vironme.tal e.richme.t and Two De.sitie. of Fish on Circular Tank Ve.ocity Profile.

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e.gine.ring（科研） 2020年第10期12卷 723-738页

作者： Joshua M. A. Caasi joseph M. Barne. Michae. e. Barne. Be.e.ictine.Colle.e School of Engineering Atchison Kansas USA South Dakota De.artme.t of Game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA

Ve.tically-suspe.de. e.vironme.tal e.richme.t has be.n shown to produce.improve.e.ts in fish growth during hatche.y re.ring in circular tanks. This study docume.te. the.e.fe.ts of a nove. suspe.de. structure.on the.ve.ocity profile.of a 3.63-m diame.e. circular tank containing juve.ile.landlocke. fall Chinook salmon (e.>Oncorhynchus tshawytschae.>) at two diffe.e.t de.sitie. (9.0 and 34.3 kg/m3). The.addition of ve.tically-suspe.de. structure.to the.tank significantly de.re.se. ve.ocitie. at ne.rly e.e.y sampling point, with ve.ocitie. typically dropping from 15 cm/s without structure.to le.s than 6 cm/s whe. structure.was pre.e.t. Fish de.sity also significantly impacte. in-tank ve.ocitie., with an inve.se.re.ationship obse.ve. be.we.n the.de.sity of fish and wate. ve.ocity. Significant inte.actions we.e.pre.e.t among the.pre.e.ce.or abse.ce.of structure.and fish de.sity. Whe. structure.and fish we.e.abse.t, the.ve.ocity at the.e.ge.of the.tank was 15.63 cm/s, which was significantly highe. than the.4.75 cm/s ve.ocity whe. both structure.and the.lowe. fish de.sity we.e.adde., which was in turn significantly highe. than the.2.29 cm/s ve.ocity obse.ve. with structure.and highe. fish de.sity. De.pite.the.pote.tially unique.fe.ture. of this study, ve.tically-suspe.de. e.vironme.tal e.richme.t and the.pre.e.ce.of fish cle.rly alte. circular tank wate. ve.ocitie., which may at le.st partially e.plain the.improve.e.ts in fish re.ring pe.formance.obse.ve. with the.use.of suspe.de. structure.

关键词： Circular Tank Ve.ocity e.vironme.tal e.richme.t Fish De.sity

What Make. Home.wne.s Conside. Prote.tive.Actions to Re.uce.Disaste. Risk?An Application of the.Pre.aution Adoption Proce.s Mode. and Life.Course.The.ry

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Inte.national Journal of Disaste. Risk Scie.ce 2021年第3期12卷 312-325页

作者： Ale.ia Stock Rache. A.Davidson joseph e.Trainor Rache. Slotte. Linda K.Nozick Jamie.B.Kruse De.artme.t of Civil and e.vironme.tal e.gine.ring University of DelawareNewarkDE 19711USA De.artme.t of Civil and e.vironme.tal e.gine.ring University of DelawareNewarkDE 19716USA School of Public Policy and Administration University of DelawareNewarkDE 19716USA Disaste. Scie.ce.and Manage.e.t University of DelawareNewarkDE 19716USA School of Civil and e.vironme.tal e.gine.ring Cornell UniversityIthacaNY 14853USA De.artme.t of e.onomics East Carolina UniversityGreenvilleNC 27858USA

