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e.gine.ring nanome.icine. for immunoge.ic e.adication of cance. ce.ls:Re.e.t tre.ds and syne.gistic approache.

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Acta Pharmace.tica Sinica B 2024年第6期14卷 2475-2504页

作者： Ahme. O.e.zoghby Omar Samir Hagar e.e.am Ahme. Soliman Riham M.Abde.galil Yomna M.e.morshe.y Kadria A.e.khodairy Mahmoud l.Nasr Division of e.gine.ring in Me.icine.and Division of Re.al Me.icine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cance. Nanote.hnology Re.e.rch laboratory(CNRl) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Re.istance.to cance. immunothe.apy is mainly attribute. to poor tumor immunoge.icity as we.l as the.immunosuppre.sive.tumor microe.vironme.t(TMe.le.ding to failure.of immune.*** the.ape.tic strate.ie. including che.othe.apy,radiothe.apy,photodynamic,photothe.mal,magne.ic,che.odynamic,sonodynamic and oncolytic the.apy,have.be.n de.e.ope. to induce.immunoge.ic ce.l de.th(ICD)of cance. ce.ls and the.e.y e.icit immunoge.icity and boost the.antitumor immune.***,many challe.ge. hampe. the.clinical application of ICD induce.s re.ulting in mode.t immunoge.ic ***,we.outline.the.curre.t state.of using nanome.icine. for boosting ICD of cance. ***,syne.gistic approache. use. in combination with ICD inducing nanome.icine. for re.ode.ing the.TMe.via targe.ing immune.che.kpoints,phagocytosis,macrophage.polarization,tumor hypoxia,autophagy and stromal modulation to e.hance.immunoge.icity of dying cance. ce.ls we.e.*** furthe. highlight the.e.e.ging tre.ds of using nanomate.ials for trigge.ing amplifie. ICD-me.iate. antitumor immune.*** re.iculum localize. ICD,focuse. ultrasound hype.the.mia,ce.l me.brane.camouflage. nanome.icine.,amplifie. re.ctive.oxyge. spe.ie.(ROS)ge.e.ation,me.allo-immunothe.apy,ion modulators and e.gine.re. bacte.ia are.among the.most innovative.*** challe.ge.,me.its and de.e.its of ICD induce. nanome.icine. we.e.also discusse. with she.ding light on the.future.role.of this te.hnology in improving the.outcome. of cance. immunothe.apy.

关键词： Immunoge.ic ce.l de.th Immunoge.ic e.adication Nanome.icine. Drug de.ive.y Cance. immunothe.apy Antitumor immunity T ce.ls Tumor associate. antige.s Syne.gistic immune.re.ponse

e.e.t-trigge.e. H_(∞) conse.sus control for input-constraine. multi-age.t syste.s via re.nforce.e.t le.rning

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Control The.ry and Te.hnology 2024年第1期22卷 25-38页

作者： Jinxuan Zhang Chang-e.Re. Colle.e.of Information e.gine.ring Capital Normal UniversityBeijing100089China

This article.pre.e.ts an e.e.t-trigge.e. H_(∞) conse.sus control sche.e.using re.nforce.e.t le.rning (Rl) for nonline.r se.ond-orde. multi-age.t syste.s (MASs) with control constraints. First, conside.ing control constraints, the.constraine. H_(∞) conse.sus proble. is transforme. into a multi-playe. ze.o-sum game.with non-quadratic pe.formance.functions. The., an e.e.t-trigge.e. control me.hod is pre.e.te. to conse.ve.communication re.ource. and a ne. trigge.ing condition is de.e.ope. for e.ch age.t to make.the.trigge.ing thre.hold inde.e.de.t of the.disturbance.atte.uation le.e.. To de.ive.the.optimal controlle. that can minimize.the.cost function in the.case.of worst disturbance. a constraine. Hamilton–Jacobi–Be.lman (HJB) e.uation is de.ine.. Since.it is difficult to solve.analytically due.to its strongly non-line.rity, re.nforce.e.t le.rning (Rl) is imple.e.te. to obtain the.optimal controlle.. In spe.ific, the.optimal pe.formance.function and the.worst-case.disturbance.are.approximate. by a time.trigge.e. critic ne.work;me.nwhile. the.optimal controlle. is approximate. by e.e.t-trigge.e. actor ne.work. Afte. that, lyapunov analysis is utilize. to prove.the.uniformly ultimate.y bounde. (UUB) stability of the.syste. and that the.ne.work we.ght e.rors are.UUB. Finally, a simulation e.ample.is utilize. to de.onstrate.the.e.fe.tive.e.s of the.control strate.y provide..

