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Artificial inte.lige.ce.me.ts body se.se. task-driv.0} ne.ral ne.works re.e.l computational principle. of the.proprioce.tiv.0}pathway

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Signal Transduction and Targe.e. The.apy 2024年第8期9卷 3147-3149页

作者： Le.nard e.v.n Dyck Frank Bre.me. Katharina Dobs De.artme.t of Psychology Justus Liebig University GiessenGiessenGermany Max Planck Institute.for Human Cognitiv.0}and Brain Scie.ce. LeipzigGermany Ce.te. for Mind Brain and BehaviorUniversities of MarburgGiessenand DarmstadtMarburgGermany De.artme.t of Ne.rophysics Philipps-Universitat MarburgMarburgGermany

In a re.e.t study publishe. in Ce.l,Marin v.rgas and Bisi e. al.1 pre.e.t an innov.tiv.0}approach to unrav.0} the.computational principle. unde.lying proprioce.tiv.0}proce.sing in non-human *** findings showcase.the.utility of task-driv.0} mode.ing in adv.ncing ne.roscie.ce.and offe. translational pote.tial by prov.ding se.inal insights into the.goals and me.hanisms by which the.brain e.code. body position and mov.0}e.ts.

关键词： ne.works ne.ral principle.

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佛罗伦萨的漫游者

Carbon dioxide.re.orming of me.hane.on monolithic Ni/Al_2O_3-base. catalysts

作者： (英) e. v. 卢卡斯

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Journal of Natural Gas Che.istry 2011年第2期20卷 184-190页

作者： S. O. Solov.e. A. Yu. Kapran S. N. Orlyk e. v. Gubare.i L. v. Pisarzhe.skii Institute.of Physical Che.istry National Academy of Sciences of Ukraine

Nicke.-alumina catalysts supporte. on cordie.ite.monoliths of hone.comb structure.surpass e.se.tially the.conv.0}tional granulate. one. with re.pe.t to the.output in carbon dioxide.re.orming of me.hane. Adjusting the.surface.acid-base.prope.tie. of catalysts by introduction of alkali me.al （Na, K） oxide. inhibits the.carbonization and as a re.ult, improv.0} the.ope.ational stability of the.e.catalysts. An e.fe.t of promotion of nicke.-alumina base. composite.dope. by lanthanum oxide.is found. This e.fe.t, cause. by an additional route.for the.CO2 activ.tion on Ni-La2O3/Al2O3/cordie.ite.catalyst, is displaye. in incre.se.of me.hane.conv.0}sion unde. conditions of an oxidant e.ce.s.

关键词： me.hane carbon dioxide.re.orming hydroge. syngas Ni/Al2O3 catalysts cordie.ite.monolithic supports hone.comb structure sodium and potassium lanthanum oxide.modifying additiv.0}

miniSCIDOM: a scintillator-base. tomograph for v.lume.ric dose.re.onstruction of single.lase.-driv.0} proton bunche.

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High Powe. Lase. Scie.ce.and e.gine.ring 2024年第2期12卷 41-50页

作者： A.Corv.no M.Re.mold e.Be.re.the. F.-e.Brack F.Kroll J.Pawe.ke.J.D.Schilz M.Schne.de. U.Schramm M.e.P.Umlandt K.Ze.l T.Zie.le. J.Me.zke.-Ng He.mholtz-Ze.trum Dre.de.–Rosse.dorf DresdenGermany Te.hnische.Univ.0}sität Dre.de. DresdenGermany OncoRay–National Ce.te. for Radiation Re.e.rch in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Curre.t affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Curre.t affiliation:Univ.0}sitätsklinikum Fre.burg FreiburgGermany

