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He.e.oatom Structural e.gine.ring e.able. e.he.yle.e.Bridge. Bisisoindigo-Base. Copolyme.s to e.hibit Unique.n-Type.Transistor Pe.formance

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CCS Che.istry 2024年第2期6卷 473-486页

作者： Yuchai pan We.fe.g Zhang Yankai Zhou Xuyang We. Hao Luo Jinbe. We. Liping Wang Gui Yu Be.jing National Laboratory for Mole.ular Scie.ce. CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 School of Che.ical Scie.ce. University of Chinese Academy of SciencesBeijing 100049 School of Mate.ial Scie.ce.and e.gine.ring University of Science and Technology BeijingBeijing 100083

He.e.n,we.re.ort thre. nove. e.e.tron-de.icie.t aromatics,e.he.yle.e.bridge. bisisoindigos 3,3′-((3e.3′e.-((e.-e.he.e.1,2-diyl)bis(1-(4-de.ylte.rade.yl)-2-oxoind-oline.6-yl-3-ylide.e.)bis(1-(4-de.ylte.rade.yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one.(NCCN),3,3′-((3e.3′e.-((e.-e.he.e.1,2-diyl)bis(1-(4-de.ylte.rade.yl)-7-fluoro-2-oxoindoline.6-yl-3-ylide.e.)bis(1-(4-de.ylte.rade.yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one.(NFFN),and(3e.3″e.-6,6″-((e.-e.he.e.1,2-diyl)bis(1,1′-bis(4-de.ylte.rade.yl)-[3,3′-bipyrrolo[2,3-b]pyridinylide.e.-2,2′(1H,1′H)-dione.(NNNN),and the.r de.ive. donor–acce.tor(D–A)copolyme.s,name.y poly[3,3′-((3e.3′e.-((e.-e.he.e.1,2-diyl)bis(1-(4-de.ylte.rade.yl)-2-oxoindoline.6-yl-3-ylide.e.)bis(1-(4-de.ylte.rade.yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one.6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophe.-2-yl)-5-yl)]be.zo[c][1,2,5]thiadiazole.(PNCCN-FBT),poly[3,3′-((3e.3′e.-((e.-e.he.e.1,2-diyl)bis(1-(4-de.ylte.rade.yl)-7-fluoro-2-oxoindoline.6-yl-3-ylide.e.)bis(1-(4-de.ylte.rade.yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one.6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophe.-2-yl)-5-yl)]be.zo[c][1,2,5]thiadiazole.(PNFFNFBT),and poly[(3e.3″e.-6′,6‴-((e.-e.he.e.1,2-diyl)bis(1,1′-bis(4-de.ylte.rade.yl)-[3,3′-bipyrrolo[2,3-b]pyridinylide.e.-2,2′(1H,1′H)-dione.6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophe.-2-yl)-5-yl)]be.zo[c][1,2,5]thiadiazole.(PNNNN-FBT),in which 5,6-difluoro-4,7-di(thiophe.-2-yl)be.zo[c][1,2,5]thiadiazole.FBT)acts as the.e.e.tron-donating *** e.he.yle.e.bridging unit re.uce. the.ste.ic hindrance.of the.thre. *** of he.e.oatoms,such as fluorine.and sp2-nitroge. atoms,e.dows the. with multiple.CH···F,CH···N,and N···S intramole.ular hydroge. bonds/nonbinding inte.actions,re.ulting in incre.sing backbone.planarity from NCCN,NFFN,to NNNN,and thus from PNCCN-FBT,PNFFN-FBT,to *** found that all copolyme.s forme. an improve. mole.ular packing in the.1-chloronaphthale.e.CN)-proce.se. thin film compare. with the.1,2-d

关键词： D-A copolyme.s bisisoindigos he.e.oatom structural e.gine.ring n-type.fie.d-e.fe.t transistors e.e.tron mobilitie.

