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Bra.n, mind, a.d be.a.ior / Floyd e. Bloom, charles a. Ne.son, a.lyne.La.e.son. 3rd ed.

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Brain, mind, and behavior / Floyd E. Bloom, Charles A. Nelso...

Ha.dwriting a.a.ysis Ba.e. on Be.ie. of Ta.ge.e. Individua. Supporting Inside. Thre.t De.e.tion

2001年

作者： Floyd e. Bloom charles a. Ne.son a.lyne.La.e.son.

a.compa.ie. by e.e.tronic a.d print supple.e.ts for te.che.s a.d stude.ts.

ISBN: (纸本)0716723891

a.compa.ie. by e.e.tronic a.d print supple.e.ts for te.che.s a.d stude.ts.

关键词： Ne.ropsychology

来源：畅想之星图书光盘版（南... 评论

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Journa. of Informa.ion Se.urity 2024年第3期15卷 308-319页

作者： Ja.on Sla.ghte. Ca.ole.e. Cha.ki Ke.le. charles Ce.te. for Cybe.se.urity Re.e.rch a.d a.a.ysis (CCRa. Capitol Technology University Laurel United States

The.Uninte.tiona. Inside. Thre.t (UIT) conce.t highlights tha. inside. thre.ts might not a.wa.s ste. from ma.icious inte.t a.d ca. occur a.ross va.ious doma.ns. This re.e.rch e.a.ine. how individua.s with me.ica. or psychologica. issue. might uninte.tiona.ly be.ome.inside. thre.ts due.to the.r pe.ce.tion of be.ng ta.ge.e.. Insights from the.surve. a.Surve. of Uninte.tiona. Me.ica. Inside. Thre.t Ca.e.ory indica.e.tha. such pe.ce.tions ca. be.linke. to unde.lying he.lth conditions. The.study e.otion a.a.ysis Ba.e. on Be.ie. of Ta.ge.e. Individua. Supporting Inside. Thre.t De.e.tion re.e.ls tha. a.ge. is a.common e.otion a.ong the.e.individua.s. The.findings sugge.t tha. UITs a.e.ofte. linke. to me.ica. or psychologica. issue., with a.ge. be.ng pre.a.e.t. To mitiga.e.the.e.risks, it is re.omme.de. tha. Inside. Thre.t progra.s inte.ra.e.e.pe.tise.from me.icine. psychology, a.d cybe.se.urity. a.ditiona.ly, ha.dwriting a.a.ysis is propose. a. a.pote.tia. tool for de.e.ting inside. thre.ts, re.le.ting the.e.olving na.ure.of thre.t a.se.sme.t me.hodologie..

关键词： Inside. Thre.t De.e.tion Ta.ge.e. Me.ica.

Using Line.r a.d Non-Line.r Te.hnique. to Cha.a.te.ize.Ga.t Coordina.ion Pa.te.ns of Two Individua.s with NGLY1 De.icie.cy

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Ca.e.Re.orts in Clinica. Me.icine 2024年第9期13卷 391-409页

作者： charles S. La.ne.Da.ia.Ma.tine. Dia. Christophe. a. Ma.a.a.Brock Futre.l Christia. a.fa.o Ha.na. e. Gusta.son Be.nha.d Sute. De.a.tme.t of He.lth a.d Huma. Pe.forma.ce University of Houston Houston TX USA Ce.te. for Ne.romotor a.d Biome.ha.ics Re.e.rch University of Houston Houston TX USA Ce.te. for Ne.ro e.gine.ring a.d Cognitive.Scie.ce University of Houston Houston TX USA Re.e.rch Ce.te. Parker University Dallas TX USA Blue.Bird Circle.Re.t Ce.te. Texas Childrens Hospital Houston TX USA Ba.lor Colle.e.of Me.icine Houston TX USA

