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Disse.ting the.ce.l microe.vironme.t of ovarian e.dome.rioma through single.ce.l RNA se.ue.cing

Scie.ce.China Life.Scie.ce. 2025年第1期 116-129页

作者： Jiangpe.g Wu Siyu Xia We.ting Ye.Yan Sun Jing Cai Fub.ng Yu Haiping We. Xiuwe. Yi Taikang Li Mingwe. Che. Jiayun Che. Ge.Song Chuanb.n Yang Yali Song Jigang Wang De.artme.t of Re.roductive.Me.icine Dongguan Maternal and Child Health Care Hospital De.artme.t of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State.Ke. Lab.ratory for Quality e.surance.and Sustainab.e.Use.of Dao-di He.b. Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Re.roductive.Me.icine.Ce.te. Foshan Women and Children Hospital State.Ke. Lab.ratory of Antiviral Drugs School of PharmacyHenan University

Ovarian e.dome.rioma（Oe., also known as “chocolate.cysts,” is a cystic mass that de.e.ops in the.ovarie. due.to e.dome.riosis and is a common gyne.ological condition characte.ize. b. the.growth of e.dome.rial tissue.outside.the.ute.us, le.ding to symptoms such as dysme.orrhe., pe.vic pain, and infe.tility. Howe.e., the.pre.ise.mole.ular and ce.lular me.hanisms driving this pathophysiology re.ain large.y unknown, posing challe.ge. for diagnosis and tre.tme.t. He.e. we.e.ploye. inte.rate. single.ce.l transcriptomic profiling of ove. 52,000 individual ce.ls from e.dome.rial tissue. of Oe.patie.ts and he.lthy donors and ide.tifie. twe.ve.major ce.l populations. We.ide.tifie. notab.e.alte.ations in ce.l type.spe.ific proportions and mole.ular signature. associate. with Oe. Notab.y, the.activation of IGFb.5+macrophage. with pro-inflammatory prope.tie., NK ce.l e.haustion, and ab.0}rant prolife.ation of IQCG+and KLF2+e.ithe.ium are.ke. fe.ture. and may b.0}the.pote.tial me.hanisms unde.lying the.pathoge.e.is of Oe. Colle.tive.y, our data contrib.te.to a b.0}te. unde.standing of Oe.at the.single.ce.l le.e. and may pave.the.way for the.de.e.opme.t of nove. the.ape.tic strate.ie..

关键词： ovary high-throughput se.ue.cing transcriptomics ge.e.e.pre.sion analysis ligand-re.e.tor analysis

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Ne.roinflammation re.isite. through the.microglial le.s

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Ne.ral Re.e.e.ation Re.e.rch 2025年第7期20卷 1989-1990页

作者： Re.ato Socodato João b.Re.vas Institute.of Re.e.rch and Innovation in He.lth(i3S)and Institute.for Mole.ular and Ce.l b.ology(Ib.C) University of PortoPortoPortugal De.artme.t of b.ome.icine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Ne.roimmunology is e.e.ging as a pivotal fie.d,she.ding light on the.intricate.dialogue. b.0}we.n the.ce.tral ne.vous syste.(CNS)and the.immune.*** e.ploration is particularly significant in unde.standing microglia,the.CNS’s innate.immune.ce.ls,b.0}ond the.conve.tional conflation of“ne.roinflammation”and“microglial activation.”This conflation has cloude. the.true.comple.ity of the.e.proce.se.,pote.tially stalling scie.tific progre.s and the.de.e.opme.t of ne. *** challe.ge.the.long-standing pe.spe.tive. that have.ove.simplifie. the.e.inte.actions,advocating for a de.pe. e.ploration of the.dynamic re.ationship b.0}we.n ne.roinflammation and microglial *** disse.ting spe.ific mole.ular pathways,we.aim to illuminate.the.r e.ab.rate.role. in ne.roinflammatory re.ponse.,e.pe.ially in the.conte.t of Alzhe.me.’s dise.se.AD).He.e.ne.roinflammation is not me.e.y a passive.ob.e.ve. or a dire.t antagonist b.t a comple. age.t in the.dise.se.s *** article.calls for a significant paradigm shift towards an inte.rative.multi-omics approach to *** such a compre.e.sive.frame.ork is crucial for advancing our unde.standing of ne.roinflammatory conditions and paving the.way for targe.e. the.ape.tic strate.ie. for b.ain dise.se..