关键词： H_(∞)optimal control Input constrains Multi-age.t syste.s(MASs) Re.nforce.e.t le.rning(Rl)

e.pe.ime.tal me.sure.e.ts of gamma-photon production and e.timation of e.e.tron/positron production on the.Pe.Al lase. facility

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Matte. and Radiation at e.tre.e. 2024年第5期9卷 32-47页

作者： F.Brun l.Ribotte.G.Boutoux X.Davoine.P.e.Masson-laborde.Y.Se.toku N.Iwata N.Blanchot D.Batani I.lantuéjoul l.le.he.bourg B.Rosse.C.Rousse.ux B.Vauzour D.Raffe.tin e.D’Humière. X.Ribe.re Ce.tre.lase.s Inte.se. e. Applications UMR 5107Universitéde Bordeaux-CNRS-CEA33405 TalenceFrance Ce. DAMCESTAF-33116 Le BarpFrance Ce. DAMDIFF-91297 ArpajonFrance Ce. LMCEUniversitéParis-Saclay91680 Bruyères-le-ChâtelFrance Institute.of lase. e.gine.ring Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan

This article.re.orts the.first me.sure.e.ts of high-e.e.gy photons produce. with the.high-inte.sity Pe.awatt Aquitaine.lase.(Pe.Al)*** e.pe.ime.ts we.e.pe.forme. during the.commissioning of the.*** lase. had an e.e.gy of about 400 J,an inte.sity of 8×10^(18)W cm^(−2),and a pulse.duration of 660 fs(FWHM).It was shot at a 2 mm-thick solid tungste. *** high-e.e.gy photons we.e.produce. mainly from the.bre.sstrahlung proce.s for re.ativistic e.e.trons acce.e.ate. inside.a plasma ge.e.ate. on the.front side.of the.*** pape. re.orts me.sure.e.ts of e.e.trons,protons and *** e.e.trons up to35 Me. with a fe.-Me. te.pe.ature.we.e.re.orde. by a spe.trome.e.,calle. Se.AMe.Spe.tre.le.tronS Angulaire.Moye.ne.ne.gie..K-and l-she.ls we.e.cle.rly de.e.te. by a photon spe.trome.e. calle. SPe.TIX(Spe.tromètre.Pe.alàCristal e. TransmIssion pour le.rayonnne.e.t X).High-e.e.gy photons we.e.diagnose. by CRACC-X(Casse.te.de.RAdiographie.Ce.tre.Chambre.rayonne.e.t X),a bre.sstrahlung *** cannon analysis is strongly de.e.de.t on the.hypothe.is adopte. for the.spe.tral *** shape. can e.hibit similar re.roductions of the.e.pe.ime.tal *** e.iminate.de.e.de.ce.on the.shape.hypothe.is and to facilitate.analysis of the.data,simulations of the.inte.action we.e.*** mode. the.me.hanisms involve.,a simulation chain including hydrodynamic,particle.in-ce.l,and Monte.Carlo simulations was *** simulations mode. the.pre.lasma ge.e.ate. at the.front of the.targe. by the.Pe.Al lase. pre.ulse.the.acce.e.ation of e.e.trons inside.the.plasma,the.ge.e.ation of Me.-range.photons from the.e.e.e.trons,and the.re.ponse.of the.de.e.tor impacte. by the.e.e.ge.ic photon *** this work e.able. re.roduction of the.e.pe.ime.tal *** high-e.e.gy photons produce. have.a large.e.ission angle.and an e.pone.tial distribution *** addition to the.analysis of the.photon spe.tra,positron production was also ***,if high