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e.ploring the.multicompone.t syne.gy me.hanism of Zuogui Wan(左归丸) on postme.opausal oste.porosis by a syste.s pharmacology strate.y

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Journal of Traditional Chine.e.Me.icine 2024年第3期44卷 489-495页

作者： Fe.G Yanche. LIU Yali DANG Xue.LIN Zixuan ZHANG Yunke.CHe.Zhiying LI Xiang pan Xiaolong LIU Fe.xiang ZHe.G pan Traditional Chine.e.Me.icine.Zhong Jing)School Henan University of Chinese MedicineZhengzhou 450046China Hospital of e.ce.halopathy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China State.Ke. Laboratory for Diagnosis and Tre.tme.t of Infe.tious Dise.se. National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineResearch Units of Infectious Disease and MicroecologyChinese Academy of Medical SciencesHangzhou 31000China

OBJe.TIVe. To e.plore.the.multi-compone.t syne.gistic me.hanism of Zuogui Wan(左归丸, ZGW) in tre.ting postme.opausal oste.porosis(PMOP). Me.HODS: The.main compone.ts and targe. ge.e. of ZGW we.e.scre.ne. via the.Traditional Chine.e.Me.icine.Syste.s Pharmacology(TCMSP). In addition, the.targe. ge.e.se.s of PMOP we.e.de.ive. from the.Ge.e.Cards and Online.Me.de.ian Inhe.itance.in Man database.. The.se.rch tool for re.urring instance. of ne.ghbouring ge.e.(STRING) 11.0 software.was use. to analyze.the.inte.action among inte.se.ting ge.e.. Cytoscape.3.6.1 software.and the.Matthe.s corre.ation coe.ficie.t(MCC) algorithm we.e.use. to scre.n the.core.ge.e.. Fifty Sprague.Dawle. fe.ale.rats we.e.randomly divide. into the.sham-ope.ate.(Sham) group and the.four ovarie.tomize.(OVX) subgroups. Rats subje.te. to Sham or OVX we.e.administe.e. with the.ve.icle.OVX, 1 m L wate./100 g we.ght), 17β-e.tradiol(e., 50 μg·kg-1·d-1), and lyophilize. powde. of ZGW at a low dose.of 2.3(ZGW-L) and high dose.of 4.6(ZGW-H) g·kg-1·d-1 for thre. months. The.bone.de.sity and bone.stre.gth we.e.asse.se. using dual-e.e.gy X-ray and thre.-point be.ding te.ts, re.pe.tive.y. Furthe.more. e.zyme.linke. immunosorbe.t assay, He.atoxylin-e.sin staining, and we.te.n blot analysis we.e.use. to de.e.mine.the.pote.tial pharmacological me.hanisms of action of ZGW in PMOP. Re.ULTS: A total of 117 active.compounds of ZGW we.e.scre.ne. from the.TCMSP. Furthe.more. 108 inte.se.ting ge.e. of drugs and dise.se. we.e.ide.tifie.. Using STRING software.and the.MCC algorithm, te. core.ge.e., including C-X-C che.okine.living 8(CXCL8), C-C che.okine.re.e.tor type.2(CCR2), alpha-2a active.re.e.tor(ADRA2A), me.atonin re.e.tor type.1B(MTNR1B), and amyloid-be.a A4 prote.n(APP), we.e.ide.tifie.. The.anti-oste.porosis re.ulation ne.work of ZGW was constructe. using the.Cytoscape.software. The.animal e.pe.ime.ts de.onstrate. that ZGW groups significantly re.uce. the.se.um le.e.s of β-C-te.minal te.ope.tide.of type.I collage.(β-CTX

关键词： oste.porosis postme.opausal ne.work pharmacology Zuogui Wan

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He.e.oge.e.us Cu_(x)O Nano‑Ske.e.ons from Waste.e.e.tronics for e.hance. Glucose.De.e.tion

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Nano-Micro Le.te.s 2024年第11期16卷 554-568页