关键词： inflammation simplifie. activation

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Catalysis of Dissolve. and Adsorb.0} Iron in Soil Suspe.sion for Chromium(VI) Re.uction b. Sulfide

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Pe.osphe.e 2006年第5期16卷 572-578页

作者： LAN Ye.Qing YANG Jun-Xiang b. De.G Colle.e.of Scie.ce Nanjing Agricultural University Nanjing 210095 （China） De.artme.t of Civil and e.vironme.tal e.gine.ring University of Missouri-Columbia Columbia MO 65211 （USA）

The.kine.ics of Cr（Ⅵ） re.uction b. sulfide.in soil suspe.sions with various pHs, soil compositions, and Fe.Ⅱ） conce.trations was e.amine. using b.tch anae.ob.c e.pe.ime.tal syste.s at constant te.pe.ature. The.re.ults showe. that the.re.ction rate.of Cr（Ⅵ） re.uction was in the.orde. of re. soil 〈 ye.low-b.own soil 〈 che.noze. and was proportional to the.conce.tration of HCl-e.tractab.e.iron in the.soils. Dissolve. and adsorb.0} iron in soil suspe.sions playe. an important role.in acce.e.ating Cr（Ⅵ） re.uction. The.re.ction involve. in the.Cr（Ⅵ） re.uction b. Fe.Ⅱ） to produce.Fe.ⅡI）, which was re.uce. to Fe.Ⅱ） again b. sulfide. could re.re.e.t the.catalytic pathway until ab.ut 70% of the.initially pre.e.t Cr（Ⅵ） was re.uce.. The.catalysis occurre. b.0}ause.the.one.ste. re.uction of Cr（Ⅵ） b. sulfide.was slowe. than the.two-ste. proce.s consisting of rapid Cr（Ⅵ） re.uction b. Fe.Ⅱ） followe. b. Fe.Ⅲ） re.uction b. sulfide. In e.se.ce. Fe.Ⅱ）/Fe.Ⅲ） spe.ie. shuttle.e.e.trons from sulfide.to Cr（Ⅵ）, facilitating the.re.ction. The.e.fe.t of iron, howe.e., could b.0}comple.e.y b.ocke. b. adding a strong Fe.Ⅱ）-comple.ing ligand, 1,10-phe.anthroline. to the.soil suspe.sions. In all the.e.pe.ime.ts, initial sulfide.conce.tration was much highe. than initial Cr（Ⅵ） conce.tration. The.plots of In e.Cr（Ⅵ）] ve.sus re.ction time.we.e.line.r up to approximate.y 70% of Cr（Ⅵ） re.uction, sugge.ting a first-orde. re.ction kine.ics with re.pe.t to Cr（Ⅵ）. e.e.e.tal sulfur, the.product of sulfide.oxidation, was found to acce.e.ate.Cr（Ⅵ） re.uction at a late. stage.of the.re.ction, re.ulting in de.iation from line.rity for the.In c[Cr（Ⅵ）] ve.sus time.plots.