关键词： proce.s positron hypothe.is

Blood Pre.sure.Profile.and Glyce.ic Control of Type.2 Diabe.ics and Hype.te.sive. at the.Yalgado Oue.raogo Unive.sity Hospital: A Re.ie. of 116 Case.

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World Journal of Cardiovascular Dise.se. 2024年第1期14卷 61-76页

作者： G. R. C. Millogo A. Thiam Y. Kambiré e. Nongkouni S. e. Dabiré l. J. Kagambéga J. K. Kologo V. N. Yaméogo P. Zabsonré De.artme.t of Cardiology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso De.artme.t of Cardiology Tengandogo University Hospital Ouagadougou Burkina Faso

Obje.tive. The.association hype.te.sion and diabe.e. is important. The.two pathologie. may influe.ce.e.ch othe.. The.aim was to study the.corre.ation be.we.n glyce.ic control and blood pre.sure.control and to de.e.mine.the.factors associate. with blood pre.sure.control. Me.hodology: This was a de.criptive.cross-se.tional study with an analytical focus ove. 7 months. Patie.ts we.e.re.ruite. as outpatie.ts and all unde.we.t ambulatory blood pre.sure.me.sure. glycate. he.oglobin and cre.tinine.me.sure.e.ts, and asse.sme.t of compliance.with tre.tme.t. Re.ults: During this pe.iod 116 patie.ts we.e.colle.te.. The.pre.ominance.was fe.ale.69%. The.me.n age.of the.patie.ts was 62 ± 7 ye.rs with a pe.k be.we.n 60 and 70 ye.rs. The.ave.age.age.of hype.te.sion was 12 ye.rs and that of diabe.e. 6 1/2 ye.rs. The.most fre.ue.tly associate. cardiovascular risk factor was a se.e.tary life.tyle.(71.5%) afte. age. 57.8% of patie.ts we.e.not controlle. at the.office. with a pre.ominance.of systolic hype.te.sion (58.2%). 61.6% of patie.ts we.e.controlle. by ambulatory blood pre.sure.me.sure. a rate.of 47.8% of white.coat hype.te.sion. Glyce.ic control was obse.ve. in 42.2% of case. and 87% of patie.ts had good re.al function (glome.ular filte. rate.≥ 60 ml/mn). The.ape.tic compliance.was good in 53.4% of case. and dual the.apy was the.most use. the.ape.tic modality 44.8% (52 patie.ts) followe. by triple.the.apy. The.factors associate. with poor blood pre.sure.control we.e.glyce.ic imbalance. non-compliance.and monothe.apy. Dual the.apy had a prote.tive.e.fe.t. Conclusion: The.association of hype.te.sion and type.2 diabe.e. is fre.ue.t. The.risk of occurre.ce.incre.se. with age. Ambulatory blood pre.sure.me.sure.is the.be.t me.hod to asse.s blood pre.sure.control. Optimization of blood pre.sure.control should also include.optimization of glyce.ic control.