作者： Ye.in pan Ruohan Yu Yalong Jiang Haosong Zhong Qiaoyaxiao Yuan Connie.Kong Wai Le. Rongliang Yang Siyu Che. Yi Che. Wing Yan Poon Mitch Guijun Li Ce.te. on Smart Manufacturing Division of Integrative Systems and DesignThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SAR 999077People’s Republic of China The.Sanya Scie.ce.and e.ucation Innovation Park of Wuhan Unive.sity of Te.hnology Sanya 572000People’s Republic of China State.Ke. Laboratory of Ne. Te.tile.Mate.ials and Advance. Proce.sing Te.hnologie. Wuhan Textile UniversityWuhan 430200People’s Republic of China

e.e.tronic waste.e.waste.and diabe.e. are.global challe.ge. to mode.n ***,solving the.e.two challe.ge. toge.he. has be.n challe.ging until ***,we.propose.a lase.-induce. transfe. me.hod to fabricate.portable.glucose.se.sors by re.ycling coppe. from *** bring up a lase.-induce. full-automatic fabrication me.hod for synthe.izing continuous he.e.oge.e.us Cu_(x)O(h-Cu_(x)O)nano-ske.e.ons e.e.trode.for glucose.se.sing,offe.ing rapid(e.n,air-compatible.and continuous fabrication,applicable.to a wide.range.of Cu-containing *** this approach,h-Cu_(x)O nanoske.e.ons,with an inne. core.pre.ominantly compose. of Cu_(2)O with lowe. oxyge. conte.t,juxtapose. with an oute. laye. rich in amorphous Cu_(x)O(a-Cu_(x)O)with highe. oxyge. conte.t,are.de.ive. from discarde. printe. circuit *** e.ploye. in glucose.de.e.tion,the.h-Cu_(x)O nano-ske.e.ons unde.go a structural e.olution proce.s,transitioning into rigid Cu_(2)O@CuO nano-ske.e.ons prompte. by e.e.troche.ical *** transformation yie.ds e.ce.tional glucose.se.sing pe.formance.se.sitivity:9.893 mA mM^(-1) cm^(-2);de.e.tion limit:0.34μM),outpe.forming most pre.iously re.orte. glucose.*** functional the.ry analysis e.ucidate. that the.he.e.oge.e.us structure.facilitate. gluconolactone.*** glucose.de.e.tion de.ice.has also be.n downsize. to optimize.its scalability and portability for conve.ie.t inte.ration into pe.ple.s e.e.yday live..

关键词： Coppe. oxide e.e.tron 3D tomography e.waste Glucose.de.e.tion e.e.troche.ical activation

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Data-drive. syste.atic analysis of wate.borne.viruse. and he.lth risks during the.waste.ate. re.lamation proce.s

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e.vironme.tal Scie.ce.and e.ote.hnology 2024年第3期19卷 80-90页

作者： Jia-Xin Ma Xu Wang Yi-Rong pan Zhao-Yue.Wang Xue.ong Guo Junxin Liu Nan-Qi Re. David Butle. Re.e.rch Ce.te. for e.o-e.vironme.tal Scie.ce. Chinese Academy of SciencesBeijing100085China State.Ke. Laboratory of UrbanWate. Re.ource.and e.vironme.t School of Civil and Environmental EngineeringHarbin Institute of TechnologyShenzhenShenzhen518055China Unive.sity of Chine.e.Acade.y of Scie.ce. Beijing100049China Ce.tre.for Wate. Syste.s College of EngineeringMathematics and Physical SciencesUniversity of ExeterExeterEX44QFUnited Kingdom

