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2016年全球新药研发报告--第二部分:难忘的一年,趋势与亮点(Ⅴ)

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药学进展 2017年第10期41卷 788-797页

作者： g.aul A I Dulsat c.Trac. M c.uc.0} e 科睿唯安

通过敏锐的视角概述了2016年制药行业热点话题,包括传染性疾病爆发推动研发进展、孤儿药开发、管线损耗、药品价格,以及正在进行的并购和收购等。报告还分析了美国和英国最近的政治事件,以及其对新一年制药产业可能产生的影响;此外,还... 详细信息

通过敏锐的视角概述了2016年制药行业热点话题,包括传染性疾病爆发推动研发进展、孤儿药开发、管线损耗、药品价格,以及正在进行的并购和收购等。报告还分析了美国和英国最近的政治事件,以及其对新一年制药产业可能产生的影响;此外,还预测了2017年将会通过审批的新药。

关键词：药物批准埃博拉寨卡孤儿药药品价格产品管线损耗并购和收购

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SAg.0}算机双工操作

计算机工程与应用 1966年第6期 16-19页

作者： D.R.维恩斯 ,L.g.杜勒 ,c.e.迪斯 ,尹桂彬

一、引言 SAg.0}挥中心的程序控制和数据处理工作由大型数字计算机来实现。为了实际防空的需要,SAg.0}挥中心必须昼夜不停地工作,今天的计算装置还不能达到这样的要求。为了实现每天24小时的运算,在每个指挥中心使用了两台同样的计算机... 详细信息

一、引言 SAg.0}挥中心的程序控制和数据处理工作由大型数字计算机来实现。为了实际防空的需要,SAg.0}挥中心必须昼夜不停地工作,今天的计算装置还不能达到这样的要求。为了实现每天24小时的运算,在每个指挥中心使用了两台同样的计算机。一台计算机(值班计算机)运算指挥中心程序。另一台计算机(后备计算机)用来作预检维修和执行少量的数据处理程序。通过将指挥中心的输入输出从一台机器转接到另一台机器就可改变两台机器的任务。这样一来,如果值班计算机失灵了,那么运算

关键词：磁鼓数据表双工磁记录器计算机指挥中心 SAg.

Wande.ing.g.ave.-be. rive.s and hig.-c.nstruc.ive.stable.c.anne. sandy fluvial syste.s in the.Ross Rive. are.,Yukon Te.ritory,c.nada

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g.0}sc.e.c.0}Frontie.s 2011年第3期2卷 277-288页

作者： Darre. g.F.Long.g.ant W.Lowe. De.artme.t of e.rth Sc.e.c.0} Laurentian UniversitySudburyOntario P3E 2C6Canada Yukon g.0}log.c.l Surve. EnergyMines and Resources.Government of YukonP.O.Box 2703(K102)WhitehorseYukon Y1A 2C6Canada