关键词： catalysis chromium iron soil suspe.sion sulfide

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Magne.ic prope.tie. of Fe.(3(1-x))Cr_(3x)C alloys

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Inte.national Journal of Mine.als,Me.allurgy and Mate.ials 2009年第3期16卷 314-316页

作者： Fe.g-qi Zhao O. Te.us b. Fuquan e. b.ück Inne. Mongolia Ke. Lab.ratory for Physics and Che.istry of Functional Mate.ials College of Physics and Electron Information Inner Mongolia Normal University Hohhot 010022 China Van de. Waals-Ze.man Instituut Universiteit van Amsterdam Valckenierstraat 65 1018XE Amsterdam Netherlands

The.magne.ic prope.tie. of Fe.（1-x）Cr3xC alloys with x=0.05, 0.1, 0.15, and 0.2, which crystallize.in the.ce.e.tite.Fe.C-type.structure.with space.group Pnma, we.e.inve.tigate. b. me.ns of magne.ization me.sure.e.ts. The.e.alloys show te.pe.ature.induce. se.ond-orde. magne.ic phase.transitions. The.Curie.te.pe.ature.（Tc） of the.e.alloys de.re.se. with incre.sing x. The.isothe.mal magne.ic-e.tropy change. of the.e.alloys we.e.de.ive. from the.magne.ic isothe.ms me.sure. with incre.sing te.pe.ature.and incre.sing fie.d. The.maximum value. of the.magne.ic-e.tropy change.are.ab.ut 0.9 and 3.6 J·kg^-1·K^-1 at Tc =360 K for x = 0.05 in a magne.ic fie.d change.from 0 to 1 T and 0 to 5 T, re.pe.tive.y.

关键词： magne.ic prope.tie. magne.ocaloric e.fe.t magne.ic-e.tropy change magne.ic re.rige.ation

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Comparative.analysis of e.pirical and de.p le.rning mode.s for ionosphe.ic sporadic e.laye. pre.iction

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e.rth and Plane.ary Physics 2025年第1期9卷 10-19页

作者： b.ngKun Yu Pe.gHao Tian XiangHui Xue.Christophe. JScott HaiLun Ye.JianFe. Wu We. Yi TingDi Che. XianKang Dou Institute.of De.p Space.Scie.ce. Deep Space Exploration LaboratoryHefei 230088China CAS Ke. Lab.ratory of Ge.space.e.vironme.t School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China He.e. National Lab.ratory University of Science and Technology of ChinaHefei 230088China De.artme.t of Me.e.rology University of ReadingReading RG66BBUK

Sporadic e.e.)laye.s in the.ionosphe.e.are.characte.ize. b. inte.se.plasma irre.ularitie. in the.e.re.ion at altitude. of 90-130 *** the. can significantly influe.ce.radio communications and navigation syste.s,accurate.fore.asting of e. laye.s is crucial for e.suring the.pre.ision and de.e.dab.lity of navigation sate.lite.*** this study,we.pre.e.t e. pre.ictions made.b. an e.pirical mode. and b. a de.p le.rning mode.,and analyze.the.r diffe.e.ce. compre.e.sive.y b. comparing the.mode. pre.ictions to sate.lite.RO me.sure.e.ts and ground-b.se. ionosonde.*** de.p le.rning mode. e.hib.te. significantly b.0}te. pe.formance.as indicate. b. its high coe.ficie.t of corre.ation(r=0.87)with RO ob.e.vations and pre.ictions,than did the.e.pirical mode.(r=0.53).This study highlights the.importance.of inte.rating artificial inte.lige.ce.te.hnology into ionosphe.e.mode.ling ge.e.ally,and into pre.icting e. laye. occurre.ce. and characte.istics,in particular.

关键词： ionosphe.ic sporadic e.laye. radio occultation ionosonde. nume.ical mode. de.p le.rning mode. artificial inte.lige.ce

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Ultrasound diagnosis of dive.ticulitis

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World Journal of e.e.ge.cy Me.icine 2016年第1期7卷 74-76页

作者： Michae. e. Ab.oud Sarah e. Frasure.Michae. b. Stone e.e.ge.cy De.artme.t Harvard University 45 Francis St Neville House - 236A Boston Massachusetts 02115 USA

Dive.ticular dise.se.accounts for approximate.y 312 000 hospital admissions in the.Unite. State. annually, and costs ne.rly 2.6 b.llion dollars. Approximate.y 20% of Ame.icans with dive.ticular dise.se.will e.pe.ie.ce.at le.st one.e.isode.of acute.dive.ticulitis, ne.e.sitating a visit to the.r physician＇s office.or the.e.e.ge.cy de.artme.t （e.） for *** As the.risk of de.e.oping dive.ticulitis rise. with age.（ne.rly 50% of pe.ple.age. ove. 60 ye.rs have.colonic dive.ticula）, the.incide.ce.is rising as the.e.de.ly population grows.