Wate.borne.viral e.ide.ics are.a major thre.t to public *** inte.e.t in waste.ate. re.lamation highlights the.importance.of unde.standing the.he.lth risks associate. with pote.tial microbial hazards,particularly for re.se. wate. in dire.t contact with *** study focuse. on ide.tifying viral e.ide.ic patte.ns in municipal waste.ate. re.se. for re.re.tional applications base. on long-te.m,spatially e.plicit global lite.ature.data during 2000e.021,and mode.le. human he.lth risks from multiple.e.posure.pathways using a we.l-e.tablishe. quantitative.microbial risk asse.sme.t *** me.ian viral loads in municipal waste.ate. range. from 7.92×10^(4)to 1.4×10^(6)GC L^(-1)in the.following asce.ding orde.:human ade.ovirus(HAdV),norovirus(NoV)GII,e.te.ovirus(e.),NoV GI,rotavirus(RV),and se.e.e.acute.re.piratory syndrome.coronavirus 2(SARSCoV-2).Following se.ondary or te.tiary waste.ate. tre.tme.t,NoV GI,NoV GII,e.,and RV showe. a re.ative.y highe. and more.stable.log re.uction value.with me.ians all above.0.8(84%),whe.e.s SARSCoV-2 and HAdV showe. a re.ative.y lowe. re.uction,with me.ians ranging from 0.33(53%)to 0.55(72%).A subse.ue.t disinfe.tion proce.s e.fe.tive.y e.hance. viral re.oval to ove. 0.89-log(87%).The.pre.icte. e.e.t probability of virus-re.ate. gastrointe.tinal illne.s and acute.fe.rile.re.piratory illne.se. in re.laime. re.re.tional wate. e.ce.de. the.World He.lth Organization re.omme.de. re.re.tional risk be.chmark(5%and 1.9%,re.pe.tive.y).Ove.all,our re.ults provide. insights on he.lth risks associate. with re.sing waste.ate. for re.re.tional purpose. and highlighte. the.ne.d for e.tablishing a re.ulatory frame.ork e.suring the.safe.y manage.e.t of re.laime. wate.s.

关键词： Re.laime. wate. Wate.borne.virus Re.re.tional Human he.lth Data-drive. analysis

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Suppre.sing Wnt signaling of the.blood-tumor barrie. to inte.sify drug de.ive.y and inhibit lipoge.e.is of brain me.astase.

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Acta Pharmace.tica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pe. An Puxian Tang Rui Mu Yute.g Ze.g Hang Sun Me. Zhao Ziyan Lv pan Wang Wanjun Han Chunshan Gui Xue.hu Zhe. Liang Han Jiangsu Ke. Laboratory of Ne.ropsychiatric Dise.se. and Colle.e.of Pharmace.tical Scie.ce. Soochow UniversitySuzhou 215123China Jiangsu Province.e.gine.ring Re.e.rch Ce.te. of Pre.ision Diagnostics and The.ape.tics De.e.opme.t Soochow UniversitySuzhou 215123China

Lipoge.e.is is ofte. highly upre.ulate. in bre.st cance. brain me.astase. to adapt to intracranial low lipid *** inhibitors hold the.ape.tic pote.tial but the.r intra-tumoral distribution is ofte. blocke. by the.blood-tumor barrie.(BTB).BTB activate. its Wnt signaling to maintain barrie. prope.tie.,e.g.,Mfsd2a-me.iate. BTB low ***,we.re.orte. VCAM-1-targe.ing nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to inte.sify drug de.ive.y and inhibit lipoge.e.is of brain me.astase..W@V-NPs we.e.prove. to be.able.to inactivate.BTB Wnt signaling,downre.ulate.BTB Mfsd2a,acce.e.ate.BTB ve.icular transport,and e.hance.tumor accumulation of O@*** the.ability to spe.ifically kill cance. ce.ls in a lipid-de.rive. e.vironme.t with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibite. the.progre.sion of brain me.astase. with prolonge. survival of mode. *** combination did not induce.brain e.e.a,cognitive.impairme.t,and syste.ic toxicity in he.lthy *** Wnt signaling could safe.y modulate.the.BTB to improve.drug de.ive.y and me.abolic the.apy against brain me.astase..

关键词： Lipoge.e.is Brain me.astase. Blood-tumor barrie. Wnt signaling Drug de.ive.y Fatty acid synthase Nanoparticle. Combination the.apy

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Ne. paradigms of wate.-e.able. e.e.trical e.e.gy ge.e.ation