Individua.s with NGLY1 De.icie.cy, a. inhe.ite. a.tosoma. re.e.sive.disorde., e.hibit hype.kine.ic move.e.ts including a.he.oid, myoclonic, dysme.ric, a.d dystonic move.e.ts impa.ting both uppe. a.d lowe. limb motion. This re.ort provide. the.first se. of la.ora.ory-ba.e. me.sure. cha.a.te.izing the.ga.t pa.te.ns of two individua.s with NGLY1 De.icie.cy, using both line.r a.d non-line.r me.sure., during tre.dmill wa.king, a.d compa.e. the. to ne.rotypica. controls. Lowe. limb kine.a.ics we.e.obta.ne. with a.ca.e.a.ba.e. motion a.a.ysis syste. a.d bila.e.a. time.norma.ize. lowe. limb joint time.se.ie. wa.e.orms we.e.de.e.ope.. Line.r me.sure. of joint ra.ge.of motion, stride.time. a.d pe.k a.gula. ve.ocity we.e.obta.ne., a.d confide.ce.inte.va.s we.e.use. to de.e.mine.if the.e.we.e.diffe.e.ce. be.we.n the.pa.ie.ts a.d control. Corre.a.ions be.we.n pa.ticipa.t a.d control me.n joint wa.e.orms we.e.ca.cula.e. a.d use. to e.a.ua.e.the.simila.itie. be.we.n pa.ie.ts a.d controls. Non-line.r me.sure. include.: joint a.gle.a.gle.dia.ra.s, pha.e.portra.t a.e.s, a.d continuous re.a.ive.pha.e.(CRP) me.sure.. The.e.me.sure. we.e.use. to a.se.s joint coordina.ion a.d control fe.ture. of the.lowe. limb motion. Pa.ticipa.ts displa.e. high corre.a.ions with the.r control counte.pa.ts for the.hip a.d kne. joint wa.e.orms, but joint motion wa. re.tricte.. Pe.k a.gula. ve.ocitie. we.e.a.so significa.tly le.s tha. those.of the.controls. Both a.gle.a.gle.a.d pha.e.portra.t a.e.s we.e.le.s tha. the.controls a.though the.ge.e.a. sha.e. of those.dia.ra.s we.e.simila. to those.of the.controls. The.NGLY1 De.icie.t pa.ticipa.ts’ CRP me.sure. displa.e. disrupte. coordina.ion pa.te.ns with the.kne.-a.kle.pa.te.ns displa.ing more.disruption tha. the.hip-kne. me.sure.. Ove.a.l, the.pa.ticipa.ts displa.e. a.functiona. wa.king pa.te.n tha. diffe.e. in ma.y qua.tita.ive.wa.s from those.of the.ne.rotypica. controls. Using both line.r a.d non-line.r me.sure. to cha.a.te.ize.ga.t provide. a.more.compre

关键词： NGLY1 Ga.t Disa.ility Kine.a.ics a.gle.a.gle.Dia.ra.s Pha.e.Portra.ts

Curre.t de.ice.,outcome.,a.d pa.n ma.a.e.e.t conside.a.ions in pe.ile.impla.t surge.y:a. upda.e. re.ie. of the.lite.a.ure

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a.ia. Journa. of a.drology 2024年第4期26卷 335-343页

作者： Nirupa.a.a.cha.Ma.a.e.din Ta.a. Woodle.Sofia.Ge.e.a.Krishna.Ha.ipra.a. Ima.i Butle. e.charles Oste.be.g III De.a.tme.t of Surge.y a.d Pe.iope.a.ive.Ca.e University of Texas at Austin Dell Medical SchoolAustinTX 78712USA De.a.tme.t of Urology Brooke Army Medical CenterSan AntonioTX 78234USA De.a.tme.t of Mole.ula. Bioscie.ce. The University of Texas at AustinAustinTX 78712USA.

Pe.ile.prosthe.is surge.y is a.de.initive.tre.tme.t for e.e.tile.dysfunction(e.).The.two ca.e.orie. of pe.ile.prosthe.is a.e.e.dorse. by profe.siona. guide.ine.,infla.a.le.pe.ile.prosthe.is(IPP)a.d ma.le.ble.pe.ile.prosthe.is(MPP).e.ch moda.ity of pe.ile.prosthe.is offe.s distinct a.va.ta.e. a.d incorpora.e. spe.ific de.ign fe.ture.,a.lowing for pe.sona.ize. de.ice.se.e.tion tha. a.igns with individua. ne.ds a.d *** the.ove.a.l complica.ion ra.e.of pe.ile.impla.t surge.y re.a.ns low,surge.ns should ma.nta.n a.high inde. of suspicion for complica.ions in the.pe.iope.a.ive.time.*** a.a.ge.ic re.ime.s including ne.ve.blocks a.d na.cotic-fre. pa.hwa.s should be.a.ministe.e. to ma.a.e.pe.iope.a.ive.***,the.high pa.ie.t sa.isfa.tion a.te. pe.ile.prosthe.is surge.y unde.score. the.succe.s of this e. tre.tme.t option.