We.hypothe.ize.that for disaste. risk mitigation,many house.olds,de.pite.be.ng aware.of the.r risk and possible.mitigation actions,ne.e. se.iously conside. doing anything about *** mitigation-focuse. de.isions,since.the.e.is no e.uivale.t to warning me.sage.,the.de.ision proce.s is like.y to e.olve.ove. an e.te.de. *** e.plore.what activate. hurricane.mitigation prote.tive.action de.isions through thre. re.e.rch que.tions:(1)to what e.te.t are.home.wne.s une.gage. in prote.tive.action de.ision making?(2)What home.wne. characte.istics are.associate. with lack of e.gage.e.t?And(3)to what e.te.t do diffe.e.t life.e.e.ts trigge. e.gage.e.t in the.de.ision-making proce.s?We.use.the.Pre.aution Adoption Proce.s Mode. to conce.tualize.e.gage.e.t as distinct from de.ision making;the.broade. prote.tive.action de.ision-making lite.ature.to e.plore.drive.s of e.gage.e.t;and Life.Course.The.ry to e.amine.pote.tial transitions from une.gage. to *** use.surve. data of home.wne.s in North Carolina to e.amine.the.e.que.tions *** sugge.t that one.third of re.ponde.ts had ne.e. e.gage. in prote.tive.action de.isions,that life.e.pe.ie.ce. diffe. in the.r occurre.ce.fre.ue.cy and e.fe.t on house.olds’mitigation de.isions,and that some.e.e.ts,such as re.ovating,re.oofing,or purchasing a home.may offe. critical mome.ts that could be.le.e.age. to e.courage.gre.te. e.gage.e.t in mitigation de.ision making.

关键词： Home.wne.s Hurricane.damage Life.course.the.ry Mitigation de.isions North Carolina Prote.tive.action

TCR-pMHC:e.visioning the.spe.ialize. dynamics of the.targe. 5-compone.t comple.

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Ce.lular & Mole.ular Immunology 2022年第6期19卷 657-659页

作者： joseph S.Murray Xe.olaüs Ge.e.ics LLC Los AngelesCA90024USA

The.me.hanose.sor the.ry of TCR function holds the./βcompone.t of the.T-ce.l antige. re.e.tor comple. ultimate.y re.ponsible.for adaptive.immunity[1,2,3].T-ce.l motility is e.visione. to provide.a force.ne.e.sary to slow TCR dynamics as it sits on the.pMHC ligand of an antige. pre.e.ting ce.l[1],which the.re.ically allows the.TCR to discriminate.diffe.e.t pMHC structure.,principally by the.so-calle. catch bonds(mostly H-bonds)at the.inte.face. of the.5-compone.t comple.(i.e.,TCRα/TCRβ/pe.tide.MHC-IIα(or,MHC-he.vy-chain)/MHC-IIβ(or MHC-light-chain)[1,2,3,4].

关键词： compone.t TCR comple.

e.aluation of thre.-dime.sional biofilms on antibacte.ial bonding age.ts containing nove. quate.nary ammonium me.hacrylate.

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Inte.national Journal of Oral Scie.ce 2014年第2期6卷 77-86页

作者： Han Zhou Michae. D We.r joseph M Antonucci Gary e.Schumache. Xue.Dong Zhou Hockin H K Xu De.artme.t of e.dodontics Prosthodontics and Operative Dentistry University of Maryland Dental School Baltimore USA State.Ke. Laboratory of Oral Dise.se. West China Hospital of Stomatology Sichuan University Biomate.ials Group Biosystems and Biomaterials Division National Institute of Standards and TechnologyGaithersburg USA Dr. Anthony Volpe.Re.e.rch Ce.te. American Dental Association Foundation Gaithersburg USA Ce.te. for Ste. Ce.l Biology & Re.e.e.ative.Me.icine University of Maryland School of Medicine Baltimore USA De.artme.t of Me.hanical e.gine.ring University of Maryland Baltimore County USA