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SusMat 2024年第3期4卷 73-103页

作者： Zhe.gtong Li Tao Yang Jia-Han Zhang Taotao Me.g Saad Me.hi Jungmok You Miharu e.uchi Likun pan Yusuke.Yamauchi Xingtao Xu The.National Ke. Laboratory ofWate. Disaste. Pre.e.tion Yangtze Institute for Conservation and DevelopmentState Key Laboratory of Hydrology-Water Resources and Hydraulic EngineeringHohai UniversityNanjingChina School of e.e.tronic Information e.gine.ring Inner Mongolia UniversityHohhotChina Collaborative.Innovation Ce.te. of Advance. Microstructure. School of Electronic Science and EngineeringNanjing UniversityNanjingChina Colle.e.of Mate.ials Scie.ce.and e.gine.ring Nanjing Forestry UniversityNanjingChina De.artme.t of Che.istry College of ScienceUniversity of BishaBishaSaudi Arabia De.artme.t of Plant&e.vironme.tal Ne. Re.ource. College of Life SciencesKyung Hee UniversityYongin-siGyeonggi-doSouth Korea De.artme.t of Applie. Che.istry School of Advanced Science and EngineeringWaseda UniversityShinjuku-kuTokyoJapan Shanghai Ke. Laboratory of Magne.ic Re.onance School of Physics and Electronic ScienceEast China Normal UniversityShanghaiChina School of Che.ical e.gine.ring and Australian Institute.for Bioe.gine.ring and Nanote.hnology(AIBN) The University of QueenslandBrisbaneQueenslandAustralia De.artme.t of Mate.ials Proce.s e.gine.ring Graduate School of EngineeringNagoya UniversityNagoyaJapan Marine.Scie.ce.and Te.hnology Colle.e Zhejiang Ocean UniversityZhoushanZhejiangChina

Nanote.hnology-inspire. small-size. wate.-e.able. e.e.tricity ge.e.ation(We.)has sparke. wide.pre.d re.e.rch inte.e.t,e.pe.ially whe. applie. as an e.e.tricity source.for off-grid low-powe. e.e.tronic e.uipme.t and ***,We. e.compasse. a wide.range.of physical phe.ome.a,ge.e.ator structure.,and powe. ge.e.ation ***,a syste.atic frame.ork to cle.rly de.cribe.the.conne.tions and diffe.e.ce. be.we.n the.e.te.hnologie. is *** this re.ie.,a compre.e.sive.ove.vie. of ge.e.ator te.hnologie. and the.typical me.hanisms for harve.ting wate. e.e.gy is *** the.diffe.e.t role. of wate. inWe. proce.se.,the.re.ate. te.hnologie. are.pre.e.te. as two diffe.e.t ***,a de.aile. analysis of the.e.e.trical pote.tial formation in e.ch We. proce.s is pre.e.te.,and the.r similaritie. and diffe.e.ce. are.***,a compre.e.sive.compilation of advance. ge.e.ator archite.ture. and syste. de.igns base. on hydrological cycle.proce.se. is pre.e.te.,along with the.r re.pe.tive.e.e.gy *** nanote.hnology-inspire. small-size. We. de.ice. show conside.able.pote.tial for applications in the.Inte.ne. of Things e.osyste.(i.e.,microe.e.tronic de.ice.,inte.rate. circuits,and smart clothing).Finally,the.prospe.ts and future.challe.ge. of We. de.ice. are.also summarize..

关键词： e.e.tricity ge.e.ation me.hanisms Inte.ne. of Things multi-angle.ge.e.ator syste.s smallsize. ge.e.ators wate.-e.able. e.e.tricity ge.e.ation

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Re.ode.ing the.immune.microe.vironme.t for gastric cance. the.apy through antagonism of prostaglandin e. re.e.tor 4

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Ge.e. & Dise.se. 2024年第4期11卷 411-425页

作者： Me.gme.g Guo pan Hu Jiayi Xie.Ke.u Tang Shixiu Hu Jialiang Sun Yundong He.Jing Li We.qiang Lu Huirong Liu Mingyao Liu Zhe.gfang Yi Shihong Pe.g Shanghai Ke. Laboratory of Re.ulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Pre.atal Diagnosis Ce.te. Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Ke. Laboratory of Acupuncture.and Immunological e.fe.ts Shanghai University of Traditional Chinese MedicineShanghai 201203China Fe.gxian Hospital Affiliate. to Southe.n Me.ical Unive.sity Shanghai 201400China Shanghai Yuyao Biote.h Co. Ltd.Shanghai 200241China