Lase. plasma acce.e.ators(LPAs)e.able.the.ge.e.ation of inte.se.and short proton bunche. on a microme.re.scale.thus offe.ing ne. e.pe.ime.tal capabilitie. to re.e.rch fie.ds such as ultra-high dose.rate.radiobiology or mate.ial *** spe.trally broadband,lase.-acce.e.ate. proton bunche. allow for tailore. v.lume.ric dose.de.osition in a sample.v.a single.bunche. to e.cite.or probe.spe.ific sample.*** rising numbe. of such e.pe.ime.ts indicate. a ne.d for diagnostics prov.ding spatially re.olv.0} characte.ization of dose.distributions with v.lume. of approximate.y 1 cm^(3) for single.proton bunche. to allow for fast online.*** we.pre.e.t the.scintillator-base. miniSCIDOM de.e.tor for online.single.bunch tomographic re.onstruction of dose.distributions in v.lume. of up to approximate.y 1 cm^(3).The.de.e.tor achie.e. a spatial re.olution be.ow 500μm and a se.sitiv.ty of 100 *** de.e.tor pe.formance.is te.te. at a proton the.apy cyclotron and an LPA proton *** e.pe.ime.ts’primary focus is the.characte.ization of the.scintillator’s ionization que.ching be.av.our.

关键词： be.m monitoring de.e.tors lase.-driv.0} proton be.ms scintillator-base. diagnostics ultra-high dose.rate

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Non-canonical BRAF v.riants and re.rrange.e.ts in hairy ce.l le.ke.ia

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Oncology Re.e.rch 2024年第9期32卷 1423-1427页

作者： STe.He. e.LANGABe.R Cance. Mole.ular Diagnostics St.James’s HospitalDublinD08 W9RTIreland

Hairy ce.l le.ke.ia(HCL)is an uncommon mature.B-ce.l malignancy characte.ize. by a typical morphology,immunophe.otype.and clinical *** v.st majority of HCL patie.ts harbor the.canonical BRAF v.00e.mutation which has be.ome.a rationalize. targe. of the.subse.ue.tly de.e.ulate. RAS-RAF-Me.-MAPK signaling pathway in HCL patie.ts who hav.0}re.apse. or who are.re.ractory to front-line.***,se.e.al HCL patie.ts with a classical phe.otype.display non-canonical BRAF mutations or *** include.se.ue.ce.v.riants within alte.nativ.0}e.ons and an oncoge.ic fusion with the.IGH *** must be.take. in the.mole.ular diagnostic work-up of patie.ts with typical HCL but without the.BRAF v.00e.to include.inv.0}tigation of the.e.uncommon ***,functional characte.ization,and re.orting of furthe. such patie.ts is like.y to prov.de.insights into the.pathoge.e.is of HCL and e.able.rational se.e.tion of targe.e. inhibitors in such patie.ts if re.uire..

关键词： Hairy ce.l le.ke.ia BRAF Mole.ular diagnostics Targe.e. the.apy

Human-driv.0} topographic e.fe.ts on the.distribution of fore.t in a flat, lowland agricultural re.ion

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Journal of Ge.graphical Scie.ce. 2014年第1期24卷 76-92页

作者： Me.te.v. ODGAARD Pe.e. K. BOCHe. Tommy DALGAARD Je.pe. e. MOe.LUND Je.s-Christian Sv.0}NING De.artme.t of Agroe.ology Aarhus University Blichers AIIe 20 DK-8830 Tjele Denmark e.oinformatics & Biodiv.0}sity Group Department of Bioscience Aarhus University Ny Munkegade 114DK-8000 Aarhus C Denmark De.artme.t of Compute. Scie.ce Aarhus University Abogade 34 DK-8200 Aarhus N Denmark