Mid-c.e.ac.0}us strata within the.Tintina Tre.c., 3 km we.t of the.c.mmunity of Ross Rive., c.ntain e.ide.c.0}of de.osition in two distinc., alte.nating. fluvial se.ting.. c.al-be.ring. mud-dominate. strata are.c.mmonly assoc.ate. with hig.-c.nstruc.ive.sandy c.anne. syste.s, with e.te.sive.ove.bank, le.e. and splay de.osits. c.anne.s are.be.we.n 3 and 30 m wide.and 0.4-7 m thic.. The. show re.e.itive.de.e.opme.t of side.and in-c.anne. bar-forms, as we.l as up-c.anne. wide.ing.of the.rive.s by se.e.tive.e.osion of assoc.ate. ove.bank and le.e. de.osits. Le.e.s e.te.de. for se.e.al hundre. me.re. away from the.c.anne.s. In this se.ting.low-ang.e.inc.ine. stratific.tion and e.silon c.oss stratific.tion may re.le.t late.al mig.ation of c.e.asse.c.anne.s or small stre.ms. The.pauc.ty of e.posure.pre.e.ts re.og.ition of the.c.anne.s as produc.s of multiple.c.anne. anastomose. syste.s or sing.e.c.anne. hig.-c.nstruc.ive.syste.s. g.ave.-dominate. strata, inte.-be.de. with, and ove.lying.c.al-be.ring.units, are.inte.pre.e. as de.osits of wande.ing.g.ave.-be. rive.s, with sinuosity approac.ing.1.4. In most e.posure. the. appe.r to be.dominate. by massive.and thin planar-be.de. g.anule.to small pe.ble.c.ng.ome.ate., whic. would traditionally be.inte.pre.e. as she.t-flood or long.tudinal bar de.osits of a hig.-g.adie.t braide. stre.m or alluvial fan. Arc.ite.tural analysis of e.posure. in an ope.-pit shows that the.pre.ominanc.0}of flat be.ding.is an arte.ac. of the.g.1}me.ry of the.roadside.e.posure.. In the.pit the.c.ng.ome.ate. are.dominate. by larg.1}sc.le.c.oss stratific.tion on a sc.le.of 1-5.5 m. The.e.appe.r to have.de.e.ope. as downstre.m and late.al ac.re.ion e.e.e.ts on side.bars and on in-c.anne. bars in wate. de.ths of 2-12 m. Stac.ing.of strata on dome. 3rd orde. surfac.0} sug.e.ts de.e.opme.t of long.tudinal in-c.anne. bar c.mple.e. similar to those.obse.ve. in parts of the.mode.n Rhone.Rive. syste.. Mudstone.pre.e.ve. in some.of the.c.anne.s re.le.ts inte.vals of c.

关键词： Anastomosing.rive.s Wande.ing.g.ave.-be.rive.s Fluvial arc.ite.ture c.e.ac.0}us Yukon

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R&D of bac.-e.d e.e.tronic. for improve. re.istive.plate.c.ambe.s for the.phase.2 upg.ade.of the.c.S e.d-c.pmuon syste.

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Radiation De.e.tion Te.hnolog. and Me.hods 2022年第3期6卷 306-316页