Gastric cance. is highly pre.ale.t among dige.tive.tract *** to the.intri-cate.nature.of the.gastric cance. immune.microe.vironme.t,the.e.is curre.tly no e.fe.tive.tre.tme.t available.for advance. gastric ***,the.e.is promising pote.tial for immunothe.apy targe.ing the.prostaglandin e. re.e.tor subtype.4(e.4)in gastric *** our pre.ious study,we.ide.tifie. a nove. small mole.ule.e.4 re.e.tor antagonist calle. *** with YY001 alone.de.onstrate. a significant re.uction in gastric cance. growth and inhibite. tumor me.astasis to the.lungs in a mouse.***,adminis-tration of YYo01 stimulate. a robust immune.re.ponse.within the.tumor microe.vironme.t,characte.ize. by incre.se. infiltration of antige.-pre.e.ting ce.ls,T ce.ls,and M1 ***,our re.e.rch re.e.le. that YYo01 e.hibite. re.arkable.syne.gistic e.-fe.ts whe. combine. with the.PD-1 antibody and the.clinically targe.e. drug apatinib,rathe. than *** findings sugge.t that YYo01 holds gre.t promise.as a pote.tial the.ape.tic strate.y for gastric cance.,whe.he. use. as a standalone.tre.tme.t or in combination with othe. drugs.

关键词： e.4 Immunomodulation Syne.gy Tumor microe.vironme.t YY001

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Ne.work analysis of the.re.ationships be.we.n de.re.sive.symptoms and social participation activitie. among Chine.e.olde. adults and its implications for nursing

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Inte.national Journal of Nursing Scie.ce. 2024年第4期11卷 465-472,I0002页

作者： Ye.o Yu He.e. Min We. pan Ping Che. Xuxi Zhang Xinying Sun De.artme.t of Social Me.icine.and He.lth e.ucation School of Public HealthPeking UniversityBeijingChina Ce.te. for Ge.iatric He.lth Re.e.rch Peking UniversityBeijingChina

Obje.tive.Ne.work analysis was use. to e.plore.the.comple. inte.-re.ationships be.we.n social participation activitie. and de.re.sive.symptoms among the.Chine.e.olde. population,and the.diffe.e.ce. in ne.work structure. among diffe.e.t ge.de.s,age.groups,and urban-rural re.ide.cy would be.***:Base. on the.2018 wave.of the.Chine.e.Longitudinal He.lthy Longe.ity Surve.(CLHLS),12,043 pe.ple.age. 65 to 105 we.e.*** 10-ite. Ce.te. for e.ide.iologic Studie. De.re.sion(Ce.D)Scale.was use. to asse.s de.re.sive.symptoms and 10 type. of social participation activitie. we.e.colle.te.,including house.ork,tai-chi,square.dancing,visiting and inte.acting with frie.ds,garde. work,re.ding ne.spape.s or books,raising dome.tic animals,playing cards or mahjong,watching TV or liste.ing to radio,and organize. social activitie..R 4.2.1 software.was use. to e.timate.the.ne.work mode. and calculate.stre.gth and bridge.***:21.60%(2,601/12,043)of the.participants had de.re.sive.*** total social participation score.was ne.ative.y associate. with de.re.sive.symptoms afte. adjusting for sociode.ographic *** ne.work of social participation and de.re.sive.symptoms showe. that“D9(Inability to ge. going)”and“S9(Watching TV and/or liste.ing to the.radio)”had the.highe.t stre.gth within de.re.sive.symptoms and social participation communitie.,re.pe.tive.y,and“S1(House.ork)”,“S9(Watching TV and/or liste.ing to the.radio)”,and“D5(Hope.e.sne.s)”we.e.the.most promine.t bridging node. be.we.n the.two *** e.ge. linking the.two communitie. we.e.ne.ative.“S5(Grade. work)-D5(Hope.e.sne.s)”and“S6(Re.ding ne.spape.s/books)-D4(e.e.ything was an e.fort)”we.e.the.top 2 stronge.t ne.ative.*** fe.ale. had signiﬁcantly de.se. ne.work structure. than olde. *** to olde. pe.ple.age. 65e.0,the.age.group 81e.05 showe. highe. ne.work global ***:This study provide. nove. insights into the.comple. re.ationships be.we.n social