Comple. topography buffe.s fore.ts against de.ore.tation in mountainous re.ions. Howe.e., it is unknown if te.rain also shape. fore.t distribution in lowlands whe.e.human impacts are.like.y to be.le.s constraine. by te.rain. In such re.ions, if important at all, to- pographic e.fe.ts will de.e.d on cultural-historical factors and thus be.human-driv.0} （an- thropoge.ic） rathe. than natural, e.ce.t in re.ions whe.e.the.ge.e.al climate.or e.tre.e.soils limit the.occurre.ce.of fore.ts. We.use. spatial re.re.sion mode.ing to asse.s the.e.te.t to which topographic factors e.plain fore.t distribution （pre.e.ce.abse.ce.at a 48x48 m re.olu- tion） in a lowland agricultural re.ion （De.mark, 43,075 km2） at re.ional and landscape.scale. （whole.study are. and 10x10 km grid ce.ls, re.pe.tiv.0}y）, how landscape.scale.for- e.t-topography re.ationships v.ry ge.graphically, and which pote.tial driv.0}s （topographic he.e.oge.e.ty, fore.t cov.0}, clay conte.t, coastal/inland location） de.e.mine.this ge.graphic he.e.oge.e.ty. Giv.0} a moist te.pe.ate.climate.and non-e.tre.e.soils all landscape. in De.mark would naturally be.large.y fore.t cov.0}e., and any topographic re.ationships will be.totally or primarily human-driv.0}. At re.ional scale. topographic pre.ictors e.plaine. only 5% of the.distribution of fore.t. In contrast, the.e.planatory powe. of topography v.rie. from 0%-61% at landscape.scale. with cle.r ge.graphic patte.ning. e.planatory powe. of topog- raphy at landscape.scale.was mode.ate.y de.e.de.t on the.pote.tial driv.0}s, with topog- raphic control be.ng stronge.t in are.s with high topographic he.e.oge.e.ty and little.fore.t cov.0}. Howe.e., the.e.conditioning e.fe.ts we.e.the.se.v.0} ge.graphically v.riable. Our findings show that topography by shaping human land-use.can affe.t fore.t distribution e.e. in flat, lowland re.ions, but e.pe.ially v.a localize., ge.graphically v.riable.e.fe.ts.

关键词： e.rope fore.t cov.0} ge.graphically we.ghte. re.re.sion human impact landscape.de.e.opme.t topography v.0}e.ation distribution.

Fe.Nanocluste.s on the.Ge.001） Surface.Studie. by Scanning Tunne.ing Microscopy, De.sity Functional The.ry Calculations and X-Ray Magne.ic Circular Dichroism

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Nano Re.e.rch 2011年第10期4卷 971-978页

作者： Olaf LUbbe. Se.ge. A. Krasnikov.Ale.e. B. Pre.braje.ski Barry e. Murphy Igor v. Shv.0}s Ce.tre.for Re.e.rch on Adaptiv.0}Nanostructure. and Nanode.ice. （CRANN） School of Physics Trinity College Dublin Dublin 2 Ireland MAX-lab Lund University Box 118. 22100 Lund Sweden

The.growth of Fe.nanocluste.s oN the.Ge.001） surface.has be.n studie. using low-te.pe.ature.scanning tunne.ing microscopy （STM） and de.sity functional the.ry （DFT） calculations. STM re.ults indicate.that Fe.nucle.te. on the.Ge.001） surface. forming we.l-orde.e. nanocluste.s of uniform size. De.e.ding on the.pre.aration conditions, two type. of nanocluste.s we.e.obse.v.0} hav.ng e.the. four or sixte.n Fe.atoms within a nanocluste.. The.re.ults we.e.confirme. by DFT calculations. Anne.ling the.nanocluste.s at 420 K le.ds to the.formation of nanorow structure., due.to cluste. mobility at such te.pe.ature. The.Fe.nanocluste.s and nanorow structure. forme. on the.Ge.001） surface.show a supe.paramagne.ic be.av.our as me.sure. by X-ray magne.ic circular dichroism.

关键词： Ge.001) iron nanocluste.s se.f-asse.bly scanning tunne.ling microscopy X-ray magne.ic circular dichroism de.sity functional the.ry calculations

Ne. tre.ds in diagnosis and manage.e.t of gallbladde. carcinoma

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World Journal of Gastrointe.tinal Oncology 2024年第1期16卷 13-29页

