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effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors

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World Journal of Gastroenterology 2006年第24期12卷 3835-3840页

作者： P Baier G Wolf-Vorbeck S Hempel UT Hopt e von dobschuetz Department of General and Visceral Surgery Albert-Ludwigs-University FreiburgGermany

AIM： To investigate the effects of experimental partial hepatectomy and normothermic ischemia-reperfusion damage on the time course of the expression of four different growth factor receptors in liver regeneration. This is relevant due to the potential therapeutic use of growth factors in stimulating liver regeneration. MeTHODS： For partial hepatectomy （PH） 80% of the liver mass was resected in Sprague Dawley rats. Ischemia and reperfusion （I/R） were induced by occlusion of the portal vein and the hepatic artery for 15 min. The epidermal growth factor receptor, hepatic growth factor receptor, fibroblast growth factor receptor and tumour necrosis factor receptor-1 were analysed by immunohistochemistry up to 72 h after injury. Quantitative RT-PCR was performed at the time point of minimal receptor expression （24 h）. ReSULTS： In immunohistochemistry, eGFR, HGFR, FGFR and TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h, a nadir after 24 h and another weak increase up to 72 h. During liver regeneration, after ischemia and reperfusion, the receptor expression was lower; the nadir at 24 h after reperfusion was the same. To evaluate whether this nadir was caused by a lack of mRNA transcription, or due to a posttranslational regulation, RT-PCR was performed at 24 h and compared to resting liver. In every probe there was specific mRNA for the receptors. eGFR, FGFR and TNFR1 mRNA expression was equal or lower than in resting liver, HGFR expression after I/R was stronger than in the control. CONCLUSION： At least partially due to a post-transcriptional process, there is a nadir in the expression of the analysed receptors 24 h after liver injury. Therefore, a therapeutic use of growth factors to stimulate liverregeneration 24 h after the damage might be not successful.

关键词： Partial hepatectomy Liver ischemia Growthfactor receptors

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Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo Marcelo Nosetto Pablo e.Villagra ezequiel Balducci Martín Pinazo Roxana P.eclesia Alejandra von Wallis Sebastián Villarino Francisco Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónaco Jimena e.Chaves Ariel Medina Ignacio Gasparri eugenio Alvarez Arnesi María Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe echevarria Pedro Fernández Marina Morsucci Dardo López Juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo Martínez Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de estudio de Agroecosistemas y Paisajes Rurales (GeAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de estudio de Agroecosistemas y Paisajes Rurales (GeAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de estudios Ambientales Integrados (CeAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（ReDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google earth engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on enhanced Vegetation Index（eVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation Modelling Resilience

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Learning the optimal power flow:environment design matters

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energy and AI 2024年第3期17卷 432-443页

作者： Thomas Wolgast Astrid Nieße Carl von Ossietzky Universität Oldenburg Department of Computing ScienceDigitalized Energy SystemsAmmerländer Heerstraße 114-118Oldenburg26129Germany

To solve the optimal power flow(OPF)problem,reinforcement learning(RL)emerges as a promising new ***,the RL-OPF literature is strongly divided regarding the exact formulation of the OPF problem as an RL *** this work,we collect and implement diverse environment design decisions from the literature regarding training data,observation space,episode definition,and reward function *** an experimental analysis,we show the significant impact of these environment design options on RL-OPF training ***,we derive some first recommendations regarding the choice of these design *** created environment framework is fully open-source and can serve as a benchmark for future research in the RL-OPF field.

关键词： Reinforcement learning Optimal power flow environment design economic Dispatch Voltage control Reactive power market

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam e.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann eva Pawlus Kian eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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New Record Ocean Temperatures and Related Climate Indicators in 2023

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Advances in Atmospheric Sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHeNG John ABRAHAM Kevin e.TReNBeRTH Tim BOYeR Michael eMANN Jiang ZHU Fan WANG Fujiang YU Ricardo LOCARNINI John FASULLO Fei ZHeNG Yuanlong LI Bin ZHANG Liying WAN Xingrong CHeN Dakui WANG Licheng FeNG Xiangzhou SONG Yulong LIU Franco ReSeGHeTTI Simona SIMONCeLLI Viktor GOUReTSKI Gengxin CHeN Alexey MISHONOV Jim ReAGAN Karina von SCHUCKMANN Yuying PAN Zhetao TAN Yujing ZHU Wangxu WeI Guancheng LI Qiuping ReN Lijuan CAO Yayang LU International Center for Climate and environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of St.Thomas School of EngineeringMinnesota 55105USA NSF National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of earth and environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China eSSIC/CISeSS-MD University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France eco-environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human *** 2023,the sea surface temperature(SST)and upper 2000 m ocean heat content(OHC)reached record *** 0–2000 m OHC in 2023 exceeded that of 2022 by 15±10 ZJ(1 Zetta Joules=1021 Joules)(updated IAP/CAS data);9±5 ZJ(NCeI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean Sea,and southern oceans recorded their highest OHC observed since the *** with the onset of a strong el Niño,the global SST reached its record high in 2023 with an annual mean of~0.23℃ higher than 2022 and an astounding>0.3℃ above 2022 values for the second half of *** density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2023.