Antibacte.ial adhe.ive. are.promising to inhibit biofilms and se.ondary carie.. The.obje.tive. of this study we.e.to synthe.ize.and incorporate.quate.nary ammonium me.hacrylate. into adhe.ive., and inve.tigate.the.alkyl chain le.gth e.fe.ts on thre.-dime.sional biofilms adhe.e.t on adhe.ive. for the.first time. Six quate.nary ammonium me.hacrylate. with chain le.gths of 3, 6, 9, 12, 16 and 18 we.e.synthe.ize. and incorporate. into Scotchbond Multi-Purpose. Stre.tococcus mutans bacte.ia we.e.culture. on re.in to form biofilms. Confocal lase. scanning microscopy was use. to me.sure.biofilm thickne.s, live.de.d volume. and live.bacte.ia pe.ce.tage.vs. distance.from re.in surface. Biofilm thickne.s was the.gre.te.t for Scotchbond control; it de.re.se. with incre.sing chain le.gth, re.ching a minimum at chain le.gth 16. Live.biofilm volume.had a similar tre.d. De.d-biofilm volume.incre.se. with incre.sing chain le.gth. The.adhe.ive.with chain le.gth 9 had 37% live.bacte.ia ne.r re.in surface. but close.to 100% live.bacte.ia in the.biofilm top se.tion. For chain le.gth 16, the.e.we.e.ne.rly 0% live.bacte.ia throughout the.thre.-dime.sional biofilm. In conclusion, strong antibacte.ial activity was achie.e. by adding quate.nary ammonium into adhe.ive. with biofilm thickne.s and live.biofilm volume.de.re.sing as chain le.gth was incre.se. from 3 to 16. Antibacte.ial adhe.ive. typically only inhibite. bacte.ia close.to its surface. howe.e., adhe.ive.with chain le.gth 16 had mostly de.d bacte.ia in the.e.tire.thre.-dime.sional biofilm. Antibacte.ial adhe.ive.with chain le.gth 16 is promising to inhibit biofilms at the.margins and combat se.ondary carie..

关键词： alkyl chain le.gth antibacte.ial bondingage.t de.tal carie. quate.naryammonium me.hacrylate Stre.tococcusmutans thre.-dime.sional biofilm

TCR-pMHC: may the.force.be.of you?

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Ce.lular & Mole.ular Immunology 2021年第7期18卷 1622-1623页

作者： joseph S.Murray Xe.olaüs Ge.e.ics LLC Los AngelesCA90024USA

The./βcompone.t of the.T-ce.l antige. re.e.tor(TCR)is a transme.brane.he.e.odime. containing ge.e.ically variable.V)domains and constant domains within e.ch polype.tide.chain.1 The.Vαand Vβdomains bind with a clonally unique.clonotypic)inte.face.angle.2 and the.comple.e.tary de.e.mining re.ions(CDR1,CDR2,and CDR3)manife.t as‘loops’be.we.n anti-paralle.β-strands of the.ove.all sandwich ofβ-she.ts with a ce.tral disulfide.*** with immunoglobulins,the.CDR1 and CDR2 loops are.e.code. in the.ge.mline.via the.particular V-re.ion DNA se.me.t involve. in the.RAG1/RAG2 re.ombination me.hanism re.ponsible.for somatic construction,toge.he. with the.D-and/or J-se.me.t,of the.third loop,CDR3.1,3 As shown by multiple.solve. X-ray crystallography structure.,the.CDRs contain the.close.t amino acid(a.a.)contacts with the.pe.tide.p)plus the.major histocompatibility comple.(MHC)prote.n(toge.he. abbre..,pMHC)composite.*** rigorous se.e.tion in the.thymus for only those.TCRs that should function prope.ly in the.particular individual afte. birth(MHC re.triction),4 T ce.ls function clonally as we.l,i.e.,diffe.e.t T-ce.l clone. display diffe.e.tial re.ponse. to not only diffe.e.t pMHC ligands but also pe.haps more.importantly,to the.same.pMHC ligands.5,6 A long-standing que.tion is how(not whe.he.)TCR V-domain binding to pMHC is ultimate.y re.ponsible.for such vast biological outcome. as prote.tion *** to infe.tious dise.se.,atopy,the.onse. of autoimmune.dise.se.,and the.succe.s of various type. of transplantation.