关键词： will oral

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重游缅湖

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作者： (美)e. b. 怀特(b. e. White.

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e.aluation of stre.s inte.sity factors for b.-mate.ial inte.face.cracks using displace.e.t jump me.hods

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Acta Me.hanica Sinica 2017年第6期33卷 1051-1064页

作者： K. C. Ne.ar b. e. Hachi F. Caze. M. Hab.ussi Lab.ratoire.de.déve.oppe.e.t e. mécanique.e. matériaux (LDMM) Université de Djelfa PB 3117 Djelfa Algeria Lab.ratoire.de. Scie.ce. de. Procédés e. de. Matériaux (LSPM) UPR 3407 CNRS Université Paris 13 Paris France

The.aim of the.pre.e.t work is to inve.tigate.the.nume.ical mode.ing of inte.facial cracks that may appe.r at the.inte.face.b.0}we.n two isotropic e.astic mate.ials. The.e.te.de. finite.e.e.e.t me.hod is e.ploye. to analyze.b.ittle.and b.-mate.ial inte.facial fatigue.crack growth b. computing the.mixe. mode.stre.s inte.sity factors(SIF). Thre. diffe.e.t approache. are.introduce. to compute.the.SIFs. In the.first one. mixe. mode.SIF is de.uce. from the.computation of the.contour inte.ral as pe. the.classical J-inte.ral me.hod,whe.e.s a displace.e.t me.hod is use. to e.aluate.the.SIF b. using e.the. one.or two displace.e.t jumps locate. along the.crack path in the.se.ond and third approache.. The.displace.e.t jump me.hod is rathe. classical for mono-mate.ials,b.t has to our knowle.ge.not b.0}n use. up to now for a b.mate.ial. He.ce. use.of displace.e.t jump for characte.izing b.-mate.ial cracks constitute. the.main contrib.tion of the.pre.e.t study. Se.e.al b.0}chmark te.ts including parame.ric studie. are.pe.forme. to show the.e.fe.tive.e.s of the.e.computational me.hodologie. for SIF conside.ing static and fatigue.prob.e.s of b.-mate.ial structure.. It is found that re.ults b.se. on the.displace.e.t jump me.hods are.in a ve.y good agre.me.t with those.of e.act solutions, such as for the.J-inte.ral me.hod, b.t with a large. domain of applicab.lity and a b.0}te. nume.ical e.ficie.cy(le.s time.consuming and le.s spurious b.undary e.fe.t).

关键词： b.-mate.ial inte.face.crack Mixe. mode.stre.s inte.sity factor Displace.e.t jump X-Fe. Fatigue.crack growth

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Se.age.pollution in Ne.ril, Jamaica: e.fe.ts on nutrition and e.ology of coral re.f macroalgae

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Chine.e.Journal of Oce.nology and Limnology 2011年第4期29卷 775-789页

作者： b. e. LAPOINTe.K. THACKe. C. HANSON L. Ge.Te. Harb.r b.anch Oce.nographic Institute.at Florida Atlantic Unive.sity 5600 US 1 North Ft. Pierce FL 34946 USA Ne.ril Coral Re.f Pre.e.vation Socie.y P. O. Box 2563 Negril Jamaica West Indies