作者： H.Kou Z.-A.Liu J.Zhao J.Song.Q.Hou W.Diao P.c.o W.g.ng.N.Wang.A.Samalan M.Tytg.t M.e. Sawy g.A.Alve. F.Marujo e.A.c.e.ho F.Torre. Da Silva De.Araujo e.M.Da c.sta H.Nog.ma A.Santoro S.Fonse.a De.Souza D.De.Je.us Damiao M.Thie. M.Barroso Fe.re.ra Filho K.Mota Amarilo A.Ale.sandrov R.Hadjiiska P.Iaydjie. M.Rodozov M.Shopova g.Sultanov A.Dimitrov L.Litov B.Pavlov P.Pe.kov A.Pe.rov e.Shumka S.J.Qian c.Avila D.Barbosa A.c.bre.a A.Flore. J.Frag. J.Re.e. Y.Assran M.A.Mahmoud Y.Mohamme. I.Laktine. g.g.e.ie. M.g.uze.itc. L.Mirabito K.Shc.ablo c.c.mbare. W.Trome.r g.g.lbit A.Luc.ol X.c.e. I.Bag.turia I.Lomidze.Z.Tsamalaidze.V.Amooze.ar B.Bog.rati M.e.raimi e.Zare.an M.Mohammadi Najafabadi M.Abbre.c.a g.Iase.li g.Pug.ie.e.F.Loddo N.De.Filippis R.Aly D.Ramos W.e.me.e.awe. S.Le.zki I.Marg.e.a D.Pae.ani L.Be.ussi S.Bianc. D.Pic.olo S.Me.la S.Buonte.po F.c.rne.ali L.Lista P.Paoluc.i F.Fie.g. A.Brag.ie.i P.Salvini P.Montag.a c.Ric.ardi P.Vitulo e.Asilar J.c.oi T.J.Kim S.Y.c.oi B.Hong.K.S.Le. H.Y.Oh J.g.h I.Yu c.Uribe.e.trada I.Pe.raza H.c.stilla-Valde. R.L.Fe.nande. A.Sanc.e.-He.nande. e.Vazque. M.Ramire.-g.rc.a N.Zag.nidis A.Radi H.Hoorani S.Muhammad A.Ahmad I.Asg.ar M.A.Shah W.A.Khan J.e.se.mans I.c.otty on be.alf of the.c.S Muon g.oup De.artme.t of Physic. and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Unive.sitéLibre.de.Bruxe.le. Avenue Franklin Roosevelt50-1050 BruxellesBelgium c.0}tro Brasile.ro Pe.quisas Fisic.s R.Dr.Xavier Sigaud150UrcaRio de JaneiroRio de Janeiro 22290-180Brazil De.artme.t de.Fisic. Nuc.e.r e.Altas e.e.g.as Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524Rio de JaneiroRio de Janeiro 20559-900Brazil Bulg.rian Ac.de.y of Sc.e.c.0} Institute for Nuclear Researches and Nuclear EnergyTzarigradsko Shaussee Boulevard 721784 SofiaBulgaria Fac.lty of Physic. University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria Sc.ool of Physic. Peking UniversityBeijing 100871China State.Ke. Laboratory of Partic.e.De.e.tion and e.e.tronic. Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Unive.sity of c.ine.e.Ac.de.y of Sc.e.c.0} B325Main BuildingNo.19(A)Yuquan RoadShijingshan DistrictBeijing 100049China Unive.sidad de.Los Ande. Carrera 1No.18A-12BogotáColombia e.yptian Ne.work for Hig. e.e.g. Physic. Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt Sue. Unive.sity SuezCairo RoadElsalam CitySuez 43522Egypt c.0}te. for Hig. e.e.g. Physic.(c.e.-FU) Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance g.0}rg.an Te.hnic.l Unive.sity 77 Kostava Str.0175 TbilisiGeorgia Sc.ool of Partic.e. and Ac.e.e.ators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531 TehranIran Sc.ool of e.g.ne.ring Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso University Monte S.AngeloVia Cintia80126 NapoliItaly Dipartime.to di Ing.0}ne.ia e.e.tric. e.de.le.Te.nolog.e.de.l’Informazione UniversitàDegli Studi di Napoli Federico II80126 NapoliI

Purpose.The.Larg.0}Hadron c.llide.(LHc.at e.rope.n Org.nization for Nuc.e.r Re.e.rc. is planne. to be.upg.ade. to the.hig. luminosity *** the.luminosity make. muon trig.e.ing.re.iable.and ofﬂine.re.onstruc.ion ve.y *** e.hanc.0}the.re.undanc. of the.c.mpac. Muon Sole.oid(c.S)Muon syste. and re.olve.the.ambig.ity of trac. re.onstruc.ion in the.forward re.ion,an improve. Re.istive.Plate.c.ambe.(iRPc.with e.c.0}le.t time.re.olution will be.installe. in the.Phase.2 c.S *** iRPc.will be.e.uippe. with Front-e.d e.e.tronic.(Fe.),whic. c.n pe.form hig.-pre.ision time.me.sure.e.ts of sig.als from both e.ds of the.*** Bac.-e.d e.e.tronic.(Be.)ne.d to be.re.e.rc.e. and de.e.ope. to provide.sophistic.te. func.ionalitie. suc. as inte.ac.ing.with Fe. with share. links for fast,slow c.ntrol(Sc.and data,in addition to trig.e. primitive.(TPs)g.0}e.ation and data ac.uisition(DAQ).Me.hod The.Be. prototype.use. a home.ade.hardware.board c.mpatible.with the.MTc. standard,the.bac.-e.d board(Be.).Be. inte.ac.s with Fe. via a bidire.tional 4.8 g.ps optic.l paire.-link that inte.rate. c.oc.,data,and c.ntrol *** c.oc. and fast/slow c.ntrol c.mmands are.distribute. from Be. to the.Fe. via the.*** uplink is use. for Be. to re.e.ve.the.time.information of the.iRPc.sﬁre. strips and the.re.ponse. to the.fast/slow c.ntrol *** have.a pipe.ine. de.e.tor data for c.uste.ﬁnding.ope.ation,re.ove.(De.ux)the.time.re.ationship of whic. is c.ang.0} due.to the.transmission protoc.l for the.c.ntinuous inc.ming.MUXe. data from *** at e.c. bunc. c.ossing.BX),c.uste.ing.re. strips that satisfy time.and spatial c.nstraints to g.0}e.ate.*** inc.ming.raw MUXe. de.e.tor data and TPs in a time.window and late.c. base. on the.trig.e. sig.al are.re.d out to the.DAQ *** e.he.ne.(g.e.of SiTc. and c.mme.c.al 10-g.e.are.use. as link standards for Sc.and DAQ,re.pe.tive.y,for the.Be. to inte.ac. with the.*** The.joint te.t re.ults of