关键词： ocean heat content salinity stratification global warming climate

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Depth Distributions of Belowground Production, Biomass and Decomposition in Restored Tallgrass Prairie

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Pedosphere 2019年第4期29卷 457-467页

作者： Adam C.von HADeN Mathew e.DORNBUSH environmental Science and Policy Graduate Program University of Wisconsin- Green Bay Green Bay WI 54311 (USA) Great Lakes Bioenergy Research Center University of Wisconsin-Madison Madison WI 53726 (USA) Department of Natural and Applied Sciences University of Wisconsin- Green Bay Green Bay WI 54311 (USA)

Grasslands store large stocks of soil organic carbon(SOC) in the subsoil, but our knowledge of belowground processes becomes less robust with depth. Vertically explicit SOC models typically assume that the depth distribution of belowground production follows the depth distribution of belowground biomass, but this assumption has not been tested. In addition to the effects of soil temperature and moisture on decomposition, some vertically explicit SOC models implement an intrinsic decrease in belowground decomposition with depth, yet this effect has rarely been observed empirically. We simultaneously measured the depth distributions of belowground biomass, production, and litter decomposition to assess whether belowground biomass depth distributions were suitable predictors of belowground production and whether belowground decomposition decreased with soil profile depth. We found that live and total(live +dead) belowground biomass was distributed relatively more shallowly than total belowground production, and thus total belowground biomass was a biased predictor of the vertical distribution of belowground production. The depth distribution of live roots eter was found to be the best predictor of total belowground production depth distribution. Using an intact decay core method,we found that belowground litter decomposition decreased by 49% from 0–10 to 30–40 cm depth, and model-simulated effects of soil temperature and moisture accounted for only 9% of the observed decrease with depth. Vertically explicit SOC models can be improved with more accurate empirical belowground production depth distribution estimates, but depth-specific decomposition rates currently implemented in SOC models are necessary to explain observed decreases in belowground litter decay with depth.

关键词： carbon decomposition litter decay model simulation roots soil organic carbon soil organic matter temperate grassland vertical rooting distributions

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A good gut feeling on Sarm1-mediated axon degeneration

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Protein & Cell 2021年第8期12卷 596-598页

作者： Victoria e.von Saucken David J.Simon Department of Biochemistry Weill Cornell Medical College Tri-Institutional MD-Ph D Program Weill Cornell Medicine Rockefeller University Memorial Sloan Kettering Cancer Center

Axons,the cable-l ike projections of neurons,experience a wide range of stressors throughout their *** result of any one of these challenges can be catastrophic,promoting degeneration of the *** degeneration is an active signaling process observed in traumatic brain injury,chemotherapy-induced peripheral neuropathies,and neurodegen erative disease (Simon and Watkins,2018;Coleman and Hoeke,2020).As a result,tremendous efforts have been made to identify biological targets that can be harnessed to block axon degeneration to treat these *** promising candidate is Sarm1 (sterile alpha and TIR motif containing protein 1),a member of the Myd88 immune adaptor protein family that itself has no clear role in innate immunity.

关键词： SARM1 ACTIVATION TRIGGeRS DeATH

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Multiply Charged Anions,Maximum Charge Acceptance,and Higher electron Affinities of Molecules,Superatoms,and Clusters

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物理化学学报 2018年第6期34卷 675-682页

作者： von SZeNTPáLY László Institut fur Theoretische Chemie Universitat Stuttgart Pfaffenwaldring 55 70569 Stuttgart Germany.