关键词： e.e.tile.dysfunction pe.ile.impla.t pe.ile.prosthe.is

Gove.na.ce.in the.e.plora.ion of globa. a.d re.iona. de.e.mina.ts of ICT de.e.opme.t

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Inte.na.iona. Journa. of Innova.ion Studie. 2024年第2期8卷 132-153页

作者： charles S.Sa.a.Simplice.a.a.ongu Nichola. Nge.a. Yola.de.e.Ngoungou School of e.onomics College of Business and EconomicsUniversity of JohannesburgJohannesburgSouth Africa De.a.tme.t of e.onornic&Da.a.Scie.ce New Uzbekistan University54 Mustaili AvenueTashkent100007Uzbekistan Unive.sity of Ya.unde.2 SoaCameroon

The.pre.e.t study a.se.se. how gove.na.ce.a.fe.ts informa.ion a.d communica.ion te.hnology(IcT)a. the.globa. le.e. continge.t on ma.roe.onomic policy fa.tors such a. tra.e.fore.gn dire.t inve.tme.t(FDI),ma.ufa.turing va.ue.a.de.,a.d a.ricultura. va.ue.*** study focuse. on 183 countrie. from 2003 to 2021,a.d the.e.pirica. e.ide.ce.is ba.e. on the.ge.e.a.ize. me.hod of mome.ts(GMM).The.following ma.n findings a.e.*** the.full sa.ple.gove.na.ce.unconditiona.ly promote. ICT de.e.opme.t,while.tra.e.ope.ne.s(industria. a.de. va.ue.mode.a.e. gove.na.ce.to promote.da.pe.)ICT *** sub-Sa.a.a. a.rica.only tra.e.ope.ne.s e.fe.tive.y mode.a.e. gove.na.ce.to induce.a. ove.a.l positive.e.fe.t on ICT,while.in the.Middle.e.st a.d North a.rica.Me.a.re.ion,a.l policy va.ia.le. mode.a.e.gove.na.ce.for a. ove.a.l positive.incide.ce.on ICT se.tor *** findings for the.Me.a.re.ion a.e.confirme. in the.e.rope.a.d Ce.tra. a.ia.e.a.re.ion,with the.e.ce.tion of the.mode.a.ing role.of industria. a.de. va.ue.which e.ge.de.s a. ove.a.l ne.a.ive.*** the.e.st a.d South a.ia.a.d the.Pa.ific(e.a.)countrie.,one.ove.a.l positive.incide.ce.is a.pa.e.t in the.role.of tra.e.ope.ne.s,while.ne. ne.a.ive.e.fe.ts a.e.e.ta.lishe. from the.mode.a.ing role. of industria. a.de. va.ue.a.d a.ricultura. a.de. *** the.a.e.ica. sub-sa.ple.a.positive.ne.a.ive.ne. e.fe.t is a.pa.e.t from the.role.of industria. a.de. va.ue.tra.e.in mode.a.ing the.incide.ce.of gove.-na.ce.on ICT se.tor ***,policy implica.ions a.e.discusse..

关键词： ICT Gove.na.ce Tra.e FDI Industry a.riculture

3-Dime.siona. Kine.a.ic Compa.ison of a.m Move.e.ts be.we.n a. Individua. with NGLY1 De.icie.cy a.d a.Ne.rotypica. Individua.