关键词： prope.ly sandwich rigorous

e.rly ve.sus Late.Trache.stomy for Ve.tilator De.e.de.ce.afte. Cardiovascular Surge.y: Long-Te.m Re.ults

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World Journal of Cardiovascular Surge.y 2013年第3期3卷 114-118页

作者： joseph M. Ladowski Hannah e. Downe. Be.ne. J. Ladowski joseph S. Ladowski Luthe.an Hospital of Indiana Fort Wayne USA

Although conce.ns e.ist about the.possibility of infe.ting a ste.notomy wound by pe.forming a trache.stomy e.rly afte. cardiac surge.y, it has be.n shown that trache.stomy pe.forme. be.ore.postope.ative.day 10 can improve.outcome. for cardiovascular surge.y patie.ts who re.uire.long-te.m ve.tilation. We.re.rospe.tive.y re.ie.e. all charts for patie.ts who unde.we.t cardiovascular surge.y and re.uire. trache.stomy at a single.institution site.from January 2005 to July 2012. Patie.ts we.e.divide. into two groups base. upon whe.he. the.r trache.stomy was pe.forme. le.s than 10 days afte. the.r initial ope.ation (e.rly trache.stomy) or ≥10 days afte. the.r initial ope.ation (late.trache.stomy). Pre.pe.ative.de.ographics and postope.ative.complications we.e.studie.. The.e.we.e.no ne. me.iastinitis e.isode. following trache.stomy. e.rly trache.stomy was associate. with highe. 90-day (74.4% vs 56.8%) and 180-day (47.4% vs 28.7%, p 0.047) survival whe. compare. to late.trache.stomy. e.rly trache.stomy afte. cardiovascular surge.y doe. not se.m to be.associate. with an incre.se. rate.of me.iastinitis but is associate. with improve. survival.

关键词： Surge.y Cardiovascular Injury Lung Inte.sive Care Me.iastinitis

Ultraviole. discharge. from a radio-fre.ue.cy syste. for pote.tial biological/che.ical applications

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Chine.e.Physics B 2017年第8期26卷 157-161页

作者： joseph Ame.e.e.She.g Pe.g De.nis Manos Ge.rgia Gwinne.t Colle.e School of Science and TechnologyLawrenceville-GA 30078USA e.FO Mississaugaon Canada L5N 6H7 Colle.e.of William and Mary Department of PhysicsWilliamsburgVA 2385USA

In this work, we.de.cribe.a ne. e.e.trode.le.s radio-fre.ue.cy（RF） e.citation te.hnique.for ge.e.ating e.cime.s in the.vacuum ultraviole.（VUV） and ultraviole.（UV） spe.tral re.ions for pote.tial biological/che.ical applications. Spe.tra data of Xe.＊_2, Xe.~＊, and KrI~＊ ge.e.ate. by this ne. te.hnique.are.pre.e.te.. Optical e.ficie.cy of the.lamp syste. range. from 3% to 6% for KrI~＊, 7% to 13% for Xe.~＊, and 15% to 20% for Xe.＊_2. Also, re.ults of irradiating e.coli with Xe.~＊discharge.from this lamp syste. is pre.e.te. to show one.of the.promising applications of such e.e.trode.le.s *** ne. RF lamp syste. offe.s an inte.e.ting addition to the.alre.dy e.isting te.hnologie. for ge.e.ating VUV and UV light for various biological, physical, and che.ical proce.se. e.pe.ially those.re.uiring large.are. for high productivity.

关键词： radio-fre.ue.cy ultraviole. light Xe.* Xe.* KrI* e.cime.s e.che.ichia coli

Building the.Capacity of He.lth Profe.sionals in Monitoring and e.aluation in a Public He.lth Institution: e.pe.ie.ce.of the.National Institute.of Public He.lth (NIPH) of Côte.d’Ivoire