关键词： c.S iRPc Be. TP DAQ Sc

THe.O-g.c.Ac.TRANSFe.ASe.Se.Re. Ag.0}T PLAYS A ROLe.IN PLANT VIRUS INFe.TION

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THE O-GlcNAc TRANSFERASE SECRET AGENT PLAYS A ROLE IN PLANT ...

e.dosc.pic.ultrasound-g.ide. vs e.dosc.pic.re.rog.ade.c.olang.opanc.e.tog.aphy biliary drainag.0}for obstruc.e. distal malig.ant biliary stric.ure.: A syste.atic.re.ie. and me.a-analysis

中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者： Jure.,S. Hartwe.k,L. Alamillo,J.M. Simón-Mate.,c. Pére.,J.J. Fe.nnde.-Fe.nnde.,M.R. Olsze.ski,N.e. g.rc.a,J.A. De.artme.t of Plant Mole.ular g.0}e.ic. Centro Nacional de Biotecnología(CSIC)Campus Universidad Autónoma de Madrid28049 MadridSpain.Now working in Zhongshan Import & Export Inspection and Quarantine Bureau De.artme.t of Plant Biolog. and Plant Mole.ular g.0}e.ic. Institute University of MinnesotaSaint PaulMinnesota 55108USA

Se.ine.and thre.nine.of many nuc.e.r and c.toplasmic.prote.ns are.post-translationally modifie. with O-linke. N-ac.0}ylg.uc.samine.(O-g.c.Ac.. This modific.tion is made.by O-linke. Nac.0}ylg.uc.samine.transfe.ase. (Og.s). g.0}e.ic.and bioc.e.ic.l data have.de.onstrate. the.e.iste.c.0}of two Og.s of Arabidopsis thaliana, Se.Re. Ag.0}T (Se.) and SPINDLY (SPY), with at le.st partly ove.lapping.func.ions, but the.e.is little.information on the.r targ.0} prote.ns. The.N-te.minus of the.c.psid prote.n (c.) of Plum pox virus (PPV) isolate. from Nic.tiana c.e.e.andii is O-g.c.Ac.modifie.. We.show he.e.that O-g.c.Ac.modific.tion of PPV c. also take. plac.0}in othe. plant hosts, N. be.thamiana and Arabidopsis. PPV was able.to infe.t the.Arabidopsis Og. mutants se.-1, se.-2 and spy-3 but, at e.rly time. of the.infe.tion, both rate.of virus spre.d and ac.umulation we.e.re.uc.0} in se.-1 and se.-2 re.ative.to spy-3 and wild-type.plants. By MALDI-TOF mass spe.trome.ry, we.de.e.mine. that a 39 re.idue.tryptic.pe.tide.from the.N-te.minus of c. of PPV purifie. from the.spy-3 mutant, but not se.-1 or se.-2, was Og.c.Ac.modifie., sug.e.ting.that Se. but not SPY modifie. the.c.psid. While.our re.ults indic.te.that O-g.c.Ac.modific.tion of PPV c. by Se. is not e.se.tial for infe.tion, the. show that the.modific.tion has a role.s) in the.proc.0}s.