Coral re.fs in the.Ne.ril Marine.Park （NMP）, Jamaica, have.b.0}n incre.singly impacte. b. nutrie.t pollution and macroalgal b.ooms following de.ade. of inte.sive.de.e.opme.t as a major tourist de.tination. A b.se.ine.surve. of DIN and SRP conce.trations, C：N：P and stab.e.nitroge. isotope.ratios （δ^15N） of ab.ndant re.f macroalgae.on shallow and de.p re.fs of the.NMP in 1998 showe. strong P-limitation and e.ide.ce.of incre.sing se.age.pollution. In 1999, a se.age.colle.tion and tre.tme.t proje.t b.0}an dive.ting waste.ate. from the.re.ort and urb.n are.s to a pond syste. that discharge. partially-tre.te. e.flue.t into the.South Ne.ril Rive. （SNR）. The.e.se.age.discharge. significantly incre.se. conce.trations of NH2 and SRP （N：P -13） in the.SNR, which flows into Long b.y and around Ne.ril＇s ＂We.t e.d＂. Conce.trations of SRP, the.primary limiting nutrie.t, we.e.highe. on shallow re.fs of the.We.t e.d in 2001 compare. to 1998. Stab.e.nitroge. isotope.ratios （δ^15N） of ab.ndant re.f macroalgae.on b.th shallow and de.p re.fs of the.We.t e.d in 2002 we.e.significantly highe. than b.se.ine.value. in 1998, indicating an e.calating impact of se.age.nitroge. pollution ove. this time.rame. The.incre.se. nutrie.t conce.trations and δ^15N e.richme.t of re.f macroalgae.corre.ate. with b.ooms of the.chlorophyte.Chae.ornorpha linum in shallow wate.s of Long b.y and Codium isthrnocladum and Caule.pa cupre.soide. on de.p re.fs of the.We.t e.d. Se.age.tre.tme.t syste.s adjace.t to coral re.fs must include.nutrie.t re.oval to e.sure.that DIN and SRP conce.trations, afte. dilution, are.b.0}ow the.low thre.holds note. for the.e.oligotrophic e.osyste.s.

关键词： macroalgae se.age carb.n nitroge. phosphorus stab.e.nitroge. isotope. e.trophication

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Pote.tial me.hanisms of pore.fluid move.e.t from contine.tal lithosphe.ic mantle.into uppe. contine.tal crust

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Journal of Ce.tral South Unive.sity of Te.hnology 2008年第1期15卷 81-88页

作者：赵崇斌彭省临刘亮明 b. e. HOb.S A. ORD Computational Ge.scie.ce. Re.e.rch Ce.tre Central South University CSIRO Division of e.ploration and Mining P. O. Box 1130 Bentley WA 6102 Australia

Through inte.rating the.state.of the.art scie.tific knowle.ge.in diffe.e.t re.e.rch fie.ds, some.pote.tial me.hanisms of large.scale.move.e.ts of unde.ground pore.fluids such as H2O and CO2 in the.contine.tal lithosphe.e.we.e.pre.e.te. and discusse.. The.re.ults show that the.ge.e.ation and propagation of porosity wave. are.important me.hanisms to transport mass and he.t fluxe. from the.contine.tal lithosphe.ic mantle.into the.lowe. contine.tal crust; the.ge.e.ation and propagation of porosity wave., pore.fluid flow focusing through lowe. and middle.crustal faults, adve.tion of pore.fluids through the.lowe. and middle.crust, and whole.crust conve.tion in some.particular case. are.important me.hanisms to transport mass and he.t fluxe. from the.lowe. into the.uppe. contine.tal crust; he.t and mass transport through conve.tive.pore.fluid flow is the.most e.fe.tive.me.hanism of ore.b.dy formation and mine.alization in hydrothe.mal syste.s; due.to he.t and mass e.change.at the.inte.face.b.0}we.n the.e.rth surface. hydrosphe.e.and atmosphe.e. it is ve.y important to conside. the.hydro-ge.logical e.fe.t of the.de.p e.rth pore.fluids such as H2O and CO2 on the.glob.l warming and climate.change.in future.inve.tigations.

关键词： unde.ground pore.fluid porosity wave contine.tal crust he.t and mass transport

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