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He.lth 2024年第8期16卷 731-749页

作者： e.me.Marie.Laure.e.sis N’gue.ta Mathilde.Manouan Anna-Corine.e.te.l Lie.a Bissouma e.hmonia Kouamé e.issi Orsot Te.chi Sagou Olivie. Yayo Ste.hane.Claon Yao e.ge.e.Konan William Yavo Agbaya Ste.hane.Oga Te.e.an Je.n Marie.Ye. joseph Aka National Institute.of Public He.lth Abidjan Cte dIvoire Ce.lule.de.Re.he.che.e. Sant de.la Re.roduction de.Cte.dIvoire.(CRe.AR-CI) Abidjan Cte dIvoire De.artme.t of Public He.lth and Biostatistics UFR of Medical Sciences Felix Houphout Boigny University Abidjan Cte dIvoire De.artme.t of Public He.lth UFR of Pharmaceutical and Biological Sciences Felix Houphout Boigny University Abidjan Cte dIvoire

Background: In the.conte.t of the.fight against HIV, a lack of skills in monitoring and e.aluating the.pe.sonne. in charge.of activitie. has be.n ide.tifie. at the.national le.e.. It was the.subje.t of a priority axis of the.national plan for monitoring and e.aluating the.fight against HIV (2006-2010) that was aime. at stre.gthe.ing the.capacitie. of actors in this are.. To incre.se.the.critical mass of compe.e.t human re.ource. in the.short te.m, the.National Institute.of Public He.lth (NIPH) of Côte.d’Ivoire.organize. monitoring and e.aluation training se.sions for he.lthcare.profe.sionals from 2011 to 2016. Me.hods: A single.case.study with multiple.le.e.s of analysis was carrie. out, combining a qualitative.surve. and a lite.ature.re.ie.. An e.aluation was carrie. out six months afte. e.ch training se.sion. In addition, the.re.ults of the.pre. and post-te.ts and of the.daily and final e.aluations that accompanie. the.various training se.sions we.e.use. to provide.furthe. information. The.qualitative.data colle.te. we.e.analyze. using INVIVO 15 software. Re.ults: Some.89 he.lth profe.sionals (69% me. and 31% wome.) working at the.national le.e. (51% at the.ce.tral le.e., including 58% in he.lth programs) and in de.e.opme.t partne. age.cie. (37%) participate. in this capacity building program. Most participants we.e.se.ior he.lth manage.s (56%), data manage.s (23%), and statisticians and compute. scie.tists (10%). Almost all the.trainings we.e.finance. by 16 te.hnical and financial partne.s (85%), mainly the.Me.SURe.e.aluation proje.t (27%). Conclusion: M&e.training, de.pite.all its impe.fe.tions, has made.it possible.to ide.tify M&e.training ne.ds at the.national le.e. and to incre.se.the.critical mass of national skills and to have.some.culture.in M&e.

关键词： Short-Te.m Training Capacity Building Monitoring and e.aluation He.lth Profe.sional Africa Côte.d’Ivoire

Che.ical e.posure. and suspe.te. impacton Gulf War Ve.e.ans

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Military Me.ical Re.e.rch 2023年第5期10卷 577-586页

作者： Rami e.haj joseph M.Re.nolds Ce.te. for Cance. Biology Immunology and InfectionChicago Medical SchoolRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

Gulf War Illne.s(GWI) e.compass a spe.trum of maladie. spe.ific to troops de.loye. during the.Pe.sian Gulf War(1990–1991). The.e.are.se.e.al hypothe.ize. factors be.ie.e. to contribute.to GWI, including(but not limite. to)e.posure. to che.ical age.ts and a fore.gn e.vironme.t(e.g., dust, polle.s, inse.ts, and microbe.). More.ve., the.inhe.e.t stre.s associate. with de.loyme.t and combat has be.n associate. with GWI. While.the.e.iology of GWI re.ains unce.tain, se.e.al studie. have.provide. strong e.ide.ce.that che.ical e.posure., e.pe.ially ne.rotoxicants,may be.unde.lying factors for the.de.e.opme.t of GWI. This mini style.pe.spe.tive.article.will focus on some.of the.major e.ide.ce.linking che.ical e.posure. to GWI de.e.opme.t and pe.siste.ce.de.ade. afte. e.posure.

关键词： Gulf War Illne.s(GWI) Sarin Ne.roinfammation Organophosphate.OP)