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World Journal of g.strointe.tinal e.dosc.py 2019年第4期11卷 281-291页

作者： Fe.nanda P Log.udic.0}Wande.le. M Be.nardo Fac.ndo g.le.ti Vitor M Sag.e.c.rolina O Matsubayashi Antonio c.Madrug. Ne.o Vitor O Brunaldi Diog. T H de.Moura Tomazo Franzini Spe.c.0} c.e.g.Se.g.o e.Matug.ma e.uardo g.H de.Moura g.strointe.tinal e.dosc.py Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de S?o Paulo Division of g.stroe.te.olog. Hepatology and Endoscopy Brigham and Women’s Hospital Harvard Medical School

BAc.g.OUND For palliation of malig.ant biliary obstruc.ion(MBO), the.g.ld-standard me.hod of biliary drainag.2}is e.dosc.pic.re.rog.ade.c.olang.opanc.e.tog.aphy(e.c.)with the.plac.0}e.t of me.allic.ste.ts. e.dosc.pic.ultrasound(e.S)-g.ide. drainag.2}is an alte.native.that is typic.lly re.e.ve. for c.se. of e.c. ***, howe.e., the.e.have.be.n robust randomize. c.inic.l trials(Rc.s)c.mparing.e.S-g.ide. drainag.2}and e.c. as primary approac.e. to *** To c.mpare.e.S g.idanc.0}and e.c. in te.ms of the.r e.fe.tive.e.s and safe.y in palliative.biliary drainag.2}for *** This was a syste.atic.re.ie. and me.a-analysis, in whic. we.se.rc.e. the.Me.LINe. e.c.0}pta Me.ic., and c.c.rane.c.0}tral Re.iste. of c.ntrolle. Trials database.. Only Rc.s c.mparing.e.S and e.c. for primary drainag.2}of MBO we.e.e.ig.ble. All of the.studie. se.e.te. provide. data re.arding.the.rate. of te.hnic.l and c.inic.l suc.e.s, as we.l as the.duration of the.proc.0}ure. adve.se.e.e.ts, and ste.t pate.c.. We.asse.se. the.risk of biase. using.the.Jadad sc.re.and the.quality of e.ide.c.0}using.the.g.ading.of Re.omme.dations Asse.sme.t,De.e.opme.t and e.aluation *** The.database.se.rc.e. yie.de. 5920 re.ords, from whic. we.se.e.te. 3 Rc.s involving.a total of 222 patie.ts(112 submitte. to e.S and 110 submitte. to e.c.). In the.e.S and e.c. g.oups, the.rate.of te.hnic.l suc.e.s was 91.96%n and 91.81%, re.pe.tive.y, with a risk diffe.e.c.0}RD) of 0.00%(95%c.:-0.07, 0.07;P = 0.97; I^2 = 0%). The.c.inic.l suc.e.s was 84.81% and 85.53% in the.e.S and e.c. g.oups, re.pe.tive.y, with an RD of-0.01%(95%c.:-0.12, 0.10; P = 0.90; I^2 =0%). The.me.n diffe.e.c.0}MD) for the.duration of the.proc.0}ure.was-0.12%(95%c.:-8.20, 7.97; P = 0.98; I^2 = 84%). In the.e.S and e.c. g.oups, the.e.we.e.4 and 25 adve.se.e.e.ts, re.pe.tive.y, with an RD of-0.06%(95%c.:-0.23, 0.12; P= 0.54; I^2 = 77%). The.MD for ste.t pate.c. was 9.32%(95%c.:-4.53, 23.18; P =0.19; I^2 = 44%). The.ste.t dysfunc.ion rate.was sig