关键词： Blood Pre.sure.Control Glyce.ic Control Hype.te.sive.and Diabe.ic Patie.ts

De.ision-Making and Manage.e.t of Se.f-Care.in Pe.sons with Traumatic Spinal Cord Injurie.: A Pre.iminary Study

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Journal of Be.avioral and Brain Scie.ce 2024年第2期14卷 47-63页

作者： Paul e. Plonski Jasmin Vassile.a Ryan Shahidi Paul B. Pe.rin William Carte. lance.l. Goe.z Ambe. Broche.ti Jame. M. Bjork Institute.for Drug and Alcohol Studie. Virginia Commonwealth University Richmond VA USA Richmond Ve.e.ans Affairs Me.ical Ce.te. Richmond VA USA De.artme.t of Psychiatry Virginia Commonwealth University Richmond VA USA De.artme.t of Psychology Virginia Commonwealth University Richmond VA USA De.artme.t of Physical Me.icine.and Re.abilitation Virginia Commonwealth University Richmond VA USA De.artme.t of Spinal Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA De.artme.t of Pharmacology and Toxicology Virginia Commonwealth University Richmond VA USA

Patie.ts and physicians unde.stand the.importance.of se.f-care.following spinal cord injury (SCI), ye. many individuals with SCI do not adhe.e.to re.omme.de. se.f-care.activitie. de.pite.logistical supports. Ne.robe.avioral de.e.minants of SCI se.f-care.be.avior, such as impulsivity, are.not wide.y studie., ye. unde.standing the. could inform e.forts to improve.SCI se.f-care. We.e.plore. associations be.we.n impulsivity and se.f-care.in an obse.vational study of 35 US adults age.18 - 50 who had traumatic SCI with paraple.ia at le.st six months be.ore.asse.sme.t. The.primary outcome.me.sure.was se.f-re.orte. se.f-care. In lASSO re.re.sion mode.s that include. all ne.robe.avioral me.sure. and de.ographics as pre.ictors of se.f-care. dispositional me.sure. of gre.te. impulsivity (ne.ative.urge.cy, lack of pre.e.itation, lack of pe.se.e.ance., and re.uce. mindfulne.s we.e.associate. with re.uce. se.f-care. Outcome.(magnitude. se.sitivity, a late.t de.ision-making parame.e. de.ive. from computationally mode.ing succe.sive.choice. in a gambling task, was also associate. with se.f-care.be.avior. The.e.re.ults are.pre.iminary;more.re.e.rch is ne.de. to de.onstrate.the.utility of the.e.findings in clinical se.tings. Information about associations be.we.n impulsivity and poor se.f-care.in pe.ple.with SCI could guide.the.de.e.opme.t of inte.ve.tions to improve.SCI se.f-care.and he.p patie.ts with e.e.ate. risks re.ate. to se.f-care.and se.ondary he.lth conditions.

关键词： Spinal Cord Injury Se.f-Care De.ision-Making Paraple.ia Impulsive.Be.avior He.lth Care

Se.f-Trigge.e. Se. Stabilization of Boole.n Control Ne.works and Its Applications

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Ie.e.CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong Zhao Jun-e.Fe.g Dawe. Zhang the.School of Mathe.atics Shandong UniversityShandong UniversityJinan 250100China

Se. stabilization is one.of the.e.se.tial proble.s in e.gine.ring syste.s, and se.f-trigge.e. control(STC) can save.the.storage.space.for inte.active.information, and can be.succe.sfully applie. in ne.worke. control syste.s with limite. communication re.ource.. In this study, the.se. stabilization proble. and STC de.ign of Boole.n control ne.works are.inve.tigate. via the.se.i-te.sor product te.hnique. On the.one.hand, the.large.t control invariant subse. is calculate. in te.ms of the.strongly conne.te. compone.ts of the.state.transition graph, by which a graph-the.re.ical condition for se. stabilization is de.ive.. On the.othe. hand, a characte.istic function is e.ploite. to de.e.mine.the.trigge.ing me.hanism and fe.sible.controls. Base. on this, the.minimum-time.and minimum-trigge.ing ope.-loop, state.fe.dback and output-fe.dback STCs for se. stabilization are.de.igne.,re.pe.tive.y. As classic applications of se.f-trigge.e. se. stabilization, se.f-trigge.e. synchronization, se.f-trigge.e. output tracking and se.f-trigge.e. output re.ulation are.discusse. as we.l. Additionally, se.e.al practical e.ample. are.give. to illustrate.the.e.fe.tive.e.s of the.re.ical re.ults.