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Ca.e.Re.orts in Clinica. Me.icine 2024年第4期13卷 122-146页

作者： charles S. La.ne.Christophe. a. Ma.a.a.Brock Futre.l Da.ia.Ma.tine. Dia. Christia. a.fa.o Ha.na. e. Gusta.son Subha.a.shmi Cha.dra.e.a.a. Rhe. M. Pha.a. Be.nha.d Sute. De.a.tme.t of He.lth a.d Huma. Pe.forma.ce University of Houston Houston TX USA Ce.te. for Ne.romotor a.d Biome.ha.ics Re.e.rch University of Houston Houston TX USA Ce.te. for Ne.ro e.gine.ring a.d Cognitive.Scie.ce University of Houston Houston TX USA De.a.tme.t of Compute. Scie.ce.a.d e.gine.ring Texas A&M University College Station TX USA Blue.Bird Circle.Re.t Ce.te. Texas Children&#8217s Hospital Houston TX USA Ba.lor Colle.e.of Me.icine Houston TX USA

NGLY1 De.icie.cy is a. ultra.ra.e.a.tosoma. re.e.sive.y inhe.ite. disorde.. Cha.a.te.istic symptoms include.a.ong othe.s, de.e.opme.ta. de.a.s, move.e.t disorde.s, live. function a.norma.itie., se.zure., a.d proble.s with te.r forma.ion. Move.e.ts a.e.hype.kine.ic a.d ma. include.dysme.ric, chore.-a.he.oid, myoclonic a.d dystonic move.e.t e.e.e.ts. To da.e. the.e.ha.e.be.n no qua.tita.ive.re.orts de.cribing a.m move.e.ts of individua.s with NGLY1 De.icie.cy. This re.ort provide. qua.tita.ive.informa.ion a.out a.se.ie. of a.m move.e.ts pe.forme. by a. individua. with NGLY1 De.icie.cy a.d a. a.e.-ma.che. ne.rotypica. pa.ticipa.t. Thre. ca.e.orie. of a.m move.e.ts we.e.te.te.: 1) ope. e.de. re.che. without spe.ific e.d point ta.ge.s;2) goa.-dire.te. re.che. tha. include. gra.ping a. obje.t;3) picking up sma.l obje.ts from a.ta.le.pla.e. in front of the.pa.ticipa.ts. a.m move.e.t kine.a.ics we.e.obta.ne. with a.ca.e.a.ba.e. motion a.a.ysis syste. a.d “initia.ion” a.d “ma.nte.a.ce. pha.e. we.e.ide.tifie. for e.ch move.e.t. The.combina.ion of the.two pha.e. wa. la.e.e. a. a.“comple.e. move.e.t. Thre.-dime.siona. a.a.ysis te.hnique. we.e.use. to qua.tify the.move.e.ts a.d include. ha.d tra.e.tory pa.hle.gth, joint motion a.e., a. we.l a. ha.d tra.e.tory a.d joint je.k cost. The.e.te.hnique. we.e.re.uire. to fully cha.a.te.ize.the.move.e.ts be.a.se.the.NGLY1 individua. wa. una.le.to pe.form move.e.ts only in the.prima.y pla.e.of progre.sion inste.d producing motion a.ross a.l thre. pla.e. of move.e.t. The.individua. with NGLY1 De.icie.cy wa. una.le.to pick up obje.ts from a.ta.le.or e.fe.tive.y comple.e.move.e.ts re.uiring crossing the.midline. The.succe.sfully comple.e. move.e.ts we.e.a.a.yze. using the.a.ove.te.hnique. a.d the.re.ults of the.two pa.ticipa.ts we.e.compa.e. sta.istica.ly. a.most a.l compa.isons re.e.le. significa.t diffe.e.ce. be.we.n the.two pa.ticipa.ts, with a.nota.le.e.ce.tion of the.3D initia.ion a.e. a. a.pe.ce.ta.e.of the.comple.e.move.e.t. The.sta.i

关键词： NGLY1 De.icie.cy De.e.opme.ta. Disorde.s Kine.a.ics 3 Dime.siona. a.a.yse.

Thre.-dime.siona. nume.ica. a.a.ysis of pla.t-soil hydra.lic inte.a.tions on pore.wa.e. pre.sure.of ve.e.a.e. slope.unde. diffe.e.t ra.nfa.l pa.te.ns

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Journa. of Rock Me.ha.ics a.d Ge.te.hnica. e.gine.ring 2024年第9期16卷 3696-3706页

作者： Ha.we. Guo charles Wa.g Wa. Ng Qi Zha.g De.a.tme.t of Civil a.d e.vironme.ta. e.gine.ring The Hong Kong University of Science and TechnologyHong KongChina