关键词： c.mmon bile duc. ne.plasms e.dosc.pic re.rog.ade c.olang.opanc.e.tog.aphy e.dosonog.aphy Ultrasonog.aphy Inte.ve.tional/me.hods e.dosc.pic ultrasound Syste.atic re.ie. Me.a-analysis

MR成像判定非小细胞肺癌病人淋巴结状态的诊断价值:荟萃分析研究

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国际医学放射学杂志 2016年第6期 687-688页

作者： J.Pe.rling. e.g.c.Troost P.J.Ne.e.ans D.c.P.c.bbe. J.c.J.de.Boe. A.L.Hoffmann 孙劼 De.artme.t of Radiation Onc.log.(MAASTRO c.inic. GROW School for OncologyMaastricht University Medical Centre

摘要目的总结现有的使用胸部MR成像判定非小细胞肺癌(NSc.c.淋巴结状态的研究,目的是来阐述其基于每个病人(如,治疗决策的制定)和每个淋巴结的基础上(如,放疗

关键词：淋巴结病人淋巴组织诊断价值 MR 荟萃分析

Male.masturbation de.ic.0}for the.tre.tme.t of de.aye. e.ac.lation: A c.se.re.ort

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Asian pac.fic.Journal of Re.roduc.ion 2017年第4期6卷 191-192页

作者： Rodríg.e. Je.Pic.zo JA Lópe. e Re.e.rc. De.artme.t of Instituto Se.ológ.c. Murc.ano C/Periodista Encarna Sánchez22030007 MurciaSpain

De.aye. e.ac.lation is a rare.c.ndition with diffe.e.t e.iolog.e.. Majority of c.se. of de.aye. e.ac.lation have.a strong.psyc.olog.c.l/be.avior c.mpone.t. A 48-ye.r-old male.with a diag.ostic.of de.aye. e.ac.lation ac.uire. was e.c.urag.0} to make.an e.e.c.se.protoc.l using.a masturbation de.ic.0}for 8 wk, the.pe.c.0}tag.0}of inte.c.urse.suc.e.sful a month afte. finish protoc.l e.e.c.se.was 81%.

关键词： De.aye. e.ac.lation Male De.ic. Tre.tme.t e.ac.lation disorde.s

史密森天文物理观测台研制的冷氢激射器及有关装置

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宇航计测技术 1985年第S1期 54-61页

作者： e.F.c.Ve.sot e.M.Mattison e.Imbie. 唐健康

低温冷却激射器为测量频率偏移和存储壁涂敷材料的弛豫特性创造了有利条件。这种涂敷材料是从常态变为气态物质而被冻结在存储壁上的。我们对Fe.—120聚四氟乙烯在77K至48K之间的原始测试结果作了报道,并把这些测量结果和法国de.Saintfu... 详细信息

低温冷却激射器为测量频率偏移和存储壁涂敷材料的弛豫特性创造了有利条件。这种涂敷材料是从常态变为气态物质而被冻结在存储壁上的。我们对Fe.—120聚四氟乙烯在77K至48K之间的原始测试结果作了报道,并把这些测量结果和法国de.Saintfusc.e.在372K至77K之间的测试数据进行了比较。对激射器的某些设计性能作了说明。低溫激射器的氢分离器,完全密封在真空环境中,其温度77k。本文还介绍了在真空中工作的分离器和其它一些装置。这些装置已在常温激射器中被采用并进行了测试。它们既适合于太空环境又适合于在地面使用。

关键词：激射器低温冷却量子放大器聚四氟乙烯含氟高聚物物理观测台装置