关键词： Boole.n control ne.works(BCNs) output re.ulation se.f-trigge.e. control se.i-te.sor product of matrice. se. stabilization synchronization

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Nonline.r wave.dispe.sion in monoatomic chains with lumpe. and distribute. masse.:discre.e.and continuum mode.s

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Applie. Mathe.atics and Me.hanics(e.glish e.ition) 2024年第4期45卷 633-648页

作者： e.GHAVANlOO S.e.-BORGI School of Me.hanical e.gine.ring Shiraz UniversityShiraz 71963-16548Iran Me.hanical e.gine.ring Program Texas A&M University at QatarDoha 23874Qatar

The.main obje.tive.of this pape. is to inve.tigate.the.influe.ce.of ine.tia of nonline.r springs on the.dispe.sion be.avior of discre.e.monoatomic chains with lumpe. and distribute. *** de.e.ope. mode. can re.re.e.t the.wave.propagation proble. in a non-homoge.e.us mate.ial consisting of he.vy inclusions e.be.de. in a *** inclusions are.ide.lize. by lumpe. masse.,and the.matrix be.we.n adjace.t inclusions is mode.e. by a nonline.r spring with distribute. ***,the.mode. is capable.of de.icting the.wave.propagation in bi-mate.ial bars,whe.e.n the.first mate.ial is re.re.e.te. by a rigid particle.and the.se.ond one.is re.re.e.te. by a nonline.r spring with distribute. *** discre.e.mode. of the.nonline.r monoatomic chain with lumpe. and distribute. masse. is first conside.e.,and a close.-form e.pre.sion of the.dispe.sion re.ation is obtaine. by the.se.ond-orde. lindste.t-Poincare.me.hod(lPM).Ne.t,a continuum mode. for the.nonline.r monoatomic chain is de.ive. dire.tly from its discre.e.lattice.mode. by a suitable.continualization *** subse.ue.t use.of the.se.ond-orde. me.hod of multiple.scale.(MMS)facilitate. the.de.ivation of the.corre.ponding nonline.r dispe.sion re.ation in a close. *** nove.tie. of the.pre.e.t study consist of(i)conside.ing the.ine.tia of nonline.r springs on the.dispe.sion be.avior of the.discre.e.mass-spring chains;(ii)de.e.oping the.se.ond-orde. lPM for the.wave.propagation in the.discre.e.chains;and(iii)de.iving a continuum mode. for the.nonline.r monoatomic chains with lumpe. and distribute. ***,a parame.ric study is conducte. to e.amine.the.e.fe.ts of the.de.ign parame.e.s and the.distribute. spring mass on the.nonline.r dispe.sion re.ations and phase.ve.ocitie. obtaine. from both the.discre.e.and continuum *** parame.e.s include.the.ratio of the.spring mass to the.lumpe. mass,the.nonline.r stiffne.s coe.ficie.t of the.spring,and the.wave.amplitude.

关键词： nonline.r mass-spring chain discre.e.mode. continuum mode. lindste.tPoincare.me.hod(lPM) me.hod of multiple.scale.(MMS) dispe.sion phase.ve.ocity

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Annual variation of adult survival of a south-te.pe.ate.House.Wre. population in Arge.tina

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Avian Re.e.rch 2024年第2期15卷 229-237页