Unde.sta.ding the.pore.wa.e. pre.sure.distribution in unsa.ura.e. soil is crucia. in pre.icting sha.low la.dslide. trigge.e. by ra.nfa.l,ma.nly whe. de.ling with diffe.e.t te.pora. pa.te.ns of ra.nfa.l ***,the.hydrologica. re.ponse.of ve.e.a.e. slope.,e.pe.ia.ly thre.-dime.siona.(3D)slope. cove.e. with shrubs,unde. diffe.e.t ra.nfa.l pa.te.ns re.a.ns uncle.r a.d re.uire. furthe. *** a.dre.s this issue.this study a.opts a.nove. 3D nume.ica. mode. for simula.ing hydra.lic inte.a.tions be.we.n the.root syste. of the.shrub a.d the.surrounding *** se.ie. of nume.ica. pa.a.e.ric studie. a.e.conducte. to inve.tiga.e.the.influe.ce. of slope.inclina.ion,ra.nfa.l pa.te.n a.d ra.nfa.l *** ra.nfa.l pa.te.ns(a.va.ce.,bimoda.,de.a.e.,a.d uniform)a.d two ra.nfa.l dura.ions(4-h inte.se.a.d 168-h mild ra.nfa.l)a.e.conside.e. to study the.hydrologica. re.ponse.of the.*** compute. re.ults show tha. 17%highe. tra.spira.ion-induce. suction is found for a.ste.pe. slope.which re.a.ns e.e. a.te. a.short,inte.se.ra.nfa.l with a.100-ye.r re.urn *** e.tre.e.ra.nfa.ls with a.va.ce.(Pa.,bimoda.(PB)a.d uniform(PU)ra.nfa.l pa.te.ns ne.d to be.conside.e. for the.short ra.nfa.l dura.ion(4 h),while.the.de.a.e.(PD)a.d uniform(PU)ra.nfa.l pa.te.ns a.e.highly re.omme.de. for long ra.nfa.l dura.ions(168 h).The.pre.e.ce.of pla.ts ca. improve.slope.sta.ility ma.ke.ly unde. e.tre.e.ra.nfa.l with a.short dura.ion(4 h).For the.long dura.ion(168 h),the.be.e.it of the.pla.t in pre.e.ving pore.wa.e. pre.sure.PWP)a.d slope.sta.ility ma. not be.sufficie.t.

关键词： Root-soil inte.a.tions Ra.nfa.l pa.te.ns Slope.sta.ility Thre.-dime.siona.(3D)

Me.a.olic re.rogra.ming of the.infla.ma.ory re.ponse.in the.ne.vous syste.:the.crossove. be.we.n infla.ma.ion a.d me.a.olism

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Ne.ra. Re.e.e.a.ion Re.e.rch 2024年第10期19卷 2189-2201页

作者： Je.us a.o-a.a.icio charles a.Dina.e.lo Rube. Lope.-Va.e. De.a.tme.t of Me.icine University of ColoradoAuroraCOUSA Institute.of Ne.roscie.ce. and Department Cell BiologyPhysiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain Ce.tro de.Inve.tiga.ión Biomédica.e. Re. sobre.e.fe.me.a.e. Ne.rode.e.e.a.iva.(CIBe.Ne.) Instituto de Salud Carlos ⅢSpain

Me.a.olism is a.funda.e.ta. proce.s by which bioche.ica.s a.e.broke. down to produce.e.e.gy(ca.a.olism) or use. to build ma.romole.ule.(a.a.olism). Me.a.olism ha. re.e.ve. re.e.e. a.te.tion a. a.me.ha.ism tha. ge.e.a.e. mole.ule. tha. modula.e.multiple.ce.lula. re.ponse.. This wa. first ide.tifie. in ca.ce. ce.ls a. the.Wa.burg e.fe.t, but it is a.so pre.e.t in immunocompe.e.t ce.ls. Studie. ha.e.re.e.le. a.bidire.tiona. influe.ce.of ce.lula. me.a.olism a.d immune.ce.l function, highlighting the.significa.ce.of me.a.olic re.rogra.ming in immune.ce.l a.tiva.ion a.d e.fe.tor functions. Me.a.olic proce.se. such a. glycolysis, oxida.ive.phosphoryla.ion, a.d fa.ty a.id oxida.ion ha.e.be.n shown to unde.go dyna.ic cha.ge. during immune.ce.l re.ponse. fa.ilita.ing the.e.e.ge.ic a.d biosynthe.ic de.a.ds. This re.ie. a.ms to provide.a.be.te. unde.sta.ding of the.me.a.olic re.rogra.ming tha. occurs in diffe.e.t immune.ce.ls upon a.tiva.ion, with a.spe.ia. focus on ce.tra. ne.vous syste. disorde.s. Unde.sta.ding the.me.a.olic cha.ge. of the.immune.re.ponse.not only provide. insights into the.funda.e.ta. me.ha.isms tha. re.ula.e.immune.ce.l function but a.so ope.s ne. a.proa.he. for the.a.e.tic stra.e.ie. a.me. a. ma.ipula.ing the.immune.syste..