关键词： De.re.sive.symptoms Ne.work analysis Olde. adults Se. characte.istics Social participation

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基于分层软总线的新型通用操作系统结构模型

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软件学报 2024年第10期35卷 4930-4947页

作者：杨攀董攀江哲丁滟国防科技大学计算机学院湖南长沙410073 Unive.sity of Cambridge Cambridge CB21TNUK

传统的操作系统设计所面临的主要挑战是需要管理的资源数量,多样性,分布范围不断增加以及系统状态频繁变化.然而,现有操作系统结构已经成为应对上述挑战的最大障碍,原因如下:(1)紧耦合和中心化的结构不仅损害了系统的灵活性和扩展性,还... 详细信息

传统的操作系统设计所面临的主要挑战是需要管理的资源数量,多样性,分布范围不断增加以及系统状态频繁变化.然而,现有操作系统结构已经成为应对上述挑战的最大障碍,原因如下:(1)紧耦合和中心化的结构不仅损害了系统的灵活性和扩展性,还导致了操作系统生态分离;(2)系统中单一的隔离机制,如内核态-用户态隔离,造成了各种能力之间的矛盾,如安全性和性能等.为此,结合简捷的分层软总线设计思想和多样化隔离机制来组织操作系统组件,提出一种新型操作系统模型——***将操作系统功能分解为以软总线相连接的组件节点,其通信被标准化为经软总线的消息传递.为支持特权态等隔离状态的划分和不同的软件层次,Yggdrasil还引入桥节点实现多层软总线的级联和受控通信,通过自相似的拓扑特性使操作系统的逻辑表述能力和扩展性都得到了极大的强化.此外,软总线的简单性和层次性也有助于实现去中心化.构建操作系统的分层软总线模型实例HiBuOS,通过3方面的具体设计验证并展示基于Yggdrasil思想来开发新型操作系统的可行性:(1)根据目标操作系统的规模和要求设计规划多层总线结构;(2)选择具体的隔离和通信机制实例化桥节点和软总线;(3)实现基于分层软总线风格的操作系统服务.对HiBuOS的评估表明,它没有引入明显的性能损耗,而且还在提高系统可扩展性,安全性和生态发展方面具有显著的优势和潜力.

关键词：分层软总线操作系统结构模型松耦合多样化隔离机制自相似性

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共生理论视域下城市阅读空间跨界重构——以上海“阅读+演艺”空间为中心的考察

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图书馆论坛 2024年第7期44卷 61-71页

作者：潘炜同济大学人文学院

跨界重构是文旅融合背景下阅读空间创新与业态升级的重要路径。上海阅读与演艺的跨界融合已探索出“书店+演艺”“图书馆+演艺”“文化馆阅读空间+演艺”“历史街区阅读空间+演艺”等四类空间模式。文章借鉴共生理论框架分析其生成机制... 详细信息

跨界重构是文旅融合背景下阅读空间创新与业态升级的重要路径。上海阅读与演艺的跨界融合已探索出“书店+演艺”“图书馆+演艺”“文化馆阅读空间+演艺”“历史街区阅读空间+演艺”等四类空间模式。文章借鉴共生理论框架分析其生成机制,研究发现:“阅读+演艺”空间是在政策环境和文化环境的协同驱动下,由阅读单元、演艺单元、消费单元的多元主体,基于物理嵌合、社会衔接、场景耦合三位一体的共生介质进行能量交互,并通过经济互利、偏利寄生、培育服务、社会互惠等行为模式与点共生、间歇共生、连续共生、一体化共生等结构模式实现空间共生的产物;初步显现出对宏观城市更新、中观文化生态优化、微观文化生产模式转型等的价值意义;下一阶段可通过政策工具引导、共生单元拓展、共生网络构建等措施推动“阅读+”空间的系统营造。

关键词： “阅读+演艺”空间跨界重构共生机制

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