作者： Gustavo J.Fe.nande. Mariana e.Carro Paulo e.llambías Grupo de.Inve.tigacion e. e.ofisiología de.Fauna Silve.tre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de.Inve.tigacion de.Biología de.Ave. IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Ide.tifying factors affe.ting the.survival of individuals is e.se.tial for unde.standing the.e.olution of life.history traits and population *** nume.ous studie. on this subje.t in north-te.pe.ate.e.vironme.ts,the.e.is a lack of e.uivale.t studie. at similar latitude. in the.***,we.use. a 14-ye.r datase. of capture.banding,and re.ighting to e.timate.the.annual variation in the.appare.t adult survival probability of a south-te.pe.ate.population of House.Wre.s(Troglodyte. ae.on bonariae..We.e.aluate. te.poral variation in sur-vival and the.e.fe.t of e.vironme.tal(climatic)and de.ographic variable.(adult abundance.total numbe. of fle.glings produce. during e.ch bre.ding se.son)on survival *** found that the.probability of adult survival de.re.se. as the.abundance.of bre.ding adults *** de.sity-de.e.de.t e.fe.t could be.re.ate. to the.re.ide.t life.tyle.of southe.n House.Wre.s,which could de.e.mine.an inte.se.compe.ition for te.ritorie. and re.ource. that ultimate.y would affe.t the.r survival.

关键词： Annual variation CJS De.sity-de.e.de.ce Survival Troglodyte. ae.on bonariae

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Be.ond p-y me.hod:A re.ie. of artificial inte.lige.ce.approache. for pre.icting late.al capacity of drille. shafts in claye. soils

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Journal of Rock Me.hanics and Ge.te.hnical e.gine.ring 2024年第9期16卷 3812-3840页

作者： M.e.Al-Atroush A.e.Aboe.e.a e.z e.-Din He.dan Civil and e.vironme.tal e.gine.ring Program Engineering Management DepartmentCollege of EngineeringPrince Sultan UniversityRiyadhSaudi Arabia De.artme.t of Structural e.gine.ring Faculty of EngineeringAin Shams UniversityCairoEgypt Structure.and Mate.ials Re.e.rch lab Prince Sultan UniversityRiyadhSaudi Arabia Compute. Scie.ce.and e.gine.ring De.artme.t Faculty of Electronic EngineeringMenoufia UniversityMenoufiaEgypt

In 2023,pivotal advance.e.ts in artificial inte.lige.ce.AI)have.significantly *** that in mind,traditional me.hodologie.,notably the.p-y approach,have.struggle. to accurate.y mode. the.comple.,nonline.r soil-structure.inte.actions of late.ally loade. large.diame.e. drille. *** study unde.take. a rigorous e.aluation of machine.le.rning(Ml)and de.p le.rning(Dl)te.hnique.,offe.ing a compre.e.sive.re.ie. of the.r application in addre.sing this ge.te.hnical challe.ge.A thorough re.ie. and comparative.analysis have.be.n carrie. out to inve.tigate.various AI mode.s such as artificial ne.ral ne.works(ANNs),re.e.ance.ve.tor machine.(RVMs),and le.st square. support ve.tor machine.(lSSVMs).It was found that de.pite.Ml approache. outpe.forming classic me.hods in pre.icting the.late.al be.avior of pile.,the.r‘black box'nature.and re.iance.only on a data-drive. approach made.the.r re.ults showcase.statistical robustne.s rathe. than cle.r ge.te.hnical insights,a fact unde.score. by the.mathe.atical e.uations de.ive. from the.e.***,the.re.e.rch ide.tifie. a gap in the.availability of drille. shaft datase.s,limiting the.e.te.dibility of curre.t findings to large.diame.e. *** e.te.sive.datase.,compile. from a se.ie. of late.al loading te.ts on fre.-he.d drille. shaft with varying prope.tie. and ge.me.rie.,was introduce. to bridge.this *** pape. conclude. with a dire.tion for future.re.e.rch,propose. the.inte.ration of physics-informe. ne.ral ne.works(PINNs),combining data-drive. mode.s with fundame.tal ge.te.hnical principle. to improve.both the.inte.pre.ability and pre.ictive.accuracy of AI applications in ge.te.hnical e.gine.ring,marking a nove. contribution to the.fie.d.

关键词： late.ally loade. drille. shaft load transfe. and failure.me.hanisms Physics-informe. ne.ral ne.works(PINNs) P-y curve. Artificial inte.lige.ce.AI) Datase.