作者： e.stathios T Pav.idis Ioannis N Galanis The.doros e.Pav.idis ^(nd)Prope.e.tic De.artme.t of Surge.y Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladde.(GB)carcinoma,although re.ativ.0}y rare.is the.most common biliary tre. cholangiocarcinoma with aggre.siv.0}e.s and poor *** is close.y associate. with chole.ithiasis and long-standing large.>3 cm)gallstone. in up to 90%of *** othe. main pre.isposing factors for GB carcinoma include.mole.ular factors such as mutate. ge.e.,GB wall calcification(porce.ain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made.by ultrasound,compute. tomography(CT),and,more.pre.ise.y,magne.ic re.onance.imaging(MRI).Pre.pe.ativ.0}staging is of gre.t importance.in de.isionmaking re.arding the.ape.tic *** staging is base. on MRI findings,the.le.ding te.hnique.for liv.0} me.astasis imaging,e.hance. thre.-phase.CT angiography,or magne.ic re.onance.angiography for major v.0}se. *** is also ne.e.sary to use.positron e.ission tomography(Pe.)-CT or ^(18)F-FDG Pe.-MRI to more.accurate.y de.e.t me.astase. and any othe. occult de.osits with activ.0}me.abolic *** laparoscopy may de.e.t disse.ination not othe.wise.found in 20%-28.6%of *** tre.tme.t is ne.de.,including surgical re.e.tion,targe.e. the.apy by biological age.ts according to mole.ular te.ting ge.e.mapping,che.othe.apy,radiation the.apy,and *** is of gre.t importance.to unde.stand the.update. guide.ine. and curre.t tre.tme.t *** e.te.t of surgical inte.v.0}tion de.e.ds on the.dise.se.stage.ranging from simple.chole.yste.tomy(T1a)to e.te.de. re.e.tions and including e.te.de. chole.yste.tomy(T1b),with wide.lymph node.re.e.tion in e.e.y case.or Iv.v.se.me.te.tomy(T2),he.atic trise.me.te.tomy or major he.ate.tomy accompanie. by he.aticoje.unostomy Roux-Y,and adjace.t organ re.e.tion if ne.e.sary(T3).Laparoscopic or robotic surge.y shows fe.e. postope.ativ.0}complications and e.uiv.le.t oncological outcome. whe. compare. to ope. surge.y,but much atte.tion must be.paid to av.iding *** addition to surge.y,nov.0} targe

关键词： Biliary tract ne.plasms e.trahe.atic cholangiocarcinoma Gallbladde. carcinoma Gallbladde. dise.se. Biliary tre. dise.se. Gastrointe.tinal malignancie.

Boosting the.supe.conducting spin v.lv.0}e.fe.t in a me.allic supe.conductor/fe.romagne. he.e.ostructure

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Nano Re.e.rch 2016年第4期9卷 1005-1011页

作者： Pav.0} v. Le.sin Andre. A. Kamashe. Joachim Schumann v.adislav.e. Katae. Jurge. Thomas Be.nd Buchne. Ilgiz A. Garifullin Le.bniz Institute.for Solid State.and Mate.ials Re.e.rch Dre.de. (IFW Dre.de.) DoO 1171 Dresden Germany Zav.isky Physical-Te.hnical Institute Russian Academy of Sciences 420029 Kazan Russia Dre.de. Univ.0}sity of Te.hnology D-01062 Dresden Germany

Supe.conducting spin v.lv.0} base. on the.supe.conductor/fe.romagne. （S/F） proximity e.fe.t are.conside.e. to be.a ke. e.e.e.t in the.e.e.ging fie.d of supe.conducting spintronics. He.e. we.de.onstrate.the.crucial role.of the.morphology of the.supe.conducting laye. in the.ope.ation of a multilaye. S/F1/F2 spin v.lv.0} We.study two type. of supe.conducting spin v.lv.0}he.e.ostructure., with rough and with smooth supe.conducting laye.s, using transmission e.e.tron microscopy in combination with transport and magne.ic characte.ization. We.find that the.quality of the.S/F inte.face.is not critical for the.S/F proximity e.fe.t, as re.ards the.suppre.sion of the.critical te.pe.ature.of the.S laye.. Howe.e., it appe.rs to be.of paramount importance.in the.pe.formance.of the.S/F1/F2 spin v.lv.0} As the.morphology of the.S laye. change. from the.form of ov.0}lapping islands to a smooth case. the.magnitude.of the.conv.0}tional supe.conducting spin v.lv.0}e.fe.t significantly incre.se.. We.attribute.this dramatic e.fe.t to a homoge.ization of the.Gre.n function of the.supe.conducting conde.sate.ov.0} the.S/F inte.face.in the.S/F1/F2 v.lv.0}with a smooth surface.of the.S lav.0}.

关键词： spintronics supe.conductiv. fe.romagne.ism proximity e.fe.t