The addition of electrons to form gas-phase multiply charged anions(MCAs)normally requires sophisticated experiments or *** this work,the factors stabilizing the MCAs,the maximum electron uptake of gas-phase molecules,X,and the electronic stability of MCAs X^(Q-),are *** drawbacks encountered when applying computational and/or conceptual density functional theory(DFT)to MCAs are *** develop and test a different model based on the valence-state *** in DFT,the electronic energy,e(N,v_(ex)),is a continuous function of the average electron number,N,and the external potential,v_(ex),of the *** valence-state-parabola is a second-order polynomial that allows extending e(N,v_(ex))to dianions and higher *** model expresses the maximum electron acceptance,Q_(max),and the higher electron affinities,A_Q,as simple functions of the firstelectron affinity,A_1,and the ionization energy,I,of the"ancestor"***,the maximum electron acceptance is Q_(max,calc)=1+12A_1/7(I-A_1).The ground-state parabola model of the conceptual DFT yields approximately half of this value,and it is termed Q_(max,GS)=?+A_1/(I-A_1).A large variety of molecules are evaluated including fullerenes,metal clusters,super-pnictogens,super-halogens(OF_3),super-alkali species(OLi_3),and neutral or charged transition-metal complexes,AB_(m )L_n^(0/+/-).The calculated second electron affinity A_(2,calc)=A_1-(7/12)(I-A_1)is linearly correlated to the literature references A_(2,lit) with a correlation coefficient R=0.998.A_2 or A_3 values are predicted for further 24 *** appearance sizes,n_(ap)^(3-),of triply charged anionic clusters and fullerenes are calculated in agreement with the literature.

关键词： Multiply charged negative ions Their appearance sizes Second electron affinity Third electronaffinity Conceptual density-functional theory Valence-state parabola model of electronegativity

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Groupoid Approach to ergodic Dynamical System of Commutative von Neumann Algebra

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Advances in Pure Mathematics 2024年第3期14卷 167-184页

作者： Nicholas O. Okeke Murphy e. egwe Physical and Mathematical Sciences Dominican University Ibadan Nigeria Department of Mathematics University of Ibadan Ibadan Nigeria

Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bounded functions L∞(X, μ) on X. We confirm that the commutative von Neumann algebras M⊂B(H), with H=L2(X, μ), are unitary equivariant to the maximal ideals of the commutative algebra C(X). Subsequenly, we use the measure groupoid to formulate the algebraic and topological structures of the commutative algebra C(X) following its action on M(X) and define its representation and ergodic dynamical system on the commutative von Neumann algebras of M of B(H) .

关键词： Measure Groupoid Groupoid equivalence ergodic Action Convolution Algebra von Neumann Algebra Generalized Space

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Mass transfer and loss of the massive semi-detached binary AI Crucis

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Research in Astronomy and Astrophysics 2010年第5期10卷 438-444页

作者： er-Gang Zhao Sheng-Bang Qian e. Femanindez Lajus Carolina von essen Li-Ying Zhu National Astronomical Observatories / Yunnan Observatory Chinese Academy of SciencesKunming 650011 China Key Laboratory for the Structure and evolution of Celestial Objects Chinese Academy ofSciences Kunming 650011 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Facultad de Ciencias Astron6micas y Geoffsicas Universidad Nacional de La Plata 1900 LaPlata Buenos Aires Argentina

AI Crucis is a short-period semi-detached massive close binary （P = 1.41771d, Sp.=B1.5） in the open cluster NGC 4103. It is a good astrophysical laboratory for investigating the formation and evolution of massive close binary stars via case A mass transfer. Orbital period variations of the system were analyzed based on one newly determined eclipse time and the others compiled from the literature. It is discovered that the orbital period of the binary is continuously increasing at a rate of dP/dt = ＋1.00（±0.04） × 10-7 d yr-1. After the long-term increase is subtracted from the O - C diagram, weak evidence indicates the presence of a cyclic oscillation with a period of 30.1yr, which may reveal a very cool stellar companion in the system. The long-term period increase can be explained by mass transfer from the less massive component to the more massive one. This is in agreement with the semidetached configuration of the binary, indicating that the system is undergoing a slow mass-transfer stage on the nuclear time scale of the secondary. However, it is found that the slow mass transfer is insufficient to cause the observed period increase, which suggests that the stellar wind from the hot component should contribute to the amount of period increase dP/dt = ＋0.54× 10-7 d yr-1 that corresponds to a mass loss rate of M˙1 = 2.72 × 10-7 M yr-1. It is estimated that the hot component lost a total mass of 4.1M during the slow mass-transfer stage and, thus, the evolution of the binary system should be changed greatly by the mass loss.

关键词： stars: binaries: close — stars: binaries: eclipsing — stars: individual (AI Crucis) — stars: early-type — stars: evolution

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