关键词： ce.tra. ne.vous syste. fa.ty a.id oxida.ion glycolysis infla.ma.ion ma.ropha.e me.a.olism microglia ne.rode.e.e.a.ion oxida.ive.phosphoryla.ion

The.de.ive.y of N-myc downstre.m-re.ula.e. ge.e.2(NDRG2)se.f-a.plifying mRNa.via.modifie. lipid na.opa.ticle. a. a.pote.tia. tre.tme.t for drug-re.ista.t a.d me.a.ta.ic ca.ce.s

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Me.ica. Re.ie. 2024年第3期4卷 235-238页

作者： Sa.dra.e.Re.nik a.it K.Tiwa.i Vive. Cha.da.charles R.a.hby Jr. De.a.tme.t of Pha.ma.e.tica. Scie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA De.a.tme.ts of Pa.hology a.d Obste.rics a.d Gyne.ology a.d Wome.’s He.lth Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA De.a.tme.t of Pha.ma.e.tica. Scie.ce. College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA De.a.tme.t of Pha.ma.e.tics a.d Pha.ma.e.tica. Te.hnology L.M.Colle.e.of Pha.ma.y AhmedabadIndia De.a.tme.t of Pha.ma.e.tica. Scie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The.prote.n,N-myc downstre.m-re.ula.e. ge.e.2(NDRG2),a.tumor suppre.sor,is significa.tly de.re.se. or a.se.t in ma.y type. of *** is a.significa.t ne.a.tive.corre.a.ion be.we.n the.le.e.s of NDRG2 a.d the.de.e.opme.t a.d progre.sion of ca.ce. tumor re.urre.ce.a.d tumor inva.ion,in diffe.e.t *** contra.t,the.in vitro a.d in vivo ove.e.pre.sion of the.NDRG2 prote.n de.re.se. the.prolife.a.ion,growth,a.he.ion a.d migra.ion of ma.y type. of ca.ce. *** in vitro ove.e.pre.sion of NDRG2 incre.se. the.e.fica.y of ce.ta.n a.tica.ce. drugs in spe.ific type. of ca.ce. *** hypothe.ize.tha. the.de.ive.y of the.mRNa.of the.NDRG2 prote.n,e.ca.sula.e. by lipid na.opa.ticle.,could re.re.e.t a.pote.tia. tre.tme.t of me.a.ta.ic a.d drug-re.ista.t *** would be.a.complishe. using a.se.f-a.plifying mRNa.tha. e.code. the.NDRG2 prote.n a.d a. RNa.de.e.de.t-RNa.polyme.a.e.obta.ne. from a. in vitrotra.scribe.(IVT)*** IVT mRNa.would be.e.ca.sula.e. in a.lipid *** e.fica.y of the.na.oformula.ion would be.de.e.mine. in culture. ca.ce. ce.ls a.d if the.re.ults a.e.positive.nude.mice.tra.spla.te. with e.the. drug-re.ista.t or me.a.ta.ic drug-re.ista.t ca.ce. ce.ls,would be.tre.te. with the.na.oformula.ion a.d monitore. for e.fica.y a.d a.ve.se.*** the.a.propria.e.pre.linica. studie. indica.e.this formula.tion is e.fica.ious a.d sa.e.it is possible.it could be.e.a.ua.e. in clinica. tria.s.

关键词： N-myc downstre.m-re.ula.e. ge.e.2(NDRG2) ca.ce. se.f-a.plifying mRNA na.opa.ticle